The network for 'positive regulation of natural killer cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of natural killer cell activation

Any process that activates or increases the frequency, rate or extent of natural killer cell activation.

NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 40.984
Stat5asignal transducer and activator of transcription 5A0.894
Stat5bsignal transducer and activator of transcription 5B0.838
Myd88myeloid differentiation primary response gene 880.704
Leprleptin receptor0.656
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.624
Lyz2lysozyme 20.590
Stat1signal transducer and activator of transcription 10.570
Rab27aRAB27A, member RAS oncogene family0.498
Il6interleukin 60.401
Kitkit oncogene0.352
Tyro3TYRO3 protein tyrosine kinase 30.311
Irf9interferon regulatory factor 90.284
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.283
Mitfmicrophthalmia-associated transcription factor0.188
Foxp3forkhead box P30.158
Stat6signal transducer and activator of transcription 60.154
Hps6Hermansky-Pudlak syndrome 60.123
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.116
Ghrgrowth hormone receptor0.106
Stat3signal transducer and activator of transcription 30.095
Il1r1interleukin 1 receptor, type I0.077
Il15rainterleukin 15 receptor, alpha chain0.070
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.066
Hps3Hermansky-Pudlak syndrome 3 homolog (human)0.061
Lystlysosomal trafficking regulator0.055
Stat2signal transducer and activator of transcription 20.054
Il15interleukin 150.049
Smad3MAD homolog 3 (Drosophila)0.049
Slc24a5solute carrier family 24, member 50.047
Trim21tripartite motif-containing 210.045
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.042
Il4rainterleukin 4 receptor, alpha0.039
Ppargperoxisome proliferator activated receptor gamma0.038
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.037
Il6stinterleukin 6 signal transducer0.036
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.028
Tgfb1transforming growth factor, beta 10.025
CblbCasitas B-lineage lymphoma b0.024
Ncoa3nuclear receptor coactivator 30.024
Nckap1lNCK associated protein 1 like0.024
Il10interleukin 100.023
Plbd2phospholipase B domain containing 20.022
Nfil3nuclear factor, interleukin 3, regulated0.019
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.018
Jak3Janus kinase 30.017
Ifnar1interferon (alpha and beta) receptor 10.016
Spna1spectrin alpha 10.016
Il2interleukin 20.015
TapbpTAP binding protein0.015
Pi4kbphosphatidylinositol 4-kinase, catalytic, beta polypeptide0.014
Map3k8mitogen-activated protein kinase kinase kinase 80.014
Trp53transformation related protein 530.013
Cd247CD247 antigen0.013
Prlrprolactin receptor0.012
Irgm1immunity-related GTPase family M member 10.012
Stx11syntaxin 110.012
Ptpn6protein tyrosine phosphatase, non-receptor type 60.012
Ttc7tetratricopeptide repeat domain 70.012
Nfe2l2nuclear factor, erythroid derived 2, like 20.012
Nr3c1nuclear receptor subfamily 3, group C, member 10.011
Jak2Janus kinase 20.011
Ticam1toll-like receptor adaptor molecule 10.011
Arid1bAT rich interactive domain 1B (SWI-like)0.011
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.011
Rab38RAB38, member of RAS oncogene family0.010
Ptgs2prostaglandin-endoperoxide synthase 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN1protein tyrosine phosphatase, non-receptor type 10.987
GAS6growth arrest-specific 60.960
DTNBP1dystrobrevin binding protein 10.865
AXLAXL receptor tyrosine kinase0.829
INSRinsulin receptor0.754
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.746
EGFRepidermal growth factor receptor0.690
GBAglucosidase, beta, acid0.659
MUTEDmuted homolog (mouse)0.526
JAK2Janus kinase 20.410
PTPRJprotein tyrosine phosphatase, receptor type, J0.373
BLOC1S3biogenesis of lysosomal organelles complex-1, subunit 30.368
RABEP1rabaptin, RAB GTPase binding effector protein 10.303
ITM2Bintegral membrane protein 2B0.221
LATlinker for activation of T cells0.219
IL15RAinterleukin 15 receptor, alpha0.211
CAV1caveolin 1, caveolae protein, 22kDa0.198
IL15interleukin 150.176
BLOC1S1biogenesis of lysosomal organelles complex-1, subunit 10.147
SNAPINSNAP-associated protein0.139
GHRgrowth hormone receptor0.136
STAP2signal transducing adaptor family member 20.112
IL2RBinterleukin 2 receptor, beta0.098
STAT5Asignal transducer and activator of transcription 5A0.085
GNSglucosamine (N-acetyl)-6-sulfatase0.077
RNF13ring finger protein 130.076
RAB14RAB14, member RAS oncogene family0.057
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.055
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.049
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.048
EPORerythropoietin receptor0.048
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.048
CTSAcathepsin A0.048
TICAM2toll-like receptor adaptor molecule 20.039
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.037
SH3BGRLSH3 domain binding glutamic acid-rich protein like0.032
LEPROTleptin receptor overlapping transcript0.031
CREG1cellular repressor of E1A-stimulated genes 10.031
HGFhepatocyte growth factor (hepapoietin A; scatter factor)0.029
GAB1GRB2-associated binding protein 10.026
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.025
LAMP1lysosomal-associated membrane protein 10.023
HEXBhexosaminidase B (beta polypeptide)0.023
BCRbreakpoint cluster region0.021
TNFAIP3tumor necrosis factor, alpha-induced protein 30.021
PTRFpolymerase I and transcript release factor0.018
AGGF1angiogenic factor with G patch and FHA domains 10.017
RDH11retinol dehydrogenase 11 (all-trans/9-cis/11-cis)0.016
LAPTM4Alysosomal protein transmembrane 4 alpha0.015
LTKleukocyte receptor tyrosine kinase0.015
IRS1insulin receptor substrate 10.014
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.014
GRB10growth factor receptor-bound protein 100.014
PLXNB1plexin B10.013
GRIP1glutamate receptor interacting protein 10.013
STAT5Bsignal transducer and activator of transcription 5B0.013
SEC22BSEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)0.012
PIAS4protein inhibitor of activated STAT, 40.012
SUMF1sulfatase modifying factor 10.011
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 20.010
TMEM59transmembrane protein 590.010
CLINT1clathrin interactor 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism