The network for 'otic vesicle development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

otic vesicle development

The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.995
Gli3GLI-Kruppel family member GLI30.990
Pax2paired box gene 20.987
Fgf8fibroblast growth factor 80.969
Pax3paired box gene 30.967
Tbx3T-box 30.962
Bmp4bone morphogenetic protein 40.956
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.928
Fgfr2fibroblast growth factor receptor 20.921
Prrx1paired related homeobox 10.914
Eya1eyes absent 1 homolog (Drosophila)0.901
Pitx2paired-like homeodomain transcription factor 20.881
Hand1heart and neural crest derivatives expressed transcript 10.879
Gbx2gastrulation brain homeobox 20.822
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.807
Fgf10fibroblast growth factor 100.800
Tcfap2atranscription factor AP-2, alpha0.781
Otx2orthodenticle homolog 2 (Drosophila)0.750
Sox9SRY-box containing gene 90.733
Hand2heart and neural crest derivatives expressed transcript 20.732
Hoxd13homeobox D130.707
Pitx1paired-like homeodomain transcription factor 10.633
Hoxa1homeobox A10.593
Foxc1forkhead box C10.566
Foxg1forkhead box G10.506
Dlx5distal-less homeobox 50.502
Hoxa13homeobox A130.487
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.470
Prrx2paired related homeobox 20.434
Fgfr1fibroblast growth factor receptor 10.425
Gli2GLI-Kruppel family member GLI20.422
Lmx1aLIM homeobox transcription factor 1 alpha0.417
Sox2SRY-box containing gene 20.414
Isl1ISL1 transcription factor, LIM/homeodomain0.389
Rargretinoic acid receptor, gamma0.309
Lef1lymphoid enhancer binding factor 10.247
Twist2twist homolog 2 (Drosophila)0.245
Meox2mesenchyme homeobox 20.245
Ednraendothelin receptor type A0.239
Hoxa11homeobox A110.230
Col5a2collagen, type V, alpha 20.223
Col3a1collagen, type III, alpha 10.221
Foxc2forkhead box C20.219
Col1a1collagen, type I, alpha 10.219
Gscgoosecoid homeobox0.217
Col2a1collagen, type II, alpha 10.205
Ror2receptor tyrosine kinase-like orphan receptor 20.203
Sox11SRY-box containing gene 110.191
Hoxa2homeobox A20.182
Chd7chromodomain helicase DNA binding protein 70.182
Jag1jagged 10.173
Msx1homeobox, msh-like 10.172
Dkk1dickkopf homolog 1 (Xenopus laevis)0.171
Hes1hairy and enhancer of split 1 (Drosophila)0.165
Alx4aristaless-like homeobox 40.163
En1engrailed 10.163
Sall4sal-like 4 (Drosophila)0.153
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.150
Msx2homeobox, msh-like 20.147
Fgf3fibroblast growth factor 30.146
Tbx1T-box 10.146
Pax6paired box gene 60.141
Alx3aristaless-like homeobox 30.134
Lhx1LIM homeobox protein 10.129
Zeb1zinc finger E-box binding homeobox 10.124
Foxh1forkhead box H10.118
Col6a2collagen, type VI, alpha 20.117
Snai1snail homolog 1 (Drosophila)0.115
Hmx3H6 homeobox 30.109
Hoxd11homeobox D110.107
Pou3f3POU domain, class 3, transcription factor 30.106
Pou5f1POU domain, class 5, transcription factor 10.106
Rarbretinoic acid receptor, beta0.105
Ascl1achaete-scute complex homolog 1 (Drosophila)0.105
Bmp7bone morphogenetic protein 70.104
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.102
Tgfb2transforming growth factor, beta 20.101
Trp63transformation related protein 630.098
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.096
Gata6GATA binding protein 60.089
Smad6MAD homolog 6 (Drosophila)0.088
Vegfavascular endothelial growth factor A0.085
Smosmoothened homolog (Drosophila)0.085
Tbx15T-box 150.083
Wnt3awingless-related MMTV integration site 3A0.082
Col1a2collagen, type I, alpha 20.077
Tcf15transcription factor 150.076
Hspg2perlecan (heparan sulfate proteoglycan 2)0.076
Fstl1follistatin-like 10.074
Tal1T-cell acute lymphocytic leukemia 10.073
Col5a1collagen, type V, alpha 10.072
Igf2bp1insulin-like growth factor 2 mRNA binding protein 10.069
Foxf1aforkhead box F1a0.069
NanogNanog homeobox0.068
Tbx2T-box 20.067
Wnt1wingless-related MMTV integration site 10.064
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf3fibroblast growth factor 30.997
eya1eyes absent homolog 10.978
fgf8afibroblast growth factor 8 a0.965
hnf1baHNF1 homeobox Ba0.952
tfap2atranscription factor AP-2 alpha0.950
flhfloating head0.919
foxi1forkhead box I10.919
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.917
prdm1aPR domain containing 1a, with ZNF domain0.914
lmx1b.1LIM homeobox transcription factor 1, beta 10.896
dlx5adistal-less homeobox gene 5a0.891
tbx1T-box 10.887
dlx2adistal-less homeobox gene 2a0.852
msxcmuscle segment homeobox C0.811
bmp2bbone morphogenetic protein 2b0.809
bmp4bone morphogenetic protein 40.806
gata2aGATA-binding protein 2a0.786
dlx4bdistal-less homeobox gene 4b0.761
sox9aSRY-box containing gene 9a0.722
foxi3aforkhead box I3a0.705
pax8paired box gene 80.672
six4bsine oculis homeobox homolog 4b0.653
fgf17fibroblast growth factor 170.629
tp63tumor protein p630.574
hand2heart and neural crest derivatives expressed transcript 20.569
shhbsonic hedgehog b0.563
sema3dsemaphorin 3d0.510
osr1odd-skipped related 1 (Drosophila)0.510
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.498
hhiphedgehog interacting protein0.496
wnt1wingless-type MMTV integration site family, member 10.478
cdx4caudal type homeo box transcription factor 40.469
gbx2gastrulation brain homeo box 20.402
snai1bsnail homolog 1b (Drosophila)0.377
igfbp3insulin-like growth factor binding protein 30.368
hoxb3ahomeo box B3a0.363
fgf4fibroblast growth factor 40.362
gcm2glial cells missing homolog 2 (Drosophila)0.351
dlx2bdistal-less homeobox gene 2b0.336
notch1anotch homolog 1a0.315
wnt3wingless-type MMTV integration site family, member 30.314
msxemuscle segment homeobox E0.313
gata3GATA-binding protein 30.302
hoxa2bhomeo box A2b0.299
fgf8bfibroblast growth factor 8 b0.290
foxa2forkhead box A20.286
ncs1aneuronal calcium sensor 1a0.282
sox2SRY-box containing gene 20.280
pomcaproopiomelanocortin a0.272
jag1bjagged 1b0.270
edn1endothelin 10.264
aldh1a2aldehyde dehydrogenase 1 family, member A20.242
pax6apaired box gene 6a0.239
raraaretinoic acid receptor, alpha a0.238
hapln3hyaluronan and proteoglycan link protein 30.235
gbx1gastrulation brain homeobox 10.235
neurod4neurogenic differentiation 40.230
jag2jagged 20.227
nkx3.2NK3 homeobox 20.225
egr2bearly growth response 2b0.224
hmx4H6 family homeobox 40.215
vcanaversican a0.208
foxc1aforkhead box C1a0.207
hoxa3ahomeo box A3a0.201
mibmind bomb0.200
pitx2paired-like homeodomain transcription factor 20.197
six2asine oculis-related homeobox 2a0.196
hoxb2ahomeo box B2a0.191
wnt4awingless-type MMTV integration site family, member 4a0.190
gata5GATA-binding protein 50.185
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.172
mecomMDS1 and EVI1 complex locus0.166
dlx4adistal-less homeobox gene 4a0.165
hmx3homeo box (H6 family) 30.163
map2k4amitogen-activated protein kinase kinase 4a0.158
ret1receptor tyrosine kinase0.157
cdh2cadherin 2, neuronal0.157
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.156
dmrt2adoublesex and mab-3 related transcription factor 2a0.155
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.150
sox3SRY-box containing gene 30.146
tal1T-cell acute lymphocytic leukemia 10.146
sox9bSRY-box containing gene 9b0.146
atp1a3bATPase, Na+/K+ transporting, alpha 3b polypeptide0.144
msxdmuscle segment homeobox D0.142
crabp2acellular retinoic acid binding protein 2, a0.139
maflv-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L0.138
fgf10afibroblast growth factor 10a0.133
hey2hairy/enhancer-of-split related with YRPW motif 20.131
sox4bSRY-box containing gene 4b0.131
wnt11wingless-type MMTV integration site family, member 110.131
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGF1fibroblast growth factor 1 (acidic)0.817
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.620
SMAD1SMAD family member 10.567
VEGFAvascular endothelial growth factor A0.402
SMAD3SMAD family member 30.348
FGF10fibroblast growth factor 100.317
HNF4Ahepatocyte nuclear factor 4, alpha0.283
SMURF2SMAD specific E3 ubiquitin protein ligase 20.261
COL1A1collagen, type I, alpha 10.144
BMP1bone morphogenetic protein 10.120
NKX2-1NK2 homeobox 10.115
SMAD4SMAD family member 40.103
FGF7fibroblast growth factor 70.095
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.092
COL5A1collagen, type V, alpha 10.071
SMAD7SMAD family member 70.069
ADAM12ADAM metallopeptidase domain 120.067
NR0B2nuclear receptor subfamily 0, group B, member 20.065
PPIL4peptidylprolyl isomerase (cyclophilin)-like 40.058
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.053
SH3BP4SH3-domain binding protein 40.052
ZNF148zinc finger protein 1480.051
WWP1WW domain containing E3 ubiquitin protein ligase 10.050
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.049
MSX2msh homeobox 20.044
PDPK13-phosphoinositide dependent protein kinase-10.044
BBS1Bardet-Biedl syndrome 10.038
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa0.036
SUPT5Hsuppressor of Ty 5 homolog (S. cerevisiae)0.036
KCTD1potassium channel tetramerisation domain containing 10.033
FSTL1follistatin-like 10.033
COL1A2collagen, type I, alpha 20.033
PAX2paired box 20.029
DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae)0.028
TRIM63tripartite motif containing 630.028
FGFR1fibroblast growth factor receptor 10.026
HIPK2homeodomain interacting protein kinase 20.026
GRB7growth factor receptor-bound protein 70.024
HRGhistidine-rich glycoprotein0.023
MTMR10myotubularin related protein 100.023
CTGFconnective tissue growth factor0.023
SIM2single-minded homolog 2 (Drosophila)0.022
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.022
RAD54L2RAD54-like 2 (S. cerevisiae)0.022
SPIN1spindlin 10.022
DNAJB14DnaJ (Hsp40) homolog, subfamily B, member 140.022
TNPO1transportin 10.021
CXXC5CXXC finger protein 50.021
ANKRD13Aankyrin repeat domain 13A0.021
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.021
MESTmesoderm specific transcript homolog (mouse)0.021
SKIv-ski sarcoma viral oncogene homolog (avian)0.021
RNF11ring finger protein 110.021
HNF1AHNF1 homeobox A0.020
DLX2distal-less homeobox 20.019
TRAF4TNF receptor-associated factor 40.019
SMURF1SMAD specific E3 ubiquitin protein ligase 10.019
RBM17RNA binding motif protein 170.019
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.019
SKILSKI-like oncogene0.018
ZMYM2zinc finger, MYM-type 20.018
COL2A1collagen, type II, alpha 10.018
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.018
NEDD4neural precursor cell expressed, developmentally down-regulated 40.018
SOX7SRY (sex determining region Y)-box 70.018
THAP2THAP domain containing, apoptosis associated protein 20.017
EYA2eyes absent homolog 2 (Drosophila)0.017
LAMC1laminin, gamma 1 (formerly LAMB2)0.017
PGFplacental growth factor0.017
COL3A1collagen, type III, alpha 10.016
SP1Sp1 transcription factor0.016
SMAD9SMAD family member 90.015
HOXA11homeobox A110.015
RBM4RNA binding motif protein 40.015
LHX2LIM homeobox 20.015
ACTN2actinin, alpha 20.014
HNF1BHNF1 homeobox B0.014
PAX3paired box 30.014
GATA2GATA binding protein 20.014
WNT7Awingless-type MMTV integration site family, member 7A0.014
SPG20spastic paraplegia 20 (Troyer syndrome)0.014
ATF7IPactivating transcription factor 7 interacting protein0.014
SIX3SIX homeobox 30.013
PRRC1proline-rich coiled-coil 10.013
DACH1dachshund homolog 1 (Drosophila)0.013
INHBAinhibin, beta A0.013
OVOL1ovo-like 1(Drosophila)0.013
SF3B1splicing factor 3b, subunit 1, 155kDa0.013
SMAD6SMAD family member 60.013
HOXC8homeobox C80.013
DLX4distal-less homeobox 40.013
HMGA2high mobility group AT-hook 20.013
PAX7paired box 70.013
CDX2caudal type homeobox 20.013
VPS24vacuolar protein sorting 24 homolog (S. cerevisiae)0.012
HYAL1hyaluronoglucosaminidase 10.012
UHRF2ubiquitin-like with PHD and ring finger domains 20.012
NLKnemo-like kinase0.012
SMAD2SMAD family member 20.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism