The network for 'positive regulation of reactive oxygen species metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of reactive oxygen species metabolic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.

NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.994
Nos3nitric oxide synthase 3, endothelial cell0.983
Trp53transformation related protein 530.980
Tlr4toll-like receptor 40.978
Myd88myeloid differentiation primary response gene 880.974
Apoeapolipoprotein E0.971
Tlr2toll-like receptor 20.967
Csf1colony stimulating factor 1 (macrophage)0.963
Lyz2lysozyme 20.953
Ccl2chemokine (C-C motif) ligand 20.952
Tnftumor necrosis factor0.934
Tgfb1transforming growth factor, beta 10.923
Stat3signal transducer and activator of transcription 30.901
Nos2nitric oxide synthase 2, inducible0.865
Mmp9matrix metallopeptidase 90.833
Ptgs2prostaglandin-endoperoxide synthase 20.783
Il6interleukin 60.767
Vegfavascular endothelial growth factor A0.765
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.737
Inpp5dinositol polyphosphate-5-phosphatase D0.728
Ccr2chemokine (C-C motif) receptor 20.722
Cd44CD44 antigen0.717
B2mbeta-2 microglobulin0.710
Ctnnb1catenin (cadherin associated protein), beta 10.707
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.707
Leprleptin receptor0.692
Klra9killer cell lectin-like receptor subfamily A, member 90.685
Rb1retinoblastoma 10.634
H2-D1histocompatibility 2, D region locus 10.578
Mdm2transformed mouse 3T3 cell double minute 20.565
FasFas (TNF receptor superfamily member 6)0.559
Socs1suppressor of cytokine signaling 10.534
Ldlrlow density lipoprotein receptor0.526
Nfe2l2nuclear factor, erythroid derived 2, like 20.518
Col1a1collagen, type I, alpha 10.514
Nos1nitric oxide synthase 1, neuronal0.510
H2-K1histocompatibility 2, K1, K region0.499
Cav1caveolin 1, caveolae protein0.481
Pkd1polycystic kidney disease 1 homolog0.479
Kdrkinase insert domain protein receptor0.450
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.445
Cxcl10chemokine (C-X-C motif) ligand 100.439
Map3k8mitogen-activated protein kinase kinase kinase 80.425
Ren1renin 1 structural0.413
Cxcl1chemokine (C-X-C motif) ligand 10.412
Il10interleukin 100.407
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.391
Rxraretinoid X receptor alpha0.379
Apcadenomatosis polyposis coli0.378
Il6stinterleukin 6 signal transducer0.373
Tgfbr2transforming growth factor, beta receptor II0.373
Tnfaip3tumor necrosis factor, alpha-induced protein 30.372
Stx11syntaxin 110.366
Akt1thymoma viral proto-oncogene 10.365
Prnpprion protein0.357
Klrc1killer cell lectin-like receptor subfamily C, member 10.354
Notch2Notch gene homolog 2 (Drosophila)0.352
Klrk1killer cell lectin-like receptor subfamily K, member 10.348
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.347
Clec4dC-type lectin domain family 4, member d0.344
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.336
Vhlvon Hippel-Lindau tumor suppressor0.336
Il1rninterleukin 1 receptor antagonist0.332
Mapk14mitogen-activated protein kinase 140.329
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.329
Ppargperoxisome proliferator activated receptor gamma0.327
Ostm1osteopetrosis associated transmembrane protein 10.326
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.319
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.301
Ccl7chemokine (C-C motif) ligand 70.298
Klra2killer cell lectin-like receptor, subfamily A, member 20.291
Ccl4chemokine (C-C motif) ligand 40.284
Pdgfbplatelet derived growth factor, B polypeptide0.260
Ms4a7membrane-spanning 4-domains, subfamily A, member 70.255
Lystlysosomal trafficking regulator0.248
H2-Q6histocompatibility 2, Q region locus 60.247
Sykbspleen tyrosine kinase0.237
Spp1secreted phosphoprotein 10.237
Gzmagranzyme A0.230
Smad3MAD homolog 3 (Drosophila)0.223
Runx1runt related transcription factor 10.222
Mef2dmyocyte enhancer factor 2D0.221
Dok1docking protein 10.220
Gzmbgranzyme B0.218
Socs3suppressor of cytokine signaling 30.218
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.216
Itgb1integrin beta 1 (fibronectin receptor beta)0.215
Hspa8heat shock protein 80.215
Ch25hcholesterol 25-hydroxylase0.212
Casp4caspase 4, apoptosis-related cysteine peptidase0.208
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.207
Usp8ubiquitin specific peptidase 80.204
Cd86CD86 antigen0.200
Kitlkit ligand0.199
Runx2runt related transcription factor 20.199
Klra7killer cell lectin-like receptor, subfamily A, member 70.198
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.195
Mapkapk2MAP kinase-activated protein kinase 20.193
Il2rginterleukin 2 receptor, gamma chain0.192
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
p38bCG7393 gene product from transcript CG7393-RA0.456
DreddDeath related ced-3/Nedd2-like protein0.149
foxoforkhead box, sub-group O0.133
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.132
myoglianinCG1838 gene product from transcript CG1838-RD0.124
drkdownstream of receptor kinase0.107
chicoCG5686 gene product from transcript CG5686-RB0.101
S6kRPS6-p70-protein kinase0.086
CblCG7037 gene product from transcript CG7037-RB0.083
TpiTriose phosphate isomerase0.077
PvrPDGF- and VEGF-receptor related0.074
Tm1Tropomyosin 10.068
Ras85DRas oncogene at 85D0.062
Traf-likeTNF-receptor-associated factor-like0.060
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.057
EndoGIEndonuclease G inhibitor0.050
PHGPxCG12013 gene product from transcript CG12013-RC0.050
SodSuperoxide dismutase0.049
Mekk1CG7717 gene product from transcript CG7717-RB0.042
CG9232CG9232 gene product from transcript CG9232-RA0.040
drddrop dead0.037
CG2852CG2852 gene product from transcript CG2852-RA0.037
Pi3K92ECG4141 gene product from transcript CG4141-RB0.035
AldhAldehyde dehydrogenase0.033
regucalcinCG1803 gene product from transcript CG1803-RA0.032
CG8907CG8907 gene product from transcript CG8907-RA0.032
CG12001CG12001 gene product from transcript CG12001-RA0.032
reporeversed polarity0.031
CG9510CG9510 gene product from transcript CG9510-RC0.031
tomosynCG17762 gene product from transcript CG17762-RB0.031
PGRP-LCPeptidoglycan recognition protein LC0.030
CG10103CG10103 gene product from transcript CG10103-RA0.029
Mob2CG11711 gene product from transcript CG11711-RC0.029
Socs36ESuppressor of cytokine signaling at 36E0.028
dj-1betaCG1349 gene product from transcript CG1349-RA0.028
Eip71CDEcdysone-induced protein 28/29kD0.027
cdicenter divider0.027
Mpk2CG5475 gene product from transcript CG5475-RB0.027
Pvf1PDGF- and VEGF-related factor 10.027
CG6543CG6543 gene product from transcript CG6543-RA0.026
Hip14Huntingtin-interacting protein 140.026
CG15611CG15611 gene product from transcript CG15611-RB0.026
kl-5male fertility factor kl50.026
CG3776CG3776 gene product from transcript CG3776-RA0.026
Jafrac1thioredoxin peroxidase 10.026
CG13369CG13369 gene product from transcript CG13369-RA0.025
GlyPGlycogen phosphorylase0.025
RhoGDICG7823 gene product from transcript CG7823-RA0.025
Pp1alpha-96AProtein phosphatase 1alpha at 96A0.024
cln3CG5582 gene product from transcript CG5582-RA0.024
ThorCG8846 gene product from transcript CG8846-RA0.024
SCAPCG33131 gene product from transcript CG33131-RA0.023
RpS10bRibosomal protein S10b0.023
AdarAdenosine deaminase acting on RNA0.023
l(3)82FdCG32464 gene product from transcript CG32464-RR0.022
CCSCG17753 gene product from transcript CG17753-RA0.021
CG6783CG6783 gene product from transcript CG6783-RC0.021
AGO2Argonaute 20.020
CG30409CG30409 gene product from transcript CG30409-RA0.020
Pvf2PDGF- and VEGF-related factor 20.020
Pkc98EProtein C kinase 98E0.019
CG1927CG1927 gene product from transcript CG1927-RA0.019
CG30427CG30427 gene product from transcript CG30427-RC0.019
imdimmune deficiency0.019
l(3)S147910lethal (3) S1479100.019
Tsp42EdTetraspanin 42Ed0.019
Tsp42EfTetraspanin 42Ef0.018
CG2118CG2118 gene product from transcript CG2118-RB0.018
MgstlMicrosomal glutathione S-transferase-like0.018
Pde8Phosphodiesterase 80.018
CG31224CG31224 gene product from transcript CG31224-RA0.018
CG11594CG11594 gene product from transcript CG11594-RB0.018
PGRP-SC2CG14745 gene product from transcript CG14745-RA0.018
CG6206CG6206 gene product from transcript CG6206-RA0.017
Spn27ASerpin 27A0.017
yip2yippee interacting protein 20.017
CG12004CG12004 gene product from transcript CG12004-RC0.017
PgdPhosphogluconate dehydrogenase0.017
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JUNjun proto-oncogene0.915
EGFRepidermal growth factor receptor0.913
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.895
TNFAIP3tumor necrosis factor, alpha-induced protein 30.878
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.868
IL8interleukin 80.863
ESR1estrogen receptor 10.829
DUSP1dual specificity phosphatase 10.821
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.816
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.795
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.700
CAV1caveolin 1, caveolae protein, 22kDa0.686
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.657
SOCS3suppressor of cytokine signaling 30.655
FOSFBJ murine osteosarcoma viral oncogene homolog0.623
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.603
TICAM2toll-like receptor adaptor molecule 20.579
FKBP1AFK506 binding protein 1A, 12kDa0.575
APPamyloid beta (A4) precursor protein0.561
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.561
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.557
PLAURplasminogen activator, urokinase receptor0.555
PTPN1protein tyrosine phosphatase, non-receptor type 10.553
VEGFAvascular endothelial growth factor A0.468
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.451
IL1R1interleukin 1 receptor, type I0.444
MAPTmicrotubule-associated protein tau0.444
GADD45GIP1growth arrest and DNA-damage-inducible, gamma interacting protein 10.427
CXCL3chemokine (C-X-C motif) ligand 30.414
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.361
SHC1SHC (Src homology 2 domain containing) transforming protein 10.348
BMP2bone morphogenetic protein 20.337
NRP1neuropilin 10.333
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.333
IGF1Rinsulin-like growth factor 1 receptor0.318
JUNBjun B proto-oncogene0.315
LCKlymphocyte-specific protein tyrosine kinase0.307
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.277
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.256
PRDX1peroxiredoxin 10.253
NOXA1NADPH oxidase activator 10.250
SMAD7SMAD family member 70.241
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.218
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.216
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.206
INSRinsulin receptor0.203
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.202
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.202
PDGFCplatelet derived growth factor C0.193
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.186
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.186
YAP1Yes-associated protein 10.179
ARRB1arrestin, beta 10.174
TGFB3transforming growth factor, beta 30.173
FYNFYN oncogene related to SRC, FGR, YES0.172
MEF2Amyocyte enhancer factor 2A0.170
SMAD4SMAD family member 40.168
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.168
CREBBPCREB binding protein0.167
KLF6Kruppel-like factor 60.167
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.166
NR0B2nuclear receptor subfamily 0, group B, member 20.160
PKN1protein kinase N10.158
ALDOBaldolase B, fructose-bisphosphate0.155
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.155
GOPCgolgi-associated PDZ and coiled-coil motif containing0.149
PLCG1phospholipase C, gamma 10.146
STAT5Asignal transducer and activator of transcription 5A0.143
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.138
ARandrogen receptor0.136
PTENphosphatase and tensin homolog0.136
FOSL2FOS-like antigen 20.135
KLF4Kruppel-like factor 4 (gut)0.132
GRB7growth factor receptor-bound protein 70.129
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.124
MPDZmultiple PDZ domain protein0.122
IL6interleukin 6 (interferon, beta 2)0.122
VAV1vav 1 guanine nucleotide exchange factor0.121
FSTL1follistatin-like 10.119
SOCS1suppressor of cytokine signaling 10.116
BCL3B-cell CLL/lymphoma 30.115
ATF2activating transcription factor 20.114
NTRK1neurotrophic tyrosine kinase, receptor, type 10.114
MAPK14mitogen-activated protein kinase 140.113
IER2immediate early response 20.107
GDF5growth differentiation factor 50.105
ZC3H12Azinc finger CCCH-type containing 12A0.105
CCND1cyclin D10.105
MAP2K4mitogen-activated protein kinase kinase 40.102
FYBFYN binding protein0.101
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.099
IFNGR1interferon gamma receptor 10.099
PKD1polycystic kidney disease 1 (autosomal dominant)0.099
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.098
BHLHE40basic helix-loop-helix family, member e400.098
TGFB1transforming growth factor, beta 10.098
PPP5Cprotein phosphatase 5, catalytic subunit0.097
IL1Binterleukin 1, beta0.095
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.061
Agtr1aangiotensin II receptor, type 1a0.049
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.047
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.045
Aqp9aquaporin 90.040
Pla1aphospholipase A1 member A0.038
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.038
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.037
Il18interleukin 180.037
Cd14CD14 molecule0.036
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.035
Procprotein C0.034
Dmgdhdimethylglycine dehydrogenase0.033
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.033
Fgafibrinogen alpha chain0.031
Irs1insulin receptor substrate 10.031
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.030
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.030
Cxcl2chemokine (C-X-C motif) ligand 20.029
Cd86CD86 molecule0.029
Cd38CD38 molecule0.028
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.028
Mbl1mannose-binding lectin (protein A) 10.027
Spp2secreted phosphoprotein 20.027
Ccl2chemokine (C-C motif) ligand 20.027
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.027
Clcn4-2chloride channel 4-20.027
Ptbp1polypyrimidine tract binding protein 10.026
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.026
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.026
Mpeg1macrophage expressed 10.025
Ghrgrowth hormone receptor0.025
Hckhemopoietic cell kinase0.025
Anxa2annexin A20.025
Anxa1annexin A10.025
Alox5aparachidonate 5-lipoxygenase activating protein0.025
Hist1h1ahistone cluster 1, H1a0.025
Ccl3chemokine (C-C motif) ligand 30.024
Slco2a1solute carrier organic anion transporter family, member 2a10.024
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.024
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.024
Irf1interferon regulatory factor 10.023
Ephx1epoxide hydrolase 1, microsomal0.023
Sirpasignal-regulatory protein alpha0.023
MdficMyoD family inhibitor domain containing0.023
Pon1paraoxonase 10.023
Ifitm3interferon induced transmembrane protein 30.023
Acsm2acyl-CoA synthetase medium-chain family member 20.023
Cd44Cd44 molecule0.022
Slit3slit homolog 3 (Drosophila)0.022
Hmox1heme oxygenase (decycling) 10.022
Syngr2synaptogyrin 20.022
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.022
Pzppregnancy-zone protein0.022
Hspa8heat shock protein 80.022
Casp1caspase 10.022
Hspb1heat shock protein 10.021
C4bpacomplement component 4 binding protein, alpha0.021
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.021
Rararetinoic acid receptor, alpha0.021
Agxt2alanine-glyoxylate aminotransferase 20.021
Fgl2fibrinogen-like 20.021
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.021
Foxa2forkhead box A20.021
C8bcomplement component 8, beta polypeptide0.020
Ggt5gamma-glutamyltransferase 50.020
Cd4Cd4 molecule0.020
Chrna2cholinergic receptor, nicotinic, alpha 2 (neuronal)0.020
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.020
Anxa5annexin A50.020
Prap1proline-rich acidic protein 10.020
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.020
Cx3cl1chemokine (C-X3-C motif) ligand 10.020
Calcrlcalcitonin receptor-like0.020
Hk1hexokinase 10.020
Tp53tumor protein p530.020
Zfp36l1zinc finger protein 36, C3H type-like 10.020
Metmet proto-oncogene0.020
Litaflipopolysaccharide-induced TNF factor0.020
Jak1Janus kinase 10.020
Lgals3lectin, galactoside-binding, soluble, 30.019
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.019
Avpr1aarginine vasopressin receptor 1A0.019
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.019
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.019
Ccl17chemokine (C-C motif) ligand 170.019
Arf6ADP-ribosylation factor 60.019
NsfN-ethylmaleimide-sensitive factor0.019
Cxcl10chemokine (C-X-C motif) ligand 100.018
Cpb2carboxypeptidase B2 (plasma)0.018
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.018
Gcgroup specific component0.018
Gstm2glutathione S-transferase mu 20.018
Prkcdprotein kinase C, delta0.018
Slc7a1solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.018
Tnfaip2tumor necrosis factor, alpha-induced protein 20.018
Lpllipoprotein lipase0.018
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism