The network for 'positive regulation of cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cytokine production

Any process that activates or increases the frequency, rate or extent of production of a cytokine.

NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase1.000
Lyz2lysozyme 20.999
Tlr4toll-like receptor 40.996
Tnftumor necrosis factor0.996
Il1binterleukin 1 beta0.986
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.982
Map3k14mitogen-activated protein kinase kinase kinase 140.980
Ccr1chemokine (C-C motif) receptor 10.980
Cd40CD40 antigen0.980
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.979
Icosinducible T-cell co-stimulator0.979
Cybbcytochrome b-245, beta polypeptide0.977
Stat1signal transducer and activator of transcription 10.975
FasFas (TNF receptor superfamily member 6)0.973
Stat3signal transducer and activator of transcription 30.973
Il4interleukin 40.970
Myd88myeloid differentiation primary response gene 880.968
Clec4nC-type lectin domain family 4, member n0.965
Birc3baculoviral IAP repeat-containing 30.956
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.949
Cxcl13chemokine (C-X-C motif) ligand 130.948
Ikzf1IKAROS family zinc finger 10.946
Il1r1interleukin 1 receptor, type I0.943
Casp1caspase 10.930
Osmroncostatin M receptor0.927
C3ar1complement component 3a receptor 10.926
Il2rginterleukin 2 receptor, gamma chain0.914
Apoeapolipoprotein E0.911
Il17ainterleukin 17A0.911
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.908
Clec4dC-type lectin domain family 4, member d0.903
Ighimmunoglobulin heavy chain complex0.899
Selpselectin, platelet0.888
Ptprcprotein tyrosine phosphatase, receptor type, C0.888
Map3k8mitogen-activated protein kinase kinase kinase 80.883
Pax8paired box gene 80.881
Il1rninterleukin 1 receptor antagonist0.881
Il10interleukin 100.879
BtkBruton agammaglobulinemia tyrosine kinase0.872
Pax2paired box gene 20.868
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.864
Ccl2chemokine (C-C motif) ligand 20.861
Ccl4chemokine (C-C motif) ligand 40.861
Ikbkbinhibitor of kappaB kinase beta0.858
Ifnginterferon gamma0.857
Cd28CD28 antigen0.854
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.853
Rargretinoic acid receptor, gamma0.853
Il2rbinterleukin 2 receptor, beta chain0.847
H2-Aahistocompatibility 2, class II antigen A, alpha0.845
Relreticuloendotheliosis oncogene0.814
Klrk1killer cell lectin-like receptor subfamily K, member 10.810
Cxcl2chemokine (C-X-C motif) ligand 20.805
Il12ainterleukin 12a0.804
Ccr9chemokine (C-C motif) receptor 90.801
Cd44CD44 antigen0.791
Il7rinterleukin 7 receptor0.790
Unc93b1unc-93 homolog B1 (C. elegans)0.784
Ccr7chemokine (C-C motif) receptor 70.782
Sfpi1SFFV proviral integration 10.773
Ccr2chemokine (C-C motif) receptor 20.773
Cd14CD14 antigen0.773
BlkB lymphoid kinase0.772
Wnt9bwingless-type MMTV integration site 9B0.771
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.769
Ccl22chemokine (C-C motif) ligand 220.765
Socs1suppressor of cytokine signaling 10.762
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.761
Tnfaip3tumor necrosis factor, alpha-induced protein 30.760
Il6stinterleukin 6 signal transducer0.756
MefvMediterranean fever0.752
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.746
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.744
Klra9killer cell lectin-like receptor subfamily A, member 90.741
Ncr1natural cytotoxicity triggering receptor 10.741
Il1rl1interleukin 1 receptor-like 10.740
Irf9interferon regulatory factor 90.734
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.726
Atp7aATPase, Cu++ transporting, alpha polypeptide0.726
Il10rainterleukin 10 receptor, alpha0.717
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.715
Gpr33G protein-coupled receptor 330.715
Jak2Janus kinase 20.714
Ciitaclass II transactivator0.701
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.699
Il4rainterleukin 4 receptor, alpha0.696
Clec4eC-type lectin domain family 4, member e0.696
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.695
Xcl1chemokine (C motif) ligand 10.692
Ltalymphotoxin A0.685
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.683
Itgalintegrin alpha L0.676
Il5interleukin 50.671
Sh2d2aSH2 domain protein 2A0.668
Socs3suppressor of cytokine signaling 30.663
Tlr2toll-like receptor 20.663
Lhx1LIM homeobox protein 10.658
Klrg1killer cell lectin-like receptor subfamily G, member 10.656
Cd80CD80 antigen0.655
Batfbasic leucine zipper transcription factor, ATF-like0.641
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fn1fibronectin 10.786
sulf2lsulfatase 2, like0.748
bmp2bbone morphogenetic protein 2b0.575
tlr3toll-like receptor 30.538
epas1bendothelial PAS domain protein 1b0.528
gpiaglucose phosphate isomerase a0.456
stat1bsignal transducer and activator of transcription 1b0.379
ip6k2inositol hexaphosphate kinase 20.373
nod1nucleotide-binding oligomerization domain containing 10.369
dnmt8DNA (cytosine-5-)-methyltransferase 80.352
egr2bearly growth response 2b0.323
c3bcomplement component c3b0.303
sid4secreted immunoglobulin domain 40.267
wnt4awingless-type MMTV integration site family, member 4a0.263
fstafollistatin a0.246
sulf1sulfatase 10.236
LOC557072caspase recruitment domain-containing protein 11-like0.221
ikzf1IKAROS family zinc finger 1 (Ikaros)0.218
ptger2aprostaglandin E receptor 2a (subtype EP2)0.213
col12a1collagen, type XII, alpha 10.206
etv2ets variant gene 20.198
hspb11heat shock protein, alpha-crystallin-related, b110.184
il6stinterleukin 6 signal transducer0.176
irak4interleukin-1 receptor-associated kinase 40.176
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.174
dlg2discs, large (Drosophila) homolog 20.173
tlr2toll-like receptor 20.170
pomt2protein-O-mannosyltransferase 20.168
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.166
igf2binsulin-like growth factor 2b0.165
ifng1-2interferon, gamma 1-20.160
cpoxcoproporphyrinogen oxidase0.160
c1qccomplement component 1, q subcomponent, C chain0.156
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.150
hspa5heat shock protein 50.150
fabp7afatty acid binding protein 7, brain, a0.146
dnmt4DNA (cytosine-5-)-methyltransferase 40.145
eporerythropoietin receptor0.143
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.143
tlr9toll-like receptor 90.140
ifnphi1interferon phi 10.140
ripk2receptor-interacting serine-threonine kinase 20.138
nos2anitric oxide synthase 2a, inducible0.137
sod2superoxide dismutase 2, mitochondrial0.135
cyp3a65cytochrome P450, family 3, subfamily A, polypeptide 650.134
pomt1protein-O-mannosyltransferase 10.130
bhlhe40basic helix-loop-helix family, member e400.129
mxamyxovirus (influenza) resistance A0.128
alcamaactivated leukocyte cell adhesion molecule a0.128
caspacaspase a0.128
matn4matrilin 40.127
btkBruton agammaglobulinemia tyrosine kinase0.127
ecscrendothelial cell-specific chemotaxis regulator0.125
mpxmyeloid-specific peroxidase0.125
crfb7cytokine receptor family member b70.120
timp2atissue inhibitor of metalloproteinase 2a0.120
hcrthypocretin (orexin) neuropeptide precursor0.119
il1binterleukin 1, beta and interleukin 1, beta0.116
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.116
hey2hairy/enhancer-of-split related with YRPW motif 20.115
tlr18toll-like receptor 180.115
pycardPYD and CARD domain containing0.113
il8interleukin 80.112
stc1lstanniocalcin 1, like0.110
pcsk5bproprotein convertase subtilisin/kexin type 5b0.109
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.109
acvr2aactivin receptor IIa0.108
ef1aelongation factor 1-alpha0.108
fkrpfukutin related protein0.108
hsd17b12bhydroxysteroid (17-beta) dehydrogenase 12b0.108
tal1T-cell acute lymphocytic leukemia 10.104
vcanbversican b0.104
dag1dystroglycan 10.103
wnt11rwingless-type MMTV integration site family, member 11, related0.102
ecrg4aesophageal cancer related gene 4a0.101
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.101
prkcqprotein kinase C, theta0.100
tnfatumor necrosis factor a (TNF superfamily, member 2)0.100
mmp9matrix metalloproteinase 90.099
defbl3defensin, beta-like 30.099
defbl1defensin, beta-like 10.099
ptk2.1protein tyrosine kinase 2a0.098
LOC100003514protein kinase C alpha type-like0.098
LOC100332193growth hormone secretagogue receptor type 1-like0.096
tiraptoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.096
igf1rainsulin-like growth factor 1a receptor0.096
limk2LIM domain kinase 20.094
timp2btissue inhibitor of metalloproteinase 2b0.094
sfrp2secreted frizzled-related protein 20.093
cd209CD209 molecule0.092
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BIRC3baculoviral IAP repeat containing 31.000
STAT1signal transducer and activator of transcription 1, 91kDa0.999
TRAF1TNF receptor-associated factor 10.999
TRAF2TNF receptor-associated factor 20.996
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.991
RIPK2receptor-interacting serine-threonine kinase 20.989
TRAF3TNF receptor-associated factor 30.988
SYKspleen tyrosine kinase0.988
JAK2Janus kinase 20.988
MYD88myeloid differentiation primary response gene (88)0.984
C1QAcomplement component 1, q subcomponent, A chain0.982
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.980
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.979
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.978
IL6interleukin 6 (interferon, beta 2)0.976
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.972
CD80CD80 molecule0.969
CXCL10chemokine (C-X-C motif) ligand 100.967
SOCS3suppressor of cytokine signaling 30.964
IL1Binterleukin 1, beta0.962
CD86CD86 molecule0.962
HLA-Fmajor histocompatibility complex, class I, F0.960
MAP3K7mitogen-activated protein kinase kinase kinase 70.959
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.951
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.947
BTN3A3butyrophilin, subfamily 3, member A30.941
TNFtumor necrosis factor0.937
HLA-Bmajor histocompatibility complex, class I, B0.935
HLA-Emajor histocompatibility complex, class I, E0.929
CCL2chemokine (C-C motif) ligand 20.928
LCKlymphocyte-specific protein tyrosine kinase0.914
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.914
CCR5chemokine (C-C motif) receptor 50.911
TLR2toll-like receptor 20.904
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.897
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.892
CXCL9chemokine (C-X-C motif) ligand 90.889
IL8interleukin 80.881
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.879
BTN3A1butyrophilin, subfamily 3, member A10.874
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.872
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.871
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.871
TANKTRAF family member-associated NFKB activator0.867
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.867
HLA-Cmajor histocompatibility complex, class I, C0.863
TAL1T-cell acute lymphocytic leukemia 10.858
BCL10B-cell CLL/lymphoma 100.856
BIRC2baculoviral IAP repeat containing 20.854
ICAM1intercellular adhesion molecule 10.854
BCL3B-cell CLL/lymphoma 30.851
IL1R1interleukin 1 receptor, type I0.846
TRADDTNFRSF1A-associated via death domain0.843
APOEapolipoprotein E0.832
HLA-Amajor histocompatibility complex, class I, A0.829
CCR1chemokine (C-C motif) receptor 10.828
IL10interleukin 100.828
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.827
CXCL2chemokine (C-X-C motif) ligand 20.803
DDIT3DNA-damage-inducible transcript 30.797
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.792
IFNGR1interferon gamma receptor 10.791
IRAK1interleukin-1 receptor-associated kinase 10.782
IL2RBinterleukin 2 receptor, beta0.779
CCL8chemokine (C-C motif) ligand 80.774
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.771
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.764
CARD11caspase recruitment domain family, member 110.763
FASFas (TNF receptor superfamily, member 6)0.760
ESR1estrogen receptor 10.752
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.751
TLR4toll-like receptor 40.748
EPAS1endothelial PAS domain protein 10.747
CCL4chemokine (C-C motif) ligand 40.744
AHRaryl hydrocarbon receptor0.741
CD40CD40 molecule, TNF receptor superfamily member 50.738
HCKhemopoietic cell kinase0.737
BTN3A2butyrophilin, subfamily 3, member A20.729
STAT2signal transducer and activator of transcription 2, 113kDa0.721
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.717
TICAM2toll-like receptor adaptor molecule 20.716
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.710
IFIH1interferon induced with helicase C domain 10.704
TRAF5TNF receptor-associated factor 50.700
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.691
IL4interleukin 40.689
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.685
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.682
IL10RAinterleukin 10 receptor, alpha0.681
MAPK14mitogen-activated protein kinase 140.673
HLA-Gmajor histocompatibility complex, class I, G0.668
TNFAIP3tumor necrosis factor, alpha-induced protein 30.661
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.659
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.655
CTLA4cytotoxic T-lymphocyte-associated protein 40.652
NMIN-myc (and STAT) interactor0.647
CCL20chemokine (C-C motif) ligand 200.643
TBK1TANK-binding kinase 10.628
KLRD1killer cell lectin-like receptor subfamily D, member 10.625
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il2rbinterleukin 2 receptor, beta0.574
Casp3caspase 30.461
Il1binterleukin 1 beta0.406
Ccl4chemokine (C-C motif) ligand 40.336
Cxcl10chemokine (C-X-C motif) ligand 100.330
Gzmkgranzyme K0.307
Csf1colony stimulating factor 1 (macrophage)0.264
RT1-DaRT1 class II, locus Da0.264
Socs3suppressor of cytokine signaling 30.236
Igsf6immunoglobulin superfamily, member 60.236
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.162
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.160
RT1-BaRT1 class II, locus Ba0.149
Cd3gCD3 molecule, gamma0.137
Ccl3chemokine (C-C motif) ligand 30.136
Jak2Janus kinase 20.135
Plauplasminogen activator, urokinase0.131
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.128
Ptger4prostaglandin E receptor 4 (subtype EP4)0.128
Il2rginterleukin 2 receptor, gamma0.121
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.116
Apol3apolipoprotein L, 30.114
Il6interleukin 60.112
Jak1Janus kinase 10.109
Cmklr1chemokine-like receptor 10.103
Calcrlcalcitonin receptor-like0.097
Ccl7chemokine (C-C motif) ligand 70.089
Myd88myeloid differentiation primary response gene 880.089
Prrx1paired related homeobox 10.085
Ptger2prostaglandin E receptor 2 (subtype EP2)0.083
Myo1bmyosin Ib0.081
Mca32mast cell antigen 320.075
Il1rl1interleukin 1 receptor-like 10.075
Plaurplasminogen activator, urokinase receptor0.071
Il13ra1interleukin 13 receptor, alpha 10.071
Gimap4GTPase, IMAP family member 40.069
Tlr4toll-like receptor 40.067
Lgals5lectin, galactose binding, soluble 50.065
RT1-Db1RT1 class II, locus Db10.065
Folr2folate receptor 2 (fetal)0.064
Tnftumor necrosis factor (TNF superfamily, member 2)0.063
Adam17ADAM metallopeptidase domain 170.063
Klrd1killer cell lectin-like receptor, subfamily D, member 10.063
RT1-A3RT1 class I, locus A30.061
Mmp12matrix metallopeptidase 120.060
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.060
Sellselectin L0.059
Ciitaclass II, major histocompatibility complex, transactivator0.058
Ccl5chemokine (C-C motif) ligand 50.058
Cd14CD14 molecule0.058
Csn2casein beta0.056
Cd8aCD8a molecule0.053
Il1r1interleukin 1 receptor, type I0.053
Vcam1vascular cell adhesion molecule 10.052
Adora2aadenosine A2a receptor0.052
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.052
Olr1082olfactory receptor 10820.050
Nrasneuroblastoma ras oncogene0.049
Neurog3neurogenin 30.049
Il1r2interleukin 1 receptor, type II0.049
Birc2baculoviral IAP repeat-containing 20.048
Vegfavascular endothelial growth factor A0.048
Il1ainterleukin 1 alpha0.048
Dpysl3dihydropyrimidinase-like 30.047
Slc15a3solute carrier family 15, member 30.047
Cxcl2chemokine (C-X-C motif) ligand 20.046
Il4rainterleukin 4 receptor, alpha0.046
Nek9NIMA (never in mitosis gene a)- related kinase 90.045
Prl8a7prolactin family 8, subfamily a, member 70.044
RatNP-3bdefensin RatNP-3 precursor0.044
Lsm14aLSM14A, SCD6 homolog A (S. cerevisiae)0.044
Arrb2arrestin, beta 20.043
Cpsf2cleavage and polyadenylation specific factor 20.043
Gfi1growth factor independent 1 transcription repressor0.043
Cd86CD86 molecule0.043
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.043
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.043
Trim47tripartite motif-containing 470.043
Ly86lymphocyte antigen 860.042
Ccr2chemokine (C-C motif) receptor 20.042
Psen1presenilin 10.041
Cd38CD38 molecule0.041
Arl5cADP-ribosylation factor-like 5C0.041
Calcbcalcitonin-related polypeptide, beta0.041
Tcf12transcription factor 120.041
Oprk1opioid receptor, kappa 10.039
Fgfr2fibroblast growth factor receptor 20.039
Cxcl13chemokine (C-X-C motif) ligand 130.039
Ccl2chemokine (C-C motif) ligand 20.038
Pspparotid secretory protein0.038
Reg3bregenerating islet-derived 3 beta0.037
Icam1intercellular adhesion molecule 10.037
Irgmimmunity-related GTPase family, M0.036
F2rl2coagulation factor II (thrombin) receptor-like 20.036
Gbp2guanylate binding protein 20.036
Clpscolipase, pancreatic0.036
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.036
Neurl3neuralized homolog 3 (Drosophila)0.035
Skap2src kinase associated phosphoprotein 20.035
Ddr1discoidin domain receptor tyrosine kinase 10.035
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism