The network for 'age dependent general metabolic decline' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

age dependent general metabolic decline

A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis.

NameDescriptionProbabilityFunc Analog Organism
Ndufa5NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 50.072
Timm17atranslocase of inner mitochondrial membrane 17a0.048
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.044
Mrpl16mitochondrial ribosomal protein L160.021
Fh1fumarate hydratase 10.019
Ndufb3NADH dehydrogenase (ubiquinone) 1 beta subcomplex 30.019
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.019
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.019
Errfi1ERBB receptor feedback inhibitor 10.019
Timm23translocase of inner mitochondrial membrane 23 homolog (yeast)0.018
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.016
Mrpl18mitochondrial ribosomal protein L180.016
Cycscytochrome c, somatic0.015
Ndufs3NADH dehydrogenase (ubiquinone) Fe-S protein 30.014
Hif1anhypoxia-inducible factor 1, alpha subunit inhibitor0.012
Samm50sorting and assembly machinery component 50 homolog (S. cerevisiae)0.012
Ndufb6NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 60.011
Suclg1succinate-CoA ligase, GDP-forming, alpha subunit0.010
Slmo2slowmo homolog 2 (Drosophila)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
TpiTriose phosphate isomerase0.511
CG6783CG6783 gene product from transcript CG6783-RC0.144
SodSuperoxide dismutase0.142
levyCG17280 gene product from transcript CG17280-RA0.059
porinCG6647 gene product from transcript CG6647-RA0.057
NLazNeural Lazarillo0.046
dj-1betaCG1349 gene product from transcript CG1349-RA0.033
CG7834CG7834 gene product from transcript CG7834-RA0.032
mRpL2mitochondrial ribosomal protein L20.029
CG30410CG30410 gene product from transcript CG30410-RB0.028
CG9306CG9306 gene product from transcript CG9306-RA0.025
PgdPhosphogluconate dehydrogenase0.020
ZwZwischenferment0.019
CG9232CG9232 gene product from transcript CG9232-RA0.019
AldhAldehyde dehydrogenase0.019
CG6543CG6543 gene product from transcript CG6543-RA0.019
amnamnesiac0.019
p38bCG7393 gene product from transcript CG7393-RA0.015
coltcongested-like trachea0.013
CG6020CG6020 gene product from transcript CG6020-RA0.013
CG11699CG11699 gene product from transcript CG11699-RA0.012
ThiolaseCG4581 gene product from transcript CG4581-RA0.011
FdhFormaldehyde dehydrogenase0.011
timtimeless0.011
PgmPhosphogluconate mutase0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NAMPTnicotinamide phosphoribosyltransferase0.015
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MOB1Mob1p0.013