The network for 'cleavage furrow formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cleavage furrow formation

Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.

NameDescriptionProbabilityFunc Analog Organism
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.916
Plk1polo-like kinase 1 (Drosophila)0.912
Ccnb2cyclin B20.892
Ccna2cyclin A20.887
Rac1RAS-related C3 botulinum substrate 10.832
Kif22kinesin family member 220.751
Kif2ckinesin family member 2C0.723
Cdk1cyclin-dependent kinase 10.717
Racgap1Rac GTPase-activating protein 10.679
Kif4kinesin family member 40.644
Ncaphnon-SMC condensin I complex, subunit H0.628
Cdc25ccell division cycle 25 homolog C (S. pombe)0.611
Prc1protein regulator of cytokinesis 10.583
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.422
Aurkbaurora kinase B0.403
Kif20akinesin family member 20A0.401
Dlgap5discs, large (Drosophila) homolog-associated protein 50.383
Fam64afamily with sequence similarity 64, member A0.369
Ccnb1cyclin B10.356
Cep55centrosomal protein 550.327
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.315
Cdca8cell division cycle associated 80.315
Aurkaaurora kinase A0.310
Gtse1G two S phase expressed protein 10.308
Birc5baculoviral IAP repeat-containing 50.299
Ckap2cytoskeleton associated protein 20.295
Kif11kinesin family member 110.293
Ube2cubiquitin-conjugating enzyme E2C0.257
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.244
Hmmrhyaluronan mediated motility receptor (RHAMM)0.239
Cdca5cell division cycle associated 50.192
Kif23kinesin family member 230.175
Tacc3transforming, acidic coiled-coil containing protein 30.155
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.151
Ccnfcyclin F0.151
Cenpacentromere protein A0.143
Wdr1WD repeat domain 10.131
Top2atopoisomerase (DNA) II alpha0.128
Mki67antigen identified by monoclonal antibody Ki 670.121
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.116
Iqgap3IQ motif containing GTPase activating protein 30.111
Spag5sperm associated antigen 50.110
Incenpinner centromere protein0.106
Lmnb1lamin B10.100
Cdkn3cyclin-dependent kinase inhibitor 30.097
Gsg2germ cell-specific gene 20.080
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.073
Diap3diaphanous homolog 3 (Drosophila)0.070
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.068
Fam83dfamily with sequence similarity 83, member D0.067
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.062
Cdkn1bcyclin-dependent kinase inhibitor 1B0.062
Tk1thymidine kinase 10.057
Rrm2ribonucleotide reductase M20.056
Mxd3Max dimerization protein 30.056
Ccdc99coiled-coil domain containing 990.055
Melkmaternal embryonic leucine zipper kinase0.054
2810417H13RikRIKEN cDNA 2810417H13 gene0.054
Tcf19transcription factor 190.048
Fam54afamily with sequence similarity 54, member A0.045
TtkTtk protein kinase0.045
E2f1E2F transcription factor 10.045
Arhgap1Rho GTPase activating protein 10.043
Neil3nei like 3 (E. coli)0.042
Cenpfcentromere protein F0.042
Pdcd6ipprogrammed cell death 6 interacting protein0.041
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.036
Ckap2lcytoskeleton associated protein 2-like0.035
Mis18bp1MIS18 binding protein 10.033
H2afxH2A histone family, member X0.032
Cenphcentromere protein H0.032
Anlnanillin, actin binding protein0.031
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.031
Eme1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.031
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.028
Brca1breast cancer 10.028
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.028
Cenpmcentromere protein M0.027
Cdc25bcell division cycle 25 homolog B (S. pombe)0.026
Anxa4annexin A40.026
Cdca7lcell division cycle associated 7 like0.026
4930427A07RikRIKEN cDNA 4930427A07 gene0.024
StilScl/Tal1 interrupting locus0.024
Sgpl1sphingosine phosphate lyase 10.024
E130306D19RikRIKEN cDNA E130306D19 gene0.023
Foxm1forkhead box M10.023
Ggta1glycoprotein galactosyltransferase alpha 1, 30.022
Tmod3tropomodulin 30.022
Espl1extra spindle poles-like 1 (S. cerevisiae)0.022
Cdc45cell division cycle 45 homolog (S. cerevisiae)0.022
Aplp2amyloid beta (A4) precursor-like protein 20.022
Man2a1mannosidase 2, alpha 10.021
LppLIM domain containing preferred translocation partner in lipoma0.021
Gnb1guanine nucleotide binding protein (G protein), beta 10.020
Tpx2TPX2, microtubule-associated protein homolog (Xenopus laevis)0.020
2900011O08RikRIKEN cDNA 2900011O08 gene0.020
Pdlim5PDZ and LIM domain 50.019
Capzbcapping protein (actin filament) muscle Z-line, beta0.019
F630043A04RikRIKEN cDNA F630043A04 gene0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
aurkbaurora kinase B0.715
ccnb1cyclin B10.600
plk1polo-like kinase 1 (Drosophila)0.498
sass6spindle assembly 6 homolog (C. elegans)0.250
ccnb2cyclin B20.172
ncapd2non-SMC condensin I complex, subunit D20.151
ccna2cyclin A20.133
cdc20cell division cycle 20 homolog0.117
kpna2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.103
tmpoathymopoietin a0.103
ttkttk protein kinase0.078
lrmplymphoid-restricted membrane protein0.070
aurkaaurora kinase A0.067
cdca8cell division cycle associated 80.066
top2atopoisomerase (DNA) II alpha0.054
ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.053
kif23kinesin family member 230.051
birc5abaculoviral IAP repeat-containing 5a0.051
nusap1nucleolar and spindle associated protein 10.051
kif11kinesin family member 110.047
ccnecyclin E0.039
tacc3transforming, acidic coiled-coil containing protein 30.035
snrpcsmall nuclear ribonucleoprotein polypeptide C0.035
gro2groucho 20.033
tymsthymidylate synthase0.032
ncaphnon-SMC condensin I complex, subunit H0.031
bub3BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)0.027
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.027
mgaMAX gene associated0.026
bonbonnie and clyde0.025
unguracil-DNA glycosylase0.024
ctsacathepsin A0.021
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.020
cstf1cleavage stimulation factor, 3' pre-RNA, subunit 10.019
pif1PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)0.018
h1mlinker histone H1M0.018
plk4polo-like kinase 4 (Drosophila)0.017
smad5MAD homolog 5 (Drosophila)0.017
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.017
rad54lRAD54-like (S. cerevisiae)0.016
smc4structural maintenance of chromosomes 40.015
rtkn2rhotekin 20.015
fancd2Fanconi anemia, complementation group D20.014
gng12aguanine nucleotide binding protein (G protein), gamma 12a0.014
LOC100536090targeting protein for Xklp2-B-like0.014
znf711zinc finger protein 7110.014
smc2structural maintenance of chromosomes 20.014
thoc5THO complex 50.013
kifc1kinesin family member C10.013
ctszcathepsin Z0.012
appl2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 20.012
mus81MUS81 endonuclease homolog (yeast)0.012
LOC554173abnormal spindles0.012
march5lmembrane-associated ring finger (C3HC4) 5, like0.011
slc35c2solute carrier family 35, member C20.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
alpha-Catalpha Catenin0.106
Rho1CG8416 gene product from transcript CG8416-RB0.037
Fcp1CG12252 gene product from transcript CG12252-RA0.022
DekCG5935 gene product from transcript CG5935-RA0.017
CG5720CG5720 gene product from transcript CG5720-RA0.014
FK506-bp2FK506-binding protein 20.012
AtpalphaNa pump alpha subunit0.012
Rpb10CG13628 gene product from transcript CG13628-RA0.012
CG14646CG14646 gene product from transcript CG14646-RA0.012
CG6523CG6523 gene product from transcript CG6523-RA0.011
Acf1ATP-dependent chromatin assembly factor large subunit0.011
Nup358Nucleoporin 3580.010
gammaTub23Cgamma-Tubulin at 23C0.010
vapvacuolar peduncle0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SNX9sorting nexin 90.695
ARHGAP1Rho GTPase activating protein 10.550
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.206
ADAM15ADAM metallopeptidase domain 150.149
SNX33sorting nexin 330.052
INCENPinner centromere protein antigens 135/155kDa0.044
FASLGFas ligand (TNF superfamily, member 6)0.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism