The network for 't helper cell lineage commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t helper cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.

NameDescriptionProbabilityFunc Analog Organism
Foxp3forkhead box P30.980
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.935
Il10interleukin 100.728
Irf9interferon regulatory factor 90.681
Ifnginterferon gamma0.679
Tnftumor necrosis factor0.654
Stat5asignal transducer and activator of transcription 5A0.649
Stat5bsignal transducer and activator of transcription 5B0.569
Il4rainterleukin 4 receptor, alpha0.527
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.512
Stat2signal transducer and activator of transcription 20.506
Lyz2lysozyme 20.492
FasFas (TNF receptor superfamily member 6)0.487
Stat6signal transducer and activator of transcription 60.405
Il6stinterleukin 6 signal transducer0.400
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.384
Socs1suppressor of cytokine signaling 10.380
Stat3signal transducer and activator of transcription 30.378
Cd19CD19 antigen0.213
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.175
Ikzf1IKAROS family zinc finger 10.163
Batfbasic leucine zipper transcription factor, ATF-like0.162
Prf1perforin 1 (pore forming protein)0.155
Il2interleukin 20.146
Rag1recombination activating gene 10.127
Sfpi1SFFV proviral integration 10.114
Stat1signal transducer and activator of transcription 10.111
Ptpn6protein tyrosine phosphatase, non-receptor type 60.109
Mmp9matrix metallopeptidase 90.106
Trp53transformation related protein 530.105
Cd28CD28 antigen0.103
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.096
Tlr4toll-like receptor 40.089
Uba7ubiquitin-like modifier activating enzyme 70.085
Irf4interferon regulatory factor 40.080
Kitkit oncogene0.067
Ccl2chemokine (C-C motif) ligand 20.052
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.051
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.050
Irf5interferon regulatory factor 50.049
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.046
Il1r1interleukin 1 receptor, type I0.046
Ciitaclass II transactivator0.045
Pdcd1programmed cell death 10.045
Ighimmunoglobulin heavy chain complex0.041
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.041
Ifnar2interferon (alpha and beta) receptor 20.038
Irf8interferon regulatory factor 80.038
Nckap1lNCK associated protein 1 like0.037
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.037
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.035
Cd40CD40 antigen0.034
Nfil3nuclear factor, interleukin 3, regulated0.030
Il21rinterleukin 21 receptor0.029
Ptgs2prostaglandin-endoperoxide synthase 20.027
Usp18ubiquitin specific peptidase 180.027
Trim21tripartite motif-containing 210.026
Il27rainterleukin 27 receptor, alpha0.026
Itgalintegrin alpha L0.025
TapbpTAP binding protein0.025
Bcl3B-cell leukemia/lymphoma 30.022
Inpp5dinositol polyphosphate-5-phosphatase D0.022
Myd88myeloid differentiation primary response gene 880.022
Mx2myxovirus (influenza virus) resistance 20.022
Leprleptin receptor0.021
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.021
Irgm2immunity-related GTPase family M member 20.020
Foxn1forkhead box N10.020
Il4interleukin 40.020
Jak3Janus kinase 30.020
Il6interleukin 60.019
Card11caspase recruitment domain family, member 110.019
Tor3atorsin family 3, member A0.019
Lgals9lectin, galactose binding, soluble 90.018
Il17rainterleukin 17 receptor A0.018
Socs3suppressor of cytokine signaling 30.017
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.017
Isg15ISG15 ubiquitin-like modifier0.017
Il12binterleukin 12b0.016
Ncoa3nuclear receptor coactivator 30.016
Znfx1zinc finger, NFX1-type containing 10.016
Smad3MAD homolog 3 (Drosophila)0.015
JunbJun-B oncogene0.015
Map3k14mitogen-activated protein kinase kinase kinase 140.015
MefvMediterranean fever0.014
Nlrp3NLR family, pyrin domain containing 30.014
Zfp36zinc finger protein 360.013
Ccl4chemokine (C-C motif) ligand 40.013
Sfnstratifin0.012
Unc93b1unc-93 homolog B1 (C. elegans)0.012
Tgfb1transforming growth factor, beta 10.012
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.012
Adaradenosine deaminase, RNA-specific0.011
Irf7interferon regulatory factor 70.011
Mvpmajor vault protein0.011
Ifit3interferon-induced protein with tetratricopeptide repeats 30.010
Relreticuloendotheliosis oncogene0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism