The network for 'pma inducible membrane protein ectodomain proteolysis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pma inducible membrane protein ectodomain proteolysis

The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist.

NameDescriptionProbabilityFunc Analog Organism
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.974
Jag1jagged 10.785
Egfrepidermal growth factor receptor0.575
Tgfb2transforming growth factor, beta 20.379
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.303
Tm9sf3transmembrane 9 superfamily member 30.289
Klf3Kruppel-like factor 3 (basic)0.282
Efnb2ephrin B20.268
Hbegfheparin-binding EGF-like growth factor0.226
Adam15a disintegrin and metallopeptidase domain 15 (metargidin)0.170
Adam9a disintegrin and metallopeptidase domain 9 (meltrin gamma)0.166
Hif1ahypoxia inducible factor 1, alpha subunit0.145
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.134
Rp2hretinitis pigmentosa 2 homolog (human)0.128
Hey2hairy/enhancer-of-split related with YRPW motif 20.123
Sos1son of sevenless homolog 1 (Drosophila)0.100
Cd44CD44 antigen0.098
Cxcr7chemokine (C-X-C motif) receptor 70.092
Ntf3neurotrophin 30.075
Nptnneuroplastin0.074
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.063
BC100451cDNA sequence BC1004510.061
Vmn1r44vomeronasal 1 receptor 440.058
Odf1outer dense fiber of sperm tails 10.054
Ggta1glycoprotein galactosyltransferase alpha 1, 30.052
Gnao1guanine nucleotide binding protein, alpha O0.046
Tgfbr1transforming growth factor, beta receptor I0.046
Sirpasignal-regulatory protein alpha0.045
Adam4a disintegrin and metallopeptidase domain 40.045
Cd46CD46 antigen, complement regulatory protein0.044
Glipr2GLI pathogenesis-related 20.043
H2afb1H2A histone family, member B10.038
Ptpn11protein tyrosine phosphatase, non-receptor type 110.034
Allcallantoicase0.033
Ncam2neural cell adhesion molecule 20.033
Tsga13testis specific gene A130.033
Nr6a1nuclear receptor subfamily 6, group A, member 10.032
Lyzl1lysozyme-like 10.030
Grb2growth factor receptor bound protein 20.030
Pros1protein S (alpha)0.030
Serpina5serine (or cysteine) peptidase inhibitor, clade A, member 50.030
Il6stinterleukin 6 signal transducer0.030
Apaf1apoptotic peptidase activating factor 10.029
Adam2a disintegrin and metallopeptidase domain 20.029
Iduaiduronidase, alpha-L-0.029
Cabyrcalcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)0.029
Dlg4discs, large homolog 4 (Drosophila)0.029
Npffneuropeptide FF-amide peptide precursor0.028
1700029F12RikRIKEN cDNA 1700029F12 gene0.028
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.027
Pde1bphosphodiesterase 1B, Ca2+-calmodulin dependent0.027
Dnm1dynamin 10.027
Aff2AF4/FMR2 family, member 20.027
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.026
Bollbol, boule-like (Drosophila)0.026
Cplx2complexin 20.026
2610015P09RikRIKEN cDNA 2610015P09 gene0.025
Mfsd1major facilitator superfamily domain containing 10.025
Slc4a8solute carrier family 4 (anion exchanger), member 80.024
Col20a1collagen, type XX, alpha 10.024
Ctnnb1catenin (cadherin associated protein), beta 10.023
Zfpm2zinc finger protein, multitype 20.023
Gata4GATA binding protein 40.023
Fkbp6FK506 binding protein 60.023
Asah1N-acylsphingosine amidohydrolase 10.023
Eps8epidermal growth factor receptor pathway substrate 80.023
Gfra4glial cell line derived neurotrophic factor family receptor alpha 40.022
Prnpprion protein0.022
Kif17kinesin family member 170.022
Cpne3copine III0.022
Olfr66olfactory receptor 660.022
Bpil1bactericidal/permeability-increasing protein-like 10.022
Dpysl4dihydropyrimidinase-like 40.022
Odf4outer dense fiber of sperm tails 40.021
4930544G11RikRIKEN cDNA 4930544G11 gene0.021
Fhl5four and a half LIM domains 50.021
Fam71f1family with sequence similarity 71, member F10.021
Actl7aactin-like 7a0.021
Slc25a2solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 20.020
Ncam1neural cell adhesion molecule 10.020
Mplmyeloproliferative leukemia virus oncogene0.020
Zfp444zinc finger protein 4440.020
1700129C05RikRIKEN cDNA 1700129C05 gene0.020
Jupjunction plakoglobin0.020
Nt5c1b5'-nucleotidase, cytosolic IB0.020
P4ha1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide0.019
Nr3c1nuclear receptor subfamily 3, group C, member 10.019
Syt11synaptotagmin XI0.019
1700018F24RikRIKEN cDNA 1700018F24 gene0.019
Epycepiphycan0.018
Col6a2collagen, type VI, alpha 20.018
Ubl4bubiquitin-like 4B0.018
Olfr64olfactory receptor 640.018
Csf2racolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.018
Far1fatty acyl CoA reductase 10.018
Tmod3tropomodulin 30.018
Rxfp2relaxin/insulin-like family peptide receptor 20.018
Plekho2pleckstrin homology domain containing, family O member 20.018
Opn1swopsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)0.018
Cd209cCD209c antigen0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ABI2abl-interactor 20.805
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.463
DLG1discs, large homolog 1 (Drosophila)0.175
SH3D19SH3 domain containing 190.046
SNX9sorting nexin 90.042
SNAP23synaptosomal-associated protein, 23kDa0.025
CPDcarboxypeptidase D0.022
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.018
RNF17ring finger protein 170.016
SNX33sorting nexin 330.015
SH3PXD2ASH3 and PX domains 2A0.015
ADAM10ADAM metallopeptidase domain 100.014
CD46CD46 molecule, complement regulatory protein0.014
DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 40.013
IFNGR1interferon gamma receptor 10.013
PICALMphosphatidylinositol binding clathrin assembly protein0.011
TMEM30Atransmembrane protein 30A0.010
RIT1Ras-like without CAAX 10.010
IL13RA1interleukin 13 receptor, alpha 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism