The network for 'negative regulation of protein activation cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein activation cascade

Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade.

NameDescriptionProbabilityFunc Analog Organism
Cd59aCD59a antigen0.995
Cfhcomplement component factor h0.576
Lumlumican0.447
Dcndecorin0.421
Cd59bCD59b antigen0.417
Adam4a disintegrin and metallopeptidase domain 40.369
Spna1spectrin alpha 10.361
C1racomplement component 1, r subcomponent A0.279
Cd55CD55 antigen0.204
Mug1murinoglobulin 10.145
Fxyd1FXYD domain-containing ion transport regulator 10.112
Bgnbiglycan0.110
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.103
Cpceruloplasmin0.094
Inhbeinhibin beta E0.073
Col3a1collagen, type III, alpha 10.064
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.060
F9coagulation factor IX0.059
Pklrpyruvate kinase liver and red blood cell0.056
Serpinf1serine (or cysteine) peptidase inhibitor, clade F, member 10.055
Fmo1flavin containing monooxygenase 10.054
C1scomplement component 1, s subcomponent0.052
Lect2leukocyte cell-derived chemotaxin 20.047
CrpC-reactive protein, pentraxin-related0.047
Thbs2thrombospondin 20.046
Rbp1retinol binding protein 1, cellular0.043
Fggfibrinogen gamma chain0.040
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.040
Itih3inter-alpha trypsin inhibitor, heavy chain 30.039
Rarres2retinoic acid receptor responder (tazarotene induced) 20.036
Serpind1serine (or cysteine) peptidase inhibitor, clade D, member 10.036
Sdc2syndecan 20.035
Timd2T-cell immunoglobulin and mucin domain containing 20.035
Cficomplement component factor i0.035
Col5a2collagen, type V, alpha 20.034
Ifitm3interferon induced transmembrane protein 30.033
Mgpmatrix Gla protein0.032
Ognosteoglycin0.030
1300017J02RikRIKEN cDNA 1300017J02 gene0.030
Aadacarylacetamide deacetylase (esterase)0.030
Afmafamin0.030
Ank1ankyrin 1, erythroid0.029
Plgplasminogen0.029
F2coagulation factor II0.028
Cxcl12chemokine (C-X-C motif) ligand 120.028
Gstt1glutathione S-transferase, theta 10.028
Mbl2mannose-binding lectin (protein C) 20.028
Albalbumin0.027
2610015P09RikRIKEN cDNA 2610015P09 gene0.027
Postnperiostin, osteoblast specific factor0.026
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.025
Emcnendomucin0.025
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.025
Apoa5apolipoprotein A-V0.025
Rnase4ribonuclease, RNase A family 40.024
Akr1c6aldo-keto reductase family 1, member C60.024
Cryba1crystallin, beta A10.024
Dnajb7DnaJ (Hsp40) homolog, subfamily B, member 70.023
Abcb4ATP-binding cassette, sub-family B (MDR/TAP), member 40.022
Sdprserum deprivation response0.022
Apofapolipoprotein F0.021
Hgdhomogentisate 1, 2-dioxygenase0.021
Fn1fibronectin 10.020
Olfml3olfactomedin-like 30.019
Tsga13testis specific gene A130.019
Lbplipopolysaccharide binding protein0.019
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.018
Pros1protein S (alpha)0.018
Osmroncostatin M receptor0.018
Gcgroup specific component0.018
Tdo2tryptophan 2,3-dioxygenase0.018
Fam164cfamily with sequence similarity 164, member C0.018
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.017
Prelpproline arginine-rich end leucine-rich repeat0.017
Itih2inter-alpha trypsin inhibitor, heavy chain 20.017
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.017
Apcsserum amyloid P-component0.016
C1rbcomplement component 1, r subcomponent B0.016
Ttrtransthyretin0.016
Itih1inter-alpha trypsin inhibitor, heavy chain 10.016
Klkb1kallikrein B, plasma 10.016
Fechferrochelatase0.016
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.016
Ctshcathepsin H0.015
Angptl1angiopoietin-like 10.015
Efemp1epidermal growth factor-containing fibulin-like extracellular matrix protein 10.015
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.015
Zfp493zinc finger protein 4930.015
Tmem176btransmembrane protein 176B0.015
Casp12caspase 120.015
Rhojras homolog gene family, member J0.015
Islrimmunoglobulin superfamily containing leucine-rich repeat0.014
Zfp57zinc finger protein 570.014
Apobapolipoprotein B0.014
Vtnvitronectin0.014
Fgbfibrinogen beta chain0.014
Sparcsecreted acidic cysteine rich glycoprotein0.014
Pcolceprocollagen C-endopeptidase enhancer protein0.014
Vmn2r1vomeronasal 2, receptor 10.014
Mug2murinoglobulin 20.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
C1Scomplement component 1, s subcomponent1.000
C1Rcomplement component 1, r subcomponent1.000
APOEapolipoprotein E0.997
SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 10.993
C3complement component 30.979
CFHcomplement factor H0.967
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.916
CFIcomplement factor I0.807
C1QAcomplement component 1, q subcomponent, A chain0.498
CD164CD164 molecule, sialomucin0.422
CPDcarboxypeptidase D0.292
HPhaptoglobin0.193
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.183
NNMTnicotinamide N-methyltransferase0.181
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.169
IFITM3interferon induced transmembrane protein 3 (1-8U)0.138
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.115
CFBcomplement factor B0.111
APOL3apolipoprotein L, 30.106
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.104
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.100
DCNdecorin0.098
PLTPphospholipid transfer protein0.082
CPceruloplasmin (ferroxidase)0.080
PLGplasminogen0.080
C2complement component 20.064
RARRES1retinoic acid receptor responder (tazarotene induced) 10.062
IFITM2interferon induced transmembrane protein 2 (1-8D)0.058
MASP2mannan-binding lectin serine peptidase 20.053
RARRES2retinoic acid receptor responder (tazarotene induced) 20.048
CFHR1complement factor H-related 10.048
PCOLCEprocollagen C-endopeptidase enhancer0.043
C1QBcomplement component 1, q subcomponent, B chain0.041
C4Bcomplement component 4B (Chido blood group)0.040
MBL2mannose-binding lectin (protein C) 2, soluble0.040
TM9SF2transmembrane 9 superfamily member 20.035
LBPlipopolysaccharide binding protein0.034
APOC1apolipoprotein C-I0.034
LCATlecithin-cholesterol acyltransferase0.029
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.026
HLA-Amajor histocompatibility complex, class I, A0.025
FN1fibronectin 10.025
C7complement component 70.025
SAA4serum amyloid A4, constitutive0.024
SEPT8septin 80.022
VSIG4V-set and immunoglobulin domain containing 40.021
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.021
LRP1low density lipoprotein receptor-related protein 10.020
HTRA1HtrA serine peptidase 10.019
HSD11B1hydroxysteroid (11-beta) dehydrogenase 10.018
CYP27A1cytochrome P450, family 27, subfamily A, polypeptide 10.018
IL1R1interleukin 1 receptor, type I0.018
TMEM176Atransmembrane protein 176A0.016
LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein0.016
C8Bcomplement component 8, beta polypeptide0.014
CTSBcathepsin B0.013
HLA-Emajor histocompatibility complex, class I, E0.013
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.013
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.013
PTGDSprostaglandin D2 synthase 21kDa (brain)0.012
APCSamyloid P component, serum0.012
TMEM140transmembrane protein 1400.012
C1RLcomplement component 1, r subcomponent-like0.012
NAMPTnicotinamide phosphoribosyltransferase0.012
HRGhistidine-rich glycoprotein0.012
CLUclusterin0.012
C8Acomplement component 8, alpha polypeptide0.012
KNG1kininogen 10.011
BST2bone marrow stromal cell antigen 20.011
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.011
OSMRoncostatin M receptor0.011
C1QCcomplement component 1, q subcomponent, C chain0.011
PPAP2Bphosphatidic acid phosphatase type 2B0.011
GPNMBglycoprotein (transmembrane) nmb0.010
TTRtransthyretin0.010
LIPClipase, hepatic0.010
IGFBP4insulin-like growth factor binding protein 40.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism