The network for 'positive regulation of proteolysis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of proteolysis

Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Ctnnb1catenin (cadherin associated protein), beta 10.999
Axin1axin 10.991
Gsk3bglycogen synthase kinase 3 beta0.972
Apcadenomatosis polyposis coli0.960
Casp4caspase 4, apoptosis-related cysteine peptidase0.958
Bcl2B-cell leukemia/lymphoma 20.955
Ptgs2prostaglandin-endoperoxide synthase 20.935
Ptenphosphatase and tensin homolog0.831
Per2period homolog 2 (Drosophila)0.817
Itga3integrin alpha 30.814
BaxBCL2-associated X protein0.812
Psme2proteasome (prosome, macropain) 28 subunit, beta0.792
PycardPYD and CARD domain containing0.788
Thbs1thrombospondin 10.783
Tgfbr1transforming growth factor, beta receptor I0.764
Il10interleukin 100.759
Casp1caspase 10.714
Mcl1myeloid cell leukemia sequence 10.681
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.676
Tlr4toll-like receptor 40.675
Il1r1interleukin 1 receptor, type I0.673
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.668
Psen1presenilin 10.613
Cyldcylindromatosis (turban tumor syndrome)0.612
Gbp5guanylate binding protein 50.604
Itgb1integrin beta 1 (fibronectin receptor beta)0.596
Dvl2dishevelled 2, dsh homolog (Drosophila)0.592
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.567
Psma4proteasome (prosome, macropain) subunit, alpha type 40.563
Cyr61cysteine rich protein 610.556
Sfrp2secreted frizzled-related protein 20.552
Stat5asignal transducer and activator of transcription 5A0.549
Prnpprion protein0.548
Thbs2thrombospondin 20.531
Socs1suppressor of cytokine signaling 10.528
Cd44CD44 antigen0.528
S100a9S100 calcium binding protein A9 (calgranulin B)0.518
Ptch2patched homolog 20.506
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.503
Ncoa3nuclear receptor coactivator 30.501
Gdnfglial cell line derived neurotrophic factor0.488
Gli2GLI-Kruppel family member GLI20.485
Kitkit oncogene0.484
Bmp4bone morphogenetic protein 40.481
Mndalmyeloid nuclear differentiation antigen like0.480
Ltbp2latent transforming growth factor beta binding protein 20.476
Rb1retinoblastoma 10.468
Vhlvon Hippel-Lindau tumor suppressor0.464
Lyz2lysozyme 20.459
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.451
Egfrepidermal growth factor receptor0.444
Wnt3awingless-related MMTV integration site 3A0.437
Vangl2vang-like 2 (van gogh, Drosophila)0.436
Fgfr1fibroblast growth factor receptor 10.429
Lrp6low density lipoprotein receptor-related protein 60.417
Psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.416
Mdm4transformed mouse 3T3 cell double minute 40.416
Mdm2transformed mouse 3T3 cell double minute 20.414
Psma2proteasome (prosome, macropain) subunit, alpha type 20.412
Map3k14mitogen-activated protein kinase kinase kinase 140.397
Vegfavascular endothelial growth factor A0.390
S100a8S100 calcium binding protein A8 (calgranulin A)0.390
Irf9interferon regulatory factor 90.375
Casp3caspase 30.374
Trp73transformation related protein 730.372
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.369
Lrp1low density lipoprotein receptor-related protein 10.368
Suz12suppressor of zeste 12 homolog (Drosophila)0.365
Ikbkbinhibitor of kappaB kinase beta0.364
Wt1Wilms tumor 1 homolog0.361
Nos3nitric oxide synthase 3, endothelial cell0.361
Npm1nucleophosmin 10.350
Fbn1fibrillin 10.345
Ilkintegrin linked kinase0.344
Mfn2mitofusin 20.340
Cdkn1bcyclin-dependent kinase inhibitor 1B0.333
Ikzf1IKAROS family zinc finger 10.331
Notch2Notch gene homolog 2 (Drosophila)0.330
Stat5bsignal transducer and activator of transcription 5B0.314
Leprleptin receptor0.312
Pax2paired box gene 20.304
Smad7MAD homolog 7 (Drosophila)0.301
Pias2protein inhibitor of activated STAT 20.297
Nphs2nephrosis 2 homolog, podocin (human)0.293
Ptrfpolymerase I and transcript release factor0.292
Smad3MAD homolog 3 (Drosophila)0.289
NmiN-myc (and STAT) interactor0.288
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.281
Il2rginterleukin 2 receptor, gamma chain0.279
Ctgfconnective tissue growth factor0.277
Wdr26WD repeat domain 260.277
Loxlysyl oxidase0.274
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.274
Coro1bcoronin, actin binding protein 1B0.272
Sfrp1secreted frizzled-related protein 10.267
Chukconserved helix-loop-helix ubiquitous kinase0.265
Ube2nubiquitin-conjugating enzyme E2N0.263
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
snr-7Protein SNR-70.018
lbp-4Protein LBP-40.013
mrps-10Protein MRPS-100.012
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
baxabcl2-associated X protein, a0.380
sparcsecreted acidic cysteine rich glycoprotein0.267
gata5GATA-binding protein 50.085
bcl2B-cell leukemia/lymphoma 20.078
bidaBH3 interacting domain death agonist0.077
ef1aelongation factor 1-alpha0.066
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.063
bcl2l1bcl2-like 10.055
tp53tumor protein p530.048
col5a2lcollagen, type V, alpha 2-like0.044
mcl1bmyeloid cell leukemia sequence 1b0.043
plxnb2aplexin b2a0.042
p4ha2procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 20.040
ccnb1cyclin B10.038
ccnb2cyclin B20.036
rasl11bRAS-like, family 11, member B0.034
bbc3BCL2 binding component 30.032
psmb4proteasome (prosome, macropain) subunit, beta type, 40.031
ihhaIndian hedgehog homolog a0.031
LOC100151531zinc finger protein Gfi-1b-like0.030
csnk1dbcasein kinase 1, delta b0.030
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.028
aldoaaaldolase a, fructose-bisphosphate, a0.028
ehd2EH-domain containing 20.027
mipamajor intrinsic protein of lens fiber a0.027
hspa9heat shock protein 90.026
s100v2S100 calcium binding protein V20.025
tnfrsfatumor necrosis factor receptor superfamily, member a0.025
mmp2matrix metalloproteinase 20.025
bcl2l10BCL2-like 10 (apoptosis facilitator)0.024
gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 10.024
psma6aproteasome (prosome, macropain) subunit, alpha type, 6a0.023
ighzimmunoglobulin heavy constant zeta0.023
psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.023
sdcbpsyndecan binding protein (syntenin)0.022
wnt11rwingless-type MMTV integration site family, member 11, related0.022
f2rcoagulation factor II (thrombin) receptor0.022
tfe3btranscription factor binding to IGHM enhancer 3b0.021
hbbe1.1hemoglobin beta embryonic-1.10.021
kdrlkinase insert domain receptor like0.021
ptenaphosphatase and tensin homolog A0.021
ntd5ntl-dependent gene 50.021
adipor1badiponectin receptor 1b0.020
fn1fibronectin 10.020
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.020
gdf6agrowth differentiation factor 6a0.020
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.019
csnk1g2acasein kinase 1, gamma 2a0.018
ints6integrator complex subunit 60.018
ctszcathepsin Z0.018
ube2d1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.018
eif5a2eukaryotic translation initiation factor 5A20.017
mapre1lmicrotubule-associated protein, RP/EB family, member 1, like0.017
ikzf1IKAROS family zinc finger 1 (Ikaros)0.017
rnasekaribonuclease, RNase K a0.017
csnk1dacasein kinase 1, delta a0.017
gna12guanine nucleotide binding protein (G protein) alpha 120.017
id1inhibitor of DNA binding 10.017
gcm2glial cells missing homolog 2 (Drosophila)0.017
fzd7afrizzled homolog 7a0.016
fstl1bfollistatin-like 1b0.016
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.016
wnt9awingless-type MMTV integration site family, member 9A0.016
znf703zinc finger protein 7030.016
abcf1ATP-binding cassette, sub-family F (GCN20), member 10.016
wnt2bbwingless-type MMTV integration site family, member 2Bb0.016
stc1lstanniocalcin 1, like0.016
sec23bSec23 homolog B (S. cerevisiae)0.016
rplp0ribosomal protein, large, P00.016
col12a1collagen, type XII, alpha 10.016
mmp9matrix metalloproteinase 90.016
il1binterleukin 1, beta and interleukin 1, beta0.015
hspa4aheat shock protein 4a0.015
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.015
trpv4transient receptor potential cation channel, subfamily V, member 40.015
ck2bcasein kinase 2 beta0.015
wif1wnt inhibitory factor 10.014
pitrm1pitrilysin metalloproteinase 10.014
kif23kinesin family member 230.014
psmb7proteasome (prosome, macropain) subunit, beta type, 70.014
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.014
gpiaglucose phosphate isomerase a0.014
smad9MAD homolog 9 (Drosophila)0.013
caspacaspase a0.013
ccng1cyclin G10.013
hmgb1ahigh-mobility group box 1a0.013
hoxb1ahomeo box B1a0.013
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.013
mycbp2MYC binding protein 20.013
rhbgRhesus blood group, B glycoprotein0.013
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.013
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.013
psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.013
pdcd2programmed cell death 20.013
tp53bp2tumor protein p53 binding protein, 20.013
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.935
Pi3K92ECG4141 gene product from transcript CG4141-RB0.910
Rpt1CG1341 gene product from transcript CG1341-RA0.839
tefutelomere fusion0.736
CG11347CG11347 gene product from transcript CG11347-RE0.662
CG9772CG9772 gene product from transcript CG9772-RB0.612
Tbp-1Tat-binding protein-10.571
grimCG4345 gene product from transcript CG4345-RA0.530
SmoxSmad on X0.512
imdimmune deficiency0.489
stanstarry night0.486
RYBPRing and YY1 Binding Protein0.471
IceCG7788 gene product from transcript CG7788-RA0.437
Tak1TGF-beta activated kinase 10.401
CG5384CG5384 gene product from transcript CG5384-RA0.397
cdc16CG6759 gene product from transcript CG6759-RA0.391
dupdouble parked0.380
SF2CG6987 gene product from transcript CG6987-RA0.373
Rpn6Proteasome p44.5 subunit0.371
yuriyuri gagarin0.340
Cyt-c-dCytochrome c distal0.327
NcNedd2-like caspase0.320
Prosbeta3Proteasome beta3 subunit0.307
p53CG33336 gene product from transcript CG33336-RB0.291
Rpn3Regulatory particle non-ATPase 30.279
stumpsCG31317 gene product from transcript CG31317-RC0.275
numbCG3779 gene product from transcript CG3779-RB0.271
Rpt4CG3455 gene product from transcript CG3455-RA0.264
Fmr1CG6203 gene product from transcript CG6203-RC0.260
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.258
Vrp1Verprolin 10.247
CG1103CG1103 gene product from transcript CG1103-RA0.241
Rpt3CG16916 gene product from transcript CG16916-RA0.229
Trxr-1Thioredoxin reductase-10.227
DreddDeath related ced-3/Nedd2-like protein0.223
CycBCyclin B0.219
B52CG10851 gene product from transcript CG10851-RB0.216
idaimaginal discs arrested0.215
Rac1CG2248 gene product from transcript CG2248-RA0.215
msl-1male-specific lethal 10.214
mtsmicrotubule star0.207
LaspCG3849 gene product from transcript CG3849-RB0.197
CG5155CG5155 gene product from transcript CG5155-RA0.195
CG3875CG3875 gene product from transcript CG3875-RA0.185
RanGapRan GTPase activating protein0.184
His3.3BHistone H3.3B0.178
CycECyclin E0.169
djdon juan0.164
dlg1discs large 10.158
drkdownstream of receptor kinase0.157
CG5355CG5355 gene product from transcript CG5355-RA0.152
Ufd1-likeUbiquitin fusion-degradation 1-like0.151
CasCAS/CSE1 segregation protein0.149
Vha100-1CG1709 gene product from transcript CG1709-RF0.149
nbsCG6754 gene product from transcript CG6754-RC0.145
bchsblue cheese0.144
CG12321CG12321 gene product from transcript CG12321-RA0.141
cicubitus interruptus0.140
AckCG14992 gene product from transcript CG14992-RA0.139
Rpn1CG7762 gene product from transcript CG7762-RA0.136
Pros45CG1489 gene product from transcript CG1489-RA0.133
MiroMitochondrial Rho0.133
mei-41meiotic 410.132
CSN1bCOP9 complex homolog subunit 1 b0.128
EgfrEpidermal growth factor receptor0.127
Mcm10Sensitized chromosome inheritance modifier 190.127
swmsecond mitotic wave missing0.127
TER94CG2331 gene product from transcript CG2331-RA0.126
Rpn9CG10230 gene product from transcript CG10230-RB0.123
fs(2)ltoPP43female sterile (2) ltoPP430.122
Ulp1CG12359 gene product from transcript CG12359-RA0.117
CblCG7037 gene product from transcript CG7037-RB0.117
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MDM2Mdm2 p53 binding protein homolog (mouse)1.000
CASP8caspase 8, apoptosis-related cysteine peptidase0.999
BCL2B-cell CLL/lymphoma 20.999
SMAD4SMAD family member 40.999
BCL2L1BCL2-like 10.999
SMURF2SMAD specific E3 ubiquitin protein ligase 20.997
XIAPX-linked inhibitor of apoptosis0.993
RB1retinoblastoma 10.991
FASLGFas ligand (TNF superfamily, member 6)0.991
FYNFYN oncogene related to SRC, FGR, YES0.981
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.974
CASP3caspase 3, apoptosis-related cysteine peptidase0.960
BAXBCL2-associated X protein0.956
TP53tumor protein p530.951
SMAD1SMAD family member 10.945
SOCS1suppressor of cytokine signaling 10.944
TRAF2TNF receptor-associated factor 20.910
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.903
FASFas (TNF receptor superfamily, member 6)0.902
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.898
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.894
SMAD3SMAD family member 30.874
SKILSKI-like oncogene0.872
SP1Sp1 transcription factor0.871
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.869
MDM4Mdm4 p53 binding protein homolog (mouse)0.863
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.861
BIDBH3 interacting domain death agonist0.857
BCL2L11BCL2-like 11 (apoptosis facilitator)0.853
PYCARDPYD and CARD domain containing0.849
UBQLN1ubiquilin 10.836
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.834
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.831
HDAC1histone deacetylase 10.821
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.815
CDC20cell division cycle 20 homolog (S. cerevisiae)0.805
CASP10caspase 10, apoptosis-related cysteine peptidase0.803
RIPK2receptor-interacting serine-threonine kinase 20.777
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.773
CREBBPCREB binding protein0.754
CASP2caspase 2, apoptosis-related cysteine peptidase0.748
RAD23BRAD23 homolog B (S. cerevisiae)0.746
GSK3Bglycogen synthase kinase 3 beta0.745
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.741
POU5F1POU class 5 homeobox 10.734
PIAS4protein inhibitor of activated STAT, 40.728
SMAD5SMAD family member 50.710
S100BS100 calcium binding protein B0.697
UBCubiquitin C0.679
PMLpromyelocytic leukemia0.676
ZMYND11zinc finger, MYND-type containing 110.674
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.665
DVL3dishevelled, dsh homolog 3 (Drosophila)0.654
HMGB1high mobility group box 10.652
CASP9caspase 9, apoptosis-related cysteine peptidase0.646
ESR1estrogen receptor 10.643
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.618
PLK1polo-like kinase 10.614
CSNK1Ecasein kinase 1, epsilon0.607
S100A6S100 calcium binding protein A60.606
BADBCL2-associated agonist of cell death0.606
RNF11ring finger protein 110.604
S100A9S100 calcium binding protein A90.595
MAP3K5mitogen-activated protein kinase kinase kinase 50.593
SMAD2SMAD family member 20.593
PSEN1presenilin 10.576
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.575
IL1R1interleukin 1 receptor, type I0.554
ADAM15ADAM metallopeptidase domain 150.548
FGF1fibroblast growth factor 1 (acidic)0.540
AXIN1axin 10.529
APAF1apoptotic peptidase activating factor 10.526
CTGFconnective tissue growth factor0.513
DAXXdeath-domain associated protein0.511
SNX9sorting nexin 90.511
ANXA2annexin A20.511
VHLvon Hippel-Lindau tumor suppressor0.509
CAV1caveolin 1, caveolae protein, 22kDa0.507
HCKhemopoietic cell kinase0.492
SNX33sorting nexin 330.484
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.483
TRAF5TNF receptor-associated factor 50.469
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.467
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.463
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.448
NLRC4NLR family, CARD domain containing 40.441
NR4A1nuclear receptor subfamily 4, group A, member 10.441
GRB2growth factor receptor-bound protein 20.440
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.439
PTENphosphatase and tensin homolog0.439
TRADDTNFRSF1A-associated via death domain0.432
S100A8S100 calcium binding protein A80.426
S100A4S100 calcium binding protein A40.406
BRCA1breast cancer 1, early onset0.400
FADDFas (TNFRSF6)-associated via death domain0.394
C4orf14chromosome 4 open reading frame 140.392
FMR1fragile X mental retardation 10.392
PRNPprion protein0.391
RPL11ribosomal protein L110.388
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.387
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rps11ribosomal protein S110.025
Rpl27aribosomal protein L27a0.018
Rpl11ribosomal protein L110.015
Rps3ribosomal protein S30.014
Ndufa13NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 130.012
Tceb2transcription elongation factor B (SIII), polypeptide 20.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism