The network for 'dna damage response signal transduction by p53 class mediator' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna damage response signal transduction by p53 class mediator

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Mdm2transformed mouse 3T3 cell double minute 20.996
Ptenphosphatase and tensin homolog0.976
Rb1retinoblastoma 10.955
Brca1breast cancer 10.896
Cdkn1bcyclin-dependent kinase inhibitor 1B0.883
Apcadenomatosis polyposis coli0.698
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.688
Kitkit oncogene0.525
Tgfb1transforming growth factor, beta 10.523
Mdm4transformed mouse 3T3 cell double minute 40.456
SkilSKI-like0.401
Ctnnb1catenin (cadherin associated protein), beta 10.329
Atmataxia telangiectasia mutated homolog (human)0.251
Nbnnibrin0.246
Thbs1thrombospondin 10.209
Hprthypoxanthine guanine phosphoribosyl transferase0.192
Brca2breast cancer 20.167
Cdkn2acyclin-dependent kinase inhibitor 2A0.162
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.156
Kitlkit ligand0.150
BrafBraf transforming gene0.141
Smc1astructural maintenance of chromosomes 1A0.135
Arid1bAT rich interactive domain 1B (SWI-like)0.133
Ep300E1A binding protein p3000.120
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.111
H2-Aahistocompatibility 2, class II antigen A, alpha0.092
Smad3MAD homolog 3 (Drosophila)0.088
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.088
2500003M10RikRIKEN cDNA 2500003M10 gene0.083
Cyldcylindromatosis (turban tumor syndrome)0.082
Hif1ahypoxia inducible factor 1, alpha subunit0.080
H2-Eb1histocompatibility 2, class II antigen E beta0.080
DaxxFas death domain-associated protein0.080
Mecp2methyl CpG binding protein 20.078
Ccnd1cyclin D10.076
E2f1E2F transcription factor 10.071
En1engrailed 10.069
Snai1snail homolog 1 (Drosophila)0.069
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.067
Stat3signal transducer and activator of transcription 30.066
Meox2mesenchyme homeobox 20.063
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.063
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.062
Mcl1myeloid cell leukemia sequence 10.061
EvlEna-vasodilator stimulated phosphoprotein0.061
Enahenabled homolog (Drosophila)0.060
Icam1intercellular adhesion molecule 10.060
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.059
Smad4MAD homolog 4 (Drosophila)0.058
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.055
Socs1suppressor of cytokine signaling 10.053
Cdk4cyclin-dependent kinase 40.051
Msh2mutS homolog 2 (E. coli)0.051
Arandrogen receptor0.051
Ets1E26 avian leukemia oncogene 1, 5' domain0.050
Mycmyelocytomatosis oncogene0.049
Irf4interferon regulatory factor 40.047
Gtse1G two S phase expressed protein 10.047
Gli3GLI-Kruppel family member GLI30.047
Kdm2blysine (K)-specific demethylase 2B0.046
Ptch1patched homolog 10.046
Mybl2myeloblastosis oncogene-like 20.045
Notch1Notch gene homolog 1 (Drosophila)0.045
Rbl1retinoblastoma-like 1 (p107)0.044
Jak3Janus kinase 30.044
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.043
H2-DMahistocompatibility 2, class II, locus DMa0.043
Foxo3forkhead box O30.041
Runx1runt related transcription factor 10.041
Mmp9matrix metallopeptidase 90.040
Dok1docking protein 10.038
Ccl2chemokine (C-C motif) ligand 20.038
Kif19akinesin family member 19A0.037
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.036
Rnf38ring finger protein 380.035
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.035
Smad2MAD homolog 2 (Drosophila)0.035
Tnftumor necrosis factor0.035
Nf1neurofibromatosis 10.034
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.033
Tsc1tuberous sclerosis 10.033
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.033
Ep400E1A binding protein p4000.032
S1pr2sphingosine-1-phosphate receptor 20.032
Tcf7l2transcription factor 7-like 2, T-cell specific, HMG-box0.031
Chst8carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 80.030
Smn1survival motor neuron 10.030
Wdr77WD repeat domain 770.030
Smc3structural maintenace of chromosomes 30.030
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.030
Arid1aAT rich interactive domain 1A (SWI-like)0.030
Abl2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)0.030
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.030
Itgb1integrin beta 1 (fibronectin receptor beta)0.030
Ythdf1YTH domain family 10.029
Irf1interferon regulatory factor 10.029
Vhlvon Hippel-Lindau tumor suppressor0.029
Stk11serine/threonine kinase 110.029
Mapk8mitogen-activated protein kinase 80.028
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gscgoosecoid0.027
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
p53CG33336 gene product from transcript CG33336-RB0.013
CtBPC-terminal Binding Protein0.012
Gap1GTPase-activating protein 10.011
imdimmune deficiency0.011
panpangolin0.011
Sir2CG5216 gene product from transcript CG5216-RA0.011
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BRCA1breast cancer 1, early onset1.000
CASP3caspase 3, apoptosis-related cysteine peptidase0.983
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.977
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.977
ATMataxia telangiectasia mutated0.976
TP53tumor protein p530.951
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.940
CASP8caspase 8, apoptosis-related cysteine peptidase0.923
CREBBPCREB binding protein0.910
NBNnibrin0.904
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.900
XIAPX-linked inhibitor of apoptosis0.899
CHEK2CHK2 checkpoint homolog (S. pombe)0.838
BCL2B-cell CLL/lymphoma 20.780
MAPK1mitogen-activated protein kinase 10.774
E2F7E2F transcription factor 70.766
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.738
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.727
CASP2caspase 2, apoptosis-related cysteine peptidase0.712
E2F8E2F transcription factor 80.689
PMLpromyelocytic leukemia0.683
CDK2cyclin-dependent kinase 20.671
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.666
FASFas (TNF receptor superfamily, member 6)0.585
H2AFXH2A histone family, member X0.581
MAPK8mitogen-activated protein kinase 80.572
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.552
EP300E1A binding protein p3000.549
MDC1mediator of DNA-damage checkpoint 10.535
BCAS2breast carcinoma amplified sequence 20.522
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.494
MAPK14mitogen-activated protein kinase 140.471
FANCD2Fanconi anemia, complementation group D20.463
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.458
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.407
TWIST1twist homolog 1 (Drosophila)0.393
MDM2Mdm2 p53 binding protein homolog (mouse)0.387
IER3immediate early response 30.384
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.382
GSK3Bglycogen synthase kinase 3 beta0.378
OTUB1OTU domain, ubiquitin aldehyde binding 10.358
CCNE1cyclin E10.354
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.344
HIPK2homeodomain interacting protein kinase 20.341
APAF1apoptotic peptidase activating factor 10.339
DAXXdeath-domain associated protein0.320
MDM4Mdm4 p53 binding protein homolog (mouse)0.313
CCND3cyclin D30.311
PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent, 1D0.282
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.280
NCOA3nuclear receptor coactivator 30.271
CASP4caspase 4, apoptosis-related cysteine peptidase0.270
SETD8SET domain containing (lysine methyltransferase) 80.262
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.258
TP53BP1tumor protein p53 binding protein 10.252
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.249
RAD50RAD50 homolog (S. cerevisiae)0.248
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.242
TNIP2TNFAIP3 interacting protein 20.240
BCL2L11BCL2-like 11 (apoptosis facilitator)0.239
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.238
DDAH2dimethylarginine dimethylaminohydrolase 20.234
UHRF2ubiquitin-like with PHD and ring finger domains 20.212
RAD18RAD18 homolog (S. cerevisiae)0.211
PARP1poly (ADP-ribose) polymerase 10.208
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.207
SP110SP110 nuclear body protein0.205
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.198
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.188
IFI16interferon, gamma-inducible protein 160.185
RASSF5Ras association (RalGDS/AF-6) domain family member 50.181
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.173
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.172
CASP9caspase 9, apoptosis-related cysteine peptidase0.172
HDAC1histone deacetylase 10.167
SETD7SET domain containing (lysine methyltransferase) 70.165
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.163
MAPK3mitogen-activated protein kinase 30.159
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.158
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.154
LRDDleucine-rich repeats and death domain containing0.146
CFLARCASP8 and FADD-like apoptosis regulator0.144
HNRNPMheterogeneous nuclear ribonucleoprotein M0.143
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.132
PLK1polo-like kinase 10.132
HIC2hypermethylated in cancer 20.131
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.125
CDC25Acell division cycle 25 homolog A (S. pombe)0.121
EGFRepidermal growth factor receptor0.119
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.118
SMURF1SMAD specific E3 ubiquitin protein ligase 10.115
RB1retinoblastoma 10.114
SP100SP100 nuclear antigen0.114
RUNX1runt-related transcription factor 10.113
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.107
RIPK2receptor-interacting serine-threonine kinase 20.105
TP53BP2tumor protein p53 binding protein, 20.103
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.099
PRKCAprotein kinase C, alpha0.097
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.097
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism