The network for 'regulation of symbiosis encompassing mutualism through parasitism' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of symbiosis encompassing mutualism through parasitism

Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association.

NameDescriptionProbabilityFunc Analog Organism
Irf7interferon regulatory factor 70.960
Tnftumor necrosis factor0.937
Rtp4receptor transporter protein 40.906
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.902
Gbp7guanylate binding protein 70.871
Rsad2radical S-adenosyl methionine domain containing 20.869
Slfn4schlafen 40.862
Parp14poly (ADP-ribose) polymerase family, member 140.859
Usp18ubiquitin specific peptidase 180.844
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.838
Cxcl10chemokine (C-X-C motif) ligand 100.830
Oas32'-5' oligoadenylate synthetase 30.828
Ifnginterferon gamma0.826
Ccl2chemokine (C-C motif) ligand 20.819
Ccl4chemokine (C-C motif) ligand 40.775
Mx2myxovirus (influenza virus) resistance 20.773
Zbp1Z-DNA binding protein 10.770
Ifi44interferon-induced protein 440.745
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.734
Tor3atorsin family 3, member A0.731
Uba7ubiquitin-like modifier activating enzyme 70.720
Trp53transformation related protein 530.670
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.669
Ifit1interferon-induced protein with tetratricopeptide repeats 10.621
Ctsgcathepsin G0.617
Isg15ISG15 ubiquitin-like modifier0.592
Il10interleukin 100.573
Ifi35interferon-induced protein 350.554
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.553
TapbpTAP binding protein0.549
Trim30atripartite motif-containing 30A0.542
Oasl12'-5' oligoadenylate synthetase-like 10.497
Trim30dtripartite motif-containing 30D0.496
Irf1interferon regulatory factor 10.463
Mx1myxovirus (influenza virus) resistance 10.459
Irf9interferon regulatory factor 90.449
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.446
Ezh2enhancer of zeste homolog 2 (Drosophila)0.444
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.409
Irgm1immunity-related GTPase family M member 10.388
Ube2l6ubiquitin-conjugating enzyme E2L 60.378
Ifit3interferon-induced protein with tetratricopeptide repeats 30.362
Irf8interferon regulatory factor 80.353
Bcl2B-cell leukemia/lymphoma 20.325
Campcathelicidin antimicrobial peptide0.313
Xcl1chemokine (C motif) ligand 10.299
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.299
FaslFas ligand (TNF superfamily, member 6)0.298
Stat1signal transducer and activator of transcription 10.298
Gzmbgranzyme B0.289
Unc93b1unc-93 homolog B1 (C. elegans)0.282
Oas1a2'-5' oligoadenylate synthetase 1A0.279
Icam1intercellular adhesion molecule 10.273
Casp4caspase 4, apoptosis-related cysteine peptidase0.270
Tlr4toll-like receptor 40.266
Bak1BCL2-antagonist/killer 10.259
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.246
Ngpneutrophilic granule protein0.245
Socs1suppressor of cytokine signaling 10.240
Samhd1SAM domain and HD domain, 10.235
Casp1caspase 10.233
Parp12poly (ADP-ribose) polymerase family, member 120.229
Sp3trans-acting transcription factor 30.217
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.212
Oas22'-5' oligoadenylate synthetase 20.208
Cd19CD19 antigen0.208
Eif2c1eukaryotic translation initiation factor 2C, 10.206
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.201
Igtpinterferon gamma induced GTPase0.199
Hdac2histone deacetylase 20.182
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.179
Cd44CD44 antigen0.177
Plac8placenta-specific 80.173
Trim25tripartite motif-containing 250.170
Trim21tripartite motif-containing 210.169
Sfpi1SFFV proviral integration 10.160
Ccr2chemokine (C-C motif) receptor 20.157
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.155
Lag3lymphocyte-activation gene 30.153
Tlr2toll-like receptor 20.153
Xaf1XIAP associated factor 10.152
Ifi47interferon gamma inducible protein 470.150
Irgm2immunity-related GTPase family M member 20.150
Elaneelastase, neutrophil expressed0.149
Ubdubiquitin D0.147
Klrk1killer cell lectin-like receptor subfamily K, member 10.144
Ifih1interferon induced with helicase C domain 10.143
Irg1immunoresponsive gene 10.142
Apoeapolipoprotein E0.142
Gbp3guanylate binding protein 30.140
Nos2nitric oxide synthase 2, inducible0.140
Ifitm3interferon induced transmembrane protein 30.139
Mtf2metal response element binding transcription factor 20.134
Slfn1schlafen 10.133
Slfn8schlafen 80.130
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.130
Rbbp4retinoblastoma binding protein 40.129
Il23ainterleukin 23, alpha subunit p190.125
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
ifnphi1interferon phi 10.172
tp53tumor protein p530.158
pkzprotein kinase containing Z-DNA binding domains0.139
xbp1X-box binding protein 10.139
LOC557072caspase recruitment domain-containing protein 11-like0.135
mibmind bomb0.108
wnt3wingless-type MMTV integration site family, member 30.093
stc1lstanniocalcin 1, like0.085
itgb3bintegrin beta 3b0.077
il1binterleukin 1, beta and interleukin 1, beta0.067
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.066
il6stinterleukin 6 signal transducer0.065
maffv-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)0.062
sult3st1sulfotransferase family 3, cytosolic sulfotransferase 10.060
stat1bsignal transducer and activator of transcription 1b0.059
tlr9toll-like receptor 90.059
ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.057
tm9sf2transmembrane 9 superfamily member 20.055
prox1prospero-related homeobox gene 10.053
LOC100004946transient receptor potential cation channel subfamily M member 4-like0.052
LOC100005232Gig2-like protein DreD0.050
nos2anitric oxide synthase 2a, inducible0.047
nod1nucleotide-binding oligomerization domain containing 10.047
creb3l3lcAMP responsive element binding protein 3-like 3 like0.045
ifng1-2interferon, gamma 1-20.045
dzip1DAZ interacting protein 10.045
tlr3toll-like receptor 30.044
LOC100000934hypothetical protein LOC1000009340.044
LOC566020Gig2-like protein DreO0.044
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.043
slc15a1bsolute carrier family 15 (oligopeptide transporter), member 1b0.043
chmp4bchromatin modifying protein 4B0.043
masp2mannan-binding lectin serine peptidase 20.042
casp8caspase 8, apoptosis-related cysteine peptidase0.042
tlr20ftoll-like receptor 20f0.042
baxabcl2-associated X protein, a0.041
pbrm1lpolybromo 1, like0.041
srsf2serine/arginine-rich splicing factor 20.039
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.039
ilf3ainterleukin enhancer binding factor 3a0.038
ppigpeptidyl-prolyl isomerase G (cyclophilin G)0.038
tardbpTAR DNA binding protein0.037
cd8aCD8 antigen, alpha polypeptide0.036
puf60bpoly-U binding splicing factor b0.036
mbtps1membrane-bound transcription factor protease, site 10.036
faddFas (tnfrsf6)-associated via death domain0.035
card14caspase recruitment domain family, member 140.035
tpd52l2atumor protein D52-like 2a0.035
cul1acullin 1a0.035
mxamyxovirus (influenza) resistance A0.034
ewsr1aEwing sarcoma breakpoint region 1a0.033
snrnp70small nuclear ribonucleoprotein 70 (U1)0.033
srrtserrate RNA effector molecule homolog (Arabidopsis)0.033
irf3interferon regulatory factor 30.033
barhl1.2BarH-like 1.20.032
prkciprotein kinase C, iota0.032
trpc6transient receptor potential cation channel, subfamily C, member 60.032
barhl1.1BarH-like 1.10.032
pdcd2programmed cell death 20.032
hnrnpmheterogeneous nuclear ribonucleoprotein M0.031
lrmplymphoid-restricted membrane protein0.031
cdk7cyclin-dependent kinase 70.031
card9caspase recruitment domain family, member 90.030
vasavasa homolog0.030
esr1estrogen receptor 10.030
pbx4pre-B-cell leukemia transcription factor 40.030
nos2bnitric oxide synthase 2b, inducible0.029
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.029
itih2inter-alpha (globulin) inhibitor H20.029
fras1Fraser syndrome 10.029
myd88myeloid differentiation primary response gene (88)0.029
ss18synovial sarcoma translocation, chromosome 18 (H. sapiens)0.029
cxc46CXC chemokine 460.028
cyp2aa1cytochrome P450, family 2, subfamily AA, polypeptide 10.028
smad5MAD homolog 5 (Drosophila)0.028
tlr22toll-like receptor 220.028
aldh8a1aldehyde dehydrogenase 8 family, member A10.028
lhbluteinizing hormone, beta polypeptide0.028
itkIL2-inducible T-cell kinase0.028
psma6bproteasome (prosome, macropain) subunit, alpha type, 6b0.028
acvr1lactivin A receptor, type I like0.027
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.027
sdf4stromal cell derived factor 40.027
ip6k2inositol hexaphosphate kinase 20.027
ticam1toll-like receptor adaptor molecule 10.027
rab5abRAB5A, member RAS oncogene family, b0.027
slc37a4asolute carrier family 37 (glucose-6-phosphate transporter), member 4a0.027
acp5bacid phosphatase 5b, tartrate resistant0.027
tlr20atoll-like receptor 20a0.027
hdac1histone deacetylase 10.027
sart3squamous cell carcinoma antigen recognised by T cells 30.027
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CTCFCG8591 gene product from transcript CG8591-RA0.074
CG3918CG3918 gene product from transcript CG3918-RA0.063
CG10103CG10103 gene product from transcript CG10103-RA0.057
CHMP2BCharged multivesicular body protein 2b0.051
vps2CG14542 gene product from transcript CG14542-RA0.041
LanB2Laminin B20.037
HmgcrHMG Coenzyme A reductase0.033
CG4968CG4968 gene product from transcript CG4968-RA0.030
CG6259CG6259 gene product from transcript CG6259-RA0.029
Chmp1CG4108 gene product from transcript CG4108-RA0.028
Vps25Vacuolar protein sorting 250.023
CG7967CG7967 gene product from transcript CG7967-RA0.023
vps24Charged multivesicular body protein 30.021
McrMacroglobulin complement-related0.020
jubAjuba LIM protein0.019
Vps20Vacuolar protein sorting 200.018
M6CG7540 gene product from transcript CG7540-RA0.017
ird1immune response deficient 10.016
CG10107CG10107 gene product from transcript CG10107-RA0.015
RfabgRetinoid- and fatty acid-binding glycoprotein0.014
Pi3K92ECG4141 gene product from transcript CG4141-RB0.014
KhcKinesin heavy chain0.013
CG8108CG8108 gene product from transcript CG8108-RA0.013
CG2224CG2224 gene product from transcript CG2224-RA0.013
ScmSex comb on midleg0.013
CG14317CG14317 gene product from transcript CG14317-RA0.013
18w18 wheeler0.012
ph-ppolyhomeotic proximal0.012
Rpd3CG7471 gene product from transcript CG7471-RA0.012
ATP7CG1886 gene product from transcript CG1886-RB0.012
CdsACDP diglyceride synthetase0.012
coroCG9446 gene product from transcript CG9446-RC0.012
Bap55Brahma associated protein 55kD0.012
Ten-mTenascin major0.012
Vap-33-1CG5014 gene product from transcript CG5014-RB0.012
DlicDynein light intermediate chain0.011
Sgt1CG9617 gene product from transcript CG9617-RA0.011
Drp1Dynamin related protein 10.011
SPESpatzle-Processing Enzyme0.011
CG14071CG14071 gene product from transcript CG14071-RA0.011
PezCG9493 gene product from transcript CG9493-RA0.011
CG4686CG4686 gene product from transcript CG4686-RA0.011
StimStromal interaction molecule0.010
Fak56DFocal Adhesion Kinase0.010
TSG101tumor suppressor protein 1010.010
rheaCG6831 gene product from transcript CG6831-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.997
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.997
IFI44interferon-induced protein 440.993
SP110SP110 nuclear body protein0.993
IFIT3interferon-induced protein with tetratricopeptide repeats 30.990
IFITM1interferon induced transmembrane protein 1 (9-27)0.989
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.989
SP1Sp1 transcription factor0.988
JUNjun proto-oncogene0.986
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.981
ISG15ISG15 ubiquitin-like modifier0.972
UBE2L6ubiquitin-conjugating enzyme E2L 60.972
TRIM21tripartite motif containing 210.971
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.964
IFI44Linterferon-induced protein 44-like0.950
CXCL10chemokine (C-X-C motif) ligand 100.942
IFIT1interferon-induced protein with tetratricopeptide repeats 10.920
DTX3Ldeltex 3-like (Drosophila)0.917
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.916
MX2myxovirus (influenza virus) resistance 2 (mouse)0.915
IRF9interferon regulatory factor 90.905
MYD88myeloid differentiation primary response gene (88)0.905
HDAC1histone deacetylase 10.888
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.878
IFITM3interferon induced transmembrane protein 3 (1-8U)0.874
IFIH1interferon induced with helicase C domain 10.874
SKILSKI-like oncogene0.839
SMAD3SMAD family member 30.821
XAF1XIAP associated factor 10.820
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.810
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.788
STAT1signal transducer and activator of transcription 1, 91kDa0.756
CXCL2chemokine (C-X-C motif) ligand 20.746
TP53tumor protein p530.743
OASL2'-5'-oligoadenylate synthetase-like0.740
FHL2four and a half LIM domains 20.728
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.727
HIPK2homeodomain interacting protein kinase 20.727
IL8interleukin 80.721
IFIT2interferon-induced protein with tetratricopeptide repeats 20.719
PTPN23protein tyrosine phosphatase, non-receptor type 230.708
IFI35interferon-induced protein 350.706
IFI6interferon, alpha-inducible protein 60.704
IFITM2interferon induced transmembrane protein 2 (1-8D)0.698
CXCL3chemokine (C-X-C motif) ligand 30.695
IRF7interferon regulatory factor 70.687
PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)0.680
SMAD4SMAD family member 40.647
FOSFBJ murine osteosarcoma viral oncogene homolog0.643
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.636
CXCL9chemokine (C-X-C motif) ligand 90.620
CXCL11chemokine (C-X-C motif) ligand 110.615
TAPBPTAP binding protein (tapasin)0.611
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.609
CCR5chemokine (C-C motif) receptor 50.595
TRIM39tripartite motif containing 390.593
DICER1dicer 1, ribonuclease type III0.574
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.564
CCL4chemokine (C-C motif) ligand 40.554
CCL8chemokine (C-C motif) ligand 80.532
WWP2WW domain containing E3 ubiquitin protein ligase 20.526
DPP4dipeptidyl-peptidase 40.518
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.498
IFI27interferon, alpha-inducible protein 270.460
PMLpromyelocytic leukemia0.449
SP100SP100 nuclear antigen0.438
IL6interleukin 6 (interferon, beta 2)0.417
IFIT5interferon-induced protein with tetratricopeptide repeats 50.411
ESR1estrogen receptor 10.406
PARP12poly (ADP-ribose) polymerase family, member 120.394
CXCL5chemokine (C-X-C motif) ligand 50.390
NCOR1nuclear receptor corepressor 10.389
CCR7chemokine (C-C motif) receptor 70.388
RNF126ring finger protein 1260.378
GFM1G elongation factor, mitochondrial 10.369
KDM6Alysine (K)-specific demethylase 6A0.368
CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.361
FN1fibronectin 10.361
DYNC1I2dynein, cytoplasmic 1, intermediate chain 20.351
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.335
CCL5chemokine (C-C motif) ligand 50.335
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.330
ADARadenosine deaminase, RNA-specific0.330
CCL20chemokine (C-C motif) ligand 200.320
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.317
CCL2chemokine (C-C motif) ligand 20.300
VCAM1vascular cell adhesion molecule 10.296
RSAD2radical S-adenosyl methionine domain containing 20.296
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.292
TRIM22tripartite motif containing 220.282
TRIM41tripartite motif containing 410.277
PLSCR1phospholipid scramblase 10.273
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.265
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.263
BST2bone marrow stromal cell antigen 20.261
RBBP4retinoblastoma binding protein 40.254
ZNF263zinc finger protein 2630.251
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.248
SRPK2SRSF protein kinase 20.247
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.242
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rpl35ribosomal protein L350.038
Rps17ribosomal protein S170.024
Rps15ribosomal protein S150.012
Rpl7aribosomal protein L7a0.012
Ndufb2NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism