The network for 'positive regulation of cell killing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cell killing

Any process that activates or increases the frequency, rate or extent of cell killing.

NameDescriptionProbabilityFunc Analog Organism
B2mbeta-2 microglobulin0.997
H2-K1histocompatibility 2, K1, K region0.993
H2-D1histocompatibility 2, D region locus 10.992
FynFyn proto-oncogene0.959
Slamf1signaling lymphocytic activation molecule family member 10.951
Klrk1killer cell lectin-like receptor subfamily K, member 10.948
TapbpTAP binding protein0.941
Klra9killer cell lectin-like receptor subfamily A, member 90.883
H2-Q7histocompatibility 2, Q region locus 70.850
Klrc1killer cell lectin-like receptor subfamily C, member 10.736
Lcklymphocyte protein tyrosine kinase0.725
FaslFas ligand (TNF superfamily, member 6)0.702
Gzmagranzyme A0.638
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.616
Stat5bsignal transducer and activator of transcription 5B0.542
Pnp2purine-nucleoside phosphorylase 20.526
Il2interleukin 20.511
Gzmkgranzyme K0.505
Stat5asignal transducer and activator of transcription 5A0.497
Irgm2immunity-related GTPase family M member 20.458
Ncr1natural cytotoxicity triggering receptor 10.433
Gzmbgranzyme B0.428
Cxcl2chemokine (C-X-C motif) ligand 20.408
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.406
Xcl1chemokine (C motif) ligand 10.399
TcraT-cell receptor alpha chain0.373
Irf9interferon regulatory factor 90.359
Icosinducible T-cell co-stimulator0.318
H2-Q6histocompatibility 2, Q region locus 60.286
ItkIL2-inducible T-cell kinase0.272
Lyz2lysozyme 20.265
Il18rapinterleukin 18 receptor accessory protein0.257
Il2rainterleukin 2 receptor, alpha chain0.228
Il2rginterleukin 2 receptor, gamma chain0.222
Il6interleukin 60.222
Il2rbinterleukin 2 receptor, beta chain0.220
Klrd1killer cell lectin-like receptor, subfamily D, member 10.219
Cd244CD244 natural killer cell receptor 2B40.213
Il18r1interleukin 18 receptor 10.193
Klra8killer cell lectin-like receptor, subfamily A, member 80.177
Sh2d2aSH2 domain protein 2A0.170
Ctswcathepsin W0.168
Cd28CD28 antigen0.155
Xcr1chemokine (C motif) receptor 10.149
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.142
Latlinker for activation of T cells0.139
Sh2d1aSH2 domain protein 1A0.135
Il1rninterleukin 1 receptor antagonist0.124
Cd160CD160 antigen0.122
Cd247CD247 antigen0.121
Ciitaclass II transactivator0.103
Sh2d1b1SH2 domain protein 1B10.102
Ctla4cytotoxic T-lymphocyte-associated protein 40.100
Tnip1TNFAIP3 interacting protein 10.100
Irg1immunoresponsive gene 10.086
Zfp36zinc finger protein 360.085
C920025E04RikRIKEN cDNA C920025E04 gene0.081
Ccl3chemokine (C-C motif) ligand 30.078
Ccr9chemokine (C-C motif) receptor 90.076
Klrb1akiller cell lectin-like receptor subfamily B member 1A0.074
Itm2bintegral membrane protein 2B0.073
Gbp2guanylate binding protein 20.071
Ccr3chemokine (C-C motif) receptor 30.071
Ccr1chemokine (C-C motif) receptor 10.069
Klra7killer cell lectin-like receptor, subfamily A, member 70.069
Stat1signal transducer and activator of transcription 10.069
Stat3signal transducer and activator of transcription 30.067
Ccl5chemokine (C-C motif) ligand 50.067
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.066
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.066
Cd8aCD8 antigen, alpha chain0.065
H2-Q5histocompatibility 2, Q region locus 50.064
Spna1spectrin alpha 10.064
Klra3killer cell lectin-like receptor, subfamily A, member 30.064
Ccl4chemokine (C-C motif) ligand 40.064
Gzmcgranzyme C0.064
Nckap1lNCK associated protein 1 like0.063
Trim21tripartite motif-containing 210.061
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.059
FasFas (TNF receptor superfamily member 6)0.056
Mmp13matrix metallopeptidase 130.055
Foxp3forkhead box P30.055
Clec4dC-type lectin domain family 4, member d0.054
Lystlysosomal trafficking regulator0.054
Cd80CD80 antigen0.053
Klrg1killer cell lectin-like receptor subfamily G, member 10.053
H2-M2histocompatibility 2, M region locus 20.053
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.053
Chl1cell adhesion molecule with homology to L1CAM0.052
H2-Q8histocompatibility 2, Q region locus 80.052
Il4rainterleukin 4 receptor, alpha0.050
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.049
Klre1killer cell lectin-like receptor family E member 10.049
Gbp7guanylate binding protein 70.049
Lair1leukocyte-associated Ig-like receptor 10.049
Slamf7SLAM family member 70.048
Ptgirprostaglandin I receptor (IP)0.048
Il7rinterleukin 7 receptor0.048
Seleselectin, endothelial cell0.048
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.048
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.163
mcl1amyeloid cell leukemia sequence 1a0.161
scarb1scavenger receptor class B, member 10.149
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.126
ednrb1endothelin receptor B0.099
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.096
stat1asignal transduction and activation of transcription 1a0.090
gabarapaGABA(A) receptor-associated protein a0.083
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.082
pax7bpaired box gene 7b0.082
LOC566020Gig2-like protein DreO0.079
apaf1apoptotic protease activating factor 10.065
sqstm1sequestosome 10.061
g6pdglucose-6-phosphate dehydrogenase0.059
ifnphi1interferon phi 10.058
prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a0.056
npy4rneuropeptide Y receptor Y40.055
styk1serine/threonine/tyrosine kinase 10.051
tbpTATA box binding protein0.051
gsk3bglycogen synthase kinase 3 beta0.051
map1lc3amicrotubule-associated protein 1 light chain 3 alpha0.049
irf11interferon regulatory factor 110.048
sdcbpsyndecan binding protein (syntenin)0.048
gmfgglia maturation factor, gamma0.047
ptpn6protein tyrosine phosphatase, non-receptor type 60.045
psmb9aproteasome (prosome, macropain) subunit, beta type, 9a0.045
stxbp2syntaxin binding protein 20.041
znf148zinc finger protein 1480.040
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.040
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.039
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.039
wacaWW domain containing adaptor with coiled-coil a0.037
phox2apaired-like homeobox 2a0.037
foxp3aforkhead box P3a0.037
ddr2bdiscoidin domain receptor family, member 2b0.036
cxcr3.2chemokine (C-X-C motif) receptor 3.20.036
casp9caspase 9, apoptosis-related cysteine protease0.035
casp8caspase 8, apoptosis-related cysteine peptidase0.034
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.033
cflarCASP8 and FADD-like apoptosis regulator0.033
isg15ISG15 ubiquitin-like modifier0.033
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.033
rhogbras homolog gene family, member Gb0.032
LOC567441interferon-induced protein with tetratricopeptide repeats 5-like0.031
ptger2bprostaglandin E receptor 2b (subtype EP2)0.031
itln1intelectin 10.031
coro1acoronin, actin binding protein, 1A0.031
litaflipopolysaccharide-induced TNF factor0.030
phrf1PHD and ring finger domains 10.030
gnsbglucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b0.029
abl1c-abl oncogene 1, non-receptor tyrosine kinase0.029
LOC567131calcitonin gene-related peptide type 1 receptor-like0.029
grnagranulin a0.029
cxc46CXC chemokine 460.029
fbxo32F-box protein 320.029
pkzprotein kinase containing Z-DNA binding domains0.028
faddFas (tnfrsf6)-associated via death domain0.028
hdac4histone deacetylase 40.028
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.028
stat1bsignal transducer and activator of transcription 1b0.028
npy7rneuropeptide Y receptor Y70.028
camk2g2calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 20.028
nitr9novel immune-type receptor 90.027
pcsk7proprotein convertase subtilisin/kexin type 70.027
irak4interleukin-1 receptor-associated kinase 40.027
ptk6aPTK6 protein tyrosine kinase 6a0.027
illr1immune-related, lectin-like receptor 10.026
tbc1d15TBC1 domain family, member 150.026
eomesbeomesodermin homolog b0.026
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.026
c1qccomplement component 1, q subcomponent, C chain0.026
il10interleukin 100.026
tlr9toll-like receptor 90.026
LOC793458peptide Y-like0.026
lrrc33leucine rich repeat containing 330.025
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.025
mxamyxovirus (influenza) resistance A0.025
zfyve28zinc finger, FYVE domain containing 280.025
cd8aCD8 antigen, alpha polypeptide0.025
defbl3defensin, beta-like 30.025
ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.024
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.024
LOC794786interferon-induced protein with tetratricopeptide repeats 1-like0.024
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.024
ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.024
gab1GRB2-associated binding protein 10.023
k31k31 gene0.023
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-Cmajor histocompatibility complex, class I, C0.936
HLA-Amajor histocompatibility complex, class I, A0.927
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.906
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.865
HLA-Bmajor histocompatibility complex, class I, B0.668
KLRD1killer cell lectin-like receptor subfamily D, member 10.652
HLA-Fmajor histocompatibility complex, class I, F0.585
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.567
IL2RBinterleukin 2 receptor, beta0.557
HLA-Gmajor histocompatibility complex, class I, G0.477
CCL4chemokine (C-C motif) ligand 40.408
SH2D1ASH2 domain containing 1A0.340
HLA-Emajor histocompatibility complex, class I, E0.327
SLAMF1signaling lymphocytic activation molecule family member 10.309
CD84CD84 molecule0.258
IL8interleukin 80.240
CCL5chemokine (C-C motif) ligand 50.234
CCR5chemokine (C-C motif) receptor 50.232
NOSTRINnitric oxide synthase trafficker0.208
IFNGinterferon, gamma0.177
CXCL3chemokine (C-X-C motif) ligand 30.173
TAPBPTAP binding protein (tapasin)0.149
CXCL2chemokine (C-X-C motif) ligand 20.137
KLRK1killer cell lectin-like receptor subfamily K, member 10.113
GBAglucosidase, beta, acid0.111
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.105
IL6interleukin 6 (interferon, beta 2)0.091
CXCL9chemokine (C-X-C motif) ligand 90.089
IL1Binterleukin 1, beta0.081
IL23Ainterleukin 23, alpha subunit p190.069
CCR7chemokine (C-C motif) receptor 70.063
DPP4dipeptidyl-peptidase 40.056
BCL2B-cell CLL/lymphoma 20.055
FASLGFas ligand (TNF superfamily, member 6)0.054
CAV1caveolin 1, caveolae protein, 22kDa0.052
CASP10caspase 10, apoptosis-related cysteine peptidase0.051
CCL8chemokine (C-C motif) ligand 80.049
GZMKgranzyme K (granzyme 3; tryptase II)0.046
CCL13chemokine (C-C motif) ligand 130.041
KLRC3killer cell lectin-like receptor subfamily C, member 30.040
CCL19chemokine (C-C motif) ligand 190.038
ITM2Bintegral membrane protein 2B0.038
CCL20chemokine (C-C motif) ligand 200.037
IL18RAPinterleukin 18 receptor accessory protein0.034
CASP8caspase 8, apoptosis-related cysteine peptidase0.034
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.031
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.028
CXCR6chemokine (C-X-C motif) receptor 60.028
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.028
CXCL10chemokine (C-X-C motif) ligand 100.028
RNF13ring finger protein 130.027
CCL2chemokine (C-C motif) ligand 20.027
CCL22chemokine (C-C motif) ligand 220.026
ITKIL2-inducible T-cell kinase0.025
PVRL4poliovirus receptor-related 40.025
GPR171G protein-coupled receptor 1710.025
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.024
XCL2chemokine (C motif) ligand 20.024
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.024
VCAM1vascular cell adhesion molecule 10.024
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.024
BAXBCL2-associated X protein0.023
BIDBH3 interacting domain death agonist0.022
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.022
KLRC2killer cell lectin-like receptor subfamily C, member 20.022
IL10interleukin 100.021
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.021
CCL7chemokine (C-C motif) ligand 70.021
RGS1regulator of G-protein signaling 10.021
IRF4interferon regulatory factor 40.020
CXCL13chemokine (C-X-C motif) ligand 130.020
STAT4signal transducer and activator of transcription 40.020
CD2CD2 molecule0.019
PRF1perforin 1 (pore forming protein)0.019
CCR4chemokine (C-C motif) receptor 40.019
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.019
CCL3chemokine (C-C motif) ligand 30.018
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D0.018
IL7Rinterleukin 7 receptor0.017
KLRB1killer cell lectin-like receptor subfamily B, member 10.017
UBDubiquitin D0.016
GZMAgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)0.016
CD48CD48 molecule0.015
CXCL5chemokine (C-X-C motif) ligand 50.015
TNFtumor necrosis factor0.015
STAP2signal transducing adaptor family member 20.015
IDEinsulin-degrading enzyme0.015
ICOSinducible T-cell co-stimulator0.015
MMP12matrix metallopeptidase 12 (macrophage elastase)0.015
BCL2L1BCL2-like 10.015
ICAM1intercellular adhesion molecule 10.014
NKG7natural killer cell group 7 sequence0.014
SH2D1BSH2 domain containing 1B0.014
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.014
KLRF1killer cell lectin-like receptor subfamily F, member 10.013
NSFN-ethylmaleimide-sensitive factor0.013
SELEselectin E0.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-EC2RT1 class Ib, locus EC20.666
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.298
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.204
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.165
Hsph1heat shock 105/110 protein 10.161
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.137
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.121
Cxcl10chemokine (C-X-C motif) ligand 100.069
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.066
RT1-CE12RT1 class I, locus CE120.040
Atf3activating transcription factor 30.039
LOC100364500RT1 class I, locus CE11-like0.038
Il2rbinterleukin 2 receptor, beta0.037
Mcpt8mast cell protease 80.032
Klrd1killer cell lectin-like receptor, subfamily D, member 10.030
Hspb1heat shock protein 10.025
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.025
Gbp2guanylate binding protein 20.023
Cd5Cd5 molecule0.022
Aif1allograft inflammatory factor 10.019
Cd2Cd2 molecule0.018
Nkg7natural killer cell group 7 sequence0.018
Gzmkgranzyme K0.018
Fut2fucosyltransferase 2 (secretor status included)0.017
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.015
RT1-S3RT1 class Ib, locus S30.014
Serpinb9serpin peptidase inhibitor, clade B (ovalbumin), member 90.013
Cacng1calcium channel, voltage-dependent, gamma subunit 10.013
Sept1septin 10.013
Ccl5chemokine (C-C motif) ligand 50.013
Il1binterleukin 1 beta0.013
Csf1colony stimulating factor 1 (macrophage)0.012
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.012
Ccl7chemokine (C-C motif) ligand 70.012
Nrasneuroblastoma ras oncogene0.012
GperG protein-coupled estrogen receptor 10.012
Asah1N-acylsphingosine amidohydrolase (acid ceramidase) 10.011
Rhohras homolog gene family, member H0.010
Cd247Cd247 molecule0.010
Stip1stress-induced phosphoprotein 10.010
Calcrlcalcitonin receptor-like0.010
Ly6cLy6-C antigen0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism