The network for 'positive regulation of t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of t cell activation

Any process that activates or increases the frequency, rate or extent of T cell activation.

NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 10.999
Tnftumor necrosis factor0.995
Cd40CD40 antigen0.994
Icosinducible T-cell co-stimulator0.994
Lyz2lysozyme 20.992
Lcklymphocyte protein tyrosine kinase0.990
Cd19CD19 antigen0.988
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.978
Leprleptin receptor0.972
Ighimmunoglobulin heavy chain complex0.968
Efnb2ephrin B20.957
FasFas (TNF receptor superfamily member 6)0.952
Tnfaip3tumor necrosis factor, alpha-induced protein 30.951
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.951
Il2rbinterleukin 2 receptor, beta chain0.936
BtkBruton agammaglobulinemia tyrosine kinase0.928
ItkIL2-inducible T-cell kinase0.917
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.915
Cd5CD5 antigen0.905
Pdcd1programmed cell death 10.902
Cd28CD28 antigen0.895
Rnf2ring finger protein 20.890
Arandrogen receptor0.887
Map3k14mitogen-activated protein kinase kinase kinase 140.881
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.879
Ccr1chemokine (C-C motif) receptor 10.873
Ltalymphotoxin A0.870
FaslFas ligand (TNF superfamily, member 6)0.868
Jak2Janus kinase 20.860
Il1r1interleukin 1 receptor, type I0.857
Stat3signal transducer and activator of transcription 30.849
FynFyn proto-oncogene0.846
Ptprcprotein tyrosine phosphatase, receptor type, C0.843
Csf1colony stimulating factor 1 (macrophage)0.833
Gli3GLI-Kruppel family member GLI30.818
Batfbasic leucine zipper transcription factor, ATF-like0.812
Cd247CD247 antigen0.784
Stat5bsignal transducer and activator of transcription 5B0.782
Cd7CD7 antigen0.780
H2-Eb1histocompatibility 2, class II antigen E beta0.779
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.779
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.778
Cd44CD44 antigen0.770
RybpRING1 and YY1 binding protein0.758
Ccr7chemokine (C-C motif) receptor 70.757
Cd86CD86 antigen0.756
Ltblymphotoxin B0.745
Cd6CD6 antigen0.744
Foxp3forkhead box P30.719
Cd96CD96 antigen0.715
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.702
Sh2d2aSH2 domain protein 2A0.698
Cd3eCD3 antigen, epsilon polypeptide0.697
Il4interleukin 40.696
Klrd1killer cell lectin-like receptor, subfamily D, member 10.679
S1pr4sphingosine-1-phosphate receptor 40.675
H2-Aahistocompatibility 2, class II antigen A, alpha0.666
Itgalintegrin alpha L0.666
Ciitaclass II transactivator0.658
Traf1TNF receptor-associated factor 10.657
Cd80CD80 antigen0.652
Il2rginterleukin 2 receptor, gamma chain0.641
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.631
Cd3gCD3 antigen, gamma polypeptide0.630
Ccr9chemokine (C-C motif) receptor 90.627
Tgfbr2transforming growth factor, beta receptor II0.622
Tgfb2transforming growth factor, beta 20.621
Rargretinoic acid receptor, gamma0.614
Klrg1killer cell lectin-like receptor subfamily G, member 10.607
Kiss1KiSS-1 metastasis-suppressor0.596
Cd4CD4 antigen0.595
H2-DMb2histocompatibility 2, class II, locus Mb20.593
Cxcr5chemokine (C-X-C motif) receptor 50.588
Ifnginterferon gamma0.578
Il4rainterleukin 4 receptor, alpha0.564
Il2interleukin 20.561
Ncr1natural cytotoxicity triggering receptor 10.561
Clec4nC-type lectin domain family 4, member n0.560
Casp8caspase 80.560
Il18rapinterleukin 18 receptor accessory protein0.547
Ccl4chemokine (C-C motif) ligand 40.545
Stat5asignal transducer and activator of transcription 5A0.536
Ccr6chemokine (C-C motif) receptor 60.529
Runx1runt related transcription factor 10.523
Fcer2aFc receptor, IgE, low affinity II, alpha polypeptide0.519
Ccr2chemokine (C-C motif) receptor 20.505
Ubdubiquitin D0.503
Casp4caspase 4, apoptosis-related cysteine peptidase0.502
Nck2non-catalytic region of tyrosine kinase adaptor protein 20.489
Cd8aCD8 antigen, alpha chain0.476
Smad4MAD homolog 4 (Drosophila)0.475
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.470
Fgfr2fibroblast growth factor receptor 20.470
Irf4interferon regulatory factor 40.462
Il1binterleukin 1 beta0.460
Ctswcathepsin W0.452
Socs1suppressor of cytokine signaling 10.449
Cd22CD22 antigen0.448
Ntf3neurotrophin 30.444
Smad3MAD homolog 3 (Drosophila)0.443
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.999
ICAM1intercellular adhesion molecule 10.881
HLA-Gmajor histocompatibility complex, class I, G0.864
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.836
HLA-Fmajor histocompatibility complex, class I, F0.833
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.830
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.825
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.812
CD86CD86 molecule0.807
CXCL9chemokine (C-X-C motif) ligand 90.806
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.799
HCKhemopoietic cell kinase0.723
HLA-DMBmajor histocompatibility complex, class II, DM beta0.700
HLA-Bmajor histocompatibility complex, class I, B0.660
GRB2growth factor receptor-bound protein 20.656
IL1R1interleukin 1 receptor, type I0.635
SH2D1ASH2 domain containing 1A0.635
SYKspleen tyrosine kinase0.634
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.622
CCR5chemokine (C-C motif) receptor 50.607
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.581
CCL5chemokine (C-C motif) ligand 50.576
CCL4chemokine (C-C motif) ligand 40.565
CCL22chemokine (C-C motif) ligand 220.562
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.558
HLA-Emajor histocompatibility complex, class I, E0.553
SOCS3suppressor of cytokine signaling 30.542
PTPRCprotein tyrosine phosphatase, receptor type, C0.538
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.534
CXCL10chemokine (C-X-C motif) ligand 100.522
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.514
ITKIL2-inducible T-cell kinase0.508
IL1Binterleukin 1, beta0.496
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.493
IL2RGinterleukin 2 receptor, gamma0.488
CD247CD247 molecule0.473
PTPN1protein tyrosine phosphatase, non-receptor type 10.472
PTPN6protein tyrosine phosphatase, non-receptor type 60.431
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.421
STAT4signal transducer and activator of transcription 40.416
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.402
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.397
CD80CD80 molecule0.387
IL2RBinterleukin 2 receptor, beta0.344
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.330
CD3GCD3g molecule, gamma (CD3-TCR complex)0.320
HLA-Cmajor histocompatibility complex, class I, C0.305
CARD11caspase recruitment domain family, member 110.295
HLA-DRB5major histocompatibility complex, class II, DR beta 50.292
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.291
FASFas (TNF receptor superfamily, member 6)0.285
IL4Rinterleukin 4 receptor0.284
JAK2Janus kinase 20.272
BCL10B-cell CLL/lymphoma 100.271
CXCL11chemokine (C-X-C motif) ligand 110.269
CD2CD2 molecule0.261
CTLA4cytotoxic T-lymphocyte-associated protein 40.260
HLA-DPB1major histocompatibility complex, class II, DP beta 10.255
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.250
PILRApaired immunoglobin-like type 2 receptor alpha0.250
IL6Rinterleukin 6 receptor0.236
IL16interleukin 16 (lymphocyte chemoattractant factor)0.231
IL7Rinterleukin 7 receptor0.223
LIN9lin-9 homolog (C. elegans)0.223
GRAP2GRB2-related adaptor protein 20.222
BLNKB-cell linker0.217
HLA-Amajor histocompatibility complex, class I, A0.212
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.208
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.207
CCL13chemokine (C-C motif) ligand 130.204
CD1CCD1c molecule0.203
CD28CD28 molecule0.202
CD52CD52 molecule0.197
SPTBspectrin, beta, erythrocytic0.196
BIRC3baculoviral IAP repeat containing 30.192
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.191
CCL2chemokine (C-C motif) ligand 20.184
IL4interleukin 40.184
PLCG1phospholipase C, gamma 10.183
NCK1NCK adaptor protein 10.181
BTKBruton agammaglobulinemia tyrosine kinase0.178
JAK1Janus kinase 10.177
IFNGinterferon, gamma0.176
IL10interleukin 100.175
EGFRepidermal growth factor receptor0.172
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.166
CCR7chemokine (C-C motif) receptor 70.165
CCL8chemokine (C-C motif) ligand 80.163
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.152
NLRC4NLR family, CARD domain containing 40.150
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.145
BTN3A1butyrophilin, subfamily 3, member A10.142
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.135
CXCL13chemokine (C-X-C motif) ligand 130.131
LY86lymphocyte antigen 860.126
CD40CD40 molecule, TNF receptor superfamily member 50.125
RXRAretinoid X receptor, alpha0.124
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.123
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.446
TcrbT-cell receptor beta chain0.226
RT1-BaRT1 class II, locus Ba0.165
Cd247Cd247 molecule0.126
RT1-Db1RT1 class II, locus Db10.063
Cd37CD37 molecule0.062
Cd5Cd5 molecule0.030
Gimap4GTPase, IMAP family member 40.022
Gzmkgranzyme K0.019
Calcrlcalcitonin receptor-like0.017
Il2rbinterleukin 2 receptor, beta0.017
Itgb7integrin, beta 70.016
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.015
RT1-BbRT1 class II, locus Bb0.015
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.015
Casp1caspase 10.014
Cd3gCD3 molecule, gamma0.014
RT1-DMaRT1 class II, locus DMa0.013
Cd2Cd2 molecule0.013
Cd53Cd53 molecule0.012
Itgadintegrin, alpha D0.012
Nkg7natural killer cell group 7 sequence0.012
Latlinker for activation of T cells0.012
Dnase1l3deoxyribonuclease 1-like 30.012
Klrk1killer cell lectin-like receptor subfamily K, member 10.011
Cd4Cd4 molecule0.011
Cd3dCD3 molecule, delta0.010
Ptger4prostaglandin E receptor 4 (subtype EP4)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism