The network for 't cell differentiation in thymus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t cell differentiation in thymus

The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.

NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 11.000
Latlinker for activation of T cells0.999
FasFas (TNF receptor superfamily member 6)0.999
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.994
FynFyn proto-oncogene0.993
Lcklymphocyte protein tyrosine kinase0.990
Trp53transformation related protein 530.990
Gli3GLI-Kruppel family member GLI30.987
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.982
TcraT-cell receptor alpha chain0.979
RybpRING1 and YY1 binding protein0.977
Gli2GLI-Kruppel family member GLI20.975
Foxp3forkhead box P30.973
Foxn1forkhead box N10.969
Cd247CD247 antigen0.968
Rag2recombination activating gene 20.968
Map3k14mitogen-activated protein kinase kinase kinase 140.968
Il2rginterleukin 2 receptor, gamma chain0.943
Zfp36zinc finger protein 360.939
Gata4GATA binding protein 40.930
Ptprcprotein tyrosine phosphatase, receptor type, C0.922
Runx1runt related transcription factor 10.913
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.907
Il2interleukin 20.905
Fgf10fibroblast growth factor 100.899
Ntf3neurotrophin 30.894
Bcl2B-cell leukemia/lymphoma 20.874
Cd44CD44 antigen0.872
Socs1suppressor of cytokine signaling 10.870
Fgfr2fibroblast growth factor receptor 20.864
Tgfb2transforming growth factor, beta 20.845
Grb2growth factor receptor bound protein 20.834
Ighimmunoglobulin heavy chain complex0.828
FosFBJ osteosarcoma oncogene0.806
Cd19CD19 antigen0.798
Pax2paired box gene 20.782
Tnftumor necrosis factor0.779
Ctnnb1catenin (cadherin associated protein), beta 10.774
Tnfaip3tumor necrosis factor, alpha-induced protein 30.773
Smad3MAD homolog 3 (Drosophila)0.766
Ltblymphotoxin B0.752
Retret proto-oncogene0.747
Efnb2ephrin B20.739
H2-Ab1histocompatibility 2, class II antigen A, beta 10.718
Irf5interferon regulatory factor 50.683
Fzd8frizzled homolog 8 (Drosophila)0.673
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.667
Ptgs2prostaglandin-endoperoxide synthase 20.666
Trp63transformation related protein 630.662
Ptpn11protein tyrosine phosphatase, non-receptor type 110.655
Rargretinoic acid receptor, gamma0.650
Smad4MAD homolog 4 (Drosophila)0.650
ItkIL2-inducible T-cell kinase0.642
Efna1ephrin A10.632
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.627
JunJun oncogene0.621
Ccr6chemokine (C-C motif) receptor 60.613
Mcl1myeloid cell leukemia sequence 10.611
Stat3signal transducer and activator of transcription 30.595
Gdnfglial cell line derived neurotrophic factor0.594
BaxBCL2-associated X protein0.583
Zap70zeta-chain (TCR) associated protein kinase0.582
Ltalymphotoxin A0.580
Fzd1frizzled homolog 1 (Drosophila)0.579
Notch1Notch gene homolog 1 (Drosophila)0.570
TcrdT-cell receptor delta chain0.570
Casp8caspase 80.557
Ptenphosphatase and tensin homolog0.543
Ifnginterferon gamma0.534
Il6stinterleukin 6 signal transducer0.531
Hrhairless0.524
Cd3eCD3 antigen, epsilon polypeptide0.518
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.505
Rararetinoic acid receptor, alpha0.503
H2-Eb1histocompatibility 2, class II antigen E beta0.501
JunbJun-B oncogene0.500
H2-K1histocompatibility 2, K1, K region0.490
Lhx1LIM homeobox protein 10.488
Il27rainterleukin 27 receptor, alpha0.486
Hes1hairy and enhancer of split 1 (Drosophila)0.479
Cd96CD96 antigen0.475
Cd4CD4 antigen0.463
Rnf2ring finger protein 20.462
Ccnd1cyclin D10.452
Atxn1ataxin 10.442
Foxf1aforkhead box F1a0.441
Vav1vav 1 oncogene0.434
Rxraretinoid X receptor alpha0.431
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.422
Cd3gCD3 antigen, gamma polypeptide0.421
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.414
Rag1recombination activating gene 10.410
TcrbT-cell receptor beta chain0.408
Stat1signal transducer and activator of transcription 10.405
Ccnd2cyclin D20.398
Ptpn14protein tyrosine phosphatase, non-receptor type 140.397
Id2inhibitor of DNA binding 20.390
Prkcdprotein kinase C, delta0.387
Mdm2transformed mouse 3T3 cell double minute 20.384
Hic1hypermethylated in cancer 10.373
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rag1recombination activating gene 10.945
il7rinterleukin 7 receptor0.477
lrrc33leucine rich repeat containing 330.366
lft1lefty10.334
dnttdeoxynucleotidyltransferase, terminal0.311
ikzf1IKAROS family zinc finger 1 (Ikaros)0.230
dlddeltaD0.176
cdh2cadherin 2, neuronal0.160
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.147
rpl7aribosomal protein L7a0.089
zgc:64115zgc:641150.087
hoxd4ahomeo box D4a0.083
chdchordin0.076
cdx4caudal type homeo box transcription factor 40.074
bocbrother of CDO0.071
dbx1adeveloping brain homeobox 1a0.066
rspo3R-spondin 3 homolog (Xenopus laevis)0.064
pdcd2programmed cell death 20.062
abcg2aATP-binding cassette, sub-family G (WHITE), member 2a0.059
LOC100151531zinc finger protein Gfi-1b-like0.058
tshz1teashirt family zinc finger 10.054
jak1Janus kinase 10.050
bmp2abone morphogenetic protein 2a0.050
cxcr3.2chemokine (C-X-C motif) receptor 3.20.050
rag2recombination activating gene 20.050
fgfr1bfibroblast growth factor receptor 1b0.047
foxd3forkhead box D30.046
ptger2aprostaglandin E receptor 2a (subtype EP2)0.045
cpne1copine I0.041
tsc22d3TSC22 domain family, member 30.040
coro1acoronin, actin binding protein, 1A0.039
si:dkey-27i16.2si:dkey-27i16.20.038
foxa2forkhead box A20.037
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.036
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.035
rpl23aribosomal protein L23a0.035
znf703zinc finger protein 7030.034
ef1aelongation factor 1-alpha0.034
lft2lefty20.032
rnf128aring finger protein 128a0.030
spry2sprouty homolog 20.030
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.030
cxcr4bchemokine (C-X-C motif), receptor 4b0.028
ccnd1cyclin D10.028
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.028
amotl2aangiomotin like 2a0.028
npm4nucleophosmin/nucleoplasmin, 40.028
her3hairy-related 30.027
ighzimmunoglobulin heavy constant zeta0.027
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.026
scdstearoyl-CoA desaturase (delta-9-desaturase)0.025
fzd7afrizzled homolog 7a0.025
cmybtranscription factor cmyb0.024
bcl2B-cell leukemia/lymphoma 20.024
notch3notch homolog 30.023
jag2jagged 20.023
fasFas (TNF receptor superfamily, member 6)0.022
hnf1bbHNF1 homeobox Bb0.022
otx1borthodenticle homolog 1b0.022
cdkn1acyclin-dependent kinase inhibitor 1A0.021
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.021
pkd2polycystic kidney disease 20.020
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.017
sox2SRY-box containing gene 20.017
tcf7transcription factor 7 (T-cell specific, HMG-box)0.017
maffv-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)0.016
her6hairy-related 60.016
ephb4beph receptor B4b0.016
lcp1lymphocyte cytosolic plastin 10.016
fgf3fibroblast growth factor 30.015
lycatlysocardiolipin acyltransferase0.015
fzd5frizzled homolog 50.015
npy8arneuropeptide Y receptor Y8a0.015
gbx2gastrulation brain homeo box 20.015
wnt8bwingless-type MMTV integration site family, member 8b0.015
crabp2bcellular retinoic acid binding protein 2, b0.014
runx3runt-related transcription factor 30.014
mybmyeloblastosis oncogene0.014
zgc:92868zgc:928680.014
st14asuppression of tumorigenicity 14 (colon carcinoma) a0.013
tbpTATA box binding protein0.013
ptk6aPTK6 protein tyrosine kinase 6a0.013
irf8interferon regulatory factor 80.013
fgfr4fibroblast growth factor receptor 40.012
ankrd6ankyrin repeat domain 60.012
LOC566708FL cytokine receptor-like0.012
cdc14bCDC14 cell division cycle 14 homolog B0.011
ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.011
ripk2receptor-interacting serine-threonine kinase 20.011
mc1rmelanocortin 1 receptor0.011
mc2rmelanocortin 2 receptor0.011
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.011
dlcdeltaC0.011
gata1aGATA binding protein 1a0.011
gfi1.1growth factor independent 1.10.011
abcg2cATP-binding cassette, sub-family G (WHITE), member 2c0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LATlinker for activation of T cells0.988
CASP8caspase 8, apoptosis-related cysteine peptidase0.971
NOTCH3notch 30.927
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.721
CD247CD247 molecule0.689
APLFaprataxin and PNKP like factor0.604
BMPR1Abone morphogenetic protein receptor, type IA0.599
EGFRepidermal growth factor receptor0.578
IL1R1interleukin 1 receptor, type I0.562
CCND1cyclin D10.455
IL2RBinterleukin 2 receptor, beta0.444
CXCR4chemokine (C-X-C motif) receptor 40.442
MPZL3myelin protein zero-like 30.432
RUNX1runt-related transcription factor 10.424
NOTCH1notch 10.411
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.409
RB1retinoblastoma 10.403
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.391
CTBP1C-terminal binding protein 10.385
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.373
DLG1discs, large homolog 1 (Drosophila)0.363
TAL1T-cell acute lymphocytic leukemia 10.334
INSRinsulin receptor0.322
GHRgrowth hormone receptor0.314
LCKlymphocyte-specific protein tyrosine kinase0.312
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.304
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.288
PTPN1protein tyrosine phosphatase, non-receptor type 10.286
BCL10B-cell CLL/lymphoma 100.263
IFNAR2interferon (alpha, beta and omega) receptor 20.262
CDK6cyclin-dependent kinase 60.252
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.243
CCND3cyclin D30.238
MDM2Mdm2 p53 binding protein homolog (mouse)0.207
IL4Rinterleukin 4 receptor0.202
IL2RGinterleukin 2 receptor, gamma0.200
SYKspleen tyrosine kinase0.195
LIG4ligase IV, DNA, ATP-dependent0.191
CD2CD2 molecule0.191
CD3GCD3g molecule, gamma (CD3-TCR complex)0.188
MKL1megakaryoblastic leukemia (translocation) 10.187
NOTCH2notch 20.183
HLA-Bmajor histocompatibility complex, class I, B0.171
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.165
STRADASTE20-related kinase adaptor alpha0.164
TNFAIP3tumor necrosis factor, alpha-induced protein 30.162
TP53tumor protein p530.157
EGR1early growth response 10.151
PLCG1phospholipase C, gamma 10.149
HLA-Amajor histocompatibility complex, class I, A0.149
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.149
BIRC3baculoviral IAP repeat containing 30.144
CASP10caspase 10, apoptosis-related cysteine peptidase0.141
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.141
IKZF3IKAROS family zinc finger 3 (Aiolos)0.130
EGR2early growth response 20.129
FSTL1follistatin-like 10.127
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.126
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.126
IL7Rinterleukin 7 receptor0.125
SHC1SHC (Src homology 2 domain containing) transforming protein 10.122
CD8ACD8a molecule0.122
TRAF1TNF receptor-associated factor 10.120
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.118
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.118
CCR7chemokine (C-C motif) receptor 70.118
GRAP2GRB2-related adaptor protein 20.113
JAK1Janus kinase 10.111
MAPK14mitogen-activated protein kinase 140.111
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.111
ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.104
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.103
GFI1Bgrowth factor independent 1B transcription repressor0.101
MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)0.101
MYOD1myogenic differentiation 10.100
JAK2Janus kinase 20.097
HLA-Cmajor histocompatibility complex, class I, C0.096
CD80CD80 molecule0.096
STAP2signal transducing adaptor family member 20.095
ZFYVE9zinc finger, FYVE domain containing 90.093
KPNA1karyopherin alpha 1 (importin alpha 5)0.093
FASFas (TNF receptor superfamily, member 6)0.090
UBASH3Bubiquitin associated and SH3 domain containing B0.089
STRADBSTE20-related kinase adaptor beta0.089
TCF12transcription factor 120.089
NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.087
CD83CD83 molecule0.085
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.084
CD69CD69 molecule0.083
CD7CD7 molecule0.081
TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.080
RPS3Aribosomal protein S3A0.077
IL7interleukin 70.076
U2AF1U2 small nuclear RNA auxiliary factor 10.075
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.075
HFEhemochromatosis0.074
FAIM3Fas apoptotic inhibitory molecule 30.074
MYOGmyogenin (myogenic factor 4)0.073
CSNK1G1casein kinase 1, gamma 10.071
BCL2L1BCL2-like 10.071
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-BaRT1 class II, locus Ba0.014
Cd247Cd247 molecule0.014
RT1-DaRT1 class II, locus Da0.013
Slfn2schlafen 20.012
Cd44Cd44 molecule0.011
RT1-BbRT1 class II, locus Bb0.011
Cd5Cd5 molecule0.011
Cd3gCD3 molecule, gamma0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism