The network for 'stem cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

stem cell development

The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.

NameDescriptionProbabilityFunc Analog Organism
Tgfb2transforming growth factor, beta 21.000
Fgfr2fibroblast growth factor receptor 21.000
Gli3GLI-Kruppel family member GLI31.000
Bmp4bone morphogenetic protein 41.000
Pitx2paired-like homeodomain transcription factor 21.000
Shhsonic hedgehog1.000
Foxc1forkhead box C11.000
Pax6paired box gene 61.000
Pax3paired box gene 31.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Egfrepidermal growth factor receptor1.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Msx2homeobox, msh-like 21.000
Fgfr1fibroblast growth factor receptor 11.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Fgf8fibroblast growth factor 80.999
Msx1homeobox, msh-like 10.999
Prrx1paired related homeobox 10.999
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.999
Ptenphosphatase and tensin homolog0.999
Notch1Notch gene homolog 1 (Drosophila)0.999
Hand2heart and neural crest derivatives expressed transcript 20.999
Dlx5distal-less homeobox 50.999
Alx4aristaless-like homeobox 40.998
Tbx3T-box 30.998
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.998
Ptpn11protein tyrosine phosphatase, non-receptor type 110.998
Runx2runt related transcription factor 20.998
Sox2SRY-box containing gene 20.998
Foxg1forkhead box G10.996
Ror2receptor tyrosine kinase-like orphan receptor 20.995
Eya1eyes absent 1 homolog (Drosophila)0.995
Foxc2forkhead box C20.994
Sox9SRY-box containing gene 90.994
Tcfap2atranscription factor AP-2, alpha0.994
Acvr1activin A receptor, type 10.994
Lhx1LIM homeobox protein 10.994
Hey2hairy/enhancer-of-split related with YRPW motif 20.993
Meox2mesenchyme homeobox 20.992
Gata4GATA binding protein 40.992
Gli2GLI-Kruppel family member GLI20.992
Apcadenomatosis polyposis coli0.991
Zic3zinc finger protein of the cerebellum 30.991
Bcl2B-cell leukemia/lymphoma 20.989
Jag1jagged 10.989
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.989
Retret proto-oncogene0.989
Hes1hairy and enhancer of split 1 (Drosophila)0.988
Rargretinoic acid receptor, gamma0.988
Vegfavascular endothelial growth factor A0.987
Isl1ISL1 transcription factor, LIM/homeodomain0.986
Bmp7bone morphogenetic protein 70.986
Hoxa1homeobox A10.986
Gata6GATA binding protein 60.983
Hspg2perlecan (heparan sulfate proteoglycan 2)0.977
Foxh1forkhead box H10.976
Tlx3T-cell leukemia, homeobox 30.976
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.975
Hoxd13homeobox D130.975
Lhx3LIM homeobox protein 30.973
Smosmoothened homolog (Drosophila)0.971
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.971
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.970
Fgf10fibroblast growth factor 100.970
Pou3f3POU domain, class 3, transcription factor 30.969
Smad6MAD homolog 6 (Drosophila)0.968
Pax2paired box gene 20.966
Tcfap2ctranscription factor AP-2, gamma0.966
Foxn1forkhead box N10.964
Mecp2methyl CpG binding protein 20.961
Foxf1aforkhead box F1a0.959
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.958
Zeb1zinc finger E-box binding homeobox 10.957
Dll4delta-like 4 (Drosophila)0.955
Lmx1bLIM homeobox transcription factor 1 beta0.953
Ptk7PTK7 protein tyrosine kinase 70.952
Trp53transformation related protein 530.952
Chd7chromodomain helicase DNA binding protein 70.950
Smad3MAD homolog 3 (Drosophila)0.950
Pkd1polycystic kidney disease 1 homolog0.949
Neurod1neurogenic differentiation 10.948
Lef1lymphoid enhancer binding factor 10.948
Nr5a1nuclear receptor subfamily 5, group A, member 10.947
Prrx2paired related homeobox 20.946
Runx1runt related transcription factor 10.943
Foxa2forkhead box A20.943
Col2a1collagen, type II, alpha 10.942
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.940
Trp63transformation related protein 630.938
Emx1empty spiracles homolog 1 (Drosophila)0.938
Gdnfglial cell line derived neurotrophic factor0.937
Neurog2neurogenin 20.937
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.936
Rararetinoic acid receptor, alpha0.935
NanogNanog homeobox0.934
Tbx15T-box 150.931
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tgfb3transforming growth factor, beta 30.973
aldh1a2aldehyde dehydrogenase 1 family, member A20.961
wnt5bwingless-type MMTV integration site family, member 5b0.955
notch1anotch homolog 1a0.954
sox2SRY-box containing gene 20.949
spry4sprouty (Drosophila) homolog 40.934
tp53tumor protein p530.931
gli1GLI-Kruppel family member 10.907
tll1tolloid-like 10.883
bmp2bbone morphogenetic protein 2b0.881
sox10SRY-box containing gene 100.868
cdh2cadherin 2, neuronal0.862
jag1bjagged 1b0.857
vcanaversican a0.836
flhfloating head0.820
crabp2acellular retinoic acid binding protein 2, a0.817
lmx1b.1LIM homeobox transcription factor 1, beta 10.793
col15a1bcollagen, type XV, alpha 1b0.771
dlx2adistal-less homeobox gene 2a0.770
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.756
oepone-eyed pinhead0.743
gdf6agrowth differentiation factor 6a0.743
mecomMDS1 and EVI1 complex locus0.741
lef1lymphocyte enhancer binding factor 10.741
tbx1T-box 10.723
fn1fibronectin 10.711
pax6apaired box gene 6a0.705
osr2odd-skipped related 2 (Drosophila)0.684
tbx16T-box gene 160.683
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.683
myod1myogenic differentiation 10.675
foxd3forkhead box D30.668
bocbrother of CDO0.649
tmem2transmembrane protein 20.634
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.633
pax6bpaired box gene 6b0.629
osr1odd-skipped related 1 (Drosophila)0.593
eya1eyes absent homolog 10.557
ascl1aachaete-scute complex-like 1a (Drosophila)0.551
nrp2bneuropilin 2b0.546
fbn2bfibrillin 2b0.545
zic1zic family member 1 (odd-paired homolog, Drosophila)0.527
foxi1forkhead box I10.519
her1hairy-related 10.510
supt6hsuppressor of Ty 6 homolog0.504
gli2aGLI-Kruppel family member GLI2a0.503
cdh1cadherin 1, epithelial0.492
shhasonic hedgehog a0.488
prdm5PR domain containing 50.477
col8a1acollagen, type VIII, alpha 1a0.471
s1pr2sphingosine-1-phosphate receptor 20.441
fgf10afibroblast growth factor 10a0.438
wnt8bwingless-type MMTV integration site family, member 8b0.433
sox32SRY-box containing gene 320.412
gata3GATA-binding protein 30.410
rargaretinoic acid receptor gamma a0.400
tbx20T-box 200.400
mibmind bomb0.392
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.388
kitakit receptor a0.387
igf1rbinsulin-like growth factor 1b receptor0.387
dlx3bdistal-less homeobox gene 3b0.385
crb2acrumbs homolog 2a0.383
snai1bsnail homolog 1b (Drosophila)0.379
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.370
hey1hairy/enhancer-of-split related with YRPW motif 10.368
pitx3paired-like homeodomain transcription factor 30.365
sema3dsemaphorin 3d0.365
id3inhibitor of DNA binding 30.358
notch3notch homolog 30.353
acvr1lactivin A receptor, type I like0.351
her7hairy and enhancer of split related-70.350
neurodneurogenic differentiation0.350
pax9paired box gene 90.350
sox19aSRY-box containing gene 19a0.344
her6hairy-related 60.342
notch1bnotch homolog 1b0.339
pax7apaired box gene 7a0.333
sall4sal-like 4 (Drosophila)0.327
mespamesoderm posterior a0.325
irx3airoquois homeobox protein 3a0.325
sema3fasemaphorin 3fa0.315
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.314
mef2camyocyte enhancer factor 2ca0.310
chsy1chondroitin sulfate synthase 10.302
gria4aglutamate receptor, ionotropic, AMPA 4a0.297
her15.1hairy and enhancer of split-related 15.10.294
lhx2bLIM homeobox 2b0.290
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.289
has2hyaluronan synthase 20.287
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.997
Ras85DRas oncogene at 85D0.995
cicubitus interruptus0.991
bratbrain tumor0.990
EgfrEpidermal growth factor receptor0.959
PtenCG5671 gene product from transcript CG5671-RB0.842
HLHm7E(spl) region transcript m70.831
HopHsp70/Hsp90 organizing protein homolog0.806
Stat92ESignal-transducer and activator of transcription protein at 92E0.788
ash2absent, small, or homeotic discs 20.774
Su(H)Suppressor of Hairless0.769
eyaeyes absent0.750
zpgzero population growth0.741
emcextra macrochaetae0.736
InRInsulin-like receptor0.694
htshu li tai shao0.669
E(spl)Enhancer of split0.646
SfmbtScm-related gene containing four mbt domains0.597
Pi3K92ECG4141 gene product from transcript CG4141-RB0.597
dallydivision abnormally delayed0.582
bambag of marbles0.496
BicDBicaudal D0.479
gcmglial cells missing0.473
Pabp2CG2163 gene product from transcript CG2163-RA0.466
HLHmgammaE(spl) region transcript mgamma0.452
Wnt4Wnt oncogene analog 40.447
bgcnbenign gonial cell neoplasm0.417
Dhc64CDynein heavy chain 64C0.414
Su(var)3-3Suppressor of variegation 3-30.407
enokenoki mushroom0.366
nocno ocelli0.366
rictorrapamycin-insensitive companion of Tor0.353
Sin3ACG8815 gene product from transcript CG8815-RC0.350
CG11347CG11347 gene product from transcript CG11347-RE0.350
vvlventral veins lacking0.350
m2E(spl) region transcript m20.340
chbchromosome bows0.328
ovoCG6824 gene product from transcript CG6824-RE0.323
Sema-1aCG18405 gene product from transcript CG18405-RD0.322
Su(z)12CG8013 gene product from transcript CG8013-RA0.317
Top2Topoisomerase 20.309
nkdnaked cuticle0.306
osaCG7467 gene product from transcript CG7467-RD0.304
amosabsent MD neurons and olfactory sensilla0.299
Mef2Myocyte enhancer factor 20.294
eveeven skipped0.282
Adf1Adh transcription factor 10.280
sogshort gastrulation0.280
emsempty spiracles0.280
Atg1Autophagy-specific gene 10.276
SnooSno oncogene0.275
par-6CG5884 gene product from transcript CG5884-RA0.273
ph-ppolyhomeotic proximal0.268
piwiCG6122 gene product from transcript CG6122-RA0.265
sosine oculis0.263
CG6751CG6751 gene product from transcript CG6751-RA0.261
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
SMAD3SMAD family member 30.999
SMAD7SMAD family member 70.998
TGFB1transforming growth factor, beta 10.998
CREBBPCREB binding protein0.996
NOTCH1notch 10.990
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.988
ARandrogen receptor0.984
SP1Sp1 transcription factor0.979
YAP1Yes-associated protein 10.979
FGFR1fibroblast growth factor receptor 10.975
SMURF2SMAD specific E3 ubiquitin protein ligase 20.974
SMAD4SMAD family member 40.970
SMAD2SMAD family member 20.966
JAG1jagged 10.963
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.955
DICER1dicer 1, ribonuclease type III0.953
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.941
APCadenomatous polyposis coli0.937
EP300E1A binding protein p3000.926
HNRNPKheterogeneous nuclear ribonucleoprotein K0.918
PAX3paired box 30.911
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.907
STAG1stromal antigen 10.900
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.897
BMP2bone morphogenetic protein 20.884
COL1A1collagen, type I, alpha 10.857
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.808
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.789
TP53tumor protein p530.780
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.765
FOXD3forkhead box D30.748
TAL1T-cell acute lymphocytic leukemia 10.743
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.737
POU3F2POU class 3 homeobox 20.719
EGFRepidermal growth factor receptor0.716
CTR9Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.716
WAPALwings apart-like homolog (Drosophila)0.701
COL6A1collagen, type VI, alpha 10.693
WWP2WW domain containing E3 ubiquitin protein ligase 20.662
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.660
FGF1fibroblast growth factor 1 (acidic)0.647
WNT3Awingless-type MMTV integration site family, member 3A0.636
BMPR1Abone morphogenetic protein receptor, type IA0.622
NOTCH3notch 30.620
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.611
ATF2activating transcription factor 20.601
POU5F1POU class 5 homeobox 10.595
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.582
TGFB3transforming growth factor, beta 30.575
COL1A2collagen, type I, alpha 20.573
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.570
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.567
PDX1pancreatic and duodenal homeobox 10.564
FSTL1follistatin-like 10.560
RAD21RAD21 homolog (S. pombe)0.560
SOX11SRY (sex determining region Y)-box 110.546
CNOT8CCR4-NOT transcription complex, subunit 80.540
PTBP1polypyrimidine tract binding protein 10.531
AXIN1axin 10.528
SMAD1SMAD family member 10.524
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.517
EIF4A1eukaryotic translation initiation factor 4A10.500
SOX1SRY (sex determining region Y)-box 10.490
CDK2cyclin-dependent kinase 20.483
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.481
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.481
SMAD6SMAD family member 60.479
BBS10Bardet-Biedl syndrome 100.478
GRB2growth factor receptor-bound protein 20.478
COL3A1collagen, type III, alpha 10.458
MSX1msh homeobox 10.453
MBNL1muscleblind-like (Drosophila)0.452
CXXC5CXXC finger protein 50.450
HIC1hypermethylated in cancer 10.441
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.434
GATA4GATA binding protein 40.430
CSNK1Ecasein kinase 1, epsilon0.426
HMGA2high mobility group AT-hook 20.426
COL5A1collagen, type V, alpha 10.422
SOX2SRY (sex determining region Y)-box 20.415
LRP6low density lipoprotein receptor-related protein 60.399
PUM1pumilio homolog 1 (Drosophila)0.394
FKBP1AFK506 binding protein 1A, 12kDa0.393
CNOT2CCR4-NOT transcription complex, subunit 20.390
HNF4Ahepatocyte nuclear factor 4, alpha0.388
NCOR1nuclear receptor corepressor 10.377
THBS1thrombospondin 10.374
COL2A1collagen, type II, alpha 10.369
FOXA2forkhead box A20.368
HNF1AHNF1 homeobox A0.367
SKILSKI-like oncogene0.364
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.357
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.357
PTK2PTK2 protein tyrosine kinase 20.356
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.351
RBPMSRNA binding protein with multiple splicing0.350
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.347
SFRP1secreted frizzled-related protein 10.343
PTPN1protein tyrosine phosphatase, non-receptor type 10.337
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nek9NIMA (never in mitosis gene a)- related kinase 90.047
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.028
Pnrc2proline-rich nuclear receptor coactivator 20.025
Nfianuclear factor I/A0.020
Igfbp5insulin-like growth factor binding protein 50.018
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.017
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.016
Ednraendothelin receptor type A0.016
Nr2f2nuclear receptor subfamily 2, group F, member 20.016
Nfibnuclear factor I/B0.014
Tgfbr2transforming growth factor, beta receptor II0.014
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.014
Hmgb1high mobility group box 10.014
Dchs1dachsous 1 (Drosophila)0.014
Col12a1collagen, type XII, alpha 10.014
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.012
Sox13SRY (sex determining region Y)-box 130.012
Nedd4neural precursor cell expressed, developmentally down-regulated 40.012
Tor1aip1torsin A interacting protein 10.011
Itpr2inositol 1,4,5-triphosphate receptor, type 20.011
Metmet proto-oncogene0.011
Gna15guanine nucleotide binding protein, alpha 150.011
Tcf4transcription factor 40.011
Hnrpdheterogeneous nuclear ribonucleoprotein D0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism