The network for 'nucleobase biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.

NameDescriptionProbabilityFunc Analog Organism
Ren1renin 1 structural0.088
Hif1ahypoxia inducible factor 1, alpha subunit0.064
Gja1gap junction protein, alpha 10.041
Rcc1regulator of chromosome condensation 10.037
Itgb1integrin beta 1 (fibronectin receptor beta)0.035
Rb1retinoblastoma 10.035
Srmspermidine synthase0.032
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.030
Atad3aATPase family, AAA domain containing 3A0.028
Rrp9RRP9, small subunit (SSU) processome component, homolog (yeast)0.024
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.024
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.024
Rrp1bribosomal RNA processing 1 homolog B (S. cerevisiae)0.023
Shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.020
Mettl1methyltransferase like 10.020
Agtr1aangiotensin II receptor, type 1a0.019
Varsvalyl-tRNA synthetase0.018
Cdt1chromatin licensing and DNA replication factor 10.018
Ints5integrator complex subunit 50.018
E2f1E2F transcription factor 10.017
Lrwd1leucine-rich repeats and WD repeat domain containing 10.017
Spp1secreted phosphoprotein 10.017
Smyd5SET and MYND domain containing 50.016
Vegfavascular endothelial growth factor A0.015
Grwd1glutamate-rich WD repeat containing 10.015
Unguracil DNA glycosylase0.014
Mybbp1aMYB binding protein (P160) 1a0.014
Tcof1Treacher Collins Franceschetti syndrome 1, homolog0.014
Timelesstimeless homolog (Drosophila)0.013
Slc7a5solute carrier family 7 (cationic amino acid transporter, y+ system), member 50.013
Mybl2myeloblastosis oncogene-like 20.012
Psmd14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.012
Fpgsfolylpolyglutamyl synthetase0.012
Pdcd6programmed cell death 60.012
BC048355cDNA sequence BC0483550.011
Phgdh3-phosphoglycerate dehydrogenase0.011
Ccnfcyclin F0.011
Snrpasmall nuclear ribonucleoprotein polypeptide A0.011
Pgls6-phosphogluconolactonase0.011
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.015
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG7322CG7322 gene product from transcript CG7322-RA0.013
CG11089CG11089 gene product from transcript CG11089-RD0.013
OatOrnithine aminotransferase precursor0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PRTFDC1phosphoribosyl transferase domain containing 10.231
GCN1L1GCN1 general control of amino-acid synthesis 1-like 1 (yeast)0.228
WDYHV1WDYHV motif containing 10.218
PSMG1proteasome (prosome, macropain) assembly chaperone 10.182
LONP1lon peptidase 1, mitochondrial0.168
YARStyrosyl-tRNA synthetase0.122
GMPSguanine monphosphate synthetase0.121
MARSmethionyl-tRNA synthetase0.097
PRPS2phosphoribosyl pyrophosphate synthetase 20.091
IARSisoleucyl-tRNA synthetase0.085
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.079
ODC1ornithine decarboxylase 10.059
AARSalanyl-tRNA synthetase0.052
EIF4EBP1eukaryotic translation initiation factor 4E binding protein 10.045
MCM6minichromosome maintenance complex component 60.044
VARSvalyl-tRNA synthetase0.044
GARSglycyl-tRNA synthetase0.042
PAICSphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase0.041
PRPS1phosphoribosyl pyrophosphate synthetase 10.039
RFC2replication factor C (activator 1) 2, 40kDa0.039
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.038
PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial)0.038
PCNAproliferating cell nuclear antigen0.035
UCK2uridine-cytidine kinase 20.033
PUS1pseudouridylate synthase 10.029
PHGDHphosphoglycerate dehydrogenase0.029
TMEM97transmembrane protein 970.029
SARSseryl-tRNA synthetase0.028
PFASphosphoribosylformylglycinamidine synthase0.026
FTSJ1FtsJ homolog 1 (E. coli)0.026
USP50ubiquitin specific peptidase 500.025
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.024
NUP93nucleoporin 93kDa0.022
SLC1A5solute carrier family 1 (neutral amino acid transporter), member 50.022
RPIAribose 5-phosphate isomerase A0.022
SLBPstem-loop binding protein0.021
BLMHbleomycin hydrolase0.018
CYCScytochrome c, somatic0.018
KIAA0020KIAA00200.018
TRIB3tribbles homolog 3 (Drosophila)0.017
GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase0.017
CASP4caspase 4, apoptosis-related cysteine peptidase0.016
RRP1Bribosomal RNA processing 1 homolog B (S. cerevisiae)0.015
BYSLbystin-like0.015
PTDSS1phosphatidylserine synthase 10.014
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.014
IPO4importin 40.013
SSRP1structure specific recognition protein 10.013
CTBP2C-terminal binding protein 20.012
PTGES3prostaglandin E synthase 3 (cytosolic)0.012
NME1non-metastatic cells 1, protein (NM23A) expressed in0.012
CARScysteinyl-tRNA synthetase0.012
MTHFD2methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase0.012
PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.012
SMSspermine synthase0.011
LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptor0.011
JUPjunction plakoglobin0.011
PPIHpeptidylprolyl isomerase H (cyclophilin H)0.011
EIF1Beukaryotic translation initiation factor 1B0.011
CCT5chaperonin containing TCP1, subunit 5 (epsilon)0.011
ASNSasparagine synthetase (glutamine-hydrolyzing)0.011
ACTL6Aactin-like 6A0.011
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.010
UBR7ubiquitin protein ligase E3 component n-recognin 7 (putative)0.010
PSAT1phosphoserine aminotransferase 10.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cfl2cofilin 2, muscle0.082
Rcn2reticulocalbin 2, EF-hand calcium binding domain0.081
Ola1Obg-like ATPase 10.075
Fam92a1family with sequence similarity 92, member A10.073
Pgrmc1progesterone receptor membrane component 10.053
RragaRas-related GTP binding A0.051
Prim1DNA primase, p49 subunit0.046
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.039
Ndnnecdin homolog (mouse)0.034
Slc7a1solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.031
Bpnt13'(2'), 5'-bisphosphate nucleotidase 10.030
Chmp5chromatin modifying protein 50.026
Sumo1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.025
Eif2s3xeukaryotic translation initiation factor 2, subunit 3, structural gene X-linked0.022
Dhfrdihydrofolate reductase0.021
Txnl1thioredoxin-like 10.020
Strapserine/threonine kinase receptor associated protein0.019
Trappc6btrafficking protein particle complex 6B0.019
RnmtRNA (guanine-7-) methyltransferase0.018
Brp16brain protein 160.018
Wdr77WD repeat domain 770.018
Cpsf2cleavage and polyadenylation specific factor 20.017
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.017
Ypel5yippee-like 5 (Drosophila)0.017
Becn1beclin 1, autophagy related0.016
Garsglycyl-tRNA synthetase0.016
RabggtbRab geranylgeranyltransferase, beta subunit0.015
Scocshort coiled-coil protein0.015
ZwintZW10 interactor0.015
Dlddihydrolipoamide dehydrogenase0.015
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.015
Pgam2phosphoglycerate mutase 2 (muscle)0.015
Ttntitin0.015
Eif4eeukaryotic translation initiation factor 4E0.014
Prpf3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.014
Bcat1branched chain aminotransferase 1, cytosolic0.014
Tnni2troponin I type 2 (skeletal, fast)0.013
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.013
Ndfip1Nedd4 family interacting protein 10.013
Pdcd10programmed cell death 100.013
Tsr2TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)0.013
Prkar2bprotein kinase, cAMP dependent regulatory, type II beta0.013
Usp14ubiquitin specific peptidase 140.013
Tomm20translocase of outer mitochondrial membrane 20 homolog (yeast)0.012
Mybpc2myosin binding protein C, fast-type0.011
Pfn2profilin 20.011
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.011
Aldh18a1aldehyde dehydrogenase 18 family, member A10.011
Nop56NOP56 ribonucleoprotein homolog (yeast)0.011
Lmbrd1LMBR1 domain containing 10.011
Pole4polymerase (DNA-directed), epsilon 4 (p12 subunit)0.010
Polr1apolymerase (RNA) I polypeptide A0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ADE13Ade13p0.038
APT2Apt2p0.031
ADE1Ade1p0.028
URA1Ura1p0.026
URA4Ura4p0.026
CLN1Cln1p0.025
UBA1Uba1p0.024
APT1Apt1p0.022
GUA1Gua1p0.021
URA2Ura2p0.021
DLD3Dld3p0.020
FUR1Fur1p0.020
ADE6Ade6p0.019
FSH1Fsh1p0.019
ZRC1Zrc1p0.018
UBX6Ubx6p0.018
MDS3Mds3p0.018
AAP1Aap1p0.017
NRM1Nrm1p0.017
CYS3Cys3p0.017
ADE2Ade2p0.016
TAE1Tae1p0.016
YJL070Chypothetical protein0.016
ADE17Ade17p0.015
ADE12Ade12p0.015
YNL010Whypothetical protein0.015
ECM30Ecm30p0.015
DCS2Dcs2p0.015
MNE1Mne1p0.014
HLR1Hlr1p0.014
PLB2Plb2p0.014
YDL121Chypothetical protein0.014
PCL1Pcl1p0.014
HTS1Hts1p0.014
URA6Ura6p0.014
YJL144Whypothetical protein0.013
PRT1Prt1p0.013
YLR264C-Ahypothetical protein0.013
SRD1Srd1p0.013
GLN1Gln1p0.013
LEU2Leu2p0.013
GUK1Guk1p0.013
URA3Ura3p0.013
ADE4Ade4p0.013
NUT2Nut2p0.013
MF(ALPHA)2Mf(alpha)2p0.013
PHM6Phm6p0.013
IMD2Imd2p0.013
BIO2Bio2p0.013
SPE3Spe3p0.013
SPL2Spl2p0.012
YAH1Yah1p0.012
DPH5Dph5p0.012
HXT3Hxt3p0.012
YLR162Whypothetical protein0.012
MER1Mer1p0.012
YOL038C-Ahypothetical protein0.012
NMT1Nmt1p0.012
ARP10Arp10p0.012
YIR035Chypothetical protein0.012
HAL5Hal5p0.012
UBP11Ubp11p0.011
LYS12Lys12p0.011
MF(ALPHA)1Mf(alpha)1p0.011
MET8Met8p0.011
GCV1Gcv1p0.011
CCS1Ccs1p0.011
MET17Met17p0.011
YEL073Chypothetical protein0.011
TOS2Tos2p0.011
CLB1Clb1p0.011
SWC7Swc7p0.011
MSA2Msa2p0.011
SNF3Snf3p0.011
MDE1Mde1p0.011
PMU1Pmu1p0.011
WSC4Wsc4p0.011
KIN3Kin3p0.011
YBR013Chypothetical protein0.011
YLR042Chypothetical protein0.011
ATP6Atp6p0.011
CUP1-1Cup1-1p0.011
YPR157Whypothetical protein0.011
FMT1Fmt1p0.011
CTP1Ctp1p0.011
SVS1Svs1p0.011
YAR068Whypothetical protein0.011
YOL014Whypothetical protein0.011
PHO3Pho3p0.010
YPR091Chypothetical protein0.010
AUA1Aua1p0.010
FAA2Faa2p0.010
RKI1Rki1p0.010
YLR063Whypothetical protein0.010
YOL013W-Ahypothetical protein0.010
SNU13Snu13p0.010
TMA108Tma108p0.010
MDN1Mdn1p0.010
ARE2Are2p0.010
UPS3Ups3p0.010