The network for 'positive regulation of stem cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of stem cell differentiation

Any process that activates or increases the frequency, rate or extent of stem cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.996
Smad4MAD homolog 4 (Drosophila)0.994
Yap1yes-associated protein 10.984
Ctnnb1catenin (cadherin associated protein), beta 10.978
Hand1heart and neural crest derivatives expressed transcript 10.972
Ptf1apancreas specific transcription factor, 1a0.953
Axin1axin 10.906
Smad3MAD homolog 3 (Drosophila)0.900
Smad1MAD homolog 1 (Drosophila)0.898
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.879
Tbx3T-box 30.876
Pax3paired box gene 30.858
Snai1snail homolog 1 (Drosophila)0.854
Apcadenomatosis polyposis coli0.848
Foxh1forkhead box H10.811
Neurod1neurogenic differentiation 10.771
Runx1runt related transcription factor 10.734
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.724
Bmp4bone morphogenetic protein 40.721
Hand2heart and neural crest derivatives expressed transcript 20.716
Ascl1achaete-scute complex homolog 1 (Drosophila)0.704
Tgfb2transforming growth factor, beta 20.698
Atoh7atonal homolog 7 (Drosophila)0.686
Smad6MAD homolog 6 (Drosophila)0.618
Nkx6-1NK6 homeobox 10.579
Gli2GLI-Kruppel family member GLI20.569
Gata6GATA binding protein 60.537
Smad7MAD homolog 7 (Drosophila)0.526
Tal1T-cell acute lymphocytic leukemia 10.519
Runx2runt related transcription factor 20.513
Ptenphosphatase and tensin homolog0.506
Prrx1paired related homeobox 10.502
Hic1hypermethylated in cancer 10.482
Wwtr1WW domain containing transcription regulator 10.469
Neurog2neurogenin 20.460
Pitx1paired-like homeodomain transcription factor 10.456
Notch1Notch gene homolog 1 (Drosophila)0.456
Gsk3bglycogen synthase kinase 3 beta0.443
Nodalnodal0.440
Sox4SRY-box containing gene 40.436
Col1a1collagen, type I, alpha 10.405
Fgfr2fibroblast growth factor receptor 20.404
Pdx1pancreatic and duodenal homeobox 10.404
Zic3zinc finger protein of the cerebellum 30.399
Nhlh1nescient helix loop helix 10.386
Neurod4neurogenic differentiation 40.379
Gata4GATA binding protein 40.378
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.361
Onecut1one cut domain, family member 10.360
Ror2receptor tyrosine kinase-like orphan receptor 20.355
Efna2ephrin A20.354
Gdf3growth differentiation factor 30.346
Gata1GATA binding protein 10.344
Foxc1forkhead box C10.342
Tead3TEA domain family member 30.338
Msx1homeobox, msh-like 10.297
Neurog3neurogenin 30.296
Insm1insulinoma-associated 10.282
Crb1crumbs homolog 1 (Drosophila)0.271
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.266
Nf1neurofibromatosis 10.254
Trp53transformation related protein 530.245
Crb2crumbs homolog 2 (Drosophila)0.241
Sox9SRY-box containing gene 90.241
Rxraretinoid X receptor alpha0.240
Gli3GLI-Kruppel family member GLI30.227
Foxf1aforkhead box F1a0.219
Foxa2forkhead box A20.217
Gata2GATA binding protein 20.217
Prph2peripherin 20.215
En1engrailed 10.213
Col5a1collagen, type V, alpha 10.210
Tcf21transcription factor 210.207
MecomMDS1 and EVI1 complex locus0.205
Fgf8fibroblast growth factor 80.202
Dok1docking protein 10.196
Fgf15fibroblast growth factor 150.196
Hoxb4homeobox B40.194
Twist2twist homolog 2 (Drosophila)0.193
Bmp2bone morphogenetic protein 20.187
Hoxa13homeobox A130.186
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.183
Nesnestin0.179
Cdkn2acyclin-dependent kinase inhibitor 2A0.174
Tgfbr2transforming growth factor, beta receptor II0.171
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.170
Lhx5LIM homeobox protein 50.158
Axin2axin20.153
Msx2homeobox, msh-like 20.150
Rnf111ring finger 1110.140
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.140
Lrp6low density lipoprotein receptor-related protein 60.137
Hoxd13homeobox D130.136
Acvr1activin A receptor, type 10.133
Pax6paired box gene 60.133
Tlx3T-cell leukemia, homeobox 30.131
Csf1colony stimulating factor 1 (macrophage)0.130
Hoxa5homeobox A50.122
Hoxb6homeobox B60.120
Tead1TEA domain family member 10.118
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pry-1Protein PRY-10.724
bar-1Protein BAR-10.604
elt-6Protein ELT-60.577
pha-4Protein PHA-40.435
egl-18Protein EGL-180.425
sma-6Protein SMA-60.199
pop-1Protein POP-10.167
eor-1Protein EOR-10.156
cdf-1Protein CDF-10.151
ten-1Protein TEN-10.150
hmg-20Protein HMG-200.122
sel-8Protein SEL-80.120
ing-3Protein ING-30.109
sec-6Protein SEC-60.101
haf-2Protein HAF-20.100
axl-1Protein AXL-10.097
lir-1Protein LIR-10.090
CELE_F59A6.5Protein F59A6.50.083
R90.1Protein R90.10.080
hmp-2Protein HMP-20.077
W06A7.2Protein W06A7.20.075
nhr-10Protein NHR-100.071
F52C9.7Protein F52C9.70.065
lag-2Protein LAG-20.063
cls-1Protein CLS-10.060
lit-1Protein LIT-10.059
faah-1Protein FAAH-10.059
smp-1Protein SMP-10.055
spr-5Protein SPR-50.053
K08D10.1Protein K08D10.10.053
hlh-1Protein HLH-10.051
del-5Protein DEL-50.050
swsn-2.1Protein SWSN-2.10.050
acin-1Protein ACIN-10.050
wip-1Protein WIP-10.047
eya-1Protein EYA-10.045
mtm-1Protein MTM-10.044
B0432.13Protein B0432.130.044
K02C4.5Protein K02C4.50.043
let-756Protein LET-7560.043
pph-4.1Protein PPH-4.10.043
sur-2Protein SUR-20.042
lin-36Protein LIN-360.040
zyg-9Protein ZYG-90.040
lin-12Protein LIN-120.040
exc-5Protein EXC-50.039
nhr-67Protein NHR-670.038
unc-73Protein UNC-730.036
F11E6.7Protein F11E6.70.036
sma-10Protein SMA-100.034
nhr-46Protein NHR-460.034
scc-1Protein SCC-10.034
CELE_M04F3.5Protein M04F3.50.034
dpy-22Protein DPY-220.034
wrm-1Protein WRM-10.033
T12E12.3Protein T12E12.30.031
tag-260Protein TAG-2600.030
lpr-2Protein LPR-20.030
T23F4.2Protein T23F4.20.030
spt-5Protein SPT-50.029
nhr-45Protein NHR-450.029
nhr-184Protein NHR-1840.029
B0001.3Protein B0001.30.029
dog-1Protein DOG-10.029
ceh-20Protein CEH-200.029
nhr-34Protein NHR-340.029
T20F5.7Protein T20F5.70.028
sas-4Protein SAS-40.027
nhr-25Protein NHR-250.027
tag-298Protein TAG-2980.027
scd-2Protein SCD-20.027
lin-1Protein LIN-10.027
glp-1Protein GLP-10.026
sav-1Protein SAV-10.026
C26B9.1Protein C26B9.10.026
K10B4.3Protein K10B4.30.026
CELE_R119.1Protein R119.10.025
agr-1Protein AGR-10.025
K02A6.2Protein K02A6.20.025
klp-18Protein KLP-180.024
ver-3Protein VER-30.024
R07B7.9Protein R07B7.90.023
fshr-1Protein FSHR-10.023
egl-46Protein EGL-460.022
CELE_Y51A2D.14Protein Y51A2D.140.022
frm-2Protein FRM-20.022
C06E4.2Protein C06E4.20.022
K04F10.1Protein K04F10.10.021
mab-5Protein MAB-50.021
din-1Protein DIN-10.021
let-60Protein LET-600.021
sago-1Protein SAGO-10.021
cyp-33C4Protein CYP-33C40.021
peb-1Protein PEB-10.020
magu-4Protein MAGU-40.020
lin-17Protein LIN-170.020
unc-130Protein UNC-1300.020
gck-2Protein GCK-20.019
nhr-70Protein NHR-700.019
mab-20Protein MAB-200.019
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
wgwingless0.898
EgfrEpidermal growth factor receptor0.551
AxnAxin0.314
CtBPC-terminal Binding Protein0.252
hhhedgehog0.242
l(2)gllethal (2) giant larvae0.220
MadMothers against dpp0.212
trxtrithorax0.191
dadaughterless0.183
hpohippo0.170
crbcrumbs0.165
nkdnaked cuticle0.143
mirrmirror0.128
pnrpannier0.090
dppdecapentaplegic0.090
hephemipterous0.089
hydhyperplastic discs0.080
MedMedea0.079
bratbrain tumor0.078
hthhomothorax0.075
ash1absent, small, or homeotic discs 10.073
CG9867CG9867 gene product from transcript CG9867-RA0.073
sogshort gastrulation0.072
dmdiminutive0.071
aopanterior open0.071
gbbglass bottom boat0.070
panpangolin0.064
tshteashirt0.061
phlpole hole0.061
tefutelomere fusion0.059
tldtolloid0.058
grogroucho0.057
Su(H)Suppressor of Hairless0.057
babobaboon0.055
saxsaxophone0.054
DlDelta0.051
Mef2Myocyte enhancer factor 20.043
eyaeyes absent0.043
spispitz0.042
GugGrunge0.040
EcREcdysone receptor0.040
shnschnurri0.039
esgescargot0.039
arrarrow0.039
tkvthickveins0.036
domedomeless0.034
enengrailed0.033
Cdk4Cyclin-dependent kinase 40.032
bynbrachyenteron0.030
cicubitus interruptus0.029
Gef26CG9491 gene product from transcript CG9491-RB0.029
oddodd skipped0.029
orboo18 RNA-binding protein0.028
armarmadillo0.027
kibrakibra ortholog0.026
stetstem cell tumor0.026
ari-1ariadne0.026
ns2nucleostemin 20.026
twstwins0.024
ovoCG6824 gene product from transcript CG6824-RE0.024
fngfringe0.023
cortoCG2530 gene product from transcript CG2530-RA0.023
CG6945CG6945 gene product from transcript CG6945-RA0.023
l(1)G0007lethal (1) G00070.023
Stat92ESignal-transducer and activator of transcription protein at 92E0.023
ababrupt0.023
ttktramtrack0.022
HmgcrHMG Coenzyme A reductase0.022
simjsimjang0.022
KrKruppel0.021
ecdecdysoneless0.021
CG9776CG9776 gene product from transcript CG9776-RA0.021
debcldeath executioner Bcl-2 homologue0.020
CG31211CG31211 gene product from transcript CG31211-RB0.020
Plc21CPhospholipase C at 21C0.020
linlines0.020
Spn27ASerpin 27A0.020
edechinoid0.020
CG5794CG5794 gene product from transcript CG5794-RB0.020
CG6854CG6854 gene product from transcript CG6854-RC0.019
18w18 wheeler0.019
coracoracle0.019
AntpAntennapedia0.019
tlltailless0.019
vgvestigial0.019
pr-set7CG3307 gene product from transcript CG3307-RC0.018
Xe7CG2179 gene product from transcript CG2179-RA0.017
osoutstretched0.017
apapterous0.017
Su(z)12CG8013 gene product from transcript CG8013-RA0.017
SsdpSequence-specific single-stranded DNA-binding protein0.017
kniknirps0.016
smsmooth0.016
fkhfork head0.016
slp1sloppy paired 10.016
Smg6CG6369 gene product from transcript CG6369-RA0.016
Deaf1Deformed epidermal autoregulatory factor-10.016
dcodiscs overgrown0.016
gcmglial cells missing0.016
opaodd paired0.015
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMAD7SMAD family member 71.000
SMAD3SMAD family member 30.996
SMURF2SMAD specific E3 ubiquitin protein ligase 20.993
COL1A1collagen, type I, alpha 10.987
SMAD1SMAD family member 10.984
HOXB5homeobox B50.968
SMAD2SMAD family member 20.962
JAG1jagged 10.959
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.957
FBLN1fibulin 10.956
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.952
COL3A1collagen, type III, alpha 10.950
YAP1Yes-associated protein 10.948
SMAD5SMAD family member 50.940
TBX5T-box 50.924
NOTCH1notch 10.908
FSTL1follistatin-like 10.881
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.851
PAX3paired box 30.823
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.778
FBN1fibrillin 10.771
COL6A2collagen, type VI, alpha 20.729
BMPR1Abone morphogenetic protein receptor, type IA0.713
HOXA5homeobox A50.696
COL1A2collagen, type I, alpha 20.692
ATN1atrophin 10.666
WWP2WW domain containing E3 ubiquitin protein ligase 20.650
SMAD6SMAD family member 60.632
SKILSKI-like oncogene0.632
SETD8SET domain containing (lysine methyltransferase) 80.599
COL5A1collagen, type V, alpha 10.555
COL5A2collagen, type V, alpha 20.553
GATA4GATA binding protein 40.531
POU3F2POU class 3 homeobox 20.509
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.433
CXXC5CXXC finger protein 50.420
LOXlysyl oxidase0.379
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.365
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.364
PARVAparvin, alpha0.363
BGNbiglycan0.362
COL4A2collagen, type IV, alpha 20.347
POU5F1POU class 5 homeobox 10.343
HOXA10homeobox A100.323
TGFB1transforming growth factor, beta 10.323
DDR2discoidin domain receptor tyrosine kinase 20.309
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.304
TGFB1I1transforming growth factor beta 1 induced transcript 10.302
HOXA1homeobox A10.288
SMURF1SMAD specific E3 ubiquitin protein ligase 10.288
LOXL1lysyl oxidase-like 10.276
LAMB1laminin, beta 10.273
LTBP2latent transforming growth factor beta binding protein 20.258
FHL2four and a half LIM domains 20.251
HOXB6homeobox B60.249
NOTCH3notch 30.241
BTRCbeta-transducin repeat containing0.240
RUNX1runt-related transcription factor 10.228
HOXA4homeobox A40.216
LPXNleupaxin0.209
FOXD3forkhead box D30.204
ELNelastin0.196
GATA2GATA binding protein 20.184
HOXA11homeobox A110.181
CTGFconnective tissue growth factor0.179
HOXB7homeobox B70.171
COL6A1collagen, type VI, alpha 10.157
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.153
POSTNperiostin, osteoblast specific factor0.149
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.149
AXIN1axin 10.145
THBS1thrombospondin 10.143
HOXB3homeobox B30.141
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.135
COL4A1collagen, type IV, alpha 10.130
LIMS1LIM and senescent cell antigen-like domains 10.130
PDX1pancreatic and duodenal homeobox 10.127
CTBP2C-terminal binding protein 20.125
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.124
CTNNBIP1catenin, beta interacting protein 10.124
TRIP6thyroid hormone receptor interactor 60.123
SMAD4SMAD family member 40.117
JAG2jagged 20.115
ARandrogen receptor0.111
SKIv-ski sarcoma viral oncogene homolog (avian)0.110
PTPN14protein tyrosine phosphatase, non-receptor type 140.105
CALD1caldesmon 10.104
TCF4transcription factor 40.103
HOXC10homeobox C100.102
HOXB9homeobox B90.101
MYOD1myogenic differentiation 10.101
TGFBR1transforming growth factor, beta receptor 10.100
AMOTL2angiomotin like 20.094
CREBBPCREB binding protein0.092
HOXC11homeobox C110.092
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.090
HOXA7homeobox A70.090
TNS1tensin 10.088
ZFYVE9zinc finger, FYVE domain containing 90.086
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.085
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a2collagen, type I, alpha 20.364
Bgnbiglycan0.289
Col3a1collagen, type III, alpha 10.267
Col5a1collagen, type V, alpha 10.184
Col12a1collagen, type XII, alpha 10.093
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.091
Col5a2collagen, type V, alpha 20.090
Elnelastin0.070
Lamc1laminin, gamma 10.068
Col4a1collagen, type IV, alpha 10.068
Loxl1lysyl oxidase-like 10.061
Acta2smooth muscle alpha-actin0.059
C1dC1D nuclear receptor co-repressor0.053
Actg2actin, gamma 2, smooth muscle, enteric0.052
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.052
Col4a2collagen, type IV, alpha 20.051
Fstl1follistatin-like 10.049
Fbln2fibulin 20.048
Col14a1collagen, type XIV, alpha 10.044
Pcolceprocollagen C-endopeptidase enhancer0.041
Myl9myosin, light chain 9, regulatory0.037
Loxlysyl oxidase0.036
Trim47tripartite motif-containing 470.034
Ptpn14protein tyrosine phosphatase, non-receptor type 140.034
Elk3ELK3, ETS-domain protein0.033
Myh9myosin, heavy chain 9, non-muscle0.030
Fbn1fibrillin 10.030
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.028
Eif2c2eukaryotic translation initiation factor 2C, 20.028
Mmp23matrix metallopeptidase 230.027
Fn1fibronectin 10.026
Wdfy1WD repeat and FYVE domain containing 10.025
Vcanversican0.024
Fndc1fibronectin type III domain containing 10.024
Celcarboxyl ester lipase0.024
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.023
Bbxbobby sox homolog (Drosophila)0.022
Tcf4transcription factor 40.022
Lama5laminin, alpha 50.020
Taglntransgelin0.020
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.020
Slit3slit homolog 3 (Drosophila)0.020
Col6a2collagen, type VI, alpha 20.019
Dchs1dachsous 1 (Drosophila)0.019
Wt1Wilms tumor 10.019
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.019
Vimvimentin0.019
LOC100360986mCG1035404-like0.018
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.018
Nos3nitric oxide synthase 3, endothelial cell0.018
C1qtnf6C1q and tumor necrosis factor related protein 60.018
Nid2nidogen 20.018
Flnafilamin A, alpha0.018
Tmem119transmembrane protein 1190.017
Mfap4microfibrillar-associated protein 40.017
RGD1565591similar to Ski protein0.017
Tmem88transmembrane protein 880.016
Pmepa1prostate transmembrane protein, androgen induced 10.016
Fblim1filamin binding LIM protein 10.016
Scarf2scavenger receptor class F, member 20.016
Tgfb1i1transforming growth factor beta 1 induced transcript 10.016
Bcrbreakpoint cluster region0.015
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.015
C1qtnf5C1q and tumor necrosis factor related protein 50.015
Ctskcathepsin K0.014
RGD1564327similar to integrin alpha 80.014
Vash2vasohibin 20.014
Ltbp4latent transforming growth factor beta binding protein 40.014
Wnt5awingless-type MMTV integration site family, member 5A0.014
Col1a1collagen, type I, alpha 10.014
Znf503zinc finger protein 5030.013
Has2hyaluronan synthase 20.013
Megf6multiple EGF-like-domains 60.013
Fam38afamily with sequence similarity 38, member A0.013
Fgfr1Fibroblast growth factor receptor 10.013
S1pr2sphingosine-1-phosphate receptor 20.013
Foxp1forkhead box P10.013
Sc65synaptonemal complex protein SC650.013
Limd1LIM domains containing 10.013
Emilin1elastin microfibril interfacer 10.013
Hmgb1high mobility group box 10.013
Gpsm3G-protein signaling modulator 3 (AGS3-like, C. elegans)0.013
Stat5bsignal transducer and activator of transcription 5B0.013
Hnrnprheterogeneous nuclear ribonucleoprotein R0.013
Egfl7EGF-like-domain, multiple 70.012
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.012
Kremen1kringle containing transmembrane protein 10.012
Ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.012
Pdzk1ip1PDZK1 interacting protein 10.012
Rap2bRAP2B, member of RAS oncogene family0.012
Zyxzyxin0.012
Ptk7PTK7 protein tyrosine kinase 70.012
Luc7l2LUC7-like 2 (S. cerevisiae)0.012
Bmp1bone morphogenetic protein 10.012
Col8a1collagen, type VIII, alpha 10.012
Hes1hairy and enhancer of split 1 (Drosophila)0.012
Rcn3reticulocalbin 3, EF-hand calcium binding domain0.012
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.012
Figfc-fos induced growth factor0.012
Mustn1musculoskeletal, embryonic nuclear protein 10.012
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism