The network for 'microtubule nucleation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

microtubule nucleation

The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).

Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pafah1b1platelet-activating factor acetylhydrolase, isoform 1b, subunit 11.000
Nr2e1nuclear receptor subfamily 2, group E, member 10.978
Dcxdoublecortin0.970
Dclk1doublecortin-like kinase 10.969
Macf1microtubule-actin crosslinking factor 10.936
Mis18bp1MIS18 binding protein 10.731
Kif2ckinesin family member 2C0.393
Cenpfcentromere protein F0.392
Th1lTH1-like homolog (Drosophila)0.367
Relnreelin0.349
Cdc25ccell division cycle 25 homolog C (S. pombe)0.336
Lancl2LanC (bacterial lantibiotic synthetase component C)-like 20.280
Clip1CAP-GLY domain containing linker protein 10.232
Fam54afamily with sequence similarity 54, member A0.219
Kif4kinesin family member 40.191
Dlgap5discs, large (Drosophila) homolog-associated protein 50.149
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.139
Aurkbaurora kinase B0.129
Spag5sperm associated antigen 50.129
Fam64afamily with sequence similarity 64, member A0.129
Casc5cancer susceptibility candidate 50.121
Emx1empty spiracles homolog 1 (Drosophila)0.113
Kif23kinesin family member 230.106
Dync1i1dynein cytoplasmic 1 intermediate chain 10.106
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.102
Plk1polo-like kinase 1 (Drosophila)0.095
Cenpmcentromere protein M0.091
CtcfCCCTC-binding factor0.090
Ckap2cytoskeleton associated protein 20.083
Ckap5cytoskeleton associated protein 50.076
Rad21RAD21 homolog (S. pombe)0.073
Ckap2lcytoskeleton associated protein 2-like0.072
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.072
Fam83dfamily with sequence similarity 83, member D0.070
Aurkaaurora kinase A0.065
Mastlmicrotubule associated serine/threonine kinase-like0.064
Ska1spindle and kinetochore associated complex subunit 10.063
Trim59tripartite motif-containing 590.060
FanciFanconi anemia, complementation group I0.060
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.058
Cdkn3cyclin-dependent kinase inhibitor 30.057
Ndufc2NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 20.057
0610010K14RikRIKEN cDNA 0610010K14 gene0.057
Iqgap3IQ motif containing GTPase activating protein 30.054
Dtldenticleless homolog (Drosophila)0.054
Racgap1Rac GTPase-activating protein 10.053
Mtap1bmicrotubule-associated protein 1B0.052
Troaptrophinin associated protein0.051
Neil3nei like 3 (E. coli)0.050
Tmpothymopoietin0.050
Kpna3karyopherin (importin) alpha 30.050
Kif20akinesin family member 20A0.049
Dynll1dynein light chain LC8-type 10.049
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.049
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.049
Ccnfcyclin F0.048
Foxm1forkhead box M10.048
Rangap1RAN GTPase activating protein 10.047
Sae1SUMO1 activating enzyme subunit 10.046
Ccnb1cyclin B10.046
Hmmrhyaluronan mediated motility receptor (RHAMM)0.045
Hcfc1host cell factor C10.044
Ncaphnon-SMC condensin I complex, subunit H0.043
Kif11kinesin family member 110.041
Cdca2cell division cycle associated 20.041
Cbx5chromobox homolog 5 (Drosophila HP1a)0.041
Rev3lREV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)0.040
Fbxo45F-box protein 450.040
Ncapd2non-SMC condensin I complex, subunit D20.039
Acot7acyl-CoA thioesterase 70.039
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.038
SonSon DNA binding protein0.037
Sec61a2Sec61, alpha subunit 2 (S. cerevisiae)0.035
Pold2polymerase (DNA directed), delta 2, regulatory subunit0.035
Top2atopoisomerase (DNA) II alpha0.034
Asna1arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)0.034
Clasp2CLIP associating protein 20.034
Usp8ubiquitin specific peptidase 80.034
Sf3b2splicing factor 3b, subunit 20.034
FancmFanconi anemia, complementation group M0.033
Traf7TNF receptor-associated factor 70.033
Cdca3cell division cycle associated 30.033
Dido1death inducer-obliterator 10.032
Nsmafneutral sphingomyelinase (N-SMase) activation associated factor0.031
Tcerg1transcription elongation regulator 1 (CA150)0.031
Top2btopoisomerase (DNA) II beta0.030
Wdr37WD repeat domain 370.030
Parp1poly (ADP-ribose) polymerase family, member 10.030
Anlnanillin, actin binding protein0.030
Ccnb2cyclin B20.030
Tdp1tyrosyl-DNA phosphodiesterase 10.030
Nusap1nucleolar and spindle associated protein 10.030
Haus4HAUS augmin-like complex, subunit 40.029
Cstf2cleavage stimulation factor, 3' pre-RNA subunit 20.029
Rrm1ribonucleotide reductase M10.029
Cenpacentromere protein A0.028
Gtse1G two S phase expressed protein 10.028
Kif18bkinesin family member 18B0.028
Mapk8mitogen-activated protein kinase 80.028
Pif1PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)0.028
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
air-1Protein AIR-10.027
gpr-1Protein GPR-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
BubR1Bub1-related kinase0.019
Klp10ACG1453 gene product from transcript CG1453-RA0.015
Grip75CG6176 gene product from transcript CG6176-RA0.014
ncdnon-claret disjunctional0.013
cnncentrosomin0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TUBGCP3tubulin, gamma complex associated protein 30.991
MZT1mitotic spindle organizing protein 10.818
TACC3transforming, acidic coiled-coil containing protein 30.770
CKAP5cytoskeleton associated protein 50.702
AURKAaurora kinase A0.694
KIF1Bkinesin family member 1B0.538
TUBB2Ctubulin, beta 2C0.501
MZT2Bmitotic spindle organizing protein 2B0.457
TUBBtubulin, beta0.405
NEK6NIMA (never in mitosis gene a)-related kinase 60.386
CDC20cell division cycle 20 homolog (S. cerevisiae)0.374
TUBA1Ctubulin, alpha 1c0.191
GTSE1G-2 and S-phase expressed 10.179
TUBA1Btubulin, alpha 1b0.171
TUBG1tubulin, gamma 10.134
TPX2TPX2, microtubule-associated, homolog (Xenopus laevis)0.129
CEP55centrosomal protein 55kDa0.126
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.104
TUBGCP5tubulin, gamma complex associated protein 50.091
LUC7L2LUC7-like 2 (S. cerevisiae)0.076
BICD1bicaudal D homolog 1 (Drosophila)0.073
UBE2Subiquitin-conjugating enzyme E2S0.063
C13orf34chromosome 13 open reading frame 340.063
PLK1polo-like kinase 10.060
WHSC1Wolf-Hirschhorn syndrome candidate 10.046
GSK3Bglycogen synthase kinase 3 beta0.042
IMMTinner membrane protein, mitochondrial0.039
NCAPD2non-SMC condensin I complex, subunit D20.039
CHEK2CHK2 checkpoint homolog (S. pombe)0.036
HMMRhyaluronan-mediated motility receptor (RHAMM)0.035
PRC1protein regulator of cytokinesis 10.033
TUBB3tubulin, beta 30.027
SRPK1SRSF protein kinase 10.023
API5apoptosis inhibitor 50.021
FBXW11F-box and WD repeat domain containing 110.021
TACC1transforming, acidic coiled-coil containing protein 10.020
UBE2Cubiquitin-conjugating enzyme E2C0.020
TUBGCP2tubulin, gamma complex associated protein 20.020
AKAP9A kinase (PRKA) anchor protein (yotiao) 90.019
KIF4Akinesin family member 4A0.019
CENPFcentromere protein F, 350/400kDa (mitosin)0.018
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.016
TUBA4Atubulin, alpha 4a0.016
ARIH2ariadne homolog 2 (Drosophila)0.016
CDC25Ccell division cycle 25 homolog C (S. pombe)0.015
CDC25Bcell division cycle 25 homolog B (S. pombe)0.015
NEK9NIMA (never in mitosis gene a)- related kinase 90.014
RAD21RAD21 homolog (S. pombe)0.013
GPSM2G-protein signaling modulator 20.013
FOXM1forkhead box M10.013
ESPL1extra spindle pole bodies homolog 1 (S. cerevisiae)0.012
APCadenomatous polyposis coli0.012
PTTG1pituitary tumor-transforming 10.012
KIF22kinesin family member 220.011
LMO4LIM domain only 40.011
NUP50nucleoporin 50kDa0.011
MDC1mediator of DNA-damage checkpoint 10.011
CITcitron (rho-interacting, serine/threonine kinase 21)0.011
MKI67antigen identified by monoclonal antibody Ki-670.011
PUM2pumilio homolog 2 (Drosophila)0.011
ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like0.011
ZNF71zinc finger protein 710.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SPC110Spc110p0.948
SPC24Spc24p0.913
SPC97Spc97p0.739
NUF2Nuf2p0.606
SPC42Spc42p0.401
MPS1Mps1p0.332
TID3Tid3p0.286
SPC25Spc25p0.155
STU2Stu2p0.143
KAR3Kar3p0.124
MTW1Mtw1p0.117
CNN1Cnn1p0.086
SPC29Spc29p0.071
NUD1Nud1p0.063
PDS1Pds1p0.053
MLP2Mlp2p0.045
DYN1Dyn1p0.041
SMC1Smc1p0.039
PRS2Prs2p0.035
ARP10Arp10p0.031
STU1Stu1p0.029
SRD1Srd1p0.028
MPS2Mps2p0.027
POL31Pol31p0.026
LEU2Leu2p0.024
BBP1Bbp1p0.024
SPC98Spc98p0.024
ECO1Eco1p0.023
YLR162Whypothetical protein0.023
CIN8Cin8p0.023
YOL038C-Ahypothetical protein0.023
SPC105Spc105p0.022
KIP1Kip1p0.022
YLR264C-Ahypothetical protein0.022
MER1Mer1p0.022
KIP2Kip2p0.021
PTI1Pti1p0.021
YLR049Chypothetical protein0.021
CUP1-1Cup1-1p0.020
YPR157Whypothetical protein0.020
YPL216Whypothetical protein0.020
ATP6Atp6p0.019
SPL2Spl2p0.019
YLR042Chypothetical protein0.019
HXT3Hxt3p0.019
ZPS1Zps1p0.019
KIN3Kin3p0.019
VIK1Vik1p0.018
YBR013Chypothetical protein0.018
DAM1Dam1p0.018
CRP1Crp1p0.017
YKR075Chypothetical protein0.017
AUA1Aua1p0.017
YAR068Whypothetical protein0.017
HHO1Hho1p0.017
HPF1Hpf1p0.017
FMT1Fmt1p0.017
RRN5Rrn5p0.017
CTF18Ctf18p0.016
YOL013W-Ahypothetical protein0.016
CPD1Cpd1p0.016
ADH2Adh2p0.016
YIL151Chypothetical protein0.016
CLB6Clb6p0.016
IZH4Izh4p0.016
NNF1Nnf1p0.015
YIR035Chypothetical protein0.015
UPS3Ups3p0.015
AQY2Aqy2p0.015
LCL1Lcl1p0.015
ARO10Aro10p0.015
YAL037C-Ahypothetical protein0.015
MF(ALPHA)2Mf(alpha)2p0.015
YPL067Chypothetical protein0.015
BSC1Bsc1p0.015
OPT2Opt2p0.015
RNP1Rnp1p0.015
SPS4Sps4p0.014
YAL064Whypothetical protein0.014
SCM4Scm4p0.014
YLL053Chypothetical protein0.014
URA3Ura3p0.014
DIC1Dic1p0.014
YML003Whypothetical protein0.014
YJL181Whypothetical protein0.014
SWE1Swe1p0.014
YLR040Chypothetical protein0.014
ICS2Ics2p0.014
KRE28Kre28p0.014
ARR2Arr2p0.014
YPR096Chypothetical protein0.014
YMR317Whypothetical protein0.014
MF(ALPHA)1Mf(alpha)1p0.014
CDC23Cdc23p0.014
YAR066Whypothetical protein0.014
HMRA1Hmra1p0.013
NRG2Nrg2p0.013
COS12Cos12p0.013
ARG8Arg8p0.013
SFI1Sfi1p0.013