The network for 'rna phosphodiester bond hydrolysis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rna phosphodiester bond hydrolysis

The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis.

NameDescriptionProbabilityFunc Analog Organism
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.895
Ccdc86coiled-coil domain containing 860.223
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.150
Wdr43WD repeat domain 430.113
Mybbp1aMYB binding protein (P160) 1a0.112
Dhx15DEAH (Asp-Glu-Ala-His) box polypeptide 150.090
Atrataxia telangiectasia and Rad3 related0.086
Rsad2radical S-adenosyl methionine domain containing 20.077
Grwd1glutamate-rich WD repeat containing 10.076
Nop2NOP2 nucleolar protein homolog (yeast)0.075
Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.072
Tars2threonyl-tRNA synthetase 2, mitochondrial (putative)0.062
Utp20UTP20, small subunit (SSU) processome component, homolog (yeast)0.060
Dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.057
Dhx16DEAH (Asp-Glu-Ala-His) box polypeptide 160.054
Ppanpeter pan homolog (Drosophila)0.052
Angangiogenin, ribonuclease, RNase A family, 50.050
Mlh1mutL homolog 1 (E. coli)0.044
Tex10testis expressed gene 100.043
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.042
D19Bwg1357eDNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed0.040
Ang3angiogenin, ribonuclease A family, member 30.039
Cpsf1cleavage and polyadenylation specific factor 10.039
Trim25tripartite motif-containing 250.038
Rbm19RNA binding motif protein 190.038
Tbrg4transforming growth factor beta regulated gene 40.038
Prpf40aPRP40 pre-mRNA processing factor 40 homolog A (yeast)0.037
Rrp12ribosomal RNA processing 12 homolog (S. cerevisiae)0.036
Actl6aactin-like 6A0.035
Ngdnneuroguidin, EIF4E binding protein0.034
Polr3apolymerase (RNA) III (DNA directed) polypeptide A0.033
Pus1pseudouridine synthase 10.033
Ttc27tetratricopeptide repeat domain 270.033
Pwp2PWP2 periodic tryptophan protein homolog (yeast)0.032
Xpo5exportin 50.031
Usp1ubiquitin specific peptidase 10.030
Droshadrosha, ribonuclease type III0.030
Elac2elaC homolog 2 (E. coli)0.027
Ddx20DEAD (Asp-Glu-Ala-Asp) box polypeptide 200.026
Lrrc40leucine rich repeat containing 400.026
B230308N11RikRIKEN cDNA B230308N11 gene0.026
Nup85nucleoporin 850.026
Atp13a1ATPase type 13A10.026
Nup54nucleoporin 540.025
Ube2l6ubiquitin-conjugating enzyme E2L 60.025
Trim32tripartite motif-containing 320.025
Eri1exoribonuclease 10.025
Ddx39DEAD (Asp-Glu-Ala-Asp) box polypeptide 390.025
Cherpcalcium homeostasis endoplasmic reticulum protein0.024
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.023
Nup155nucleoporin 1550.023
Fam203afamily with sequence similarity 203, member A0.023
Pprc1peroxisome proliferative activated receptor, gamma, coactivator-related 10.023
Srmspermidine synthase0.022
Cnot7CCR4-NOT transcription complex, subunit 70.022
Ddx21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.022
Gnl3guanine nucleotide binding protein-like 3 (nucleolar)0.022
Nubp1nucleotide binding protein 10.021
Ifi27l2ainterferon, alpha-inducible protein 27 like 2A0.020
Rbm34RNA binding motif protein 340.020
Smad4MAD homolog 4 (Drosophila)0.020
Pdcd11programmed cell death 110.020
Samd9lsterile alpha motif domain containing 9-like0.020
Ccdc101coiled-coil domain containing 1010.020
Pus7lpseudouridylate synthase 7 homolog (S. cerevisiae)-like0.020
Ear3eosinophil-associated, ribonuclease A family, member 30.020
Bms1BMS1 homolog, ribosome assembly protein (yeast)0.020
Wdr3WD repeat domain 30.020
Polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.019
Heatr1HEAT repeat containing 10.019
Rcl1RNA terminal phosphate cyclase-like 10.019
Nup107nucleoporin 1070.019
Ear1eosinophil-associated, ribonuclease A family, member 10.019
Wdr55WD repeat domain 550.019
Dbr1debranching enzyme homolog 1 (S. cerevisiae)0.019
Rfc2replication factor C (activator 1) 20.019
Ctu2cytosolic thiouridylase subunit 2 homolog (S. pombe)0.018
Xab2XPA binding protein 20.018
Mettl3methyltransferase like 30.018
Lyz2lysozyme 20.018
Ftsj3FtsJ homolog 3 (E. coli)0.018
2410042D21RikRIKEN cDNA 2410042D21 gene0.017
Rnase4ribonuclease, RNase A family 40.017
Wdr74WD repeat domain 740.017
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.017
NipblNipped-B homolog (Drosophila)0.017
Haus6HAUS augmin-like complex, subunit 60.016
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.016
Eftud2elongation factor Tu GTP binding domain containing 20.016
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.016
Ddx54DEAD (Asp-Glu-Ala-Asp) box polypeptide 540.016
Nop56NOP56 ribonucleoprotein homolog (yeast)0.016
Prpf3PRP3 pre-mRNA processing factor 3 homolog (yeast)0.016
Ercc3excision repair cross-complementing rodent repair deficiency, complementation group 30.016
Nanos2nanos homolog 2 (Drosophila)0.016
Noc4lnucleolar complex associated 4 homolog (S. cerevisiae)0.016
Ear2eosinophil-associated, ribonuclease A family, member 20.015
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.015
Ear12eosinophil-associated, ribonuclease A family, member 120.015
Stat1signal transducer and activator of transcription 10.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rrp1ribosomal RNA processing 1 homolog (S. cerevisiae)0.022
noc4lnucleolar complex associated 4 homolog (S. cerevisiae)0.012
polr1apolymerase (RNA) I polypeptide A0.012
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.012
nup43nucleoporin 430.011
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG4159CG4159 gene product from transcript CG4159-RA0.126
AGO1Argonaute-10.119
CG8939CG8939 gene product from transcript CG8939-RA0.096
CG6712CG6712 gene product from transcript CG6712-RA0.075
RpI1RNA polymerase I subunit0.062
pashapartner of drosha0.051
CG5018CG5018 gene product from transcript CG5018-RA0.047
CG1785CG1785 gene product from transcript CG1785-RA0.046
CG10289CG10289 gene product from transcript CG10289-RA0.046
CG12499CG12499 gene product from transcript CG12499-RA0.045
CG5728CG5728 gene product from transcript CG5728-RA0.044
ppanpeter pan0.041
l(3)07882lethal (3) 078820.041
CG9799CG9799 gene product from transcript CG9799-RA0.040
CG11417CG11417 gene product from transcript CG11417-RA0.036
CG14544CG14544 gene product from transcript CG14544-RA0.035
CG12301CG12301 gene product from transcript CG12301-RA0.034
droshaCG8730 gene product from transcript CG8730-RA0.030
Mat89BaMaternal transcript 89Ba0.030
Mtr3CG8025 gene product from transcript CG8025-RA0.030
CG4554CG4554 gene product from transcript CG4554-RA0.029
Dbp73DDead box protein 73D0.027
CG7728CG7728 gene product from transcript CG7728-RA0.026
Rpp30RNaseP protein p300.026
CG11123CG11123 gene product from transcript CG11123-RA0.026
CG6133CG6133 gene product from transcript CG6133-RA0.025
trsntranslin0.025
CG6724CG6724 gene product from transcript CG6724-RA0.024
CG11660CG11660 gene product from transcript CG11660-RA0.024
Smg6CG6369 gene product from transcript CG6369-RA0.023
CG32344CG32344 gene product from transcript CG32344-RA0.022
CG2875CG2875 gene product from transcript CG2875-RB0.022
CG9300CG9300 gene product from transcript CG9300-RA0.021
CG9143CG9143 gene product from transcript CG9143-RA0.021
CG11180CG11180 gene product from transcript CG11180-RA0.020
CG8414CG8414 gene product from transcript CG8414-RA0.020
bysby S60.020
CG10341CG10341 gene product from transcript CG10341-RB0.020
CG11486CG11486 gene product from transcript CG11486-RG0.019
MlfMyelodysplasia/myeloid leukemia factor0.019
TfIISRNA polymerase II elongation factor0.019
CG2260CG2260 gene product from transcript CG2260-RA0.019
CG13185CG13185 gene product from transcript CG13185-RB0.019
l(1)1Bilethal (1) 1Bi0.019
l(2)09851lethal (2) 098510.018
Dcr-1Dicer-10.017
CG9004CG9004 gene product from transcript CG9004-RA0.017
pallpallbearer0.017
l(1)G0004lethal (1) G00040.016
rinrasputin0.016
CG15027CG15027 gene product from transcript CG15027-RA0.016
CG7856CG7856 gene product from transcript CG7856-RA0.015
ird1immune response deficient 10.015
Art8Arginine methyltransferase 80.015
Rrp46CG4043 gene product from transcript CG4043-RA0.014
CG7339CG7339 gene product from transcript CG7339-RA0.014
CG3071CG3071 gene product from transcript CG3071-RA0.014
CG13773CG13773 gene product from transcript CG13773-RA0.014
Hrb98DEHeterogeneous nuclear ribonucleoprotein at 98DE0.014
CG12325CG12325 gene product from transcript CG12325-RA0.014
Atg18Autophagy-specific gene 180.014
l(2)k09022lethal (2) k090220.013
RpLP0-likeRibosomal protein LP0-like0.013
l(1)G0289lethal (1) G02890.013
CG4553CG4553 gene product from transcript CG4553-RA0.013
Dbp45ADEAD box protein 45A0.013
vlsvalois0.013
CG9246CG9246 gene product from transcript CG9246-RA0.013
CG11897CG11897 gene product from transcript CG11897-RA0.013
Art3Arginine methyltransferase 30.013
CG9630CG9630 gene product from transcript CG9630-RA0.012
CG7275CG7275 gene product from transcript CG7275-RA0.012
CG5033CG5033 gene product from transcript CG5033-RA0.012
CG9154CG9154 gene product from transcript CG9154-RA0.011
msd5mitotic spindle density 50.011
Nopp140CG7421 gene product from transcript CG7421-RB0.011
CG16753CG16753 gene product from transcript CG16753-RA0.011
RpI135RNA polymerase I 135kD subunit0.011
LaspCG3849 gene product from transcript CG3849-RB0.011
CG7839CG7839 gene product from transcript CG7839-RA0.010
CG9596CG9596 gene product from transcript CG9596-RB0.010
wcdwicked0.010
CG7845CG7845 gene product from transcript CG7845-RB0.010
CG3817CG3817 gene product from transcript CG3817-RA0.010
CG8005CG8005 gene product from transcript CG8005-RA0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EXOSC3exosome component 31.000
EXOSC2exosome component 21.000
EXOSC4exosome component 40.998
EXOSC10exosome component 100.998
EIF2C2eukaryotic translation initiation factor 2C, 20.996
EXOSC7exosome component 70.995
TNRC6Atrinucleotide repeat containing 6A0.992
EIF2C1eukaryotic translation initiation factor 2C, 10.989
DIS3LDIS3 mitotic control homolog (S. cerevisiae)-like0.984
CNOT1CCR4-NOT transcription complex, subunit 10.972
CNOT8CCR4-NOT transcription complex, subunit 80.896
EXOSC9exosome component 90.877
TNRC6Btrinucleotide repeat containing 6B0.826
TNRC6Ctrinucleotide repeat containing 6C0.800
PABPC1poly(A) binding protein, cytoplasmic 10.773
EXOSC8exosome component 80.684
CNOT6CCR4-NOT transcription complex, subunit 60.667
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.644
UPF1UPF1 regulator of nonsense transcripts homolog (yeast)0.626
CNOT2CCR4-NOT transcription complex, subunit 20.622
DIS3DIS3 mitotic control homolog (S. cerevisiae)0.574
RPP40ribonuclease P/MRP 40kDa subunit0.566
EXOSC1exosome component 10.338
BTG1B-cell translocation gene 1, anti-proliferative0.326
CNOT6LCCR4-NOT transcription complex, subunit 6-like0.316
EXOSC5exosome component 50.308
UPF2UPF2 regulator of nonsense transcripts homolog (yeast)0.303
FTSJ3FtsJ homolog 3 (E. coli)0.295
NUP107nucleoporin 107kDa0.285
EIF2C4eukaryotic translation initiation factor 2C, 40.265
NR2E3nuclear receptor subfamily 2, group E, member 30.258
PAN3PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)0.249
NOL11nucleolar protein 110.246
CNOT7CCR4-NOT transcription complex, subunit 70.229
TGS1trimethylguanosine synthase 10.228
CNOT3CCR4-NOT transcription complex, subunit 30.216
EIF2C3eukaryotic translation initiation factor 2C, 30.214
PIGWphosphatidylinositol glycan anchor biosynthesis, class W0.167
BMS1BMS1 homolog, ribosome assembly protein (yeast)0.162
CNOT10CCR4-NOT transcription complex, subunit 100.148
WDR75WD repeat domain 750.136
RUVBL2RuvB-like 2 (E. coli)0.131
SMG1SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)0.125
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.113
PFASphosphoribosylformylglycinamidine synthase0.113
NUP85nucleoporin 85kDa0.112
C10orf2chromosome 10 open reading frame 20.112
CPSF2cleavage and polyadenylation specific factor 2, 100kDa0.104
MAK16MAK16 homolog (S. cerevisiae)0.104
NAT10N-acetyltransferase 10 (GCN5-related)0.103
CSTF2cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa0.087
MPHOSPH6M-phase phosphoprotein 60.086
DICER1dicer 1, ribonuclease type III0.084
LTV1LTV1 homolog (S. cerevisiae)0.083
WDR3WD repeat domain 30.081
SAC3D1SAC3 domain containing 10.077
PPANpeter pan homolog (Drosophila)0.076
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.072
TRIM25tripartite motif containing 250.071
DGCR8DiGeorge syndrome critical region gene 80.070
IPO8importin 80.069
TSNAXtranslin-associated factor X0.069
TARBP2TAR (HIV-1) RNA binding protein 20.065
EIF2S1eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa0.058
TRMT1TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)0.058
EEF1Geukaryotic translation elongation factor 1 gamma0.056
KARSlysyl-tRNA synthetase0.054
CYLDcylindromatosis (turban tumor syndrome)0.054
TERTtelomerase reverse transcriptase0.053
WDR12WD repeat domain 120.051
EIF5Beukaryotic translation initiation factor 5B0.050
SHQ1SHQ1 homolog (S. cerevisiae)0.050
NOP2NOP2 nucleolar protein homolog (yeast)0.050
POLR2Bpolymerase (RNA) II (DNA directed) polypeptide B, 140kDa0.049
NOLC1nucleolar and coiled-body phosphoprotein 10.046
ZC3HAV1zinc finger CCCH-type, antiviral 10.046
NOC3Lnucleolar complex associated 3 homolog (S. cerevisiae)0.044
NOP56NOP56 ribonucleoprotein homolog (yeast)0.043
TARDBPTAR DNA binding protein0.042
DROSHAdrosha, ribonuclease type III0.042
DKC1dyskeratosis congenita 1, dyskerin0.042
NUFIP1nuclear fragile X mental retardation protein interacting protein 10.041
NUP133nucleoporin 133kDa0.040
HEATR1HEAT repeat containing 10.038
SSBSjogren syndrome antigen B (autoantigen La)0.038
SENP1SUMO1/sentrin specific peptidase 10.037
SKIV2L2superkiller viralicidic activity 2-like 2 (S. cerevisiae)0.036
BCL2L11BCL2-like 11 (apoptosis facilitator)0.035
UPF3BUPF3 regulator of nonsense transcripts homolog B (yeast)0.035
ASCC2activating signal cointegrator 1 complex subunit 20.034
USP4ubiquitin specific peptidase 4 (proto-oncogene)0.033
REXO4REX4, RNA exonuclease 4 homolog (S. cerevisiae)0.033
PAN2PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)0.033
RPIAribose 5-phosphate isomerase A0.032
NSUN2NOP2/Sun domain family, member 20.031
NOL8nucleolar protein 80.031
SYMPKsymplekin0.031
TRMT6tRNA methyltransferase 6 homolog (S. cerevisiae)0.031
WDR43WD repeat domain 430.031
BYSLbystin-like0.031
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC688869similar to cytochrome c oxidase, subunit VIb polypeptide 10.011
Ndufb10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 100.011
Ndufa13NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 130.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RRP46Rrp46p0.980
RRP4Rrp4p0.970
CSL4Csl4p0.966
MTR3Mtr3p0.929
LRP1Lrp1p0.892
RRP45Rrp45p0.865
SKI6Ski6p0.858
RRP42Rrp42p0.848
ENP1Enp1p0.811
ECM16Ecm16p0.801
MPP6Mpp6p0.785
SOF1Sof1p0.781
NAN1Nan1p0.758
MRD1Mrd1p0.729
BFR2Bfr2p0.728
GAR1Gar1p0.719
NOP14Nop14p0.709
KRR1Krr1p0.673
CBF5Cbf5p0.580
RRP6Rrp6p0.580
RRP40Rrp40p0.575
DIP2Dip2p0.554
UTP25Utp25p0.525
RRP14Rrp14p0.518
IMP4Imp4p0.493
IMP3Imp3p0.472
UTP11Utp11p0.472
UTP23Utp23p0.470
PRP43Prp43p0.458
FAF1Faf1p0.456
SKI7Ski7p0.440
UTP8Utp8p0.405
EFG1Efg1p0.399
AIR1Air1p0.393
ESF2Esf2p0.349
MPP10Mpp10p0.348
SAS10Sas10p0.341
DIS3Dis3p0.339
NOP1Nop1p0.336
DRS1Drs1p0.330
UTP13Utp13p0.322
TRM112Trm112p0.316
NOC4Noc4p0.312
PXR1Pxr1p0.296
UTP20Utp20p0.290
NOP6Nop6p0.286
NOB1Nob1p0.272
UTP18Utp18p0.248
RRP7Rrp7p0.246
ESF1Esf1p0.241
PWP2Pwp2p0.240
BUD21Bud21p0.232
HMT1Hmt1p0.220
RIO1Rio1p0.203
EBP2Ebp2p0.192
RPL15ARpl15ap0.188
NOP8Nop8p0.186
RRN7Rrn7p0.179
UTP10Utp10p0.178
RPL22ARpl22ap0.174
MPT5Mpt5p0.170
SUI2Sui2p0.166
GRC3Grc3p0.163
RPA14Rpa14p0.162
FYV7Fyv7p0.160
DBP7Dbp7p0.160
RIX1Rix1p0.158
RPS17ARps17ap0.154
RPS7ARps7ap0.153
URA2Ura2p0.151
NOC2Noc2p0.150
TMA23Tma23p0.148
RNT1Rnt1p0.147
NOP9Nop9p0.145
PAN3Pan3p0.144
PAB1Pab1p0.143
KRE33Kre33p0.143
SHQ1Shq1p0.142
RIX7Rix7p0.139
PNO1Pno1p0.135
CWC24Cwc24p0.133
ENP2Enp2p0.132
SLX9Slx9p0.129
NOP10Nop10p0.129
SGD1Sgd1p0.127
YHB1Yhb1p0.126
SKI3Ski3p0.125
RPF1Rpf1p0.119
SPN1Spn1p0.118
RRN3Rrn3p0.118
DHR2Dhr2p0.113
RPS21ARps21ap0.111
CMS1Cms1p0.109
NUP82Nup82p0.108
RRN6Rrn6p0.107
THG1Thg1p0.107
UTP7Utp7p0.107
DBP3Dbp3p0.107
UTP4Utp4p0.103
RNH203Rnh203p0.100