The network for 'regulation of interleukin 6 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of interleukin 6 production

Any process that modulates the frequency, rate, or extent of interleukin-6 production.

NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 41.000
Myd88myeloid differentiation primary response gene 881.000
Tnftumor necrosis factor1.000
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a1.000
Lyz2lysozyme 21.000
Map3k14mitogen-activated protein kinase kinase kinase 140.994
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.979
Casp4caspase 4, apoptosis-related cysteine peptidase0.977
Il1r1interleukin 1 receptor, type I0.973
Ltalymphotoxin A0.972
Il4interleukin 40.966
Traf6TNF receptor-associated factor 60.956
Otx2orthodenticle homolog 2 (Drosophila)0.952
Ikzf1IKAROS family zinc finger 10.950
Irak4interleukin-1 receptor-associated kinase 40.883
Cd44CD44 antigen0.883
Cd40CD40 antigen0.862
Arrb2arrestin, beta 20.861
Il1binterleukin 1 beta0.857
FasFas (TNF receptor superfamily member 6)0.852
Nlrp3NLR family, pyrin domain containing 30.851
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.840
Stat3signal transducer and activator of transcription 30.810
Il10interleukin 100.806
Casp1caspase 10.789
Map3k8mitogen-activated protein kinase kinase kinase 80.789
Foxn1forkhead box N10.785
Tnfaip3tumor necrosis factor, alpha-induced protein 30.691
Emx1empty spiracles homolog 1 (Drosophila)0.679
Trim30dtripartite motif-containing 30D0.666
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.666
Clec4nC-type lectin domain family 4, member n0.662
Ighimmunoglobulin heavy chain complex0.654
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.649
Pax2paired box gene 20.649
Birc3baculoviral IAP repeat-containing 30.613
Ptgs2prostaglandin-endoperoxide synthase 20.563
Ccl2chemokine (C-C motif) ligand 20.550
Prf1perforin 1 (pore forming protein)0.537
Emx2empty spiracles homolog 2 (Drosophila)0.518
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.505
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.503
Arrb1arrestin, beta 10.494
Gbx2gastrulation brain homeobox 20.483
Ccl4chemokine (C-C motif) ligand 40.460
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.456
Ifnginterferon gamma0.453
Gdnfglial cell line derived neurotrophic factor0.447
MefvMediterranean fever0.444
Cd19CD19 antigen0.443
BtkBruton agammaglobulinemia tyrosine kinase0.427
Trim30atripartite motif-containing 30A0.426
Il2interleukin 20.425
Lifleukemia inhibitory factor0.418
Il1rl1interleukin 1 receptor-like 10.409
Lhx1LIM homeobox protein 10.404
Inpp5dinositol polyphosphate-5-phosphatase D0.396
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.393
Cd14CD14 antigen0.391
Pthlhparathyroid hormone-like peptide0.381
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.373
Map3k7mitogen-activated protein kinase kinase kinase 70.365
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.364
Mmp9matrix metallopeptidase 90.358
Ifnar1interferon (alpha and beta) receptor 10.358
Wnt1wingless-related MMTV integration site 10.355
Wnt4wingless-related MMTV integration site 40.343
Ptprcprotein tyrosine phosphatase, receptor type, C0.332
Dkk1dickkopf homolog 1 (Xenopus laevis)0.331
Irak3interleukin-1 receptor-associated kinase 30.315
Hspa5heat shock protein 50.314
Ltbrlymphotoxin B receptor0.313
Card11caspase recruitment domain family, member 110.309
Apoeapolipoprotein E0.307
Gbp5guanylate binding protein 50.282
Pax6paired box gene 60.274
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.271
Il6interleukin 60.267
Zic3zinc finger protein of the cerebellum 30.263
En1engrailed 10.262
Cd33CD33 antigen0.260
Phox2bpaired-like homeobox 2b0.250
Stat1signal transducer and activator of transcription 10.250
Nodalnodal0.249
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.247
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.241
Cxcl13chemokine (C-X-C motif) ligand 130.239
CblbCasitas B-lineage lymphoma b0.239
Gli2GLI-Kruppel family member GLI20.227
Mmp8matrix metallopeptidase 80.216
Phc1polyhomeotic-like 1 (Drosophila)0.215
Il7interleukin 70.210
Hcsthematopoietic cell signal transducer0.208
Il1rninterleukin 1 receptor antagonist0.208
FaslFas ligand (TNF superfamily, member 6)0.208
Relreticuloendotheliosis oncogene0.203
SharpinSHANK-associated RH domain interacting protein0.200
Tcf3transcription factor 30.196
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.195
TcraT-cell receptor alpha chain0.194
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MYD88myeloid differentiation primary response gene (88)0.997
IRAK2interleukin-1 receptor-associated kinase 20.962
IRAK1interleukin-1 receptor-associated kinase 10.913
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.808
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.707
MAP2K4mitogen-activated protein kinase kinase 40.659
LAMP1lysosomal-associated membrane protein 10.373
TNFAIP3tumor necrosis factor, alpha-induced protein 30.348
BIRC3baculoviral IAP repeat containing 30.339
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.337
JUNjun proto-oncogene0.251
TLR4toll-like receptor 40.217
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.196
TRAF1TNF receptor-associated factor 10.177
SMAD3SMAD family member 30.160
ZC3H12Azinc finger CCCH-type containing 12A0.132
TRADDTNFRSF1A-associated via death domain0.128
CD14CD14 molecule0.119
ZNF496zinc finger protein 4960.114
ARRB2arrestin, beta 20.114
CPNE6copine VI (neuronal)0.105
IL1R1interleukin 1 receptor, type I0.099
PELI3pellino homolog 3 (Drosophila)0.087
IL10RAinterleukin 10 receptor, alpha0.087
TRAF6TNF receptor-associated factor 60.083
TLR2toll-like receptor 20.083
HSF1heat shock transcription factor 10.079
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.077
IRAK3interleukin-1 receptor-associated kinase 30.072
IL22RA1interleukin 22 receptor, alpha 10.067
TICAM2toll-like receptor adaptor molecule 20.063
UBASH3Bubiquitin associated and SH3 domain containing B0.060
PYDC2pyrin domain containing 20.060
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.059
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.057
MAPK14mitogen-activated protein kinase 140.055
SETD8SET domain containing (lysine methyltransferase) 80.055
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.055
AXLAXL receptor tyrosine kinase0.054
TRAF2TNF receptor-associated factor 20.054
BIRC2baculoviral IAP repeat containing 20.053
C19orf50chromosome 19 open reading frame 500.051
MEFVMediterranean fever0.047
IL22RA2interleukin 22 receptor, alpha 20.046
TNFtumor necrosis factor0.045
GATA2GATA binding protein 20.044
NLRC4NLR family, CARD domain containing 40.044
TNIP1TNFAIP3 interacting protein 10.043
LAPTM5lysosomal protein transmembrane 50.042
SOCS3suppressor of cytokine signaling 30.041
IRAK4interleukin-1 receptor-associated kinase 40.038
TXNthioredoxin0.037
SOD2superoxide dismutase 2, mitochondrial0.037
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.036
CCL20chemokine (C-C motif) ligand 200.035
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.035
MARK2MAP/microtubule affinity-regulating kinase 20.035
FADDFas (TNFRSF6)-associated via death domain0.034
GNMTglycine N-methyltransferase0.033
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.033
TOLLIPtoll interacting protein0.030
TRIM21tripartite motif containing 210.028
SHC1SHC (Src homology 2 domain containing) transforming protein 10.027
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.026
SH3KBP1SH3-domain kinase binding protein 10.026
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.025
JAK1Janus kinase 10.025
LMO2LIM domain only 2 (rhombotin-like 1)0.025
HSPB1heat shock 27kDa protein 10.024
DUSP1dual specificity phosphatase 10.022
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.022
FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)0.021
SYKspleen tyrosine kinase0.021
ZC3H12Czinc finger CCCH-type containing 12C0.021
CCR1chemokine (C-C motif) receptor 10.021
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.020
BAG3BCL2-associated athanogene 30.020
EPORerythropoietin receptor0.020
BTKBruton agammaglobulinemia tyrosine kinase0.020
HDAC9histone deacetylase 90.020
SP1Sp1 transcription factor0.020
TRIM22tripartite motif containing 220.019
TNIP2TNFAIP3 interacting protein 20.019
LY86lymphocyte antigen 860.019
ATF2activating transcription factor 20.018
HSPA6heat shock 70kDa protein 6 (HSP70B')0.018
PLEKpleckstrin0.018
CXCL2chemokine (C-X-C motif) ligand 20.018
HSPH1heat shock 105kDa/110kDa protein 10.018
KIAA1712KIAA17120.018
CFL1cofilin 1 (non-muscle)0.018
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.017
GATA1GATA binding protein 1 (globin transcription factor 1)0.017
LIMK1LIM domain kinase 10.017
C14orf43chromosome 14 open reading frame 430.017
TRIM34tripartite motif containing 340.017
ARRB1arrestin, beta 10.017
LRP6low density lipoprotein receptor-related protein 60.017
SLAMF1signaling lymphocytic activation molecule family member 10.017
IRF7interferon regulatory factor 70.017
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.183
Hspa5heat shock protein 50.167
Gja6gap junction protein, alpha 60.145
Ccl4chemokine (C-C motif) ligand 40.136
Gzmkgranzyme K0.119
Ccl3chemokine (C-C motif) ligand 30.110
Casp12caspase 120.091
LOC24906RoBo-10.090
Mmp12matrix metallopeptidase 120.085
Fosl1fos-like antigen 10.078
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.077
Npffr2neuropeptide FF receptor 20.073
Il1binterleukin 1 beta0.072
Acrv1acrosomal vesicle protein 10.063
Junbjun B proto-oncogene0.061
Sox17SRY (sex determining region Y)-box 170.061
Csf1colony stimulating factor 1 (macrophage)0.059
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.054
FaslgFas ligand (TNF superfamily, member 6)0.053
Slc7a3solute carrier family 7 (cationic amino acid transporter, y+ system), member 30.051
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.049
Cxcl2chemokine (C-X-C motif) ligand 20.047
Il9rinterleukin 9 receptor0.043
Stat3signal transducer and activator of transcription 30.041
Errfi1ERBB receptor feedback inhibitor 10.038
Calhm2calcium homeostasis modulator 20.037
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.037
Hspa8heat shock protein 80.037
Avparginine vasopressin0.036
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.036
Pdia6protein disulfide isomerase family A, member 60.035
Zfp36zinc finger protein 360.034
Il2rginterleukin 2 receptor, gamma0.034
Adora2aadenosine A2a receptor0.034
Cfpcomplement factor properdin0.033
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.033
C5ar1complement component 5a receptor 10.033
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.031
Il6interleukin 60.031
Cxcr3chemokine (C-X-C motif) receptor 30.030
Arhgap4Rho GTPase activating protein 40.030
Shc1SHC (Src homology 2 domain containing) transforming protein 10.030
Prl8a7prolactin family 8, subfamily a, member 70.029
Tnni3troponin I type 3 (cardiac)0.029
Rhbdl1rhomboid, veinlet-like 1 (Drosophila)0.029
Il1r1interleukin 1 receptor, type I0.028
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.028
Syt8synaptotagmin VIII0.027
Ghrgrowth hormone receptor0.027
Grm6glutamate receptor, metabotropic 60.027
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.027
A2malpha-2-macroglobulin0.026
Ciitaclass II, major histocompatibility complex, transactivator0.026
Rps6ka1ribosomal protein S6 kinase polypeptide 10.026
Sh2b3SH2B adaptor protein 30.026
Socs3suppressor of cytokine signaling 30.026
Slc22a7solute carrier family 22 (organic anion transporter), member 70.026
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.025
Lpllipoprotein lipase0.025
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.024
Cx3cr1chemokine (C-X3-C motif) receptor 10.024
Pax6paired box 60.024
Alox5arachidonate 5-lipoxygenase0.024
Ifna1interferon-alpha 10.023
Itgamintegrin, alpha M0.023
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.023
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.023
Rassf5Ras association (RalGDS/AF-6) domain family member 50.022
Tlr4toll-like receptor 40.022
JunJun oncogene0.022
Ptger2prostaglandin E receptor 2 (subtype EP2)0.022
Hspe1heat shock protein 1 (chaperonin 10)0.021
Mcpt3mast cell peptidase 30.021
Slc14a2solute carrier family 14 (urea transporter), member 20.021
Dusp1dual specificity phosphatase 10.020
Pipprolactin induced protein0.020
Fgbfibrinogen beta chain0.020
Gm2aGM2 ganglioside activator0.020
Edn1endothelin 10.020
Myd88myeloid differentiation primary response gene 880.019
C1qtnf6C1q and tumor necrosis factor related protein 60.019
Nraddneurotrophin receptor associated death domain0.019
RGD1309079similar to Ab2-0950.019
Ece1endothelin converting enzyme 10.019
RGD1561143similar to cell surface receptor FDFACT0.019
Gfpt1glutamine fructose-6-phosphate transaminase 10.018
Chrna7cholinergic receptor, nicotinic, alpha 70.018
Mmp8matrix metallopeptidase 80.018
LOC690358similar to PR domain containing 110.018
Olr416olfactory receptor 4160.018
Mapk14mitogen activated protein kinase 140.018
LOC681996similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 10.018
Eporerythropoietin receptor0.017
Ptafrplatelet-activating factor receptor0.017
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.017
RGD1305793similar to hypothetical protein FLJ201540.016
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.016
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.016
Oprk1opioid receptor, kappa 10.016
Adora2badenosine A2B receptor0.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism