The network for 'negative regulation of cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cytokine production

Any process that stops, prevents, or reduces the rate of production of a cytokine.

NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase0.997
Tlr4toll-like receptor 40.995
Tnftumor necrosis factor0.983
Il1r1interleukin 1 receptor, type I0.982
Myd88myeloid differentiation primary response gene 880.980
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.977
Stat3signal transducer and activator of transcription 30.965
Lyz2lysozyme 20.965
Casp1caspase 10.963
AxlAXL receptor tyrosine kinase0.954
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.950
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.949
Pax8paired box gene 80.927
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.926
Batfbasic leucine zipper transcription factor, ATF-like0.913
Socs1suppressor of cytokine signaling 10.913
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.909
Slamf1signaling lymphocytic activation molecule family member 10.866
Traf6TNF receptor-associated factor 60.832
Stat1signal transducer and activator of transcription 10.822
Cd44CD44 antigen0.812
Trim30atripartite motif-containing 30A0.793
Gbp7guanylate binding protein 70.778
Pdcd1programmed cell death 10.777
Il10interleukin 100.747
Il10rainterleukin 10 receptor, alpha0.735
Apoeapolipoprotein E0.722
Esr1estrogen receptor 1 (alpha)0.718
Ptenphosphatase and tensin homolog0.664
Fshrfollicle stimulating hormone receptor0.651
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.635
Inhbainhibin beta-A0.634
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.630
Birc3baculoviral IAP repeat-containing 30.609
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.609
Il1binterleukin 1 beta0.585
Cd40CD40 antigen0.583
Relreticuloendotheliosis oncogene0.568
Amhanti-Mullerian hormone0.559
Mmp8matrix metallopeptidase 80.548
Trp63transformation related protein 630.547
Ccl4chemokine (C-C motif) ligand 40.543
Duox2dual oxidase 20.538
Nlrp3NLR family, pyrin domain containing 30.531
Map3k8mitogen-activated protein kinase kinase kinase 80.525
Trim21tripartite motif-containing 210.523
Tlr2toll-like receptor 20.481
Irf1interferon regulatory factor 10.477
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.459
Csf1colony stimulating factor 1 (macrophage)0.459
Wnt4wingless-related MMTV integration site 40.458
Tgfbr2transforming growth factor, beta receptor II0.455
Icosinducible T-cell co-stimulator0.439
Gpr132G protein-coupled receptor 1320.434
Il2rbinterleukin 2 receptor, beta chain0.431
Il1rl1interleukin 1 receptor-like 10.429
Cd86CD86 antigen0.411
PycardPYD and CARD domain containing0.409
Aim2absent in melanoma 20.395
Itgb2lintegrin beta 2-like0.382
Rhohras homolog gene family, member H0.381
Hic1hypermethylated in cancer 10.381
Cd19CD19 antigen0.363
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.361
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.354
Gli2GLI-Kruppel family member GLI20.351
Arrb1arrestin, beta 10.346
Rargretinoic acid receptor, gamma0.345
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.342
Ascl1achaete-scute complex homolog 1 (Drosophila)0.340
FasFas (TNF receptor superfamily member 6)0.339
Tgfb1transforming growth factor, beta 10.337
Arrb2arrestin, beta 20.337
Ifngr1interferon gamma receptor 10.333
Ccr2chemokine (C-C motif) receptor 20.329
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.328
Iigp1interferon inducible GTPase 10.322
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.319
Tnip1TNFAIP3 interacting protein 10.319
Cd80CD80 antigen0.315
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.311
Inpp5dinositol polyphosphate-5-phosphatase D0.311
Il4rainterleukin 4 receptor, alpha0.309
Gata4GATA binding protein 40.307
Ifnginterferon gamma0.302
2010106G01RikRIKEN cDNA 2010106G01 gene0.298
Neurog2neurogenin 20.296
Adam8a disintegrin and metallopeptidase domain 80.296
Aoahacyloxyacyl hydrolase0.295
Ptf1apancreas specific transcription factor, 1a0.294
Snai1snail homolog 1 (Drosophila)0.292
FaslFas ligand (TNF superfamily, member 6)0.291
Unc93b1unc-93 homolog B1 (C. elegans)0.290
Map3k3mitogen-activated protein kinase kinase kinase 30.289
Cd14CD14 antigen0.284
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.278
Cxcl10chemokine (C-X-C motif) ligand 100.278
Nos2nitric oxide synthase 2, inducible0.276
Gnrh1gonadotropin releasing hormone 10.276
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nod1nucleotide-binding oligomerization domain containing 10.230
il6stinterleukin 6 signal transducer0.195
LOC557072caspase recruitment domain-containing protein 11-like0.190
anxa1bannexin A1b0.164
gsnbgelsolin b0.128
eya2eyes absent homolog 2 (Drosophila)0.127
crip2cysteine-rich protein 20.125
fgf8afibroblast growth factor 8 a0.124
eporerythropoietin receptor0.117
ccnb1cyclin B10.106
cpoxcoproporphyrinogen oxidase0.103
pglyrp6peptidoglycan recognition protein 60.101
pycardPYD and CARD domain containing0.095
cav1caveolin 10.093
foxi2forkhead box I20.089
ripk2receptor-interacting serine-threonine kinase 20.089
shhasonic hedgehog a0.089
cmybtranscription factor cmyb0.088
bmp2bbone morphogenetic protein 2b0.086
ptger2aprostaglandin E receptor 2a (subtype EP2)0.085
card9caspase recruitment domain family, member 90.082
gfergrowth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)0.079
rargaretinoic acid receptor gamma a0.079
LOC100332193growth hormone secretagogue receptor type 1-like0.077
ip6k2inositol hexaphosphate kinase 20.074
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.070
tal1T-cell acute lymphocytic leukemia 10.068
tgfb3transforming growth factor, beta 30.067
dvl3dishevelled, dsh homolog 3 (Drosophila)0.067
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.066
sepw1selenoprotein W, 10.066
elk4ELK4, ETS-domain protein0.064
tmprss4atransmembrane protease, serine 4a0.064
tnfatumor necrosis factor a (TNF superfamily, member 2)0.063
il6rinterleukin 6 receptor0.062
slc12a9solute carrier family 12 (potassium/chloride transporters), member 90.061
tfebtranscription factor EB0.060
tlr3toll-like receptor 30.060
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.060
pglyrp5peptidoglycan recognition protein 50.059
idh1isocitrate dehydrogenase 1 (NADP+), soluble0.059
nrp1aneuropilin 1a0.057
vcanaversican a0.057
foxj1bforkhead box J1b0.057
entpd1ectonucleoside triphosphate diphosphohydrolase 10.056
rasl11bRAS-like, family 11, member B0.056
egr2bearly growth response 2b0.055
il7rinterleukin 7 receptor0.054
mkrn4makorin, ring finger protein, 40.054
c8acomplement component 8, alpha polypeptide0.054
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.054
LOC100151531zinc finger protein Gfi-1b-like0.053
sox11aSRY-box containing gene 11a0.052
nfe2nuclear factor, erythroid-derived 20.052
jak1Janus kinase 10.051
clic2chloride intracellular channel 20.050
sepw2bselenoprotein W, 2b0.050
capns1acalpain, small subunit 1 a0.050
pias4bprotein inhibitor of activated STAT, 4b0.049
sid4secreted immunoglobulin domain 40.049
nr2f2nuclear receptor subfamily 2, group F, member 20.049
dnmt8DNA (cytosine-5-)-methyltransferase 80.049
tbx5bT-box 5b0.048
ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.047
cdc14aaCDC14 cell division cycle 14 homolog A, a0.047
fgf20afibroblast growth factor 20a0.046
onecutlone cut domain, family member, like0.046
stat1bsignal transducer and activator of transcription 1b0.046
foxn1forkhead box N10.046
icn2ictacalcin 20.046
osr1odd-skipped related 1 (Drosophila)0.045
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.045
spry4sprouty (Drosophila) homolog 40.045
stc1lstanniocalcin 1, like0.044
ctsl1acathepsin L, 1 a0.043
insrainsulin receptor a0.043
hcrthypocretin (orexin) neuropeptide precursor0.042
zbtb22bzinc finger and BTB domain containing 22b0.042
sox3SRY-box containing gene 30.042
tcf12transcription factor 120.042
usp10ubiquitin specific peptidase 100.042
nos2anitric oxide synthase 2a, inducible0.041
rpe65bretinal pigment epithelium-specific protein 65b0.041
vtg6vitellogenin 60.041
capn9calpain 90.041
rarabretinoic acid receptor, alpha b0.040
spns2spinster homolog 2 (Drosophila)0.040
ifnphi1interferon phi 10.040
fasFas (TNF receptor superfamily, member 6)0.040
anxa1aannexin A1a0.040
il1binterleukin 1, beta and interleukin 1, beta0.039
scinlbscinderin like b0.039
rrp12ribosomal RNA processing 12 homolog (S. cerevisiae)0.039
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.987
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.980
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.973
C1QAcomplement component 1, q subcomponent, A chain0.960
IL1R1interleukin 1 receptor, type I0.939
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.931
IRAK1interleukin-1 receptor-associated kinase 10.919
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.877
TRAF6TNF receptor-associated factor 60.861
NOTCH1notch 10.779
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.774
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.761
IRAK2interleukin-1 receptor-associated kinase 20.740
MYD88myeloid differentiation primary response gene (88)0.705
SMN1survival of motor neuron 1, telomeric0.702
CREBBPCREB binding protein0.700
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.683
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.646
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.643
SLAMF1signaling lymphocytic activation molecule family member 10.637
NCOR2nuclear receptor corepressor 20.622
TAL1T-cell acute lymphocytic leukemia 10.613
TRAF1TNF receptor-associated factor 10.597
RXRAretinoid X receptor, alpha0.583
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.543
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.538
ANXA1annexin A10.533
CXCL9chemokine (C-X-C motif) ligand 90.524
CCR5chemokine (C-C motif) receptor 50.520
PMLpromyelocytic leukemia0.502
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.453
ARRB1arrestin, beta 10.447
CCL22chemokine (C-C motif) ligand 220.427
GAS6growth arrest-specific 60.426
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.425
CCL4chemokine (C-C motif) ligand 40.406
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.397
CD84CD84 molecule0.375
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.361
SETD8SET domain containing (lysine methyltransferase) 80.359
ZNF496zinc finger protein 4960.358
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.335
S100A10S100 calcium binding protein A100.330
APOA1apolipoprotein A-I0.325
APOC1apolipoprotein C-I0.324
IL6interleukin 6 (interferon, beta 2)0.313
MED15mediator complex subunit 150.313
PRKD2protein kinase D20.312
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.307
CCL2chemokine (C-C motif) ligand 20.299
BCL3B-cell CLL/lymphoma 30.293
CXCL3chemokine (C-X-C motif) ligand 30.291
CCL8chemokine (C-C motif) ligand 80.285
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.282
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.281
LAMP1lysosomal-associated membrane protein 10.272
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.256
DSG2desmoglein 20.256
TNFtumor necrosis factor0.249
MAP3K2mitogen-activated protein kinase kinase kinase 20.246
APPamyloid beta (A4) precursor protein0.245
EPORerythropoietin receptor0.241
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.237
MEF2Cmyocyte enhancer factor 2C0.234
TNFAIP3tumor necrosis factor, alpha-induced protein 30.223
CCR7chemokine (C-C motif) receptor 70.218
MEFVMediterranean fever0.215
AXLAXL receptor tyrosine kinase0.208
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.205
NOTCH3notch 30.205
NLRP3NLR family, pyrin domain containing 30.203
PPARAperoxisome proliferator-activated receptor alpha0.203
CCL7chemokine (C-C motif) ligand 70.200
RANBP3RAN binding protein 30.196
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.195
TRIM5tripartite motif containing 50.192
IL23Ainterleukin 23, alpha subunit p190.189
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.179
SOCS3suppressor of cytokine signaling 30.179
C1QCcomplement component 1, q subcomponent, C chain0.178
IL10interleukin 100.177
TGFB1transforming growth factor, beta 10.174
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.170
TEKTEK tyrosine kinase, endothelial0.168
ABI2abl-interactor 20.160
SLAMF8SLAM family member 80.159
CCR4chemokine (C-C motif) receptor 40.156
RARAretinoic acid receptor, alpha0.155
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.153
IL4Rinterleukin 4 receptor0.152
HLA-DRB4major histocompatibility complex, class II, DR beta 40.152
IL1Binterleukin 1, beta0.152
IL10RAinterleukin 10 receptor, alpha0.152
IRF7interferon regulatory factor 70.147
APOEapolipoprotein E0.147
LAIR1leukocyte-associated immunoglobulin-like receptor 10.145
IFNGinterferon, gamma0.143
SHC1SHC (Src homology 2 domain containing) transforming protein 10.142
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.220
JunJun oncogene0.097
Muc1mucin 1, cell surface associated0.092
Icam1intercellular adhesion molecule 10.087
Arl11ADP-ribosylation factor-like 110.080
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.080
Stat3signal transducer and activator of transcription 30.075
Il6interleukin 60.068
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.063
Cd2Cd2 molecule0.063
Lgals3lectin, galactoside-binding, soluble, 30.057
Timp1TIMP metallopeptidase inhibitor 10.048
Ehfets homologous factor0.044
Cnr2cannabinoid receptor 2 (macrophage)0.044
Rhogras homolog gene family, member G (rho G)0.043
Scarf2scavenger receptor class F, member 20.041
Pyypeptide YY (mapped)0.041
Rararetinoic acid receptor, alpha0.039
Trim47tripartite motif-containing 470.038
Elk3ELK3, ETS-domain protein0.037
Cd80Cd80 molecule0.037
Akr1b8aldo-keto reductase family 1, member B80.036
Ccl3chemokine (C-C motif) ligand 30.036
Il2rginterleukin 2 receptor, gamma0.036
Arhgap4Rho GTPase activating protein 40.035
Scn10asodium channel, voltage-gated, type X, alpha subunit0.035
Tp53tumor protein p530.034
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.034
Ccl2chemokine (C-C motif) ligand 20.033
Cd44Cd44 molecule0.033
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.032
Hspa1aheat shock 70kD protein 1A0.030
S1pr2sphingosine-1-phosphate receptor 20.029
Ripk3receptor-interacting serine-threonine kinase 30.029
Junbjun B proto-oncogene0.029
Svs1seminal vesicle secretory protein 10.026
Bdkrb2bradykinin receptor B20.026
Clca4chloride channel accessory 40.026
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.026
Tcp11t-complex protein 110.026
Slco2a1solute carrier organic anion transporter family, member 2a10.026
Sbno2strawberry notch homolog 2 (Drosophila)0.025
Gstm1glutathione S-transferase mu 10.024
Plaurplasminogen activator, urokinase receptor0.023
Cyp2a3cytochrome P450, family 2, subfamily a, polypeptide 30.023
Hspb1heat shock protein 10.023
Drd3dopamine receptor D30.022
Tgif1TGFB-induced factor homeobox 10.021
Scgb1a1secretoglobin, family 1A, member 1 (uteroglobin)0.021
Grb7growth factor receptor bound protein 70.020
Prkchprotein kinase C, eta0.020
MGC112715hypothetical protein LOC6908990.020
Cd8bCD8b molecule0.020
Mc5rmelanocortin 5 receptor0.020
Tmem88transmembrane protein 880.020
Barhl2BarH-like homeobox 20.019
Litaflipopolysaccharide-induced TNF factor0.018
Ptpn1protein tyrosine phosphatase, non-receptor type 10.018
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.018
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.018
Mmp12matrix metallopeptidase 120.018
Dok1docking protein 10.018
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.018
Cd37CD37 molecule0.017
Ramp1receptor (G protein-coupled) activity modifying protein 10.017
Il2rbinterleukin 2 receptor, beta0.017
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.017
Itpr2inositol 1,4,5-triphosphate receptor, type 20.016
Ccl22chemokine (C-C motif) ligand 220.016
Cd14CD14 molecule0.016
Zfp36l1zinc finger protein 36, C3H type-like 10.016
Lypd3Ly6/Plaur domain containing 30.015
Tlr4toll-like receptor 40.015
Klf6Kruppel-like factor 60.015
Chmp1achromatin modifying protein 1A0.015
Col8a1collagen, type VIII, alpha 10.015
Itga7integrin, alpha 70.015
Foxa2forkhead box A20.015
Il17reinterleukin 17 receptor E0.015
Scamp2secretory carrier membrane protein 20.015
Gjb3gap junction protein, beta 30.015
Ctrcchymotrypsin C (caldecrin)0.014
Casp12caspase 120.014
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.014
Irak3interleukin-1 receptor-associated kinase 30.014
Ptger4prostaglandin E receptor 4 (subtype EP4)0.014
Fcnbficolin B0.014
Cldn3claudin 30.014
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.014
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.014
C5ar1complement component 5a receptor 10.014
Slfn2schlafen 20.014
Cfpcomplement factor properdin0.014
Bdkrb1bradykinin receptor B10.013
Prkcdprotein kinase C, delta0.013
Ppp3r2protein phosphatase 3, regulatory subunit B, beta isoform0.013
Efnb1ephrin B10.013
Itgb1integrin, beta 10.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism