The network for 'nucleotide excision repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nucleotide excision repair

A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

NameDescriptionProbabilityFunc Analog Organism
Msh2mutS homolog 2 (E. coli)0.859
Trp53transformation related protein 530.746
Timelesstimeless homolog (Drosophila)0.586
Mdm2transformed mouse 3T3 cell double minute 20.527
Dnajc9DnaJ (Hsp40) homolog, subfamily C, member 90.460
Atmataxia telangiectasia mutated homolog (human)0.437
Mdm4transformed mouse 3T3 cell double minute 40.410
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.310
Xpaxeroderma pigmentosum, complementation group A0.218
Tomm70atranslocase of outer mitochondrial membrane 70 homolog A (yeast)0.208
Rb1retinoblastoma 10.175
Nf1neurofibromatosis 10.124
Parp1poly (ADP-ribose) polymerase family, member 10.111
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.096
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.092
Brca1breast cancer 10.087
Anp32eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.085
Hmgb1high mobility group box 10.082
Foxo3forkhead box O30.080
Eftud2elongation factor Tu GTP binding domain containing 20.075
Ormdl1ORM1-like 1 (S. cerevisiae)0.071
Ewsr1Ewing sarcoma breakpoint region 10.070
Nup85nucleoporin 850.070
Dsg4desmoglein 40.068
Nclnucleolin0.065
Lsm3LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.062
Lsm2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.060
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.059
E2f1E2F transcription factor 10.059
Rnf7ring finger protein 70.058
Prmt1protein arginine N-methyltransferase 10.054
Xpcxeroderma pigmentosum, complementation group C0.052
Prpf40aPRP40 pre-mRNA processing factor 40 homolog A (yeast)0.051
Trim28tripartite motif-containing 280.048
Actr6ARP6 actin-related protein 6 homolog (yeast)0.046
Hdac2histone deacetylase 20.046
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.045
WwoxWW domain-containing oxidoreductase0.044
Cdkn1bcyclin-dependent kinase inhibitor 1B0.044
Srsf9serine/arginine-rich splicing factor 90.043
Dtymkdeoxythymidylate kinase0.043
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.043
Cry1cryptochrome 1 (photolyase-like)0.041
Tbcbtubulin folding cofactor B0.040
Siva1SIVA1, apoptosis-inducing factor0.039
Srsf4serine/arginine-rich splicing factor 40.039
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.039
Stk11serine/threonine kinase 110.038
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.038
Tsc1tuberous sclerosis 10.037
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.037
Nup188nucleoporin 1880.036
Rrm1ribonucleotide reductase M10.036
Polepolymerase (DNA directed), epsilon0.035
Hist1h2bmhistone cluster 1, H2bm0.033
Ints9integrator complex subunit 90.033
Rttnrotatin0.032
Rev1REV1 homolog (S. cerevisiae)0.032
Mapk14mitogen-activated protein kinase 140.032
WrnWerner syndrome homolog (human)0.032
Snrnp40small nuclear ribonucleoprotein 40 (U5)0.031
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.030
Nup133nucleoporin 1330.030
Ptch1patched homolog 10.029
2700029M09RikRIKEN cDNA 2700029M09 gene0.029
Tipintimeless interacting protein0.029
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.029
2500003M10RikRIKEN cDNA 2500003M10 gene0.029
Gtf2h2general transcription factor II H, polypeptide 20.028
Dutdeoxyuridine triphosphatase0.028
Rfc1replication factor C (activator 1) 10.028
Nbnnibrin0.027
Cdk9cyclin-dependent kinase 9 (CDC2-related kinase)0.027
Rnf8ring finger protein 80.026
Terf1telomeric repeat binding factor 10.025
Eif1axeukaryotic translation initiation factor 1A, X-linked0.025
Ssrp1structure specific recognition protein 10.025
Psmg2proteasome (prosome, macropain) assembly chaperone 20.025
Ptenphosphatase and tensin homolog0.024
Gins4GINS complex subunit 4 (Sld5 homolog)0.024
Smn1survival motor neuron 10.024
E130303B06RikRIKEN cDNA E130303B06 gene0.024
Rpgrip1lRpgrip1-like0.024
Mlh1mutL homolog 1 (E. coli)0.024
Naa50N(alpha)-acetyltransferase 50, NatE catalytic subunit0.023
Gtl3gene trap locus 30.023
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.023
Fancd2Fanconi anemia, complementation group D20.023
Sae1SUMO1 activating enzyme subunit 10.023
Bmi1Bmi1 polycomb ring finger oncogene0.023
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.023
Zfp444zinc finger protein 4440.023
Gmnngeminin0.022
Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.022
AI314976expressed sequence AI3149760.022
Ep300E1A binding protein p3000.022
Cdc123cell division cycle 123 homolog (S. cerevisiae)0.021
Mybl2myeloblastosis oncogene-like 20.021
Huwe1HECT, UBA and WWE domain containing 10.021
Nup107nucleoporin 1070.021
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
his-42Protein HIS-420.015
his-6Protein HIS-60.011
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mus205mutagen-sensitive 2050.975
mus201mutagen-sensitive 2010.952
mei-9meiotic 90.922
Brca2Breast cancer 2, early onset homolog0.870
spn-Aspindle A0.799
lokloki0.788
hayhaywire0.595
DNApol-etaCG7143 gene product from transcript CG7143-RA0.590
spn-Bspindle B0.582
mus101mutagen-sensitive 1010.559
mus308mutagen-sensitive 3080.545
mei-41meiotic 410.497
spn-Espindle E0.486
CG5524CG5524 gene product from transcript CG5524-RA0.391
His2AvHistone H2A variant0.372
okrokra0.366
RecQ5homolog of RecQ0.320
MAGECG10059 gene product from transcript CG10059-RA0.314
RnrLRibonucleoside diphosphate reductase large subunit0.309
Rpt4CG3455 gene product from transcript CG3455-RA0.307
nbsCG6754 gene product from transcript CG6754-RC0.293
rad50CG6339 gene product from transcript CG6339-RD0.285
Chrac-14CG13399 gene product from transcript CG13399-RA0.259
Rpn9CG10230 gene product from transcript CG10230-RB0.222
Ercc1CG10215 gene product from transcript CG10215-RA0.199
IrbpInverted repeat-binding protein0.189
Mcm7Minichromosome maintenance 70.172
Tbp-1Tat-binding protein-10.161
mus301mutagen-sensitive 3010.136
picpiccolo0.122
Smc5CG32438 gene product from transcript CG32438-RE0.119
mus209mutagen-sensitive 2090.113
RecQ4CG7487 gene product from transcript CG7487-RA0.097
mus304mutagen-sensitive 3040.080
mus312mutagen-sensitive 3120.077
magomago nashi0.069
Mcm3Minichromosome maintenance 30.068
mus309mutagen-sensitive 3090.067
mre11meiotic recombination 110.066
Rev1CG12189 gene product from transcript CG12189-RA0.060
CG15220CG15220 gene product from transcript CG15220-RA0.050
Rpt3CG16916 gene product from transcript CG16916-RA0.042
eastenhanced adult sensory threshold0.041
Rpt1CG1341 gene product from transcript CG1341-RA0.038
Pros29Proteasome 29kD subunit0.036
p53CG33336 gene product from transcript CG33336-RB0.035
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.035
RassfRas association family member0.032
alphalphabet0.031
TctpTranslationally controlled tumor protein0.030
CG4771CG4771 gene product from transcript CG4771-RA0.030
Mnn1Menin 10.029
Tip60CG6121 gene product from transcript CG6121-RA0.028
spn-Dspindle D0.028
debcldeath executioner Bcl-2 homologue0.027
Rpn11CG18174 gene product from transcript CG18174-RA0.027
eggeggless0.026
Ge-1CG6181 gene product from transcript CG6181-RA0.026
RpA-70Replication Protein A 700.023
Ku80CG18801 gene product from transcript CG18801-RA0.022
Pros28.1Proteasome 28kD subunit 10.022
Rat1CG10354 gene product from transcript CG10354-RA0.021
flflfalafel0.021
Prosbeta3Proteasome beta3 subunit0.020
CDC45LCG3658 gene product from transcript CG3658-RA0.019
stwlstonewall0.019
CG17331CG17331 gene product from transcript CG17331-RA0.019
CG5384CG5384 gene product from transcript CG5384-RA0.018
Rpn12CG4157 gene product from transcript CG4157-RA0.017
Art1Arginine methyltransferase 10.016
Tpr2Tetratricopeptide repeat protein 20.016
Bap55Brahma associated protein 55kD0.015
CG18271CG18271 gene product from transcript CG18271-RB0.015
me31Bmaternal expression at 31B0.015
CG13779CG13779 gene product from transcript CG13779-RA0.015
ltlight0.014
Rpn1CG7762 gene product from transcript CG7762-RA0.014
snfsans fille0.014
Art4Arginine methyltransferase 40.013
Nipped-BCG17704 gene product from transcript CG17704-RI0.013
CG9772CG9772 gene product from transcript CG9772-RB0.013
Jafrac1thioredoxin peroxidase 10.012
Spf45CG17540 gene product from transcript CG17540-RB0.012
Pros26Proteasome 26kD subunit0.012
Smg6CG6369 gene product from transcript CG6369-RA0.011
tefutelomere fusion0.011
Cct5T-complex Chaperonin 50.011
msl-2male-specific lethal 20.011
Prosalpha5Proteasome alpha5 subunit0.011
imdimmune deficiency0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RPA1replication protein A1, 70kDa1.000
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.999
H2AFXH2A histone family, member X0.999
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.998
BRCA1breast cancer 1, early onset0.997
PSMD13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.995
ERCC3excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)0.994
RPA3replication protein A3, 14kDa0.993
CDK7cyclin-dependent kinase 70.992
GTF2H1general transcription factor IIH, polypeptide 1, 62kDa0.989
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.988
MSH6mutS homolog 6 (E. coli)0.987
RAD50RAD50 homolog (S. cerevisiae)0.987
BLMBloom syndrome, RecQ helicase-like0.986
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.983
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.979
ERCC6excision repair cross-complementing rodent repair deficiency, complementation group 60.968
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.968
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 100.961
CHAF1Achromatin assembly factor 1, subunit A (p150)0.955
PCNAproliferating cell nuclear antigen0.955
MDC1mediator of DNA-damage checkpoint 10.951
RAD23BRAD23 homolog B (S. cerevisiae)0.943
FANCD2Fanconi anemia, complementation group D20.938
RFC1replication factor C (activator 1) 1, 145kDa0.937
NBNnibrin0.935
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.932
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.914
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa0.908
DDX39BDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.892
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.892
ERCC8excision repair cross-complementing rodent repair deficiency, complementation group 80.862
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.839
TP53tumor protein p530.780
MSH3mutS homolog 3 (E. coli)0.779
CCNHcyclin H0.779
THOC4THO complex 40.755
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.745
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.725
APLFaprataxin and PNKP like factor0.713
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.677
XAB2XPA binding protein 20.599
EXO1exonuclease 10.569
SLX1BSLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)0.545
GTF2H2general transcription factor IIH, polypeptide 2, 44kDa0.536
XPCxeroderma pigmentosum, complementation group C0.486
ERCC4excision repair cross-complementing rodent repair deficiency, complementation group 40.479
SMC1Astructural maintenance of chromosomes 1A0.474
POLD2polymerase (DNA directed), delta 2, regulatory subunit 50kDa0.466
MNAT1menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)0.459
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.455
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.448
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.416
ERCC1excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)0.413
FANCGFanconi anemia, complementation group G0.410
WWOXWW domain containing oxidoreductase0.410
RPA2replication protein A2, 32kDa0.363
WRNWerner syndrome, RecQ helicase-like0.346
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.305
CHEK2CHK2 checkpoint homolog (S. pombe)0.286
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.280
THOC1THO complex 10.279
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.278
ATMataxia telangiectasia mutated0.274
EP300E1A binding protein p3000.260
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.251
XPAxeroderma pigmentosum, complementation group A0.249
THOC5THO complex 50.243
RAD9ARAD9 homolog A (S. pombe)0.242
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.240
BRCA2breast cancer 2, early onset0.239
PNKPpolynucleotide kinase 3'-phosphatase0.227
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.202
THOC2THO complex 20.201
HUS1HUS1 checkpoint homolog (S. pombe)0.191
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.189
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.176
C20orf94chromosome 20 open reading frame 940.146
DDB2damage-specific DNA binding protein 2, 48kDa0.146
RFC2replication factor C (activator 1) 2, 40kDa0.144
RAD18RAD18 homolog (S. cerevisiae)0.143
LIG1ligase I, DNA, ATP-dependent0.143
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.141
NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 10.117
ATRataxia telangiectasia and Rad3 related0.109
CHTOPchromatin target of PRMT10.101
KDM4Alysine (K)-specific demethylase 4A0.101
PMS1PMS1 postmeiotic segregation increased 1 (S. cerevisiae)0.096
PARP1poly (ADP-ribose) polymerase 10.095
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 30.092
PPIEpeptidylprolyl isomerase E (cyclophilin E)0.092
TERF2telomeric repeat binding factor 20.083
RBBP5retinoblastoma binding protein 50.077
TP53BP1tumor protein p53 binding protein 10.077
HIST1H4Ahistone cluster 1, H4a0.077
CCDC101coiled-coil domain containing 1010.068
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.067
KRT5keratin 50.067
DNMT1DNA (cytosine-5-)-methyltransferase 10.066
ERCC2excision repair cross-complementing rodent repair deficiency, complementation group 20.064
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RAD4Rad4p0.977
RAD7Rad7p0.946
RAD3Rad3p0.906
SPT16Spt16p0.875
RAD1Rad1p0.870
RTF1Rtf1p0.840
RFA1Rfa1p0.825
SSL1Ssl1p0.822
CTR9Ctr9p0.807
RAD52Rad52p0.788
TFB4Tfb4p0.749
RPB3Rpb3p0.746
RAD14Rad14p0.738
SUS1Sus1p0.694
TFB3Tfb3p0.691
RAD23Rad23p0.686
SAW1Saw1p0.646
TFB1Tfb1p0.542
SEM1Sem1p0.530
RAD5Rad5p0.506
HTB1Htb1p0.495
RAD16Rad16p0.483
MSH2Msh2p0.445
TFA1Tfa1p0.423
HTA1Hta1p0.419
MEC1Mec1p0.418
RAD26Rad26p0.404
RPO21Rpo21p0.372
HPR1Hpr1p0.372
RAD18Rad18p0.357
TFB5Tfb5p0.348
REV3Rev3p0.347
MSH6Msh6p0.336
RAD2Rad2p0.332
SWI1Swi1p0.330
RPN1Rpn1p0.323
MSH3Msh3p0.299
TFB2Tfb2p0.288
RAD9Rad9p0.264
HHF2Hhf2p0.250
POL32Pol32p0.249
SNF11Snf11p0.215
RAD10Rad10p0.200
PAF1Paf1p0.194
RFA2Rfa2p0.193
CDC21Cdc21p0.192
CCL1Ccl1p0.183
SSL2Ssl2p0.174
POL31Pol31p0.170
RAD53Rad53p0.170
CKB1Ckb1p0.157
HHT2Hht2p0.154
RPT3Rpt3p0.151
CDC9Cdc9p0.141
SGV1Sgv1p0.135
RAD27Rad27p0.132
LEO1Leo1p0.132
POL30Pol30p0.132
TFA2Tfa2p0.131
KIN28Kin28p0.125
RLF2Rlf2p0.125
YRA1Yra1p0.119
SWD3Swd3p0.112
RPT6Rpt6p0.107
SPT5Spt5p0.107
CDC31Cdc31p0.107
RPN10Rpn10p0.095
PSY4Psy4p0.092
ELC1Elc1p0.092
RPN2Rpn2p0.088
SNF5Snf5p0.088
APN1Apn1p0.086
NTG1Ntg1p0.084
BYE1Bye1p0.083
THO2Tho2p0.080
MFT1Mft1p0.080
RFC1Rfc1p0.079
RAD17Rad17p0.079
TEL1Tel1p0.077
CKB2Ckb2p0.076
MSI1Msi1p0.076
TFG1Tfg1p0.073
DNA2Dna2p0.067
MMS1Mms1p0.066
POB3Pob3p0.064
HDA2Hda2p0.063
HOR2Hor2p0.062
ALG14Alg14p0.061
MUS81Mus81p0.060
UME1Ume1p0.060
RSC8Rsc8p0.059
RNR1Rnr1p0.059
BRN1Brn1p0.057
THP2Thp2p0.055
MEX67Mex67p0.055
LIF1Lif1p0.054
RAD28Rad28p0.051
RAD24Rad24p0.050
ELF1Elf1p0.050
KEM1Kem1p0.049