The network for 'negative regulation of nervous system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nervous system development

Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.

NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI30.998
Efnb2ephrin B20.996
Pax3paired box gene 30.992
Shhsonic hedgehog0.989
Apcadenomatosis polyposis coli0.987
Hand2heart and neural crest derivatives expressed transcript 20.986
Pbx1pre B-cell leukemia transcription factor 10.981
Ctnnb1catenin (cadherin associated protein), beta 10.979
Foxc1forkhead box C10.978
Fgfr2fibroblast growth factor receptor 20.975
Isl1ISL1 transcription factor, LIM/homeodomain0.968
Ntf3neurotrophin 30.962
Sox9SRY-box containing gene 90.962
Msx1homeobox, msh-like 10.958
Retret proto-oncogene0.954
Otx2orthodenticle homolog 2 (Drosophila)0.948
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.947
Fgf8fibroblast growth factor 80.943
Appamyloid beta (A4) precursor protein0.933
Smad3MAD homolog 3 (Drosophila)0.929
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.918
Gli2GLI-Kruppel family member GLI20.916
Ephb2Eph receptor B20.915
Bdnfbrain derived neurotrophic factor0.914
Ptpn11protein tyrosine phosphatase, non-receptor type 110.912
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.901
Pax6paired box gene 60.893
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.892
Notch1Notch gene homolog 1 (Drosophila)0.879
Hoxa13homeobox A130.872
Smad6MAD homolog 6 (Drosophila)0.871
Fgfr1fibroblast growth factor receptor 10.865
Tlx3T-cell leukemia, homeobox 30.851
Gdnfglial cell line derived neurotrophic factor0.849
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.842
UncxUNC homeobox0.841
Nos3nitric oxide synthase 3, endothelial cell0.839
Robo1roundabout homolog 1 (Drosophila)0.833
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.827
Sox2SRY-box containing gene 20.820
Bmp7bone morphogenetic protein 70.816
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.816
Dab1disabled homolog 1 (Drosophila)0.799
Emx1empty spiracles homolog 1 (Drosophila)0.798
Wnt3awingless-related MMTV integration site 3A0.790
Ptenphosphatase and tensin homolog0.766
Klk1b5kallikrein 1-related peptidase b50.761
Hand1heart and neural crest derivatives expressed transcript 10.753
Ptf1apancreas specific transcription factor, 1a0.735
Gli1GLI-Kruppel family member GLI10.731
Hoxd13homeobox D130.721
Pax2paired box gene 20.695
Gata4GATA binding protein 40.690
Hoxd11homeobox D110.682
Pou3f3POU domain, class 3, transcription factor 30.680
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.677
Tbx3T-box 30.676
Pitx1paired-like homeodomain transcription factor 10.676
Hoxa10homeobox A100.674
Neurod1neurogenic differentiation 10.673
Pitx2paired-like homeodomain transcription factor 20.669
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.668
Hoxa11homeobox A110.664
Agtr2angiotensin II receptor, type 20.661
Fgf10fibroblast growth factor 100.656
Hoxa1homeobox A10.650
Foxd2forkhead box D20.635
Insm1insulinoma-associated 10.632
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.630
Efsembryonal Fyn-associated substrate0.628
Clstn1calsyntenin 10.624
Epha4Eph receptor A40.624
Meox2mesenchyme homeobox 20.620
Ptk2PTK2 protein tyrosine kinase 20.614
Neurog2neurogenin 20.610
Ror2receptor tyrosine kinase-like orphan receptor 20.606
Chd7chromodomain helicase DNA binding protein 70.605
Eya4eyes absent 4 homolog (Drosophila)0.604
Psen1presenilin 10.604
Lhx1LIM homeobox protein 10.600
Efna2ephrin A20.596
En1engrailed 10.595
Sema5bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B0.593
Hmx3H6 homeobox 30.583
Ascl1achaete-scute complex homolog 1 (Drosophila)0.579
Phox2apaired-like homeobox 2a0.571
Axin1axin 10.571
Eya1eyes absent 1 homolog (Drosophila)0.571
Prrx1paired related homeobox 10.567
Id1inhibitor of DNA binding 10.566
Hoxb4homeobox B40.565
Tgfb2transforming growth factor, beta 20.563
Hoxa2homeobox A20.560
Col2a1collagen, type II, alpha 10.559
Dlx1distal-less homeobox 10.558
Foxg1forkhead box G10.557
Fgf3fibroblast growth factor 30.551
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.021
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
robo2roundabout homolog 20.852
pax6apaired box gene 6a0.777
phox2apaired-like homeobox 2a0.724
ascl1aachaete-scute complex-like 1a (Drosophila)0.702
ptf1apancreas specific transcription factor, 1a0.656
wnt11rwingless-type MMTV integration site family, member 11, related0.641
alcamaactivated leukocyte cell adhesion molecule a0.595
bmp2bbone morphogenetic protein 2b0.461
gli1GLI-Kruppel family member 10.389
cdh2cadherin 2, neuronal0.389
sox11bSRY-box containing gene 11b0.336
otx2orthodenticle homolog 20.331
dlx2adistal-less homeobox gene 2a0.329
foxa1forkhead box A10.305
pax6bpaired box gene 6b0.302
shhbsonic hedgehog b0.282
robo3roundabout homolog 30.273
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.265
spry4sprouty (Drosophila) homolog 40.247
efnb1ephrin B10.240
barhl2BarH-like 20.235
neurod4neurogenic differentiation 40.228
fgf3fibroblast growth factor 30.217
tbx1T-box 10.187
six3bsine oculis homeobox homolog 3b0.184
cntn2contactin 20.181
fabp7afatty acid binding protein 7, brain, a0.179
gdf6agrowth differentiation factor 6a0.174
arxaristaless related homeobox0.173
wnt10awingless-type MMTV integration site family, member 10a0.172
otpborthopedia homolog b0.168
dag1dystroglycan 10.167
notch3notch homolog 30.166
irx1airoquois homeobox protein 1, a0.166
her12hairy-related 120.165
neo1neogenin 10.164
lef1lymphocyte enhancer binding factor 10.158
efnb2aephrin B2a0.151
jag2jagged 20.149
lhx2bLIM homeobox 2b0.148
slit3slit (Drosophila) homolog 30.147
myf5myogenic factor 50.145
foxn4forkhead box N40.145
foxp2forkhead box P20.144
mecomMDS1 and EVI1 complex locus0.142
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.139
tbx5aT-box 5a0.135
irx5airoquois homeobox protein 5a0.135
nkd1naked cuticle homolog 1 (Drosophila)0.134
ccnb1cyclin B10.133
hoxb3ahomeo box B3a0.132
meis2.2myeloid ecotropic viral integration site 2.20.130
pax7apaired box gene 7a0.128
sox3SRY-box containing gene 30.126
ephb4beph receptor B4b0.125
pcdh8protocadherin 80.121
gsnagelsolin a0.119
fzd7afrizzled homolog 7a0.118
atoh1aatonal homolog 1a0.117
dlx5adistal-less homeobox gene 5a0.110
sox2SRY-box containing gene 20.110
fgfr3fibroblast growth factor receptor 30.108
etv2ets variant gene 20.106
fzd10frizzled homolog 100.103
bocbrother of CDO0.103
sox21aSRY-box containing gene 21a0.102
pitx3paired-like homeodomain transcription factor 30.101
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.100
irx4airoquois homeobox protein 4a0.097
shhasonic hedgehog a0.096
lamb1alaminin, beta 1a0.089
wnt1wingless-type MMTV integration site family, member 10.087
zic1zic family member 1 (odd-paired homolog, Drosophila)0.086
onecutlone cut domain, family member, like0.081
cxcr4bchemokine (C-X-C motif), receptor 4b0.079
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.079
notch1anotch homolog 1a0.078
csnk1a1casein kinase 1, alpha 10.077
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.075
her6hairy-related 60.073
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.073
her3hairy-related 30.072
cdx4caudal type homeo box transcription factor 40.071
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.069
foxi1forkhead box I10.068
tbx16T-box gene 160.067
vsx2visual system homeobox 20.066
kdrlkinase insert domain receptor like0.066
fgfr4fibroblast growth factor receptor 40.066
hoxb2ahomeo box B2a0.066
copebcore promoter element binding protein0.066
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.064
ptpraprotein tyrosine phosphatase, receptor type, A0.064
gli3GLI-Kruppel family member GLI30.064
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.966
E(spl)Enhancer of split0.922
TBPHCG10327 gene product from transcript CG10327-RC0.911
CaMKIICalcium/calmodulin-dependent protein kinase II0.894
skpACG16983 gene product from transcript CG16983-RD0.828
cicubitus interruptus0.805
Eps-15Epidermal growth factor receptor pathway substrate clone 150.694
chicoCG5686 gene product from transcript CG5686-RB0.675
ctpcut up0.636
Pi3K92ECG4141 gene product from transcript CG4141-RB0.632
neuroliginCG13772 gene product from transcript CG13772-RA0.626
MED4Mediator complex subunit 40.620
Mob2CG11711 gene product from transcript CG11711-RC0.612
HLHm7E(spl) region transcript m70.610
SAKSak kinase0.607
HLHmgammaE(spl) region transcript mgamma0.571
Stat92ESignal-transducer and activator of transcription protein at 92E0.536
G-oalpha47AG protein oalpha 47A0.533
MED6Mediator complex subunit 60.513
Hr51Hormone receptor 510.508
mod(mdg4)modifier of mdg40.473
witwishful thinking0.446
LrrkLeucine-rich repeat kinase0.442
Pk61CProtein kinase 61C0.442
AlkCG8250 gene product from transcript CG8250-RA0.438
eyaeyes absent0.422
Trim9CG31721 gene product from transcript CG31721-RB0.421
CkIIalphaCasein kinase II alpha subunit0.408
HGTXCG13475 gene product from transcript CG13475-RB0.395
trioCG18214 gene product from transcript CG18214-RA0.377
jebjelly belly0.373
HLHm5E(spl) region transcript m50.371
shotshort stop0.370
Akt1CG4006 gene product from transcript CG4006-RA0.369
gcmglial cells missing0.359
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.353
HLHmbetaE(spl) region transcript mbeta0.349
RanBPMRan-binding protein M0.339
Fas1Fasciclin 10.322
myoglianinCG1838 gene product from transcript CG1838-RD0.312
rictorrapamycin-insensitive companion of Tor0.304
cindrCIN85 and CD2AP orthologue0.302
mewmultiple edematous wings0.295
sosine oculis0.294
snssticks and stones0.283
LanALaminin A0.268
PtenCG5671 gene product from transcript CG5671-RB0.261
lblladybird late0.252
Fak56DFocal Adhesion Kinase0.251
slp1sloppy paired 10.244
Tao-1CG14217 gene product from transcript CG14217-RF0.231
Wnt5Wnt oncogene analog 50.224
eveeven skipped0.216
unc-5CG8166 gene product from transcript CG8166-RA0.216
nwknervous wreck0.213
MED11Mediator complex subunit 110.209
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.792
GSK3Bglycogen synthase kinase 3 beta0.700
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.470
HDAC2histone deacetylase 20.387
JAG1jagged 10.358
FYNFYN oncogene related to SRC, FGR, YES0.313
SMAD7SMAD family member 70.303
SMAD2SMAD family member 20.301
TRAF2TNF receptor-associated factor 20.232
TRAF5TNF receptor-associated factor 50.221
ZMYND11zinc finger, MYND-type containing 110.215
GRB7growth factor receptor-bound protein 70.209
NOTCH1notch 10.206
SCHIP1schwannomin interacting protein 10.198
CCT8chaperonin containing TCP1, subunit 8 (theta)0.198
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.195
FGF1fibroblast growth factor 1 (acidic)0.185
RNF11ring finger protein 110.173
MED10mediator complex subunit 100.171
TRAF1TNF receptor-associated factor 10.161
BMP2bone morphogenetic protein 20.160
BCAR1breast cancer anti-estrogen resistance 10.155
PSEN2presenilin 2 (Alzheimer disease 4)0.153
MED28mediator complex subunit 280.152
POU3F2POU class 3 homeobox 20.143
ATXN1ataxin 10.142
PAX3paired box 30.140
NOTCH3notch 30.127
FGFR2fibroblast growth factor receptor 20.126
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.125
FBXW11F-box and WD repeat domain containing 110.124
WIPF1WAS/WASL interacting protein family, member 10.123
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.122
BTRCbeta-transducin repeat containing0.113
JAG2jagged 20.111
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.106
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.100
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.099
APPamyloid beta (A4) precursor protein0.097
SIN3ASIN3 homolog A, transcription regulator (yeast)0.095
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.094
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.093
COX5Bcytochrome c oxidase subunit Vb0.092
WASLWiskott-Aldrich syndrome-like0.091
SNX9sorting nexin 90.088
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.086
TRADDTNFRSF1A-associated via death domain0.082
EGFRepidermal growth factor receptor0.081
MMP14matrix metallopeptidase 14 (membrane-inserted)0.079
GOLGA2golgin A20.078
LRP1low density lipoprotein receptor-related protein 10.077
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.075
CDK8cyclin-dependent kinase 80.075
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.075
GAS7growth arrest-specific 70.074
NR4A1nuclear receptor subfamily 4, group A, member 10.072
NEDD9neural precursor cell expressed, developmentally down-regulated 90.071
YAP1Yes-associated protein 10.068
ETFAelectron-transfer-flavoprotein, alpha polypeptide0.067
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.067
PTPN1protein tyrosine phosphatase, non-receptor type 10.066
AXIN1axin 10.066
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.064
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.061
PTPRCprotein tyrosine phosphatase, receptor type, C0.060
TCP1t-complex 10.058
HCKhemopoietic cell kinase0.058
MAPTmicrotubule-associated protein tau0.057
FGAfibrinogen alpha chain0.057
MOBKL3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.056
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.055
PDIA3protein disulfide isomerase family A, member 30.051
BMP1bone morphogenetic protein 10.050
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.049
COX6Ccytochrome c oxidase subunit VIc0.049
PTK2PTK2 protein tyrosine kinase 20.049
RBBP4retinoblastoma binding protein 40.048
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.047
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.047
SMAD1SMAD family member 10.045
NEDD4neural precursor cell expressed, developmentally down-regulated 40.044
CLASP1cytoplasmic linker associated protein 10.044
SPRR2Asmall proline-rich protein 2A0.043
TOP2Btopoisomerase (DNA) II beta 180kDa0.042
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.042
LUC7L2LUC7-like 2 (S. cerevisiae)0.042
SFRP1secreted frizzled-related protein 10.041
PRKD2protein kinase D20.041
OLIG2oligodendrocyte lineage transcription factor 20.041
MAGI1membrane associated guanylate kinase, WW and PDZ domain containing 10.041
TSC1tuberous sclerosis 10.040
SOX1SRY (sex determining region Y)-box 10.040
HDAC1histone deacetylase 10.039
MED15mediator complex subunit 150.039
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Btg2BTG family, member 20.819
Nedd4neural precursor cell expressed, developmentally down-regulated 40.659
Cav1caveolin 1, caveolae protein0.583
Marcksmyristoylated alanine rich protein kinase C substrate0.440
Dab2disabled homolog 2 (Drosophila)0.397
Nr4a1nuclear receptor subfamily 4, group A, member 10.346
Tcf4transcription factor 40.313
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.267
Ascl1achaete-scute complex homolog 1 (Drosophila)0.261
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.226
Junbjun B proto-oncogene0.223
Notch1Notch homolog 1, translocation-associated (Drosophila)0.220
Ubtfupstream binding transcription factor, RNA polymerase I0.197
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.193
Atp2b3ATPase, Ca++ transporting, plasma membrane 30.183
S100a6S100 calcium binding protein A60.182
Sptan1spectrin, alpha, non-erythrocytic 10.180
Cd5Cd5 molecule0.172
Galr3galanin receptor 30.168
Rtn1reticulon 10.168
Cd86CD86 molecule0.157
S100a11S100 calcium binding protein A11 (calizzarin)0.157
Anxa5annexin A50.155
A3galt2alpha 1,3-galactosyltransferase 20.155
Lgals9lectin, galactoside-binding, soluble, 90.152
Gdf11growth differentiation factor 110.150
Unc5bunc-5 homolog B (C. elegans)0.148
Anxa2annexin A20.147
Igfbp5insulin-like growth factor binding protein 50.147
Sirpasignal-regulatory protein alpha0.146
Ncam1neural cell adhesion molecule 10.144
Lgals5lectin, galactose binding, soluble 50.143
Neurod2neurogenic differentiation 20.142
Vcpvalosin-containing protein0.141
Cd37CD37 molecule0.139
Sept8septin 80.139
Egr1early growth response 10.138
Usf2upstream transcription factor 2, c-fos interacting0.135
Rararetinoic acid receptor, alpha0.134
Sv2asynaptic vesicle glycoprotein 2a0.131
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.129
Gna15guanine nucleotide binding protein, alpha 150.127
Nrxn3neurexin 30.127
Cd44Cd44 molecule0.126
Rhoaras homolog gene family, member A0.123
Chrna9cholinergic receptor, nicotinic, alpha 90.122
Ddr2discoidin domain receptor tyrosine kinase 20.122
Cishcytokine inducible SH2-containing protein0.118
S100a4S100 calcium-binding protein A40.117
Gzmmgranzyme M (lymphocyte met-ase 1)0.114
Col5a2collagen, type V, alpha 20.114
Epn2epsin 20.112
Vav1vav 1 guanine nucleotide exchange factor0.112
Pls3plastin 3 (T-isoform)0.110
Fgfr2fibroblast growth factor receptor 20.110
Nr5a1nuclear receptor subfamily 5, group A, member 10.110
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.108
Crygecrystallin, gamma E0.107
Cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.105
Gpc1glypican 10.103
Tnrtenascin R0.103
Pcdha13protocadherin alpha 130.102
Phyhipphytanoyl-CoA 2-hydroxylase interacting protein0.101
Cd9CD9 molecule0.101
Fmnl1formin-like 10.098
Foxs1forkhead box S10.097
Ralgdsral guanine nucleotide dissociation stimulator0.097
Nr4a3nuclear receptor subfamily 4, group A, member 30.097
Oprd1opioid receptor, delta 10.096
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.096
Ddr1discoidin domain receptor tyrosine kinase 10.095
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.094
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.093
Nlgn2neuroligin 20.093
Col1a1collagen, type I, alpha 10.093
Itgamintegrin, alpha M0.092
Foxd3forkhead box D30.091
Gp1bbglycoprotein Ib (platelet), beta polypeptide0.090
Anxa1annexin A10.089
Gja1gap junction protein, alpha 10.089
Sox13SRY (sex determining region Y)-box 130.088
Ageradvanced glycosylation end product-specific receptor0.088
Mogmyelin oligodendrocyte glycoprotein0.088
Cxcr5chemokine (C-X-C motif) receptor 50.085
Cav2caveolin 20.085
Krt20keratin 200.085
Myo16myosin XVI0.085
Sgsm1small G protein signaling modulator 10.084
Grm8glutamate receptor, metabotropic 80.084
Pcdhgc3protocadherin gamma subfamily C, 30.084
Tgfbr2transforming growth factor, beta receptor II0.083
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.083
Robo2roundabout homolog 2 (Drosophila)0.083
Astn1astrotactin 10.083
Egr3early growth response 30.082
Foxc2forkhead box C20.082
Crygccrystallin, gamma C0.082
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism