The network for 'negative regulation of cholesterol transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cholesterol transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.999
Gli3GLI-Kruppel family member GLI30.976
Fgfr3fibroblast growth factor receptor 30.940
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.907
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.841
Axin1axin 10.826
Ctnnb1catenin (cadherin associated protein), beta 10.712
Apoeapolipoprotein E0.539
Tbx3T-box 30.534
Bmp4bone morphogenetic protein 40.530
Traf6TNF receptor-associated factor 60.453
Otx2orthodenticle homolog 2 (Drosophila)0.447
Shhsonic hedgehog0.392
Abcg5ATP-binding cassette, sub-family G (WHITE), member 50.379
Lrp6low density lipoprotein receptor-related protein 60.363
Ldlrlow density lipoprotein receptor0.319
Npc1Niemann Pick type C10.319
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.291
Arandrogen receptor0.280
Runx2runt related transcription factor 20.243
Hand1heart and neural crest derivatives expressed transcript 10.241
Ror2receptor tyrosine kinase-like orphan receptor 20.213
Tbrachyury0.185
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.170
Pitx1paired-like homeodomain transcription factor 10.161
Pkd1polycystic kidney disease 1 homolog0.159
Klf15Kruppel-like factor 150.147
Lrp2low density lipoprotein receptor-related protein 20.144
Vangl2vang-like 2 (van gogh, Drosophila)0.130
Irak4interleukin-1 receptor-associated kinase 40.119
IhhIndian hedgehog0.116
Nr0b1nuclear receptor subfamily 0, group B, member 10.105
Foxa2forkhead box A20.104
Apoa1apolipoprotein A-I0.095
C3complement component 30.095
Nos3nitric oxide synthase 3, endothelial cell0.091
Myd88myeloid differentiation primary response gene 880.091
Pla2g10phospholipase A2, group X0.090
Zp2zona pellucida glycoprotein 20.086
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.081
Lef1lymphoid enhancer binding factor 10.081
En1engrailed 10.071
Hes1hairy and enhancer of split 1 (Drosophila)0.070
Nr0b2nuclear receptor subfamily 0, group B, member 20.069
Fgf9fibroblast growth factor 90.068
Zbtb16zinc finger and BTB domain containing 160.067
Pitx2paired-like homeodomain transcription factor 20.064
Abcg8ATP-binding cassette, sub-family G (WHITE), member 80.063
Nr5a1nuclear receptor subfamily 5, group A, member 10.063
Gata4GATA binding protein 40.062
Lrp5low density lipoprotein receptor-related protein 50.062
Ppargperoxisome proliferator activated receptor gamma0.062
Smpd3sphingomyelin phosphodiesterase 3, neutral0.060
Hoxa13homeobox A130.059
Fgf4fibroblast growth factor 40.057
Cubncubilin (intrinsic factor-cobalamin receptor)0.057
Tff1trefoil factor 10.056
Lgals2lectin, galactose-binding, soluble 20.055
Mesdc2mesoderm development candidate 20.055
Fbp2fructose bisphosphatase 20.055
SspoSCO-spondin0.054
Otogotogelin0.054
Foxc1forkhead box C10.053
Tex19.2testis expressed gene 19.20.053
Dkk1dickkopf homolog 1 (Xenopus laevis)0.051
Pthlhparathyroid hormone-like peptide0.050
Scarb1scavenger receptor class B, member 10.050
Mertkc-mer proto-oncogene tyrosine kinase0.050
Dhcr77-dehydrocholesterol reductase0.049
Rxraretinoid X receptor alpha0.048
Pofut1protein O-fucosyltransferase 10.045
Pick1protein interacting with C kinase 10.045
Srfserum response factor0.044
Col2a1collagen, type II, alpha 10.044
Sertad2SERTA domain containing 20.044
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.043
Capn9calpain 90.043
Srcrb4dscavenger receptor cysteine rich domain containing, group B (4 domains)0.043
Alppl2alkaline phosphatase, placental-like 20.043
Sox13SRY-box containing gene 130.043
Amhanti-Mullerian hormone0.042
Kcnk7potassium channel, subfamily K, member 70.042
Sctsecretin0.042
DaoD-amino acid oxidase0.042
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.042
Gsg1germ cell-specific gene 10.042
Zp3zona pellucida glycoprotein 30.041
Sox9SRY-box containing gene 90.041
Wapwhey acidic protein0.041
Foxd2forkhead box D20.040
Lmnalamin A0.038
Mep1ameprin 1 alpha0.038
Pax3paired box gene 30.038
Amhr2anti-Mullerian hormone type 2 receptor0.038
Col4a3collagen, type IV, alpha 30.038
Fgfr1fibroblast growth factor receptor 10.038
Scd1stearoyl-Coenzyme A desaturase 10.038
Sall4sal-like 4 (Drosophila)0.038
Slc6a20bsolute carrier family 6 (neurotransmitter transporter), member 20B0.038
Peli2pellino 20.037
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
APOA1apolipoprotein A-I1.000
ALBalbumin1.000
HPhaptoglobin0.978
APOC1apolipoprotein C-I0.953
MYD88myeloid differentiation primary response gene (88)0.906
APOEapolipoprotein E0.792
IRAK2interleukin-1 receptor-associated kinase 20.638
A2Malpha-2-macroglobulin0.489
APOC3apolipoprotein C-III0.386
LCATlecithin-cholesterol acyltransferase0.369
APOA2apolipoprotein A-II0.351
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.312
PELI3pellino homolog 3 (Drosophila)0.299
FGAfibrinogen alpha chain0.210
TRAF6TNF receptor-associated factor 60.192
MED15mediator complex subunit 150.122
TTRtransthyretin0.085
IRAK3interleukin-1 receptor-associated kinase 30.080
HNF4Ahepatocyte nuclear factor 4, alpha0.065
AHSGalpha-2-HS-glycoprotein0.063
APOC2apolipoprotein C-II0.058
LDLRlow density lipoprotein receptor0.046
ECSITECSIT homolog (Drosophila)0.034
PLTPphospholipid transfer protein0.031
DHCR77-dehydrocholesterol reductase0.027
SMAD3SMAD family member 30.026
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.024
APOBapolipoprotein B (including Ag(x) antigen)0.022
TXNDC2thioredoxin domain containing 2 (spermatozoa)0.020
IRAK4interleukin-1 receptor-associated kinase 40.013
PELI1pellino homolog 1 (Drosophila)0.013
SREBF1sterol regulatory element binding transcription factor 10.012
PELI2pellino homolog 2 (Drosophila)0.011
CREBBPCREB binding protein0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism