The network for 'dna templated transcriptional preinitiation complex assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna templated transcriptional preinitiation complex assembly

The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.

NameDescriptionProbabilityFunc Analog Organism
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.859
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.854
Lhx1LIM homeobox protein 10.598
Dkk1dickkopf homolog 1 (Xenopus laevis)0.577
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.574
Pax8paired box gene 80.534
Ror2receptor tyrosine kinase-like orphan receptor 20.439
Pax2paired box gene 20.425
Gdnfglial cell line derived neurotrophic factor0.416
Tbrachyury0.384
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.292
Psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.222
Esr2estrogen receptor 2 (beta)0.208
Klklotho0.191
Fgf8fibroblast growth factor 80.183
Thrbthyroid hormone receptor beta0.175
TbpTATA box binding protein0.174
Psmd14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.163
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.148
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.143
Wnt10bwingless related MMTV integration site 10b0.142
Wnt4wingless-related MMTV integration site 40.136
Wnt3awingless-related MMTV integration site 3A0.129
Wnt6wingless-related MMTV integration site 60.119
Rargretinoic acid receptor, gamma0.116
Kcnd3potassium voltage-gated channel, Shal-related family, member 30.115
Lmx1aLIM homeobox transcription factor 1 alpha0.109
Wnt2bwingless related MMTV integration site 2b0.108
Drg1developmentally regulated GTP binding protein 10.105
Pou3f3POU domain, class 3, transcription factor 30.105
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.103
Porcnporcupine homolog (Drosophila)0.102
Fzd10frizzled homolog 10 (Drosophila)0.099
Ttc7tetratricopeptide repeat domain 70.097
Vax1ventral anterior homeobox containing gene 10.096
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.095
Arntaryl hydrocarbon receptor nuclear translocator0.094
BC018465cDNA sequence BC0184650.093
Tbcbtubulin folding cofactor B0.092
Rarbretinoic acid receptor, beta0.092
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.091
Ncor1nuclear receptor co-repressor 10.090
Otx2orthodenticle homolog 2 (Drosophila)0.090
Hoxa13homeobox A130.089
Trp73transformation related protein 730.082
Amhr2anti-Mullerian hormone type 2 receptor0.082
Hoxa4homeobox A40.081
Slc34a2solute carrier family 34 (sodium phosphate), member 20.080
Epha1Eph receptor A10.080
Barx2BarH-like homeobox 20.079
Fzd1frizzled homolog 1 (Drosophila)0.078
Gli1GLI-Kruppel family member GLI10.078
Hoxa2homeobox A20.077
Gtf2f1general transcription factor IIF, polypeptide 10.076
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.075
Il11interleukin 110.075
Otx1orthodenticle homolog 1 (Drosophila)0.074
Rarsarginyl-tRNA synthetase0.074
Mrpl13mitochondrial ribosomal protein L130.072
Wnt9awingless-type MMTV integration site 9A0.071
Rab23RAB23, member RAS oncogene family0.070
Snrpa1small nuclear ribonucleoprotein polypeptide A'0.069
Sim2single-minded homolog 2 (Drosophila)0.069
Psma6proteasome (prosome, macropain) subunit, alpha type 60.068
Emx2empty spiracles homolog 2 (Drosophila)0.068
En1engrailed 10.068
Emid2EMI domain containing 20.067
Neurog1neurogenin 10.065
Trp63transformation related protein 630.064
Tnni2troponin I, skeletal, fast 20.062
Gli3GLI-Kruppel family member GLI30.062
Mrpl12mitochondrial ribosomal protein L120.061
Fgf17fibroblast growth factor 170.060
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.059
Col13a1collagen, type XIII, alpha 10.058
IhhIndian hedgehog0.058
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.057
Shhsonic hedgehog0.056
Duox2dual oxidase 20.055
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.054
Scube1signal peptide, CUB domain, EGF-like 10.054
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.053
Fgf18fibroblast growth factor 180.053
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.053
Harshistidyl-tRNA synthetase0.052
Tbx2T-box 20.052
Efna4ephrin A40.052
Cdx1caudal type homeobox 10.051
Clic3chloride intracellular channel 30.051
Tbpl1TATA box binding protein-like 10.051
3110079O15RikRIKEN cDNA 3110079O15 gene0.051
Vstm2bV-set and transmembrane domain containing 2B0.050
Irs1insulin receptor substrate 10.050
Hes5hairy and enhancer of split 5 (Drosophila)0.050
Tctex1d4Tctex1 domain containing 40.050
Fgf15fibroblast growth factor 150.049
Klf5Kruppel-like factor 50.049
Pknox1Pbx/knotted 1 homeobox0.049
Rpa1replication protein A10.048
Gli2GLI-Kruppel family member GLI20.048
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.863
Taf12TBP-associated factor 120.544
Taf4TBP-associated factor 40.500
Rpt4CG3455 gene product from transcript CG3455-RA0.443
CG7386CG7386 gene product from transcript CG7386-RA0.344
Rpn11CG18174 gene product from transcript CG18174-RA0.336
CG8159CG8159 gene product from transcript CG8159-RB0.256
TbpTATA binding protein0.228
Mov34CG3416 gene product from transcript CG3416-RA0.221
Prosalpha7Proteasome alpha7 subunit0.211
Rcd1Reduction in Cnn dots 10.191
Rpn9CG10230 gene product from transcript CG10230-RB0.175
Prosbeta7Proteasome beta7 subunit0.170
Ada2bCG9638 gene product from transcript CG9638-RA0.149
CG15436CG15436 gene product from transcript CG15436-RA0.128
CG12393CG12393 gene product from transcript CG12393-RB0.124
CG14317CG14317 gene product from transcript CG14317-RA0.111
bab2CG9102 gene product from transcript CG9102-RA0.108
Uch-L3Ubiquitin C-terminal hydrolase0.108
Pros35Proteasome 35kD subunit0.106
Rpn7CG5378 gene product from transcript CG5378-RA0.084
Pros45CG1489 gene product from transcript CG1489-RA0.082
CG6654CG6654 gene product from transcript CG6654-RA0.081
Pros29Proteasome 29kD subunit0.070
CG4709CG4709 gene product from transcript CG4709-RA0.066
Taf1TBP-associated factor 10.065
ToporsTopoisomerase I-interacting protein0.065
Taf6TBP-associated factor 60.063
Tbp-1Tat-binding protein-10.062
CSN7COP9 complex homolog subunit 70.061
Spt3CG3169 gene product from transcript CG3169-RA0.059
BRWD3CG31132 gene product from transcript CG31132-RA0.059
CG5146CG5146 gene product from transcript CG5146-RA0.059
uexunextended0.058
Sry-betaSerendipity beta0.057
Rpt3CG16916 gene product from transcript CG16916-RA0.057
CG17568CG17568 gene product from transcript CG17568-RA0.056
CG12321CG12321 gene product from transcript CG12321-RA0.051
CG1792CG1792 gene product from transcript CG1792-RA0.051
l(2)37Celethal (2) 37Ce0.051
Prosbeta2Proteasome beta2 subunit0.047
CG13779CG13779 gene product from transcript CG13779-RA0.047
padpoils au dos0.047
Saf6SAGA factor-like TAF60.047
Nipped-ACG33554 gene product from transcript CG33554-RE0.043
CG17244CG17244 gene product from transcript CG17244-RA0.043
Rpt1CG1341 gene product from transcript CG1341-RA0.042
CG10435CG10435 gene product from transcript CG10435-RA0.041
Rpn1CG7762 gene product from transcript CG7762-RA0.039
CG14071CG14071 gene product from transcript CG14071-RA0.038
idaimaginal discs arrested0.038
rowrelative of woc0.036
B-H1BarH10.035
Elongin-CElongin C0.035
CG9573CG9573 gene product from transcript CG9573-RA0.035
CG6163CG6163 gene product from transcript CG6163-RA0.034
Sgf29CG30390 gene product from transcript CG30390-RA0.034
Taf8TBP-associated factor 80.033
CG3407CG3407 gene product from transcript CG3407-RA0.033
CG10333CG10333 gene product from transcript CG10333-RA0.033
LamLamin0.033
CG13349CG13349 gene product from transcript CG13349-RA0.032
HP1eCG8120 gene product from transcript CG8120-RA0.031
CG14074CG14074 gene product from transcript CG14074-RA0.031
Taf10TBP-associated factor 100.031
Rpn6Proteasome p44.5 subunit0.030
CG11188CG11188 gene product from transcript CG11188-RA0.027
PcafCG4107 gene product from transcript CG4107-RA0.027
CG10959CG10959 gene product from transcript CG10959-RA0.026
CG5147CG5147 gene product from transcript CG5147-RA0.026
Roc1aCG16982 gene product from transcript CG16982-RB0.026
CG11448CG11448 gene product from transcript CG11448-RA0.026
CG4424CG4424 gene product from transcript CG4424-RA0.025
maf-SCG9954 gene product from transcript CG9954-RA0.025
CSN4COP9 complex homolog subunit 40.025
CG18764CG18764 gene product from transcript CG18764-RA0.025
CG10139CG10139 gene product from transcript CG10139-RA0.024
DpckDephospho-CoA kinase0.024
rnorhinoceros0.024
CG3589CG3589 gene product from transcript CG3589-RA0.023
CG9293CG9293 gene product from transcript CG9293-RB0.023
tratransformer0.023
NC2alphaCG10318 gene product from transcript CG10318-RA0.023
CG6506CG6506 gene product from transcript CG6506-RA0.023
CG7879CG7879 gene product from transcript CG7879-RB0.022
Rpn12CG4157 gene product from transcript CG4157-RA0.022
LSm3CG31184 gene product from transcript CG31184-RA0.022
TfIIA-LTranscription factor IIA L0.022
CG11906CG11906 gene product from transcript CG11906-RA0.022
Bap55Brahma associated protein 55kD0.022
CG14551CG14551 gene product from transcript CG14551-RA0.022
DllDistal-less0.021
CG31961CG31961 gene product from transcript CG31961-RA0.021
CG3226CG3226 gene product from transcript CG3226-RA0.021
CG32685CG32685 gene product from transcript CG32685-RC0.021
Su(var)3-3Suppressor of variegation 3-30.020
Lim1CG11354 gene product from transcript CG11354-RA0.020
CstF-64Cleavage stimulation factor 64 kilodalton subunit0.020
Mfap1Microfibril-associated protein 10.019
CG14546CG14546 gene product from transcript CG14546-RA0.019
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TBPTATA box binding protein1.000
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.992
TAF9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa0.903
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.792
TAF5TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa0.785
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.742
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 100.734
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.516
TAF1TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa0.485
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.460
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 30.394
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.379
TAF1ATATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa0.363
GTF2Bgeneral transcription factor IIB0.343
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.259
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.232
TBPL1TBP-like 10.232
PSMD13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.230
GTF2A2general transcription factor IIA, 2, 12kDa0.202
TAF1CTATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa0.144
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.127
NCOA6nuclear receptor coactivator 60.111
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.110
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.105
MED25mediator complex subunit 250.084
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.082
TAF6LTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa0.077
TRRAPtransformation/transcription domain-associated protein0.074
RXRAretinoid X receptor, alpha0.074
TAF2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa0.071
TAF10TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa0.070
NCOA1nuclear receptor coactivator 10.065
SETD7SET domain containing (lysine methyltransferase) 70.064
TAF11TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa0.057
MED26mediator complex subunit 260.043
KAT2BK(lysine) acetyltransferase 2B0.041
TAF12TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa0.036
GTF2A1general transcription factor IIA, 1, 19/37kDa0.036
PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 90.032
CSNK1A1casein kinase 1, alpha 10.027
DRAP1DR1-associated protein 1 (negative cofactor 2 alpha)0.026
HMGN2high mobility group nucleosomal binding domain 20.026
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.023
SORBS3sorbin and SH3 domain containing 30.022
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa0.018
ARNTaryl hydrocarbon receptor nuclear translocator0.016
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.016
FAM190Bfamily with sequence similarity 190, member B0.016
SETSET nuclear oncogene0.016
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.015
MED21mediator complex subunit 210.014
TAF7TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa0.013
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.012
CDK7cyclin-dependent kinase 70.012
TAF3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa0.011
RARAretinoic acid receptor, alpha0.011
TAF6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa0.011
ATXN7ataxin 70.011
BRF1BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)0.011
NCOA3nuclear receptor coactivator 30.010
MAGED2melanoma antigen family D, 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.789
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.568
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.565
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.249
Psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.061
Psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.038
Psmd7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.036
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.034
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.030
Nsfl1cNSFL1 (p97) cofactor (p47)0.030
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.027
Strapserine/threonine kinase receptor associated protein0.020
Vcpvalosin-containing protein0.020
Psmb3proteasome (prosome, macropain) subunit, beta type 30.019
Psmd11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.019
Pfdn2prefoldin subunit 20.016
Karslysyl-tRNA synthetase0.016
Psmb5proteasome (prosome, macropain) subunit, beta type 50.014
Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.012
Prmt1protein arginine methyltransferase 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SPT15Spt15p0.999
TAF10Taf10p0.999
TAF4Taf4p0.987
BUR6Bur6p0.964
TAF12Taf12p0.887
TAF3Taf3p0.872
TOA1Toa1p0.854
RPT6Rpt6p0.836
TAF7Taf7p0.809
TAF6Taf6p0.740
SRB6Srb6p0.716
MED2Med2p0.690
TFG2Tfg2p0.671
MOT1Mot1p0.597
TAF9Taf9p0.559
SUA7Sua7p0.538
TFG1Tfg1p0.500
TOA2Toa2p0.447
MED1Med1p0.446
ROX3Rox3p0.438
RPN9Rpn9p0.392
PGD1Pgd1p0.346
TAF8Taf8p0.341
SPT16Spt16p0.340
TFA1Tfa1p0.338
RPT1Rpt1p0.290
BRF1Brf1p0.251
RAD23Rad23p0.243
KAP114Kap114p0.236
RPT2Rpt2p0.229
MED6Med6p0.223
GAL11Gal11p0.221
NHP6ANhp6ap0.205
TAF5Taf5p0.203
CSE2Cse2p0.203
TAF11Taf11p0.192
MED4Med4p0.181
RPN13Rpn13p0.175
SPT20Spt20p0.162
MED8Med8p0.154
RPT3Rpt3p0.148
SRB7Srb7p0.148
RPT4Rpt4p0.146
SAS4Sas4p0.141
RPT5Rpt5p0.132
SRB4Srb4p0.131
SLU7Slu7p0.128
SOH1Soh1p0.128
SRB2Srb2p0.127
CAB3Cab3p0.122
RNA15Rna15p0.122
CKB1Ckb1p0.116
RPN6Rpn6p0.115
SUB1Sub1p0.115
SPT8Spt8p0.114
NUT2Nut2p0.113
SRB5Srb5p0.106
RPN1Rpn1p0.095
HHT1Hht1p0.092
RRT5Rrt5p0.090
MTC1Mtc1p0.088
RPB4Rpb4p0.087
SEM1Sem1p0.084
RTS2Rts2p0.065
HIT1Hit1p0.065
SRD1Srd1p0.064
HDA2Hda2p0.063
IOC4Ioc4p0.061
RPN2Rpn2p0.060
YLR264C-Ahypothetical protein0.060
LEU2Leu2p0.057
ADA2Ada2p0.057
RPN10Rpn10p0.054
SPT2Spt2p0.052
DST1Dst1p0.051
YOL038C-Ahypothetical protein0.050
YKL063Chypothetical protein0.050
TFC4Tfc4p0.049
RTF1Rtf1p0.047
MER1Mer1p0.047
ARP10Arp10p0.046
YLR162Whypothetical protein0.045
TAF2Taf2p0.045
ARG8Arg8p0.044
YPR157Whypothetical protein0.044
TYE7Tye7p0.044
HXT3Hxt3p0.043
RNR2Rnr2p0.042
TAF13Taf13p0.042
LEO1Leo1p0.042
TSC3Tsc3p0.042
YIR035Chypothetical protein0.041
CTK3Ctk3p0.041
YER137Chypothetical protein0.041
PDR16Pdr16p0.040
ATP6Atp6p0.039
SAS5Sas5p0.039
YLR042Chypothetical protein0.039
PEX19Pex19p0.037
PSY4Psy4p0.037