The network for 'positive regulation of protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.996
Hif1ahypoxia inducible factor 1, alpha subunit0.829
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.723
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.656
Axin1axin 10.652
Apcadenomatosis polyposis coli0.646
Egfrepidermal growth factor receptor0.580
Grb2growth factor receptor bound protein 20.566
Gsk3bglycogen synthase kinase 3 beta0.557
Dvl2dishevelled 2, dsh homolog (Drosophila)0.512
Smad6MAD homolog 6 (Drosophila)0.441
Smad7MAD homolog 7 (Drosophila)0.434
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.383
Vangl2vang-like 2 (van gogh, Drosophila)0.350
Tgfbr2transforming growth factor, beta receptor II0.305
Shc1src homology 2 domain-containing transforming protein C10.290
Prnpprion protein0.284
Fgfr2fibroblast growth factor receptor 20.248
Rbl2retinoblastoma-like 20.232
Fgfr3fibroblast growth factor receptor 30.201
Itgb1integrin beta 1 (fibronectin receptor beta)0.200
Ptpn11protein tyrosine phosphatase, non-receptor type 110.196
Jag1jagged 10.184
Hprthypoxanthine guanine phosphoribosyl transferase0.183
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.183
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.180
Stat1signal transducer and activator of transcription 10.178
Efnb2ephrin B20.170
Fgfr1fibroblast growth factor receptor 10.170
Vegfavascular endothelial growth factor A0.167
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.165
Psma2proteasome (prosome, macropain) subunit, alpha type 20.159
Cyldcylindromatosis (turban tumor syndrome)0.156
Akt1thymoma viral proto-oncogene 10.150
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.147
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.141
Smosmoothened homolog (Drosophila)0.132
Atf4activating transcription factor 40.131
Bmp4bone morphogenetic protein 40.131
Acvr1activin A receptor, type 10.128
Trim30dtripartite motif-containing 30D0.125
Nf1neurofibromatosis 10.124
Cops5COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)0.123
Rnf111ring finger 1110.123
Hhexhematopoietically expressed homeobox0.123
Rargretinoic acid receptor, gamma0.123
Tbx3T-box 30.122
Trp53transformation related protein 530.119
Smurf2SMAD specific E3 ubiquitin protein ligase 20.118
Psen1presenilin 10.116
Meox2mesenchyme homeobox 20.115
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.114
Tgfb2transforming growth factor, beta 20.111
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.108
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.108
Tlr4toll-like receptor 40.106
Rnf11ring finger protein 110.105
Jag2jagged 20.102
Pdpk13-phosphoinositide dependent protein kinase 10.102
Edaectodysplasin-A0.102
Il6interleukin 60.099
Gclmglutamate-cysteine ligase, modifier subunit0.099
Clstn1calsyntenin 10.098
Notch1Notch gene homolog 1 (Drosophila)0.096
Ccnb2cyclin B20.095
Ednrbendothelin receptor type B0.093
Stat3signal transducer and activator of transcription 30.090
Pkd1polycystic kidney disease 1 homolog0.089
Trim30atripartite motif-containing 30A0.089
Bhlhe40basic helix-loop-helix family, member e400.087
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.086
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.086
Eif2c1eukaryotic translation initiation factor 2C, 10.085
Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.081
SkilSKI-like0.081
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.081
Appamyloid beta (A4) precursor protein0.077
Smurf1SMAD specific E3 ubiquitin protein ligase 10.074
Ehmt2euchromatic histone lysine N-methyltransferase 20.073
Ror2receptor tyrosine kinase-like orphan receptor 20.073
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.072
Prkceprotein kinase C, epsilon0.072
Adam17a disintegrin and metallopeptidase domain 170.071
Sox4SRY-box containing gene 40.071
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.070
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.070
Psma4proteasome (prosome, macropain) subunit, alpha type 40.068
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.067
Fcgr2bFc receptor, IgG, low affinity IIb0.067
Nr6a1nuclear receptor subfamily 6, group A, member 10.067
Mitfmicrophthalmia-associated transcription factor0.064
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.063
Ptch1patched homolog 10.062
Rb1retinoblastoma 10.062
Cops4COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)0.061
Pias2protein inhibitor of activated STAT 20.061
Pick1protein interacting with C kinase 10.060
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.060
Nudt3nudix (nucleotide diphosphate linked moiety X)-type motif 30.059
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.059
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ima-3Protein IMA-30.038
uaf-1Protein UAF-10.034
spk-1Protein SPK-10.034
rnr-1Protein RNR-10.034
daf-4Protein DAF-40.033
mex-3Protein MEX-30.031
rpt-1Protein RPT-10.030
pcn-1Protein PCN-10.028
klp-16Protein KLP-160.028
egl-18Protein EGL-180.027
cam-1Protein CAM-10.027
daf-21Protein DAF-210.021
rpn-7Protein RPN-70.021
stam-1Protein STAM-10.020
lin-25Protein LIN-250.018
taf-5Protein TAF-50.017
eor-2Protein EOR-20.016
rpn-1Protein RPN-10.016
bath-42Protein BATH-420.016
unc-76Protein UNC-760.015
axl-1Protein AXL-10.014
pqn-65Protein PQN-650.014
sel-10Protein SEL-100.014
C05C10.5Protein C05C10.50.014
CELE_C24H12.5Protein C24H12.50.012
mex-5Protein MEX-50.012
sma-3Protein SMA-30.012
mom-2Protein MOM-20.012
hcp-2Protein HCP-20.012
ubxn-4Protein UBXN-40.011
nhr-100Protein NHR-1000.011
madf-5Protein MADF-50.011
imb-2Protein IMB-20.011
pry-1Protein PRY-10.011
Y47D3A.29Protein Y47D3A.290.011
K02A6.3Protein K02A6.30.010
bar-1Protein BAR-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
twstwins0.349
Pi3K92ECG4141 gene product from transcript CG4141-RB0.333
hpohippo0.147
l(2)k14710lethal (2) k147100.146
MadMothers against dpp0.138
Top1Topoisomerase 10.120
RYBPRing and YY1 Binding Protein0.086
SF2CG6987 gene product from transcript CG6987-RA0.085
cortoCG2530 gene product from transcript CG2530-RA0.085
Cul-5Cullin-50.085
fz2frizzled 20.079
dshdishevelled0.077
Vap-33-1CG5014 gene product from transcript CG5014-RB0.072
drkdownstream of receptor kinase0.067
Mov34CG3416 gene product from transcript CG3416-RA0.060
rlrolled0.057
CSN4COP9 complex homolog subunit 40.055
Cul-4Cullin-40.052
Ras85DRas oncogene at 85D0.051
Atg1Autophagy-specific gene 10.051
slmbsupernumerary limbs0.045
CblCG7037 gene product from transcript CG7037-RB0.044
Rpn6Proteasome p44.5 subunit0.043
cdc16CG6759 gene product from transcript CG6759-RA0.042
CG33129CG33129 gene product from transcript CG33129-RE0.042
dlg1discs large 10.042
CG13349CG13349 gene product from transcript CG13349-RA0.040
tantantalus0.040
Fcp1CG12252 gene product from transcript CG12252-RA0.040
smosmoothened0.040
cdc23CG2508 gene product from transcript CG2508-RA0.040
pgant3polypeptide GalNAc transferase 30.039
Uba1Ubiquitin activating enzyme 10.039
TER94CG2331 gene product from transcript CG2331-RA0.037
CG12321CG12321 gene product from transcript CG12321-RA0.035
fryfurry0.034
tefutelomere fusion0.032
CkIIalphaCasein kinase II alpha subunit0.031
cavcaravaggio0.031
Su(H)Suppressor of Hairless0.031
UbcD2Ubiquitin conjugating enzyme 20.030
InRInsulin-like receptor0.030
matsmob as tumor suppressor0.030
CG31998CG31998 gene product from transcript CG31998-RA0.029
Sulf1Sulfated0.029
Cenp-CCG31258 gene product from transcript CG31258-RA0.029
AGO1Argonaute-10.029
dltdiscs lost0.028
weeCG4488 gene product from transcript CG4488-RA0.028
CG4673CG4673 gene product from transcript CG4673-RB0.028
cutletCG33122 gene product from transcript CG33122-RA0.028
SaraSmad anchor for receptor activation0.028
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.027
CG30382CG30382 gene product from transcript CG30382-RB0.027
Cul-2Cullin-20.026
agoarchipelago0.026
CSN1bCOP9 complex homolog subunit 1 b0.026
auxauxillin0.026
SbfSET domain binding factor0.025
Vps35Vacuolar protein sorting 350.025
CG1109CG1109 gene product from transcript CG1109-RA0.025
Ube3aUbiquitin protein ligase E3A0.025
Mob4CG3403 gene product from transcript CG3403-RA0.024
CasCAS/CSE1 segregation protein0.024
shtdshattered0.023
CG5384CG5384 gene product from transcript CG5384-RA0.023
Ras64BRas oncogene at 64B0.022
dcodiscs overgrown0.022
StamSignal transducing adaptor molecule0.021
vps2CG14542 gene product from transcript CG14542-RA0.021
trpmltransient receptor potential mucolipin0.021
krzkurtz0.021
wdbwiderborst0.021
sqzsqueeze0.020
Pros54Proteasome 54kD subunit0.020
sec15CG7034 gene product from transcript CG7034-RA0.020
Dcr-2Dicer-20.020
CG5798CG5798 gene product from transcript CG5798-RA0.020
CG33523CG33523 gene product from transcript CG33523-RD0.020
Akt1CG4006 gene product from transcript CG4006-RA0.020
G9aCG2995 gene product from transcript CG2995-RA0.019
Rpn3Regulatory particle non-ATPase 30.019
Tbp-1Tat-binding protein-10.018
Elongin-BElongin B0.018
zfh2Zn finger homeodomain 20.018
Psf2CG18013 gene product from transcript CG18013-RA0.018
stepsteppke0.018
taitaiman0.018
Drp1Dynamin related protein 10.018
dosdaughter of sevenless0.017
Orc1Origin recognition complex subunit 10.017
swshort wing0.017
E23Early gene at 230.017
l(1)G0007lethal (1) G00070.017
granny-smithgranny smith0.017
ClkClock0.017
ctaconcertina0.017
myoglianinCG1838 gene product from transcript CG1838-RD0.017
CG9866CG9866 gene product from transcript CG9866-RA0.017
Klp3AKinesin-like protein at 3A0.017
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMURF2SMAD specific E3 ubiquitin protein ligase 20.993
CDC20cell division cycle 20 homolog (S. cerevisiae)0.992
CDC27cell division cycle 27 homolog (S. cerevisiae)0.982
SMAD1SMAD family member 10.969
CSNK1Ecasein kinase 1, epsilon0.959
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.958
SNX9sorting nexin 90.958
CREBBPCREB binding protein0.957
SMAD2SMAD family member 20.940
SMAD4SMAD family member 40.931
ADAM15ADAM metallopeptidase domain 150.928
SKP1S-phase kinase-associated protein 10.919
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.891
SMAD3SMAD family member 30.887
CUL2cullin 20.886
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.836
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.829
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.820
RNF11ring finger protein 110.820
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.817
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.815
ANAPC4anaphase promoting complex subunit 40.783
DNM1dynamin 10.750
FASLGFas ligand (TNF superfamily, member 6)0.743
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.729
UBCubiquitin C0.722
RB1retinoblastoma 10.712
IL1R1interleukin 1 receptor, type I0.702
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.677
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.588
TRAF2TNF receptor-associated factor 20.532
FKBP1AFK506 binding protein 1A, 12kDa0.515
CDC16cell division cycle 16 homolog (S. cerevisiae)0.500
TRAF1TNF receptor-associated factor 10.499
VHLvon Hippel-Lindau tumor suppressor0.475
MAP3K5mitogen-activated protein kinase kinase kinase 50.466
TADA3transcriptional adaptor 30.464
DVL1dishevelled, dsh homolog 1 (Drosophila)0.462
DVL3dishevelled, dsh homolog 3 (Drosophila)0.461
RBX1ring-box 1, E3 ubiquitin protein ligase0.459
ARandrogen receptor0.453
NCF1neutrophil cytosolic factor 10.434
FBXW11F-box and WD repeat domain containing 110.428
ANAPC7anaphase promoting complex subunit 70.413
PRNPprion protein0.410
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.408
AXIN1axin 10.396
ANAPC11anaphase promoting complex subunit 110.374
CUL5cullin 50.358
SMN1survival of motor neuron 1, telomeric0.353
PSEN1presenilin 10.348
NEDD4neural precursor cell expressed, developmentally down-regulated 40.344
DNM2dynamin 20.343
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.337
PLK1polo-like kinase 10.335
IGF2Rinsulin-like growth factor 2 receptor0.328
EPAS1endothelial PAS domain protein 10.318
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.316
SMAD7SMAD family member 70.313
MDM2Mdm2 p53 binding protein homolog (mouse)0.312
TRADDTNFRSF1A-associated via death domain0.306
SMC6structural maintenance of chromosomes 60.294
NEDD8neural precursor cell expressed, developmentally down-regulated 80.293
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.278
ZMYND11zinc finger, MYND-type containing 110.276
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.271
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.259
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.257
BMP2bone morphogenetic protein 20.257
CUL1cullin 10.233
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.219
CUL4Acullin 4A0.213
EPORerythropoietin receptor0.210
ANAPC1anaphase promoting complex subunit 10.207
TCEB2transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)0.206
CDC23cell division cycle 23 homolog (S. cerevisiae)0.200
COPS6COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)0.199
TRAF5TNF receptor-associated factor 50.198
NCF2neutrophil cytosolic factor 20.195
APPamyloid beta (A4) precursor protein0.194
UHRF2ubiquitin-like with PHD and ring finger domains 20.194
SNX6sorting nexin 60.193
DVL2dishevelled, dsh homolog 2 (Drosophila)0.190
MDM4Mdm4 p53 binding protein homolog (mouse)0.187
ATXN3ataxin 30.187
ZNF420zinc finger protein 4200.185
MPDZmultiple PDZ domain protein0.185
LRP6low density lipoprotein receptor-related protein 60.182
FBXL15F-box and leucine-rich repeat protein 150.170
PIAS4protein inhibitor of activated STAT, 40.167
TRAF3TNF receptor-associated factor 30.163
PSEN2presenilin 2 (Alzheimer disease 4)0.159
SYVN1synovial apoptosis inhibitor 1, synoviolin0.157
TGFB1transforming growth factor, beta 10.152
HPhaptoglobin0.150
SYNRGsynergin, gamma0.148
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.148
ANKRD28ankyrin repeat domain 280.147
SORT1sortilin 10.144
CYBAcytochrome b-245, alpha polypeptide0.144
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RPN4Rpn4p0.053
CDC16Cdc16p0.026
RPT6Rpt6p0.025
UBC13Ubc13p0.023
NPL4Npl4p0.021
RAD23Rad23p0.020
UBP6Ubp6p0.018
AFT1Aft1p0.017
CDC23Cdc23p0.017
SPT16Spt16p0.014
ECO1Eco1p0.013
CKA1Cka1p0.013
NBL1Nbl1p0.012
BNR1Bnr1p0.012
RPN2Rpn2p0.011
ECM29Ecm29p0.011
RIM13Rim13p0.011
ATG9Atg9p0.011
CDC34Cdc34p0.010