The network for 'negative adaptation of signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative adaptation of signaling pathway

The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.

NameDescriptionProbabilityFunc Analog Organism
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.559
Arrb2arrestin, beta 20.485
Arrb1arrestin, beta 10.403
Drd2dopamine receptor D20.185
Dlg4discs, large homolog 4 (Drosophila)0.159
Pnpla2patatin-like phospholipase domain containing 20.151
Klklotho0.128
Cckbrcholecystokinin B receptor0.094
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.093
ND6NADH dehydrogenase subunit 60.088
Adrb2adrenergic receptor, beta 20.084
Ppargperoxisome proliferator activated receptor gamma0.080
Pgrprogesterone receptor0.070
Adrbk1adrenergic receptor kinase, beta 10.068
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.059
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.052
Sipa1signal-induced proliferation associated gene 10.043
Fliiflightless I homolog (Drosophila)0.039
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.029
Arhgef1Rho guanine nucleotide exchange factor (GEF) 10.025
Npy6rneuropeptide Y receptor Y60.024
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.023
Mafavian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog0.023
Pde6aphosphodiesterase 6A, cGMP-specific, rod, alpha0.022
Mtap2microtubule-associated protein 20.022
Cfhcomplement component factor h0.022
Oprm1opioid receptor, mu 10.021
Calcrlcalcitonin receptor-like0.020
Grm1glutamate receptor, metabotropic 10.020
Mkl1MKL (megakaryoblastic leukemia)/myocardin-like 10.019
Grk6G protein-coupled receptor kinase 60.019
Syt6synaptotagmin VI0.019
Grid1glutamate receptor, ionotropic, delta 10.019
Mas1MAS1 oncogene0.019
Pitpnm1phosphatidylinositol transfer protein, membrane-associated 10.018
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.017
Tectbtectorin beta0.017
Hrh1histamine receptor H10.016
Htr75-hydroxytryptamine (serotonin) receptor 70.016
Gucy2eguanylate cyclase 2e0.015
Myh9myosin, heavy polypeptide 9, non-muscle0.015
Sstr4somatostatin receptor 40.015
Cdkn1bcyclin-dependent kinase inhibitor 1B0.015
Npy2rneuropeptide Y receptor Y20.014
Galnt6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 60.014
Prkceprotein kinase C, epsilon0.013
Adrb1adrenergic receptor, beta 10.013
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.013
Sstr1somatostatin receptor 10.013
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.012
Hrkharakiri, BCL2 interacting protein (contains only BH3 domain)0.012
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.012
Chrm1cholinergic receptor, muscarinic 1, CNS0.012
Shc3src homology 2 domain-containing transforming protein C30.012
Akt1thymoma viral proto-oncogene 10.012
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.012
Rp1retinitis pigmentosa 1 (human)0.011
Grm2glutamate receptor, metabotropic 20.011
Drd1adopamine receptor D1A0.011
Crhr1corticotropin releasing hormone receptor 10.010
Arpc4actin related protein 2/3 complex, subunit 40.010
Cnr1cannabinoid receptor 1 (brain)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
odr-3Protein ODR-30.940
grk-2Protein GRK-20.451
pkg-1Protein PKG-10.438
ocr-2Protein OCR-20.304
osm-9Protein OSM-90.211
rgs-3Protein RGS-30.089
unc-42Protein UNC-420.072
tax-6Protein TAX-60.031
npr-1Protein NPR-10.030
vab-3Protein VAB-30.030
lin-11Protein LIN-110.029
lim-7Protein LIM-70.029
nphp-1Protein NPHP-10.022
osm-5Protein OSM-50.021
unc-98Protein UNC-980.019
dbl-1Protein DBL-10.018
ccch-1Protein CCCH-10.017
unc-7Protein UNC-70.016
tub-1Protein TUB-10.015
F52C12.4Protein F52C12.40.013
ZC581.3Protein ZC581.30.013
syd-2Protein SYD-20.012
gyg-1Protein GYG-10.012
F55C12.1Protein F55C12.10.011
CELE_F07G6.8Protein F07G6.80.011
pph-1Protein PPH-10.011
T15B12.1Protein T15B12.10.011
dma-1Protein DMA-10.011
CELE_Y43F8B.2Protein Y43F8B.20.010
T19B10.3Protein T19B10.30.010
C04A11.2Protein C04A11.20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAP3K5mitogen-activated protein kinase kinase kinase 50.498
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.285
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.132
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.115
MPDZmultiple PDZ domain protein0.112
MAPK10mitogen-activated protein kinase 100.092
ZNF496zinc finger protein 4960.086
CFL1cofilin 1 (non-muscle)0.050
GNMTglycine N-methyltransferase0.048
HDAC6histone deacetylase 60.045
ADORA2Aadenosine A2a receptor0.045
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.036
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.036
YY1YY1 transcription factor0.035
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.024
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.021
MDM2Mdm2 p53 binding protein homolog (mouse)0.017
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.015
LIMK1LIM domain kinase 10.013
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.011
CDK7cyclin-dependent kinase 70.011
DGKZdiacylglycerol kinase, zeta0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Kcnb2potassium voltage gated channel, Shab-related subfamily, member 20.153
Adora2aadenosine A2a receptor0.142
Rftn2raftlin family member 20.115
Slc14a2solute carrier family 14 (urea transporter), member 20.115
Znf483zinc finger protein 4830.100
Prph2peripherin 20.094
Pde1bphosphodiesterase 1B, calmodulin-dependent0.086
Pomcproopiomelanocortin0.076
Trhrthyrotropin releasing hormone receptor0.068
Dlg4discs, large homolog 4 (Drosophila)0.050
Zfp382zinc finger protein 3820.049
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.049
Hoxa1homeo box A10.045
Fbxo10F-box protein 100.043
Cx3cr1chemokine (C-X3-C motif) receptor 10.042
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.041
SeboxSEBOX homeobox0.040
UncxUNC homeobox0.040
Chrna2cholinergic receptor, nicotinic, alpha 2 (neuronal)0.038
Magmyelin-associated glycoprotein0.038
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.038
Hoxc4homeo box C40.038
Acrv1acrosomal vesicle protein 10.037
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.037
Pou3f2POU class 3 homeobox 20.037
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.035
St18suppression of tumorigenicity 180.034
Kcnn3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 30.032
Rgs9regulator of G-protein signaling 90.030
Nmbrneuromedin B receptor0.030
Grpgastrin releasing peptide0.029
Csf1colony stimulating factor 1 (macrophage)0.029
Itgamintegrin, alpha M0.029
Impg2interphotoreceptor matrix proteoglycan 20.028
Chrna7cholinergic receptor, nicotinic, alpha 70.027
Grk1G protein-coupled receptor kinase 10.027
Git1G protein-coupled receptor kinase interacting ArfGAP 10.027
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.027
Hcrtr1hypocretin (orexin) receptor 10.026
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.025
Pitx3paired-like homeodomain 30.024
RGD1308049similar to RIKEN cDNA 2410004C240.024
Syt6synaptotagmin VI0.024
LOC286987hemiferrin, transferrin-like protein0.024
N5DNA binding protein N50.024
Lims1LIM and senescent cell antigen-like domains 10.024
Gad2glutamate decarboxylase 20.024
Dsppdentin sialophosphoprotein0.024
Scn3asodium channel, voltage-gated, type III, alpha0.023
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.023
Mamdc4MAM domain containing 40.022
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.022
Syt8synaptotagmin VIII0.022
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.022
Fgf14fibroblast growth factor 140.022
Il9rinterleukin 9 receptor0.021
Dnm3dynamin 30.021
Coro1acoronin, actin binding protein 1A0.021
Ctsjcathepsin J0.020
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.020
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.020
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.020
Chrnb3cholinergic receptor, nicotinic, beta 30.020
Syn3synapsin III0.020
Syt5synaptotagmin V0.020
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.020
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.020
Htr65-hydroxytryptamine (serotonin) receptor 60.019
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.019
Syngap1synaptic Ras GTPase activating protein 1 homolog (rat)0.019
Gria1glutamate receptor, ionotropic, AMPA 10.019
Lnpepleucyl/cystinyl aminopeptidase0.018
Olr1654olfactory receptor 16540.018
Pla2g2cphospholipase A2, group IIC0.018
Fgf7fibroblast growth factor 70.018
RGD1309414similar to KIAA0913 protein0.018
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.018
Grik1glutamate receptor, ionotropic, kainate 10.017
Svs4seminal vesicle secretory protein 40.017
Sncbsynuclein, beta0.017
Accn3amiloride-sensitive cation channel 30.017
Epha8Eph receptor A80.017
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.017
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.017
Ptmsparathymosin0.017
Gucy2fguanylate cyclase 2F0.016
RGD1565057similar to hypothetical protein FLJ328710.016
Gja6gap junction protein, alpha 60.016
LOC687035similar to Tripartite motif protein 560.016
Avparginine vasopressin0.016
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.016
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.016
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.016
Dgkzdiacylglycerol kinase zeta0.016
Hcrthypocretin0.016
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.015
Camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.015
Adora1adenosine A1 receptor0.015
Amphamphiphysin0.015
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism