The network for 'positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway

Any process that increases the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G-protein coupled receptor signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
Cd247CD247 antigen0.421
Drd2dopamine receptor D20.320
Gpr27G protein-coupled receptor 270.253
Wnt2bwingless related MMTV integration site 2b0.234
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.231
Cckbrcholecystokinin B receptor0.212
Adora2aadenosine A2a receptor0.188
Npy2rneuropeptide Y receptor Y20.179
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.175
Mmp24matrix metallopeptidase 240.167
Ppyr1pancreatic polypeptide receptor 10.166
Npy5rneuropeptide Y receptor Y50.149
Mybpc3myosin binding protein C, cardiac0.145
Nos3nitric oxide synthase 3, endothelial cell0.141
Kcns2K+ voltage-gated channel, subfamily S, 20.136
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.134
Cntn3contactin 30.131
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.126
Gsx1GS homeobox 10.126
Mc5rmelanocortin 5 receptor0.124
Pthlhparathyroid hormone-like peptide0.117
Il2rbinterleukin 2 receptor, beta chain0.117
Oprk1opioid receptor, kappa 10.097
Cacng5calcium channel, voltage-dependent, gamma subunit 50.089
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.083
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.083
Ryr3ryanodine receptor 30.082
Rtbdnretbindin0.081
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.081
Ptafrplatelet-activating factor receptor0.081
Crhr1corticotropin releasing hormone receptor 10.079
Rhbdf1rhomboid family 1 (Drosophila)0.075
Leprleptin receptor0.071
Tacr1tachykinin receptor 10.070
Rit2Ras-like without CAAX 20.068
Nr3c1nuclear receptor subfamily 3, group C, member 10.068
Ctrb1chymotrypsinogen B10.067
Gabrqgamma-aminobutyric acid (GABA) A receptor, subunit theta0.067
Chrm1cholinergic receptor, muscarinic 1, CNS0.065
Vipvasoactive intestinal polypeptide0.065
Lhbluteinizing hormone beta0.064
Slc16a8solute carrier family 16 (monocarboxylic acid transporters), member 80.064
Htr65-hydroxytryptamine (serotonin) receptor 60.063
Kcnk4potassium channel, subfamily K, member 40.062
Smyd1SET and MYND domain containing 10.062
Fgf4fibroblast growth factor 40.061
Galr1galanin receptor 10.061
Klk4kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)0.059
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.058
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.058
Esr1estrogen receptor 1 (alpha)0.058
C2cd4cC2 calcium-dependent domain containing 4C0.057
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.056
Ntsr2neurotensin receptor 20.055
Admadrenomedullin0.055
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.053
Pcdh12protocadherin 120.052
Adra2cadrenergic receptor, alpha 2c0.052
Grid1glutamate receptor, ionotropic, delta 10.051
Mchr1melanin-concentrating hormone receptor 10.050
Adra2badrenergic receptor, alpha 2b0.049
Lepleptin0.048
Sntb1syntrophin, basic 10.048
Nrg3neuregulin 30.046
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.046
St8sia5ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 50.046
Sstr4somatostatin receptor 40.044
Dsppdentin sialophosphoprotein0.044
Rprmreprimo, TP53 dependent G2 arrest mediator candidate0.043
Smad9MAD homolog 9 (Drosophila)0.043
Pitx3paired-like homeodomain transcription factor 30.042
Nppbnatriuretic peptide type B0.042
Tac2tachykinin 20.042
Gpr50G-protein-coupled receptor 500.041
Nos1nitric oxide synthase 1, neuronal0.041
Adra2aadrenergic receptor, alpha 2a0.041
Shc3src homology 2 domain-containing transforming protein C30.040
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.039
Ccbp2chemokine binding protein 20.038
Slc18a3solute carrier family 18 (vesicular monoamine), member 30.037
Tbrachyury0.036
Rgs9regulator of G-protein signaling 90.036
Gng4guanine nucleotide binding protein (G protein), gamma 40.036
Adrb1adrenergic receptor, beta 10.035
Nxph2neurexophilin 20.035
Kcne1lpotassium voltage-gated channel, Isk-related family, member 1-like, pseudogene0.035
Gabra2gamma-aminobutyric acid (GABA) A receptor, subunit alpha 20.035
Lhx6LIM homeobox protein 60.035
Pdynprodynorphin0.035
Fgf16fibroblast growth factor 160.034
Sox7SRY-box containing gene 70.034
Cux2cut-like homeobox 20.034
Gabrg1gamma-aminobutyric acid (GABA) A receptor, subunit gamma 10.034
Alkanaplastic lymphoma kinase0.034
Cd8b1CD8 antigen, beta chain 10.033
Syt10synaptotagmin X0.033
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.033
Has1hyaluronan synthase10.033
Tgfatransforming growth factor alpha0.033
Npy1rneuropeptide Y receptor Y10.033
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG13253CG13253 gene product from transcript CG13253-RB0.686
TbhTyramine beta hydroxylase0.598
timtimeless0.356
perperiod0.239
CG34400CG34400 gene product from transcript CG34400-RD0.238
crycryptochrome0.210
ClkClock0.151
CG18437CG18437 gene product from transcript CG18437-RB0.122
fd85Eforkhead domain 85E0.119
unc79CG5237 gene product from transcript CG5237-RB0.096
Nmdar1NMDA receptor 10.081
pdfrPDF receptor0.081
Ilp3Insulin-like peptide 30.069
PIP5K59BCG3682 gene product from transcript CG3682-RE0.059
5-HT1ASerotonin receptor 1A0.053
tauCG31057 gene product from transcript CG31057-RA0.053
ShawShaker cognate w0.050
IhI[[h]] channel0.050
highikaru genki0.049
DskDrosulfakinin0.047
dnr1defense repressor 10.045
Fer248 related 20.045
iavinactive0.030
CanA-14FCalcineurin A at 14F0.026
CCKLR-17D1CCK-like receptor at 17D10.025
Atf-2Activating transcription factor-20.024
CG14989CG14989 gene product from transcript CG14989-RB0.022
Ast-CAllatostatin C0.021
Tdc2Tyrosine decarboxylase 20.021
VGATVesicular GABA Transporter0.021
RdlResistant to dieldrin0.021
DhDiuretic hormone0.019
Ilp2Insulin-like peptide 20.019
capaRcapa receptor0.017
OambOctopamine receptor in mushroom bodies0.017
CG34353CG34353 gene product from transcript CG34353-RA0.017
5-HT7Serotonin receptor 70.015
CG9997CG9997 gene product from transcript CG9997-RA0.015
CG31221CG31221 gene product from transcript CG31221-RA0.014
PdfPigment-dispersing factor0.013
CG17575CG17575 gene product from transcript CG17575-RA0.013
eloFelongase F0.013
DopEcRCG18314 gene product from transcript CG18314-RB0.012
CG13565CG13565 gene product from transcript CG13565-RA0.012
pyxpyrexia0.012
SP2353CG8403 gene product from transcript CG8403-RA0.012
Task6CG9637 gene product from transcript CG9637-RC0.012
Obp56eOdorant-binding protein 56e0.011
tadrtorn and diminished rhabdomeres0.011
CG14034CG14034 gene product from transcript CG14034-RB0.011
GluClalphaCG7535 gene product from transcript CG7535-RG0.011
CG9236CG9236 gene product from transcript CG9236-RA0.010
CG42629CG42629 gene product from transcript CG42629-RB0.010
Rh6Rhodopsin 60.010
Tsf3Transferrin 30.010
CG34139CG34139 gene product from transcript CG34139-RD0.010
CG32154CG32154 gene product from transcript CG32154-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DRD2dopamine receptor D20.991
NAMPTnicotinamide phosphoribosyltransferase0.490
CRHcorticotropin releasing hormone0.329
NECAB2N-terminal EF-hand calcium binding protein 20.269
CALM1calmodulin 1 (phosphorylase kinase, delta)0.065
MEOX2mesenchyme homeobox 20.050
ADORA1adenosine A1 receptor0.047
ADORA2Aadenosine A2a receptor0.042
PAX3paired box 30.027
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.016
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.015
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Arpp21cAMP-regulated phosphoprotein 210.163
Mapk4mitogen-activated protein kinase 40.142
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.129
Drd1adopamine receptor D1A0.111
Il1r2interleukin 1 receptor, type II0.101
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.098
Adora2aadenosine A2a receptor0.084
Pfkfb46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 40.071
Pnmtphenylethanolamine-N-methyltransferase0.070
Pnocprepronociceptin0.061
Fam65afamily with sequence similarity 65, member A0.061
Cntn4contactin 40.059
Arcactivity-regulated cytoskeleton-associated protein0.051
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.047
Vipvasoactive intestinal peptide0.045
Cckbrcholecystokinin B receptor0.043
RT1-M5RT1 class Ib, locus M50.041
Trhr2thyrotropin releasing hormone receptor 20.035
Cckcholecystokinin0.035
Vipr1vasoactive intestinal peptide receptor 10.034
Tpsab1tryptase alpha/beta 10.034
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.033
Pde1bphosphodiesterase 1B, calmodulin-dependent0.033
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.031
Tagln3transgelin 30.031
Selpselectin P0.031
Strnstriatin, calmodulin binding protein0.030
Olr1469olfactory receptor Olr14690.030
Rgs9regulator of G-protein signaling 90.029
Olr37olfactory receptor 370.028
Tcof1Treacher Collins-Franceschetti syndrome 1 homolog (human)0.028
Grm7glutamate receptor, metabotropic 70.027
Syt4synaptotagmin IV0.025
Snap25synaptosomal-associated protein 250.023
Grip2glutamate receptor interacting protein 20.023
Cplx1complexin 10.023
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.022
Egr4early growth response 40.021
Pdynprodynorphin0.020
Adora1adenosine A1 receptor0.019
Chrm1cholinergic receptor, muscarinic 10.019
Kcnv1potassium channel, subfamily V, member 10.018
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.018
Lin7blin-7 homolog b (C. elegans)0.018
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.018
Kcnk1potassium channel, subfamily K, member 10.017
Sstr1somatostatin receptor 10.017
Kcnj9potassium inwardly-rectifying channel, subfamily J, member 90.017
Cacna1gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.017
Epha3Eph receptor A30.017
Tpsb2tryptase beta 20.017
Drd2dopamine receptor D20.016
Nxph3neurexophilin 30.016
Ptch1patched homolog 1 (Drosophila)0.016
Pou3f4POU class 3 homeobox 40.015
Epha5EphA50.015
Tbxa2rthromboxane A2 receptor0.014
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.014
Arnt2aryl hydrocarbon receptor nuclear translocator 20.014
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.013
Kcnf1potassium voltage-gated channel, subfamily F, member 10.013
Inhbainhibin beta-A0.013
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.013
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.013
Mchr1melanin-concentrating hormone receptor 10.012
Fosl1fos-like antigen 10.012
Olr1504olfactory receptor 15040.012
Hpcahippocalcin0.011
Dlgap2discs, large (Drosophila) homolog-associated protein 20.011
Sstsomatostatin0.011
Dnahc6dynein, axonemal, heavy chain 60.011
Syn1synapsin I0.011
Mpp3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)0.011
Gpr176G protein-coupled receptor 1760.011
Scn3asodium channel, voltage-gated, type III, alpha0.011
Ptpn5protein tyrosine phosphatase, non-receptor type 50.011
Magmyelin-associated glycoprotein0.011
Grid1glutamate receptor, ionotropic, delta 10.011
Pcsk1proprotein convertase subtilisin/kexin type 10.011
Isl1ISL LIM homeobox 10.010
Map6microtubule-associated protein 60.010
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.010
SvopSV2 related protein0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism