The network for 'negative regulation of neuron death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of neuron death

Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.

NameDescriptionProbabilityFunc Analog Organism
Nr3c1nuclear receptor subfamily 3, group C, member 10.980
Emx1empty spiracles homolog 1 (Drosophila)0.967
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.964
Trp53transformation related protein 530.952
Bdnfbrain derived neurotrophic factor0.948
Ptenphosphatase and tensin homolog0.941
Ntf3neurotrophin 30.923
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.918
FosFBJ osteosarcoma oncogene0.895
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.887
BaxBCL2-associated X protein0.881
AxlAXL receptor tyrosine kinase0.878
Phox2apaired-like homeobox 2a0.875
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.857
Otx2orthodenticle homolog 2 (Drosophila)0.856
Nf1neurofibromatosis 10.853
Pax3paired box gene 30.833
Stat3signal transducer and activator of transcription 30.830
Pax6paired box gene 60.823
Leprleptin receptor0.799
Phox2bpaired-like homeobox 2b0.799
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.745
Mt1metallothionein 10.723
Mdm2transformed mouse 3T3 cell double minute 20.718
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.715
Grid1glutamate receptor, ionotropic, delta 10.710
Drd2dopamine receptor D20.703
Sox2SRY-box containing gene 20.690
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.677
Dusp1dual specificity phosphatase 10.662
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.648
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.637
Mt2metallothionein 20.636
Tgfbr1transforming growth factor, beta receptor I0.635
Epas1endothelial PAS domain protein 10.628
Pitx2paired-like homeodomain transcription factor 20.625
Dlx1distal-less homeobox 10.608
Gli2GLI-Kruppel family member GLI20.604
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.586
Ptpn11protein tyrosine phosphatase, non-receptor type 110.583
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.569
Egr1early growth response 10.555
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.555
Bcl2B-cell leukemia/lymphoma 20.554
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.551
Gli3GLI-Kruppel family member GLI30.539
Prnpprion protein0.532
Lhx3LIM homeobox protein 30.532
Gabra2gamma-aminobutyric acid (GABA) A receptor, subunit alpha 20.511
Igf1insulin-like growth factor 10.511
Fgfr2fibroblast growth factor receptor 20.508
Msx2homeobox, msh-like 20.508
Isl1ISL1 transcription factor, LIM/homeodomain0.507
Gria4glutamate receptor, ionotropic, AMPA4 (alpha 4)0.507
En1engrailed 10.499
Nfe2l2nuclear factor, erythroid derived 2, like 20.497
Eya1eyes absent 1 homolog (Drosophila)0.495
Ror1receptor tyrosine kinase-like orphan receptor 10.474
Sox10SRY-box containing gene 100.465
Gabrg2gamma-aminobutyric acid (GABA) A receptor, subunit gamma 20.456
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.456
Sim1single-minded homolog 1 (Drosophila)0.452
UncxUNC homeobox0.450
Stx1asyntaxin 1A (brain)0.430
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.427
Thrbthyroid hormone receptor beta0.424
Gdnfglial cell line derived neurotrophic factor0.420
Apoeapolipoprotein E0.418
Lhx5LIM homeobox protein 50.413
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.404
Zfp36zinc finger protein 360.398
Rb1retinoblastoma 10.397
JunJun oncogene0.392
Stat5bsignal transducer and activator of transcription 5B0.386
Pax7paired box gene 70.383
Ptgs2prostaglandin-endoperoxide synthase 20.376
Tcfap2atranscription factor AP-2, alpha0.371
Cnr1cannabinoid receptor 1 (brain)0.366
Pgrprogesterone receptor0.362
Stat5asignal transducer and activator of transcription 5A0.348
Ghrgrowth hormone receptor0.346
Aplp2amyloid beta (A4) precursor-like protein 20.345
Pthlhparathyroid hormone-like peptide0.341
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.339
Lifleukemia inhibitory factor0.328
Gscgoosecoid homeobox0.326
Foxf1aforkhead box F1a0.326
Dnm1dynamin 10.324
Emx2empty spiracles homolog 2 (Drosophila)0.322
Rxraretinoid X receptor alpha0.319
Esr1estrogen receptor 1 (alpha)0.308
Atmataxia telangiectasia mutated homolog (human)0.306
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.305
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.305
Hif3ahypoxia inducible factor 3, alpha subunit0.303
Gad2glutamic acid decarboxylase 20.299
Egfrepidermal growth factor receptor0.296
Neurod1neurogenic differentiation 10.294
Vegfavascular endothelial growth factor A0.294
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ram-2Protein RAM-20.011
F45D3.2Protein F45D3.20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.037
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.027
bnc2basonuclin 20.022
nrp2aneuropilin 2a0.021
appaamyloid beta (A4) precursor protein a0.020
bdnfbrain-derived neurotrophic factor0.018
dlx5adistal-less homeobox gene 5a0.016
gcm2glial cells missing homolog 2 (Drosophila)0.015
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.014
eif5aeukaryotic translation initiation factor 5A0.014
cnr1cannabinoid receptor 10.014
grnagranulin a0.013
cct6achaperonin containing TCP1, subunit 6A (zeta 1)0.013
trpv6transient receptor potential cation channel, subfamily V, member 60.013
psen1presenilin 10.013
nrp1aneuropilin 1a0.012
barhl1.2BarH-like 1.20.012
foxp2forkhead box P20.012
foxo3bforkhead box O3b0.012
gpr126G protein-coupled receptor 1260.011
nrp2bneuropilin 2b0.011
leprleptin receptor0.011
rps2ribosomal protein S20.011
alcamaactivated leukocyte cell adhesion molecule a0.010
thtyrosine hydroxylase0.010
pax7apaired box gene 7a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
p53CG33336 gene product from transcript CG33336-RB0.700
Sir2CG5216 gene product from transcript CG5216-RA0.513
CG8155CG8155 gene product from transcript CG8155-RA0.192
nabCG33545 gene product from transcript CG33545-RC0.169
eyaeyes absent0.167
bchsblue cheese0.161
stcksteamer duck0.126
weeCG4488 gene product from transcript CG4488-RA0.114
aopanterior open0.098
e(y)3enhancer of yellow 30.096
fhfrataxin homolog0.080
CG32528CG32528 gene product from transcript CG32528-RA0.074
locolocomotion defects0.071
DAAMDishevelled Associated Activator of Morphogenesis0.070
crolcrooked legs0.069
msl-1male-specific lethal 10.067
LamCLamin C0.062
tefutelomere fusion0.058
robo3CG5423 gene product from transcript CG5423-RA0.057
Mpk2CG5475 gene product from transcript CG5475-RB0.054
argosCG4531 gene product from transcript CG4531-RA0.053
DreddDeath related ced-3/Nedd2-like protein0.052
PvrPDGF- and VEGF-receptor related0.051
bab2CG9102 gene product from transcript CG9102-RA0.051
trioCG18214 gene product from transcript CG18214-RA0.049
cutletCG33122 gene product from transcript CG33122-RA0.049
Klp68DKinesin-like protein at 68D0.048
Snap25Synapse protein 250.047
AdarAdenosine deaminase acting on RNA0.045
PargPoly(ADP-ribose) glycohydrolase0.043
Ube3aUbiquitin protein ligase E3A0.041
tipEtemperature-induced paralytic E0.038
cindrCIN85 and CD2AP orthologue0.035
chicoCG5686 gene product from transcript CG5686-RB0.034
Ras64BRas oncogene at 64B0.034
Pgam5Phosphoglycerate mutase 50.033
Ced-12CG5336 gene product from transcript CG5336-RA0.033
CG11486CG11486 gene product from transcript CG11486-RG0.032
mus201mutagen-sensitive 2010.030
Ppt1Palmitoyl-protein thioesterase 10.030
PhKgammaPhosphorylase kinase gamma0.030
debcldeath executioner Bcl-2 homologue0.029
RhoGEF2CG9635 gene product from transcript CG9635-RF0.028
rdgAretinal degeneration A0.028
IndyI'm not dead yet0.028
cpacapping protein alpha0.028
Pink1PTEN-induced putative kinase 10.027
MiroMitochondrial Rho0.027
RpL5Ribosomal protein L50.027
Taf1TBP-associated factor 10.026
eastenhanced adult sensory threshold0.026
Myo31DFMyosin 31DF0.026
Vap-33-1CG5014 gene product from transcript CG5014-RB0.025
Atg1Autophagy-specific gene 10.025
Fmr1CG6203 gene product from transcript CG6203-RC0.024
AP-2CG7807 gene product from transcript CG7807-RB0.024
CG6650CG6650 gene product from transcript CG6650-RA0.024
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.884
VEGFAvascular endothelial growth factor A0.833
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.802
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.535
EGFRepidermal growth factor receptor0.515
EP300E1A binding protein p3000.466
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.425
ESR1estrogen receptor 10.407
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.302
SMN1survival of motor neuron 1, telomeric0.249
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.229
RPL18Aribosomal protein L18a0.219
BCL2L11BCL2-like 11 (apoptosis facilitator)0.200
INSRinsulin receptor0.175
CAV1caveolin 1, caveolae protein, 22kDa0.172
IL8interleukin 80.170
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.163
BCL2L1BCL2-like 10.160
STAT5Asignal transducer and activator of transcription 5A0.157
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.151
NRP1neuropilin 10.144
MAPTmicrotubule-associated protein tau0.140
LATlinker for activation of T cells0.139
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.126
CCR5chemokine (C-C motif) receptor 50.110
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.104
TRIB3tribbles homolog 3 (Drosophila)0.097
SOCS3suppressor of cytokine signaling 30.094
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.094
SOS1son of sevenless homolog 1 (Drosophila)0.085
NCOR2nuclear receptor corepressor 20.084
APPamyloid beta (A4) precursor protein0.083
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.080
NTRK1neurotrophic tyrosine kinase, receptor, type 10.079
PTPN23protein tyrosine phosphatase, non-receptor type 230.078
APLFaprataxin and PNKP like factor0.075
VHLvon Hippel-Lindau tumor suppressor0.075
NONOnon-POU domain containing, octamer-binding0.074
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.074
AGAP5ArfGAP with GTPase domain, ankyrin repeat and PH domain 50.073
HSPA8heat shock 70kDa protein 80.072
ASNSasparagine synthetase (glutamine-hydrolyzing)0.071
RUNX1runt-related transcription factor 10.069
CREBBPCREB binding protein0.068
FYNFYN oncogene related to SRC, FGR, YES0.067
NR4A1nuclear receptor subfamily 4, group A, member 10.067
GH1growth hormone 10.065
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.064
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.062
HSPA1Bheat shock 70kDa protein 1B0.061
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.060
NOXA1NADPH oxidase activator 10.060
AGAP7ArfGAP with GTPase domain, ankyrin repeat and PH domain 70.059
MAP2K1mitogen-activated protein kinase kinase 10.058
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.054
GAS6growth arrest-specific 60.054
PTPN1protein tyrosine phosphatase, non-receptor type 10.053
PDCD6IPprogrammed cell death 6 interacting protein0.051
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.050
PRKCZprotein kinase C, zeta0.049
JUNjun proto-oncogene0.048
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.047
PDZD11PDZ domain containing 110.046
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.046
PPARGperoxisome proliferator-activated receptor gamma0.046
PPP5Cprotein phosphatase 5, catalytic subunit0.045
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.044
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.044
BCORBCL6 corepressor0.043
CCL8chemokine (C-C motif) ligand 80.043
NAMPTnicotinamide phosphoribosyltransferase0.042
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.041
SFPQsplicing factor proline/glutamine-rich0.039
HIPK2homeodomain interacting protein kinase 20.039
RPS6ribosomal protein S60.039
APOC1apolipoprotein C-I0.038
NCF1neutrophil cytosolic factor 10.037
HDAC4histone deacetylase 40.037
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.036
CCL4chemokine (C-C motif) ligand 40.036
SH3KBP1SH3-domain kinase binding protein 10.036
TSG101tumor susceptibility gene 1010.035
CSH2chorionic somatomammotropin hormone 20.034
FOSFBJ murine osteosarcoma viral oncogene homolog0.034
SH3RF1SH3 domain containing ring finger 10.034
GNL3guanine nucleotide binding protein-like 3 (nucleolar)0.033
PPIDpeptidylprolyl isomerase D0.032
PINK1PTEN induced putative kinase 10.032
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.031
HNF4Ahepatocyte nuclear factor 4, alpha0.031
CCL5chemokine (C-C motif) ligand 50.031
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.031
CXCL9chemokine (C-X-C motif) ligand 90.029
EIF4A1eukaryotic translation initiation factor 4A10.029
ATF3activating transcription factor 30.029
CCL13chemokine (C-C motif) ligand 130.029
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.028
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a1nuclear receptor subfamily 4, group A, member 10.244
Dusp1dual specificity phosphatase 10.198
Nr4a3nuclear receptor subfamily 4, group A, member 30.166
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.146
Errfi1ERBB receptor feedback inhibitor 10.145
Pebp1phosphatidylethanolamine binding protein 10.141
FosFBJ osteosarcoma oncogene0.126
Il1binterleukin 1 beta0.120
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.120
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.118
Tbxas1thromboxane A synthase 1, platelet0.108
Reg3gregenerating islet-derived 3 gamma0.095
Zfp36zinc finger protein 360.093
Mmp12matrix metallopeptidase 120.091
C1rcomplement component 1, r subcomponent0.086
Ednrbendothelin receptor type B0.085
Nkx6-1NK6 homeobox 10.084
Pipprolactin induced protein0.082
Agtr1aangiotensin II receptor, type 1a0.082
Tnftumor necrosis factor (TNF superfamily, member 2)0.081
Acot12acyl-CoA thioesterase 120.080
Cd86CD86 molecule0.078
Prl6a1prolactin family 6, subfamily a, member 10.077
Prlhrprolactin releasing hormone receptor0.075
Prl3d1Prolactin family 3, subfamily d, member 10.070
Prl3d4prolactin family 3, subfamily d, member 40.070
Sod2superoxide dismutase 2, mitochondrial0.069
Oaz1ornithine decarboxylase antizyme 10.068
Ddr1discoidin domain receptor tyrosine kinase 10.066
Btg2BTG family, member 20.064
Atf3activating transcription factor 30.062
Aldoaaldolase A, fructose-bisphosphate0.062
Il1r1interleukin 1 receptor, type I0.061
Junbjun B proto-oncogene0.060
Pkm2pyruvate kinase, muscle0.058
Dock8dedicator of cytokinesis 80.058
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.057
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.056
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.056
Tcf4transcription factor 40.055
Smad3SMAD family member 30.054
Calcbcalcitonin-related polypeptide, beta0.054
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.053
Mmp3matrix metallopeptidase 30.053
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.052
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.052
Ccr5chemokine (C-C motif) receptor 50.052
Ptpn6protein tyrosine phosphatase, non-receptor type 60.051
Cd40lgCD40 ligand0.051
Mcpt1mast cell protease 10.051
Socs3suppressor of cytokine signaling 30.050
Eif4beukaryotic translation initiation factor 4B0.050
Hoxb8homeo box B80.050
Ciitaclass II, major histocompatibility complex, transactivator0.049
FaslgFas ligand (TNF superfamily, member 6)0.049
Gzmbgranzyme B0.049
Fkbp4FK506 binding protein 40.048
Fstl1follistatin-like 10.046
Olr837olfactory receptor 8370.046
Ppyr1pancreatic polypeptide receptor 10.045
Eef2eukaryotic translation elongation factor 20.045
Ccl2chemokine (C-C motif) ligand 20.045
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.045
Folh1folate hydrolase 10.044
JunJun oncogene0.044
Rab1bRAB1B, member RAS oncogene family0.044
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.043
Casrcalcium-sensing receptor0.043
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.043
Cxcl10chemokine (C-X-C motif) ligand 100.043
Ccdc124coiled-coil domain containing 1240.043
Fgf18fibroblast growth factor 180.043
Egr1early growth response 10.043
Hspa8heat shock protein 80.042
Trpc4transient receptor potential cation channel, subfamily C, member 40.042
Nefmneurofilament, medium polypeptide0.042
Bcl2B-cell CLL/lymphoma 20.042
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.042
Shox2short stature homeobox 20.041
Ccl3chemokine (C-C motif) ligand 30.041
Tas2r118taste receptor, type 2, member 1180.041
RT1-M5RT1 class Ib, locus M50.040
Mef2dmyocyte enhancer factor 2D0.040
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.040
Cyp11b3cytochrome P450, family 11, subfamily b, polypeptide 30.040
Pxdnperoxidasin homolog (Drosophila)0.040
Cdk4cyclin-dependent kinase 40.040
Hnrnpuheterogeneous nuclear ribonucleoprotein U0.040
Stx1asyntaxin 1A (brain)0.040
Marcksmyristoylated alanine rich protein kinase C substrate0.039
Cysscystatin S0.039
Lphn2latrophilin 20.038
Vom2r44vomeronasal 2 receptor 440.038
Il8rbinterleukin 8 receptor, beta0.038
Ccl4chemokine (C-C motif) ligand 40.038
Rararetinoic acid receptor, alpha0.038
Smad1SMAD family member 10.038
Pgk1phosphoglycerate kinase 10.037
BadBCL2-associated agonist of cell death0.037
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism