The network for 'nls bearing protein import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nls bearing protein import into nucleus

The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane.

NameDescriptionProbabilityFunc Analog Organism
Wdr77WD repeat domain 770.557
Tfdp1transcription factor Dp 10.470
Eif3beukaryotic translation initiation factor 3, subunit B0.372
Ddx21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.174
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.169
Nsun2NOL1/NOP2/Sun domain family member 20.164
Varsvalyl-tRNA synthetase0.126
Ctpscytidine 5'-triphosphate synthase0.121
Gspt1G1 to S phase transition 10.104
Nolc1nucleolar and coiled-body phosphoprotein 10.099
Ezh2enhancer of zeste homolog 2 (Drosophila)0.076
Pprc1peroxisome proliferative activated receptor, gamma, coactivator-related 10.069
Ftsj3FtsJ homolog 3 (E. coli)0.066
Mybbp1aMYB binding protein (P160) 1a0.065
Srsf2serine/arginine-rich splicing factor 20.061
Grwd1glutamate-rich WD repeat containing 10.051
Ddx39DEAD (Asp-Glu-Ala-Asp) box polypeptide 390.049
Pa2g4proliferation-associated 2G40.048
Cct6achaperonin containing Tcp1, subunit 6a (zeta)0.044
Ncbp1nuclear cap binding protein subunit 10.042
G3bp1Ras-GTPase-activating protein SH3-domain binding protein 10.041
Epas1endothelial PAS domain protein 10.041
Prmt5protein arginine N-methyltransferase 50.040
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.038
2610027L16RikRIKEN cDNA 2610027L16 gene0.037
Nop58NOP58 ribonucleoprotein homolog (yeast)0.035
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.035
Noc4lnucleolar complex associated 4 homolog (S. cerevisiae)0.034
Cirh1acirrhosis, autosomal recessive 1A (human)0.032
Egln1EGL nine homolog 1 (C. elegans)0.030
Bzw1basic leucine zipper and W2 domains 10.029
Cse1lchromosome segregation 1-like (S. cerevisiae)0.029
Hnrnpuheterogeneous nuclear ribonucleoprotein U0.028
Dis3DIS3 mitotic control homolog (S. cerevisiae)0.028
Rad23bRAD23b homolog (S. cerevisiae)0.026
Byslbystin-like0.026
Xpo5exportin 50.026
Ubap2ubiquitin-associated protein 20.025
Pcbp1poly(rC) binding protein 10.025
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.025
Caprin1cell cycle associated protein 10.023
Abce1ATP-binding cassette, sub-family E (OABP), member 10.022
Larp1La ribonucleoprotein domain family, member 10.021
Vegfavascular endothelial growth factor A0.021
Rrp12ribosomal RNA processing 12 homolog (S. cerevisiae)0.021
Dmddystrophin, muscular dystrophy0.021
Srmspermidine synthase0.020
Naa15N(alpha)-acetyltransferase 15, NatA auxiliary subunit0.020
Adssadenylosuccinate synthetase, non muscle0.018
Actl6aactin-like 6A0.018
Nop2NOP2 nucleolar protein homolog (yeast)0.017
B3gnt1UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 10.017
H2afzH2A histone family, member Z0.017
Psme3proteaseome (prosome, macropain) 28 subunit, 30.017
Tcof1Treacher Collins Franceschetti syndrome 1, homolog0.017
Rcc2regulator of chromosome condensation 20.016
Smyd5SET and MYND domain containing 50.016
Srsf1serine/arginine-rich splicing factor 10.016
Ranbp1RAN binding protein 10.016
Smad3MAD homolog 3 (Drosophila)0.016
Fkrpfukutin related protein0.016
Pde12phosphodiesterase 120.015
Usp1ubiquitin specific peptidase 10.015
Kpnb1karyopherin (importin) beta 10.015
2310008H09RikRIKEN cDNA 2310008H09 gene0.015
Kpna3karyopherin (importin) alpha 30.015
Tsr1TSR1, 20S rRNA accumulation, homolog (yeast)0.015
Rqcd1rcd1 (required for cell differentiation) homolog 1 (S. pombe)0.015
Ptges3prostaglandin E synthase 3 (cytosolic)0.014
Iarsisoleucine-tRNA synthetase0.014
Rangap1RAN GTPase activating protein 10.014
Hmga1-rs1high mobility group AT-hook I, related sequence 10.014
RanRAN, member RAS oncogene family0.014
Kat2aK(lysine) acetyltransferase 2A0.014
Lbrlamin B receptor0.014
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.014
Nup50nucleoporin 500.014
Lamc1laminin, gamma 10.013
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.013
Odc1ornithine decarboxylase, structural 10.013
Rsl1d1ribosomal L1 domain containing 10.013
Kpna2karyopherin (importin) alpha 20.012
Nup93nucleoporin 930.012
Fam98afamily with sequence similarity 98, member A0.012
Tcerg1transcription elongation regulator 1 (CA150)0.012
Hnrpllheterogeneous nuclear ribonucleoprotein L-like0.012
Metap1methionyl aminopeptidase 10.012
Prkciprotein kinase C, iota0.012
Sdc4syndecan 40.012
Col4a1collagen, type IV, alpha 10.012
FasFas (TNF receptor superfamily member 6)0.012
Usp10ubiquitin specific peptidase 100.012
Rrn3RRN3 RNA polymerase I transcription factor homolog (yeast)0.012
Tmem48transmembrane protein 480.011
Kif3bkinesin family member 3B0.011
SetSET nuclear oncogene0.011
Foxk2forkhead box K20.011
Rxraretinoid X receptor alpha0.011
Hdgfhepatoma-derived growth factor0.011
Zbed4zinc finger, BED domain containing 40.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mibmind bomb0.095
sarsseryl-tRNA synthetase0.037
lamc1laminin, gamma 10.017
lamb1alaminin, beta 1a0.016
disp1dispatched homolog 1 (Drosophila)0.015
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.013
dmddystrophin0.012
ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.012
chd7chromodomain helicase DNA binding protein 70.011
lamb2laminin, beta 2 (laminin S)0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
traltrailer hitch0.055
Nup214Nucleoporin 2140.052
MtorMegator0.044
CG31739CG31739 gene product from transcript CG31739-RA0.029
embembargoed0.021
wechCG42396 gene product from transcript CG42396-RC0.021
Edc3Enhancer of decapping 30.020
CDC45LCG3658 gene product from transcript CG3658-RA0.017
Tao-1CG14217 gene product from transcript CG14217-RF0.017
CG2926CG2926 gene product from transcript CG2926-RA0.017
Nup98Nucleoporin 980.015
CG8108CG8108 gene product from transcript CG8108-RA0.015
Top2Topoisomerase 20.015
CG7332CG7332 gene product from transcript CG7332-RA0.014
CG9776CG9776 gene product from transcript CG9776-RA0.014
Nup160Nucleoporin 1600.013
MEP-1CG1244 gene product from transcript CG1244-RG0.012
dalaoCG7055 gene product from transcript CG7055-RA0.012
Nup153Nucleoporin 1530.011
Upf1CG1559 gene product from transcript CG1559-RA0.011
rinrasputin0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
KPNB1karyopherin (importin) beta 11.000
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.995
RANRAN, member RAS oncogene family0.993
IPO7importin 70.811
IPO5importin 50.661
NUP153nucleoporin 153kDa0.583
RAD21RAD21 homolog (S. pombe)0.481
RECQLRecQ protein-like (DNA helicase Q1-like)0.466
DDX21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.349
KPNA3karyopherin alpha 3 (importin alpha 4)0.323
NUP50nucleoporin 50kDa0.311
TNPO1transportin 10.239
LBRlamin B receptor0.237
AMD1adenosylmethionine decarboxylase 10.170
KPNA4karyopherin alpha 4 (importin alpha 3)0.168
XPO1exportin 1 (CRM1 homolog, yeast)0.124
NUP98nucleoporin 98kDa0.099
MESDC2mesoderm development candidate 20.096
NLKnemo-like kinase0.091
XPO5exportin 50.078
EIF1AXeukaryotic translation initiation factor 1A, X-linked0.073
RPL7ribosomal protein L70.065
ETF1eukaryotic translation termination factor 10.063
BAZ1Abromodomain adjacent to zinc finger domain, 1A0.062
XPOTexportin, tRNA (nuclear export receptor for tRNAs)0.061
NAA15N(alpha)-acetyltransferase 15, NatA auxiliary subunit0.060
UBA2ubiquitin-like modifier activating enzyme 20.054
CDAN1congenital dyserythropoietic anemia, type I0.034
RANBP2RAN binding protein 20.032
AHCTF1AT hook containing transcription factor 10.031
SACSspastic ataxia of Charlevoix-Saguenay (sacsin)0.030
RANBP1RAN binding protein 10.030
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.027
PTMAprothymosin, alpha0.026
HSPD1heat shock 60kDa protein 1 (chaperonin)0.026
CSE1LCSE1 chromosome segregation 1-like (yeast)0.025
UTRNutrophin0.024
DNM1Ldynamin 1-like0.023
EIF3Jeukaryotic translation initiation factor 3, subunit J0.021
KIF5Bkinesin family member 5B0.021
APCadenomatous polyposis coli0.020
DMDdystrophin0.020
GTPBP4GTP binding protein 40.019
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.018
MAXMYC associated factor X0.018
CHEK2CHK2 checkpoint homolog (S. pombe)0.018
HDAC2histone deacetylase 20.017
FBXO30F-box protein 300.017
RCC1regulator of chromosome condensation 10.016
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.016
XPO7exportin 70.015
NXF1nuclear RNA export factor 10.015
C10orf18chromosome 10 open reading frame 180.015
GSPT1G1 to S phase transition 10.015
SETSET nuclear oncogene0.015
EIF4Eeukaryotic translation initiation factor 4E0.014
YTHDF2YTH domain family, member 20.013
PSME4proteasome (prosome, macropain) activator subunit 40.013
GCN1L1GCN1 general control of amino-acid synthesis 1-like 1 (yeast)0.013
ARID4BAT rich interactive domain 4B (RBP1-like)0.013
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.013
CBX5chromobox homolog 50.012
SMSspermine synthase0.012
CRY1cryptochrome 1 (photolyase-like)0.012
E2F3E2F transcription factor 30.012
TCERG1transcription elongation regulator 10.011
MSH6mutS homolog 6 (E. coli)0.011
PPP2R5Eprotein phosphatase 2, regulatory subunit B', epsilon isoform0.011
MAPRE1microtubule-associated protein, RP/EB family, member 10.011
CBX1chromobox homolog 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
NSP1Nsp1p0.867
NUP49Nup49p0.789
NUP1Nup1p0.571
MEX67Mex67p0.474
NUP82Nup82p0.442
NUP2Nup2p0.438
NUP116Nup116p0.432
NIC96Nic96p0.319
NUP157Nup157p0.310
GLE2Gle2p0.179
KAP95Kap95p0.168
CSE1Cse1p0.129
NUP100Nup100p0.088
NUP192Nup192p0.077
NUP145Nup145p0.054
NUP85Nup85p0.041
POM152Pom152p0.039
URA2Ura2p0.039
NUP170Nup170p0.034
NUP42Nup42p0.031
NUP57Nup57p0.030
GLE1Gle1p0.025
HOHop0.023
KAP104Kap104p0.022
NUP188Nup188p0.022
YLR264C-Ahypothetical protein0.022
SRD1Srd1p0.021
CRM1Crm1p0.020
ARP10Arp10p0.020
CAR1Car1p0.019
YAR068Whypothetical protein0.019
LEU2Leu2p0.018
RSC8Rsc8p0.018
YLR162Whypothetical protein0.017
MER1Mer1p0.017
YOL038C-Ahypothetical protein0.017
POM34Pom34p0.016
SPO74Spo74p0.016
MLP2Mlp2p0.016
YLR042Chypothetical protein0.016
YAR066Whypothetical protein0.015
URA3Ura3p0.015
ARG8Arg8p0.015
CUP1-1Cup1-1p0.015
YPR157Whypothetical protein0.014
ATP6Atp6p0.014
ZPS1Zps1p0.014
HXT3Hxt3p0.013
SPL2Spl2p0.013
YLR040Chypothetical protein0.013
AUA1Aua1p0.013
HPF1Hpf1p0.013
YIR035Chypothetical protein0.013
YBR013Chypothetical protein0.012
YOL013W-Ahypothetical protein0.012
PRS2Prs2p0.012
FMT1Fmt1p0.012
MF(ALPHA)2Mf(alpha)2p0.012
YJL218Whypothetical protein0.012
SCM4Scm4p0.012
SWC7Swc7p0.012
IZH4Izh4p0.012
YAL064Whypothetical protein0.011
COS12Cos12p0.011
HHT2Hht2p0.011
NUP159Nup159p0.011
DIC1Dic1p0.011
MF(ALPHA)1Mf(alpha)1p0.011
CPD1Cpd1p0.011
BSC1Bsc1p0.011
OPT2Opt2p0.011
YIL151Chypothetical protein0.011
YAL037C-Ahypothetical protein0.011
YPR096Chypothetical protein0.011
BIO2Bio2p0.011
SRP54Srp54p0.011
NRG2Nrg2p0.011
ADH2Adh2p0.011
YPL067Chypothetical protein0.010
BRN1Brn1p0.010
CRP1Crp1p0.010
TSC3Tsc3p0.010
PTI1Pti1p0.010
MET8Met8p0.010
PTR2Ptr2p0.010
NDC1Ndc1p0.010
UPS3Ups3p0.010
ALT2Alt2p0.010
YJL160Chypothetical protein0.010
YKR075Chypothetical protein0.010