The network for 'positive regulation of mitochondrial membrane permeability involved in apoptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of mitochondrial membrane permeability involved in apoptotic process

Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process.

NameDescriptionProbabilityFunc Analog Organism
BaxBCL2-associated X protein1.000
Bcl2l11BCL2-like 11 (apoptosis facilitator)1.000
Bcl2B-cell leukemia/lymphoma 21.000
Mcl1myeloid cell leukemia sequence 10.996
Bak1BCL2-antagonist/killer 10.994
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.986
Trp53transformation related protein 530.980
Bcl2l1BCL2-like 10.971
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.943
Axin1axin 10.868
Pbx1pre B-cell leukemia transcription factor 10.862
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.781
Vhlvon Hippel-Lindau tumor suppressor0.646
Pdcd6ipprogrammed cell death 6 interacting protein0.630
SharpinSHANK-associated RH domain interacting protein0.617
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.465
Ighimmunoglobulin heavy chain complex0.458
Smad3MAD homolog 3 (Drosophila)0.434
Kitkit oncogene0.379
Mta1metastasis associated 10.337
Lystlysosomal trafficking regulator0.317
Tnfaip3tumor necrosis factor, alpha-induced protein 30.275
Wt1Wilms tumor 1 homolog0.273
Prrx1paired related homeobox 10.267
Foxg1forkhead box G10.252
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.216
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.214
Apcadenomatosis polyposis coli0.165
BmfBCL2 modifying factor0.162
Lrp6low density lipoprotein receptor-related protein 60.150
Bbc3BCL2 binding component 30.147
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.138
Atxn2ataxin 20.122
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.116
Mtormechanistic target of rapamycin (serine/threonine kinase)0.116
Pax2paired box gene 20.110
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.106
Prkciprotein kinase C, iota0.105
Mfn2mitofusin 20.090
Ehd3EH-domain containing 30.088
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.088
Mapk1mitogen-activated protein kinase 10.080
BidBH3 interacting domain death agonist0.077
Zeb1zinc finger E-box binding homeobox 10.072
Rararetinoic acid receptor, alpha0.071
Prrx2paired related homeobox 20.058
Mapk9mitogen-activated protein kinase 90.054
Galk1galactokinase 10.049
Traf3ip2TRAF3 interacting protein 20.046
Bmp7bone morphogenetic protein 70.045
Bach1BTB and CNC homology 10.044
Pgam1phosphoglycerate mutase 10.043
Ednraendothelin receptor type A0.043
Sox2SRY-box containing gene 20.043
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.043
Klf6Kruppel-like factor 60.041
Rps27lribosomal protein S27-like0.040
2700094K13RikRIKEN cDNA 2700094K13 gene0.040
Atf3activating transcription factor 30.039
Tbx1T-box 10.037
Mapk8mitogen-activated protein kinase 80.035
Cd151CD151 antigen0.035
Epn1epsin 10.034
Aladaminolevulinate, delta-, dehydratase0.034
Mapk14mitogen-activated protein kinase 140.034
Ern1endoplasmic reticulum (ER) to nucleus signalling 10.034
Gsk3aglycogen synthase kinase 3 alpha0.033
Pgk1phosphoglycerate kinase 10.032
Gdnfglial cell line derived neurotrophic factor0.032
Rarbretinoic acid receptor, beta0.031
Nr2c2nuclear receptor subfamily 2, group C, member 20.029
BrafBraf transforming gene0.029
Dlx5distal-less homeobox 50.028
Ccnd1cyclin D10.027
Msx1homeobox, msh-like 10.026
Ikzf1IKAROS family zinc finger 10.025
Tbx10T-box 100.025
Hoxa3homeobox A30.024
Rrm2bribonucleotide reductase M2 B (TP53 inducible)0.024
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.024
Dusp1dual specificity phosphatase 10.024
Gstz1glutathione transferase zeta 1 (maleylacetoacetate isomerase)0.023
Usp9xubiquitin specific peptidase 9, X chromosome0.023
Dach1dachshund 1 (Drosophila)0.023
Dnm1dynamin 10.023
Klf4Kruppel-like factor 4 (gut)0.022
Lrrk2leucine-rich repeat kinase 20.022
Arpc4actin related protein 2/3 complex, subunit 40.022
Ep300E1A binding protein p3000.022
Rspo2R-spondin 2 homolog (Xenopus laevis)0.021
Rabep1rabaptin, RAB GTPase binding effector protein 10.021
Hoxa2homeobox A20.021
Casp3caspase 30.021
Mdm2transformed mouse 3T3 cell double minute 20.021
Ehd4EH-domain containing 40.021
NansN-acetylneuraminic acid synthase (sialic acid synthase)0.020
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.020
Dlx2distal-less homeobox 20.020
TcrdT-cell receptor delta chain0.020
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JUNjun proto-oncogene0.899
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.867
FOSFBJ murine osteosarcoma viral oncogene homolog0.779
BCL2B-cell CLL/lymphoma 20.777
BCL2L11BCL2-like 11 (apoptosis facilitator)0.676
BAK1BCL2-antagonist/killer 10.568
BCL2L1BCL2-like 10.511
BAXBCL2-associated X protein0.493
BADBCL2-associated agonist of cell death0.233
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.185
JUNBjun B proto-oncogene0.171
ATF3activating transcription factor 30.170
IER2immediate early response 20.143
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.087
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.083
MAPK8mitogen-activated protein kinase 80.079
BIDBH3 interacting domain death agonist0.072
BECN1beclin 1, autophagy related0.069
HUWE1HECT, UBA and WWE domain containing 10.061
DUSP1dual specificity phosphatase 10.057
BIKBCL2-interacting killer (apoptosis-inducing)0.055
RDH11retinol dehydrogenase 11 (all-trans/9-cis/11-cis)0.052
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.051
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.042
TP53BP2tumor protein p53 binding protein, 20.039
PXMP2peroxisomal membrane protein 2, 22kDa0.036
FKBP8FK506 binding protein 8, 38kDa0.032
BBC3BCL2 binding component 30.031
JDP2Jun dimerization protein 20.030
AMBRA1autophagy/beclin-1 regulator 10.025
HDAC6histone deacetylase 60.024
OXA1Loxidase (cytochrome c) assembly 1-like0.021
AXIN1axin 10.021
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.020
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.020
TELO2TEL2, telomere maintenance 2, homolog (S. cerevisiae)0.019
MAGEH1melanoma antigen family H, 10.019
OCIAD1OCIA domain containing 10.019
RNF144Bring finger protein 144B0.018
ACAT1acetyl-CoA acetyltransferase 10.016
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.016
EGR1early growth response 10.015
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.015
FOSL1FOS-like antigen 10.014
JUNDjun D proto-oncogene0.014
NR4A1nuclear receptor subfamily 4, group A, member 10.013
ZHX1zinc fingers and homeoboxes 10.013
DDIT3DNA-damage-inducible transcript 30.013
TMEM11transmembrane protein 110.013
BLOC1S3biogenesis of lysosomal organelles complex-1, subunit 30.013
KLF4Kruppel-like factor 4 (gut)0.012
ZFAND5zinc finger, AN1-type domain 50.012
BHLHE40basic helix-loop-helix family, member e400.012
SIX1SIX homeobox 10.012
BCL2L2BCL2-like 20.012
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.011
CXCL2chemokine (C-X-C motif) ligand 20.011
MS4A7membrane-spanning 4-domains, subfamily A, member 70.011
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.011
E4F1E4F transcription factor 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism