The network for 'regulation of natural killer cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of natural killer cell activation

Any process that modulates the frequency, rate or extent of natural killer cell activation.

NameDescriptionProbabilityFunc Analog Organism
Slamf1signaling lymphocytic activation molecule family member 10.998
Tlr4toll-like receptor 40.957
Stat1signal transducer and activator of transcription 10.921
Sh2d1b1SH2 domain protein 1B10.910
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.910
Stat5asignal transducer and activator of transcription 5A0.903
Rab27aRAB27A, member RAS oncogene family0.868
Stat5bsignal transducer and activator of transcription 5B0.841
Mitfmicrophthalmia-associated transcription factor0.744
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.712
Irf9interferon regulatory factor 90.709
Hps6Hermansky-Pudlak syndrome 60.699
Icosinducible T-cell co-stimulator0.617
Tyro3TYRO3 protein tyrosine kinase 30.593
Ptprcprotein tyrosine phosphatase, receptor type, C0.563
Il7rinterleukin 7 receptor0.521
Il15rainterleukin 15 receptor, alpha chain0.516
Lair1leukocyte-associated Ig-like receptor 10.493
Klrd1killer cell lectin-like receptor, subfamily D, member 10.412
Myd88myeloid differentiation primary response gene 880.384
Cd28CD28 antigen0.366
Inpp5dinositol polyphosphate-5-phosphatase D0.361
Lcklymphocyte protein tyrosine kinase0.350
Ctsdcathepsin D0.334
Nckap1lNCK associated protein 1 like0.327
Cd244CD244 natural killer cell receptor 2B40.301
Stap1signal transducing adaptor family member 10.280
Cst7cystatin F (leukocystatin)0.257
Plbd2phospholipase B domain containing 20.244
Sh2d1aSH2 domain protein 1A0.244
Il21rinterleukin 21 receptor0.213
Il15interleukin 150.213
Il2rginterleukin 2 receptor, gamma chain0.177
Hps3Hermansky-Pudlak syndrome 3 homolog (human)0.170
Ly9lymphocyte antigen 90.169
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.157
Pdcd1lg2programmed cell death 1 ligand 20.152
Vav1vav 1 oncogene0.149
Ticam1toll-like receptor adaptor molecule 10.140
Foxp3forkhead box P30.130
Hcsthematopoietic cell signal transducer0.126
Stat2signal transducer and activator of transcription 20.120
Pyhin1pyrin and HIN domain family, member 10.116
Gpr65G-protein coupled receptor 650.104
Cd247CD247 antigen0.103
Trim21tripartite motif-containing 210.101
Rasgrp1RAS guanyl releasing protein 10.097
Il4rainterleukin 4 receptor, alpha0.097
Klrk1killer cell lectin-like receptor subfamily K, member 10.095
Mertkc-mer proto-oncogene tyrosine kinase0.092
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.089
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.088
Ifnar1interferon (alpha and beta) receptor 10.086
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.083
Cd3gCD3 antigen, gamma polypeptide0.082
Slasrc-like adaptor0.079
Lystlysosomal trafficking regulator0.078
Cd37CD37 antigen0.073
Sellselectin, lymphocyte0.071
Ccr9chemokine (C-C motif) receptor 90.070
Gnrh1gonadotropin releasing hormone 10.069
Ncoa3nuclear receptor coactivator 30.069
Rhohras homolog gene family, member H0.068
Cd69CD69 antigen0.065
Arhgap9Rho GTPase activating protein 90.065
Slamf7SLAM family member 70.064
WasWiskott-Aldrich syndrome homolog (human)0.063
Kitkit oncogene0.063
Itga4integrin alpha 40.061
Sykbspleen tyrosine kinase0.060
Sash3SAM and SH3 domain containing 30.060
Myo1fmyosin IF0.059
Stat4signal transducer and activator of transcription 40.059
Hcls1hematopoietic cell specific Lyn substrate 10.058
Dock2dedicator of cyto-kinesis 20.057
Aif1allograft inflammatory factor 10.057
Parvgparvin, gamma0.056
Cxcr6chemokine (C-X-C motif) receptor 60.055
Ap1m1adaptor-related protein complex AP-1, mu subunit 10.054
Cd72CD72 antigen0.052
CblbCasitas B-lineage lymphoma b0.051
Rab38RAB38, member of RAS oncogene family0.049
Cd2CD2 antigen0.048
Gpr18G protein-coupled receptor 180.048
Gzmbgranzyme B0.047
Timp1tissue inhibitor of metalloproteinase 10.047
Cd3dCD3 antigen, delta polypeptide0.047
Arhgap15Rho GTPase activating protein 150.045
Igf1insulin-like growth factor 10.045
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.044
Slamf8SLAM family member 80.044
Leprleptin receptor0.043
Gfi1growth factor independent 10.043
Stat6signal transducer and activator of transcription 60.042
Nfil3nuclear factor, interleukin 3, regulated0.042
Rpl3ribosomal protein L30.040
Dtnbp1dystrobrevin binding protein 10.040
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN1protein tyrosine phosphatase, non-receptor type 10.963
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.726
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.659
DTNBP1dystrobrevin binding protein 10.649
AXLAXL receptor tyrosine kinase0.639
GAS6growth arrest-specific 60.569
GBAglucosidase, beta, acid0.465
MUTEDmuted homolog (mouse)0.348
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.303
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.287
INSRinsulin receptor0.268
SH2D1ASH2 domain containing 1A0.261
BLOC1S3biogenesis of lysosomal organelles complex-1, subunit 30.229
IL23Ainterleukin 23, alpha subunit p190.208
BLOC1S1biogenesis of lysosomal organelles complex-1, subunit 10.137
SNAPINSNAP-associated protein0.132
IL15interleukin 150.108
CD84CD84 molecule0.096
RABEP1rabaptin, RAB GTPase binding effector protein 10.092
SLAMF1signaling lymphocytic activation molecule family member 10.090
IL15RAinterleukin 15 receptor, alpha0.049
BCAR1breast cancer anti-estrogen resistance 10.043
HGFhepatocyte growth factor (hepapoietin A; scatter factor)0.038
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 20.034
RAB14RAB14, member RAS oncogene family0.030
STAP2signal transducing adaptor family member 20.027
THAP2THAP domain containing, apoptosis associated protein 20.026
EXOC8exocyst complex component 80.024
GNSglucosamine (N-acetyl)-6-sulfatase0.023
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.022
ITM2Bintegral membrane protein 2B0.022
LATlinker for activation of T cells0.020
AGGF1angiogenic factor with G patch and FHA domains 10.018
CREG1cellular repressor of E1A-stimulated genes 10.017
EPS8epidermal growth factor receptor pathway substrate 80.015
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.015
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.015
IL2RBinterleukin 2 receptor, beta0.014
CD247CD247 molecule0.014
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.014
JAK2Janus kinase 20.014
PTK2PTK2 protein tyrosine kinase 20.012
TICAM2toll-like receptor adaptor molecule 20.011
PTPN11protein tyrosine phosphatase, non-receptor type 110.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism