The network for 'positive regulation of chromosome segregation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of chromosome segregation

Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.996
Ctnnb1catenin (cadherin associated protein), beta 10.977
Ube2cubiquitin-conjugating enzyme E2C0.927
Ccna2cyclin A20.921
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.914
Ptenphosphatase and tensin homolog0.901
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.854
Plk1polo-like kinase 1 (Drosophila)0.837
Ccnb2cyclin B20.828
Ccnb1cyclin B10.748
Cdk1cyclin-dependent kinase 10.744
Apcadenomatosis polyposis coli0.732
Ccnfcyclin F0.691
Aurkbaurora kinase B0.622
Cdc25ccell division cycle 25 homolog C (S. pombe)0.591
Cdca5cell division cycle associated 50.561
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.546
Kif2ckinesin family member 2C0.544
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.544
Cdca8cell division cycle associated 80.521
Prc1protein regulator of cytokinesis 10.411
Mki67antigen identified by monoclonal antibody Ki 670.363
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.352
Kif22kinesin family member 220.301
Kif4kinesin family member 40.289
Axin1axin 10.275
Hmmrhyaluronan mediated motility receptor (RHAMM)0.270
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.262
Cenpacentromere protein A0.249
Kif20akinesin family member 20A0.249
H2afxH2A histone family, member X0.244
Ckap2cytoskeleton associated protein 20.235
Psen1presenilin 10.230
Ckap2lcytoskeleton associated protein 2-like0.225
Cdkn1bcyclin-dependent kinase inhibitor 1B0.224
Cdkn3cyclin-dependent kinase inhibitor 30.222
Cenpfcentromere protein F0.203
Usp9xubiquitin specific peptidase 9, X chromosome0.188
Birc5baculoviral IAP repeat-containing 50.181
Lmnb1lamin B10.176
Dlgap5discs, large (Drosophila) homolog-associated protein 50.169
Melkmaternal embryonic leucine zipper kinase0.167
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.159
Rcc1regulator of chromosome condensation 10.152
Fam64afamily with sequence similarity 64, member A0.151
Gtse1G two S phase expressed protein 10.149
Aurkaaurora kinase A0.143
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.140
Brca1breast cancer 10.132
Rrm2ribonucleotide reductase M20.130
Incenpinner centromere protein0.129
Trim28tripartite motif-containing 280.125
Ppp4cprotein phosphatase 4, catalytic subunit0.119
Mdm2transformed mouse 3T3 cell double minute 20.117
Spag5sperm associated antigen 50.113
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.108
Kif11kinesin family member 110.106
Wbp2WW domain binding protein 20.103
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.101
StilScl/Tal1 interrupting locus0.099
Espl1extra spindle poles-like 1 (S. cerevisiae)0.098
E2f1E2F transcription factor 10.095
Atf2activating transcription factor 20.092
Cenpncentromere protein N0.088
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.084
Ccnd1cyclin D10.084
Kif23kinesin family member 230.081
Sgol1shugoshin-like 1 (S. pombe)0.080
Ncapgnon-SMC condensin I complex, subunit G0.077
Ccne1cyclin E10.075
Mybl2myeloblastosis oncogene-like 20.074
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.074
Rangap1RAN GTPase activating protein 10.068
Gsg2germ cell-specific gene 20.067
Mta2metastasis-associated gene family, member 20.065
Lrp6low density lipoprotein receptor-related protein 60.064
Nf2neurofibromatosis 20.062
Bmi1Bmi1 polycomb ring finger oncogene0.061
Ska1spindle and kinetochore associated complex subunit 10.061
2810417H13RikRIKEN cDNA 2810417H13 gene0.059
Depdc1bDEP domain containing 1B0.058
Ccdc99coiled-coil domain containing 990.056
Kitkit oncogene0.054
Cdca2cell division cycle associated 20.052
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.052
Idh3gisocitrate dehydrogenase 3 (NAD+), gamma0.051
Ruvbl2RuvB-like protein 20.051
Cenpecentromere protein E0.048
E2f8E2F transcription factor 80.048
Prmt5protein arginine N-methyltransferase 50.047
Smad4MAD homolog 4 (Drosophila)0.047
Dazap1DAZ associated protein 10.044
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.042
Fam83dfamily with sequence similarity 83, member D0.041
Mxd3Max dimerization protein 30.040
Diap3diaphanous homolog 3 (Drosophila)0.038
Ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.038
Hcfc1host cell factor C10.037
Racgap1Rac GTPase-activating protein 10.037
Cdk2cyclin-dependent kinase 20.036
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
CELE_C24H12.5Protein C24H12.50.479
pcn-1Protein PCN-10.263
rnr-1Protein RNR-10.193
hcp-2Protein HCP-20.121
mcm-3Protein MCM-30.118
tpxl-1Protein TPXL-10.115
orc-5Protein ORC-50.108
T19H12.2Protein T19H12.20.105
klp-19Protein KLP-190.095
cyb-3Protein CYB-30.084
mcm-7Protein MCM-70.083
puf-7Protein PUF-70.083
flh-1Protein FLH-10.076
T09B4.1Protein T09B4.10.072
csn-3Protein CSN-30.068
mex-3Protein MEX-30.067
egg-1Protein EGG-10.067
puf-6Protein PUF-60.067
F56F11.4Protein F56F11.40.066
air-2Protein AIR-20.065
zif-1Protein ZIF-10.065
clec-87Protein CLEC-870.062
zen-4Protein ZEN-40.060
nasp-2Protein NASP-20.058
dsh-2Protein DSH-20.056
sun-1Protein SUN-10.056
bath-42Protein BATH-420.055
cyb-2.1Protein CYB-2.10.055
wago-1Protein WAGO-10.052
bub-1Protein BUB-10.046
ucr-2.3Protein UCR-2.30.044
vps-33.2Protein VPS-33.20.044
B0205.9Protein B0205.90.044
knl-1Protein KNL-10.043
cyb-1Protein CYB-10.043
retr-1Protein RETR-10.040
pme-2Protein PME-20.039
F58G11.3Protein F58G11.30.037
crn-1Protein CRN-10.037
CELE_W02F12.3Protein W02F12.30.037
air-1Protein AIR-10.036
lst-1Protein LST-10.036
apn-1Protein APN-10.036
B0261.7Protein B0261.70.035
spn-4Protein SPN-40.035
egg-3Protein EGG-30.034
W05F2.6Protein W05F2.60.034
tra-4Protein TRA-40.033
pos-1Protein POS-10.033
ZC410.3Protein ZC410.30.032
F55G1.6Protein F55G1.60.032
cyb-2.2Protein CYB-2.20.031
toe-2Protein TOE-20.031
rfc-4Protein RFC-40.031
T22D1.5Protein T22D1.50.030
F11E6.7Protein F11E6.70.030
mcm-5Protein MCM-50.030
C37C3.9Protein C37C3.90.029
ZK863.4Protein ZK863.40.028
vha-18Protein VHA-180.027
mcm-2Protein MCM-20.026
zwl-1Protein ZWL-10.026
zyg-1Protein ZYG-10.026
ife-3Protein IFE-30.025
T28D9.4Protein T28D9.40.025
gln-6Protein GLN-60.025
mex-1Protein MEX-10.024
T08B2.11Protein T08B2.110.023
ZK507.6Protein ZK507.60.023
puf-11Protein PUF-110.022
mdf-2Protein MDF-20.022
C28C12.12Protein C28C12.120.022
cks-1Protein CKS-10.022
spas-1Protein SPAS-10.021
Y42H9B.3Protein Y42H9B.30.021
perm-1Protein PERM-10.020
npp-7Protein NPP-70.020
panl-2Protein PANL-20.020
F56A6.4Protein F56A6.40.020
tag-153Protein TAG-1530.020
CELE_B0238.9Protein B0238.90.020
capg-2Protein CAPG-20.019
C31H1.8Protein C31H1.80.019
ify-1Protein IFY-10.019
taf-5Protein TAF-50.019
trr-1Protein TRR-10.018
trcs-1Protein TRCS-10.018
Y48G1C.7Protein Y48G1C.70.018
klc-1Protein KLC-10.018
set-16Protein SET-160.017
T05B9.1Protein T05B9.10.017
cdc-25.1Protein CDC-25.10.017
ZK328.4Protein ZK328.40.017
F18A1.7Protein F18A1.70.017
rpa-2Protein RPA-20.017
set-32Protein SET-320.017
toca-2Protein TOCA-20.017
Y51F10.2Protein Y51F10.20.017
hpo-9Protein HPO-90.017
CELE_Y23H5A.3Protein Y23H5A.30.016
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ccna2cyclin A20.886
ccnb1cyclin B10.729
sass6spindle assembly 6 homolog (C. elegans)0.520
plk1polo-like kinase 1 (Drosophila)0.428
kif23kinesin family member 230.392
aurkbaurora kinase B0.271
marcksbmyristoylated alanine rich protein kinase C substrate b0.085
nusap1nucleolar and spindle associated protein 10.073
si:ch211-244o22.2si:ch211-244o22.20.058
znf711zinc finger protein 7110.058
pou5f1POU domain, class 5, transcription factor 10.056
tacc3transforming, acidic coiled-coil containing protein 30.050
wu:fi04f09wu:fi04f090.050
g2e3G2/M-phase specific E3 ubiquitin ligase0.044
pglyrp2peptidoglycan recognition protein 20.044
aurkaaurora kinase A0.042
cdca8cell division cycle associated 80.042
kpna2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.042
kif11kinesin family member 110.040
cdc20cell division cycle 20 homolog0.039
ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.035
si:ch211-69g19.2si:ch211-69g19.20.030
ptpraprotein tyrosine phosphatase, receptor type, A0.029
suv39h1bsuppressor of variegation 3-9 homolog 1b0.028
rbpjarecombination signal binding protein for immunoglobulin kappa J region a0.026
zgc:162965zgc:1629650.026
ncaphnon-SMC condensin I complex, subunit H0.026
cfl2lcofilin 2, like0.026
zgc:154063zgc:1540630.025
ccnb2cyclin B20.023
ttkttk protein kinase0.023
rspo3R-spondin 3 homolog (Xenopus laevis)0.022
fzd7bfrizzled homolog 7b0.022
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.022
pif1PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)0.021
rtkn2rhotekin 20.019
lndc1ly6/neurotoxin domain containing 10.019
vasavasa homolog0.019
mbd3amethyl-CpG binding domain protein 3a0.019
ccnecyclin E0.019
si:dkey-181m9.9si:dkey-181m9.90.018
cep55lcentrosomal protein 55 like0.017
cdc25cell division cycle 25 homolog0.017
zgc:112425zgc:1124250.017
dhfrdihydrofolate reductase0.017
spsb1splA/ryanodine receptor domain and SOCS box containing 10.016
atp6v1hATPase, H+ transporting, lysosomal, V1 subunit H0.016
mapk3mitogen-activated protein kinase 30.016
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.015
arid4aAT rich interactive domain 4A (RBP1-like)0.014
comtacatechol-O-methyltransferase a0.014
eif4g2aeukaryotic translation initiation factor 4, gamma 2a0.014
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.014
depdc1aDEP domain containing 1a0.014
hmgb1ahigh-mobility group box 1a0.014
LOC100536090targeting protein for Xklp2-B-like0.014
LOC557062hypothetical protein LOC5570620.013
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.013
ef1aelongation factor 1-alpha0.013
gmnngeminin, DNA replication inhibitor0.013
gnb1bguanine nucleotide binding protein (G protein), beta polypeptide 1b0.013
si:ch211-57k11.10si:ch211-57k11.100.013
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.013
ncapgnon-SMC condensin I complex, subunit G0.013
piguphosphatidylinositol glycan anchor biosynthesis, class U0.013
lrmplymphoid-restricted membrane protein0.013
si:ch211-197n10.2si:ch211-197n10.20.012
mgaMAX gene associated0.012
psen1presenilin 10.012
esco2establishment of cohesion 1 homolog 20.012
matr3lmatrin 3-like0.012
cul1acullin 1a0.012
brca2breast cancer 2, early onset0.012
htra1aHtrA serine peptidase 1a0.011
birc5bbaculoviral IAP repeat-containing 5B0.011
nod1nucleotide-binding oligomerization domain containing 10.011
kpna3karyopherin (importin) alpha 30.011
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.011
nuf2NUF2, NDC80 kinetochore complex component, homolog0.011
wdhd1WD repeat and HMG-box DNA binding protein 10.011
fmr1fragile X mental retardation 10.011
zgc:86764zgc:867640.011
zgc:77051zgc:770510.011
skp2S-phase kinase-associated protein 2 (p45)0.011
ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.010
capn2bcalpain 2, (m/II) large subunit b0.010
cul3acullin 3a0.010
ewsr1aEwing sarcoma breakpoint region 1a0.010
hcfc1ahost cell factor C1a0.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycACyclin A0.607
cmetCENP-meta0.391
pimpimples0.320
CycBCyclin B0.231
dupdouble parked0.186
CycB3Cyclin B30.110
hpohippo0.077
SseSeparase0.066
ncdnon-claret disjunctional0.065
Dcr-1Dicer-10.065
bratbrain tumor0.044
idaimaginal discs arrested0.042
cdc16CG6759 gene product from transcript CG6759-RA0.038
Cks30ACyclin-dependent kinase subunit 30A0.037
Psf2CG18013 gene product from transcript CG18013-RA0.034
BubR1Bub1-related kinase0.033
stisticky0.033
Ras85DRas oncogene at 85D0.032
jubAjuba LIM protein0.032
DrefDNA replication-related element factor0.032
ballballchen0.031
scrascraps0.024
wun2wunen-20.024
Hr4CG16902 gene product from transcript CG16902-RC0.024
Su(H)Suppressor of Hairless0.023
cavcaravaggio0.022
l(1)G0148lethal (1) G01480.022
CG4680CG4680 gene product from transcript CG4680-RA0.021
Spc105RSpc105-related0.021
DNApol-alpha60DNA polymerase alpha 60kD0.021
CG9772CG9772 gene product from transcript CG9772-RB0.021
Mcm10Sensitized chromosome inheritance modifier 190.020
dhddeadhead0.020
lmglemming0.018
Nuf2CG8902 gene product from transcript CG8902-RA0.016
Cenp-CCG31258 gene product from transcript CG31258-RA0.016
phopleiohomeotic0.015
vtdverthandi0.015
Taspase1Taspase 10.014
cdc23CG2508 gene product from transcript CG2508-RA0.013
trolterribly reduced optic lobes0.012
Kap-alpha3karyopherin alpha30.012
nosnanos0.012
prosprospero0.011
Trf4-1CG11265 gene product from transcript CG11265-RE0.011
sxcsuper sex combs0.011
ChroChromator0.011
SMC2CG10212 gene product from transcript CG10212-RA0.011
wcdwicked0.010
Dap160Dynamin associated protein 1600.010
Klp3AKinesin-like protein at 3A0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC20cell division cycle 20 homolog (S. cerevisiae)1.000
CDC27cell division cycle 27 homolog (S. cerevisiae)0.999
CDK2cyclin-dependent kinase 20.987
ANAPC4anaphase promoting complex subunit 40.924
CCNA2cyclin A20.915
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.904
RB1retinoblastoma 10.902
CDT1chromatin licensing and DNA replication factor 10.354
ANAPC7anaphase promoting complex subunit 70.286
RBL1retinoblastoma-like 1 (p107)0.279
ORC1origin recognition complex, subunit 10.275
CCNB1cyclin B10.219
ANAPC11anaphase promoting complex subunit 110.154
RBL2retinoblastoma-like 2 (p130)0.151
ANAPC5anaphase promoting complex subunit 50.148
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.145
CDK1cyclin-dependent kinase 10.144
CDC16cell division cycle 16 homolog (S. cerevisiae)0.134
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.133
CDC23cell division cycle 23 homolog (S. cerevisiae)0.128
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.126
SMC6structural maintenance of chromosomes 60.123
CDC26cell division cycle 26 homolog (S. cerevisiae)0.105
PLK1polo-like kinase 10.093
SKP2S-phase kinase-associated protein 2 (p45)0.091
E2F1E2F transcription factor 10.090
ORC2origin recognition complex, subunit 20.087
ANAPC1anaphase promoting complex subunit 10.086
SIRT2sirtuin 20.070
CDKN3cyclin-dependent kinase inhibitor 30.063
SPC24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.045
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.044
CLSPNclaspin0.044
CCNE1cyclin E10.037
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.036
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.030
CASC5cancer susceptibility candidate 50.029
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.025
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.021
E2F5E2F transcription factor 5, p130-binding0.020
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)0.020
AXIN1axin 10.020
AURKBaurora kinase B0.020
MAD2L1BPMAD2L1 binding protein0.020
CKS2CDC28 protein kinase regulatory subunit 20.017
RBBP8retinoblastoma binding protein 80.016
CDC7cell division cycle 7 homolog (S. cerevisiae)0.015
PTTG1pituitary tumor-transforming 10.015
NEK2NIMA (never in mitosis gene a)-related kinase 20.014
BRCA2breast cancer 2, early onset0.014
CDC25Ccell division cycle 25 homolog C (S. pombe)0.013
PPIGpeptidylprolyl isomerase G (cyclophilin G)0.013
CUL2cullin 20.013
SKA1spindle and kinetochore associated complex subunit 10.013
KIF18Akinesin family member 18A0.012
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ASK1Ask1p0.998
DAD4Dad4p0.979
SPC34Spc34p0.936
DAD1Dad1p0.832
DAM1Dam1p0.751
HSK3Hsk3p0.731
DAD2Dad2p0.711
SPC19Spc19p0.664
DUO1Duo1p0.645
DAD3Dad3p0.412
CLB1Clb1p0.212
CLB3Clb3p0.162
CDC23Cdc23p0.140
MMS21Mms21p0.093
PDS1Pds1p0.093
NSE4Nse4p0.083
CLB4Clb4p0.060
CKS1Cks1p0.054
CDC26Cdc26p0.053
PFS1Pfs1p0.049
CDC6Cdc6p0.049
APC2Apc2p0.041
YPL014Whypothetical protein0.039
SMC4Smc4p0.038
HSL1Hsl1p0.030
SLK19Slk19p0.030
VIK1Vik1p0.029
MSA2Msa2p0.024
KRE29Kre29p0.024
MER1Mer1p0.022
CDC27Cdc27p0.021
BFA1Bfa1p0.018
SRD1Srd1p0.018
NSE1Nse1p0.018
CDC16Cdc16p0.018
FMT1Fmt1p0.017
SLI15Sli15p0.017
LEU2Leu2p0.017
ARP10Arp10p0.016
YAR068Whypothetical protein0.015
DSN1Dsn1p0.015
ADH2Adh2p0.015
IME1Ime1p0.015
YOL038C-Ahypothetical protein0.015
CLB6Clb6p0.014
YLR264C-Ahypothetical protein0.014
NDD1Ndd1p0.014
YLR162Whypothetical protein0.014
IME2Ime2p0.014
SPO12Spo12p0.014
SPL2Spl2p0.014
MF(ALPHA)2Mf(alpha)2p0.014
CUP1-1Cup1-1p0.014
REC102Rec102p0.014
YDL186Whypothetical protein0.014
CDC20Cdc20p0.013
URA3Ura3p0.013
ARG8Arg8p0.013
YBR013Chypothetical protein0.013
KIN3Kin3p0.013
ACM1Acm1p0.012
HST3Hst3p0.012
SPS4Sps4p0.012
YPR157Whypothetical protein0.012
MF(ALPHA)1Mf(alpha)1p0.012
NUF2Nuf2p0.012
DTR1Dtr1p0.012
CHA1Cha1p0.012
PRS2Prs2p0.012
ATP6Atp6p0.012
WSC4Wsc4p0.011
SHE1She1p0.011
ALT2Alt2p0.011
YHR035Whypothetical protein0.011
YML053Chypothetical protein0.011
ICS2Ics2p0.011
RRT5Rrt5p0.011
PTI1Pti1p0.011
AUA1Aua1p0.011
YAR066Whypothetical protein0.011
HXT3Hxt3p0.011
JLP2Jlp2p0.011
VAC17Vac17p0.011
HPF1Hpf1p0.011
SPC25Spc25p0.011
ZPS1Zps1p0.010
YIR035Chypothetical protein0.010
IZH4Izh4p0.010
STB1Stb1p0.010
YGK3Ygk3p0.010