The network for 'cytokine metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytokine metabolic process

The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 880.981
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.980
Tlr4toll-like receptor 40.972
Il10interleukin 100.966
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.961
Tnftumor necrosis factor0.960
Il4interleukin 40.957
Ccr2chemokine (C-C motif) receptor 20.953
Il1r1interleukin 1 receptor, type I0.952
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.945
Cd40CD40 antigen0.933
Sfpi1SFFV proviral integration 10.932
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.912
Cd19CD19 antigen0.907
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.796
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.789
Map3k14mitogen-activated protein kinase kinase kinase 140.786
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.778
Stat5bsignal transducer and activator of transcription 5B0.739
Birc3baculoviral IAP repeat-containing 30.724
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.717
Ccr7chemokine (C-C motif) receptor 70.703
Foxp3forkhead box P30.640
Ikbkginhibitor of kappaB kinase gamma0.638
Cd7CD7 antigen0.625
Clec4dC-type lectin domain family 4, member d0.620
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.609
Cd80CD80 antigen0.607
Icosinducible T-cell co-stimulator0.588
Stat6signal transducer and activator of transcription 60.583
Lyz2lysozyme 20.582
Irf4interferon regulatory factor 40.573
Ccl2chemokine (C-C motif) ligand 20.560
Map3k8mitogen-activated protein kinase kinase kinase 80.548
Il4rainterleukin 4 receptor, alpha0.537
Casp4caspase 4, apoptosis-related cysteine peptidase0.532
Ifnar2interferon (alpha and beta) receptor 20.525
Ccr6chemokine (C-C motif) receptor 60.524
Tnfaip3tumor necrosis factor, alpha-induced protein 30.488
Stat3signal transducer and activator of transcription 30.472
Fcgr2bFc receptor, IgG, low affinity IIb0.453
Cxcr2chemokine (C-X-C motif) receptor 20.442
Sellselectin, lymphocyte0.410
Il2rainterleukin 2 receptor, alpha chain0.409
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.405
FaslFas ligand (TNF superfamily, member 6)0.399
Il27rainterleukin 27 receptor, alpha0.377
Il1binterleukin 1 beta0.366
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.364
Cd5CD5 antigen0.361
Ltalymphotoxin A0.357
Pdcd1programmed cell death 10.349
Traf1TNF receptor-associated factor 10.345
Ikzf1IKAROS family zinc finger 10.336
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.332
Casp1caspase 10.324
Socs1suppressor of cytokine signaling 10.303
Il1rl1interleukin 1 receptor-like 10.300
Clec4eC-type lectin domain family 4, member e0.295
Cxcl13chemokine (C-X-C motif) ligand 130.294
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.293
Tnip1TNFAIP3 interacting protein 10.281
FcrlaFc receptor-like A0.269
Klrg1killer cell lectin-like receptor subfamily G, member 10.267
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.267
C3ar1complement component 3a receptor 10.267
Irf1interferon regulatory factor 10.256
Traf3ip2TRAF3 interacting protein 20.254
Il10rainterleukin 10 receptor, alpha0.247
Bcl3B-cell leukemia/lymphoma 30.246
Fgd3FYVE, RhoGEF and PH domain containing 30.239
Cd28CD28 antigen0.237
Il1ainterleukin 1 alpha0.235
Clec4nC-type lectin domain family 4, member n0.222
Ccr3chemokine (C-C motif) receptor 30.216
Csf1colony stimulating factor 1 (macrophage)0.210
Ccr1chemokine (C-C motif) receptor 10.209
Tlr7toll-like receptor 70.209
Ifnginterferon gamma0.207
Itgalintegrin alpha L0.207
Ccr5chemokine (C-C motif) receptor 50.197
Map3k7mitogen-activated protein kinase kinase kinase 70.196
Cd44CD44 antigen0.195
Cd4CD4 antigen0.193
Mmp8matrix metallopeptidase 80.188
Lair1leukocyte-associated Ig-like receptor 10.182
Il1f9interleukin 1 family, member 90.181
Cybbcytochrome b-245, beta polypeptide0.179
Cd14CD14 antigen0.177
Asprv1aspartic peptidase, retroviral-like 10.176
Klrk1killer cell lectin-like receptor subfamily K, member 10.176
Inhbainhibin beta-A0.172
Irg1immunoresponsive gene 10.170
Relreticuloendotheliosis oncogene0.170
Ccl3chemokine (C-C motif) ligand 30.168
Il18r1interleukin 18 receptor 10.165
Flt3FMS-like tyrosine kinase 30.160
Il2interleukin 20.159
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.154
Il1rninterleukin 1 receptor antagonist0.154
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
eporerythropoietin receptor0.040
mmp9matrix metalloproteinase 90.035
LOC100332193growth hormone secretagogue receptor type 1-like0.033
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.029
irak4interleukin-1 receptor-associated kinase 40.029
tnfatumor necrosis factor a (TNF superfamily, member 2)0.026
cpoxcoproporphyrinogen oxidase0.024
tlr18toll-like receptor 180.023
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.022
bmp2bbone morphogenetic protein 2b0.022
cdkn1acyclin-dependent kinase inhibitor 1A0.021
fn1fibronectin 10.021
LOC100003514protein kinase C alpha type-like0.021
sp2sp2 transcription factor0.021
nod1nucleotide-binding oligomerization domain containing 10.020
nod2nucleotide-binding oligomerization domain containing 20.019
stc1lstanniocalcin 1, like0.019
stat1bsignal transducer and activator of transcription 1b0.019
il8interleukin 80.018
hcrthypocretin (orexin) neuropeptide precursor0.018
ppardbperoxisome proliferator-activated receptor delta b0.018
mtpmicrosomal triglyceride transfer protein0.018
tlr2toll-like receptor 20.018
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.018
nfycnuclear transcription factor Y, gamma0.018
isg15ISG15 ubiquitin-like modifier0.018
ctsl1acathepsin L, 1 a0.018
tlr3toll-like receptor 30.017
dag1dystroglycan 10.017
csf3rcolony stimulating factor 3 receptor (granulocyte)0.017
igfbp1ainsulin-like growth factor binding protein 1a0.017
vcanbversican b0.017
smyd3SET and MYND domain containing 30.017
traf6TNF receptor-associated factor 60.016
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.016
foxd3forkhead box D30.016
ryr1bryanodine receptor 1b (skeletal)0.016
igf2ainsulin-like growth factor 2a0.016
matn4matrilin 40.016
tiraptoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.016
btkBruton agammaglobulinemia tyrosine kinase0.016
atf3activating transcription factor 30.015
ghrlghrelin/obestatin preprohormone0.015
fxyd1FXYD domain containing ion transport regulator 1 (phospholemman)0.015
LOC557072caspase recruitment domain-containing protein 11-like0.015
il6rinterleukin 6 receptor0.015
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.015
chrna4cholinergic receptor, nicotinic, alpha 40.015
amotl2aangiomotin like 2a0.015
csadcysteine sulfinic acid decarboxylase0.014
dnm2dynamin 20.014
c1qccomplement component 1, q subcomponent, C chain0.014
hbae1hemoglobin alpha embryonic-10.014
dkk1bdickkopf 1b0.014
fcho2FCH domain only 20.014
fbxl14bF-box and leucine-rich repeat protein 14b0.014
wnt4awingless-type MMTV integration site family, member 4a0.014
dusp1dual specificity phosphatase 10.014
mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.013
smarcal1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 10.013
LOC100534776toll-like receptor 7-like0.013
pdcd2programmed cell death 20.013
kctd12.1potassium channel tetramerisation domain containing 12.10.013
tlr20atoll-like receptor 20a0.013
comtacatechol-O-methyltransferase a0.013
wnt4bwingless-type MMTV integration site family, member 4b0.013
maffv-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)0.013
mmp13amatrix metalloproteinase 13a0.013
spry2sprouty homolog 20.013
tal2T-cell acute lymphocytic leukemia 20.013
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.013
smc1alstructural maintenance of chromosomes 1A, like0.013
gatsl2GATS protein-like 20.013
fzd9bfrizzled homolog 9b0.013
lgi1bleucine-rich, glioma inactivated 1b0.012
elovl1aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1a0.012
inhbaainhibin, beta Aa0.012
ifng1-2interferon, gamma 1-20.012
hoxc8ahomeo box C8a0.012
vtg1vitellogenin 10.012
sass6spindle assembly 6 homolog (C. elegans)0.012
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.012
prok2prokineticin 20.012
ptk2.1protein tyrosine kinase 2a0.012
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.012
tdhL-threonine dehydrogenase0.012
alkanaplastic lymphoma kinase (Ki-1)0.012
glulaglutamate-ammonia ligase (glutamine synthase) a0.011
abl1c-abl oncogene 1, non-receptor tyrosine kinase0.011
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.011
rasgef1bbRasGEF domain family, member 1Bb0.011
hsd17b3hydroxysteroid (17-beta) dehydrogenase 30.011
smoxspermine oxidase0.011
prkcbbprotein kinase C, beta b0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.948
TICAM2toll-like receptor adaptor molecule 20.794
RIPK2receptor-interacting serine-threonine kinase 20.775
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.704
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.694
BIRC3baculoviral IAP repeat containing 30.656
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.651
CD80CD80 molecule0.613
SYKspleen tyrosine kinase0.496
IL4Rinterleukin 4 receptor0.456
BTN3A3butyrophilin, subfamily 3, member A30.450
STAT2signal transducer and activator of transcription 2, 113kDa0.441
BTN3A1butyrophilin, subfamily 3, member A10.423
IL1R1interleukin 1 receptor, type I0.391
BTN3A2butyrophilin, subfamily 3, member A20.388
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.381
CD2CD2 molecule0.275
TRAF5TNF receptor-associated factor 50.273
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.234
IL1Binterleukin 1, beta0.226
MYD88myeloid differentiation primary response gene (88)0.219
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.216
LATlinker for activation of T cells0.212
IRF7interferon regulatory factor 70.206
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.175
IL2RBinterleukin 2 receptor, beta0.170
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.168
DDIT3DNA-damage-inducible transcript 30.153
PTPN6protein tyrosine phosphatase, non-receptor type 60.139
LCKlymphocyte-specific protein tyrosine kinase0.131
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.129
IL8interleukin 80.126
TRAF1TNF receptor-associated factor 10.126
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.122
CD247CD247 molecule0.107
TNFAIP3tumor necrosis factor, alpha-induced protein 30.105
PIAS4protein inhibitor of activated STAT, 40.105
SH2D1ASH2 domain containing 1A0.104
CASP10caspase 10, apoptosis-related cysteine peptidase0.095
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.094
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.090
KLF6Kruppel-like factor 60.085
PRF1perforin 1 (pore forming protein)0.078
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.076
IL10RAinterleukin 10 receptor, alpha0.075
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.074
CTLA4cytotoxic T-lymphocyte-associated protein 40.073
IRAK2interleukin-1 receptor-associated kinase 20.070
BCL3B-cell CLL/lymphoma 30.069
KLF4Kruppel-like factor 4 (gut)0.068
CFLARCASP8 and FADD-like apoptosis regulator0.068
DUSP1dual specificity phosphatase 10.068
CARD11caspase recruitment domain family, member 110.067
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.067
MAP3K8mitogen-activated protein kinase kinase kinase 80.066
CD86CD86 molecule0.065
TLR2toll-like receptor 20.065
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.063
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.063
IL1R2interleukin 1 receptor, type II0.062
HLA-Gmajor histocompatibility complex, class I, G0.060
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.060
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.058
CDHR2cadherin-related family member 20.057
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.055
IL6Rinterleukin 6 receptor0.055
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.055
PLAURplasminogen activator, urokinase receptor0.055
IL1RNinterleukin 1 receptor antagonist0.051
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.051
INSRinsulin receptor0.050
TRAF2TNF receptor-associated factor 20.049
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.048
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.048
BTN2A2butyrophilin, subfamily 2, member A20.048
PDPK13-phosphoinositide dependent protein kinase-10.048
FCN1ficolin (collagen/fibrinogen domain containing) 10.048
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.047
SLAMF1signaling lymphocytic activation molecule family member 10.046
IRF4interferon regulatory factor 40.045
BTKBruton agammaglobulinemia tyrosine kinase0.045
CD1CCD1c molecule0.045
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.045
TREM1triggering receptor expressed on myeloid cells 10.045
TRIM21tripartite motif containing 210.044
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.044
SIGLEC7sialic acid binding Ig-like lectin 70.043
CXCL2chemokine (C-X-C motif) ligand 20.042
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.040
BLNKB-cell linker0.040
NLRP3NLR family, pyrin domain containing 30.039
HK3hexokinase 3 (white cell)0.038
UBASH3Bubiquitin associated and SH3 domain containing B0.037
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.037
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.036
BCL10B-cell CLL/lymphoma 100.036
IFNGinterferon, gamma0.035
IRF8interferon regulatory factor 80.035
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.034
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Igsf6immunoglobulin superfamily, member 60.283
Ccl3chemokine (C-C motif) ligand 30.242
Ccl2chemokine (C-C motif) ligand 20.114
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.073
Tlr2toll-like receptor 20.063
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.044
Akr1c18aldo-keto reductase family 1, member C180.041
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.031
Cybbcytochrome b-245, beta polypeptide0.030
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.027
Clrn3clarin 30.027
Il1binterleukin 1 beta0.024
Dnase1l3deoxyribonuclease 1-like 30.023
Sellselectin L0.023
FosFBJ osteosarcoma oncogene0.022
Cd44Cd44 molecule0.022
Cxcl3chemokine (C-X-C motif) ligand 30.022
Il1ainterleukin 1 alpha0.021
Cst7cystatin F (leukocystatin)0.021
Cxcl2chemokine (C-X-C motif) ligand 20.020
Cd247Cd247 molecule0.019
F2rl2coagulation factor II (thrombin) receptor-like 20.019
Mmp12matrix metallopeptidase 120.019
Rassf5Ras association (RalGDS/AF-6) domain family member 50.018
Prdm1PR domain containing 1, with ZNF domain0.017
Gzmkgranzyme K0.017
Muskmuscle, skeletal, receptor tyrosine kinase0.016
Cubncubilin (intrinsic factor-cobalamin receptor)0.016
Fcer1aFc fragment of IgE, high affinity I, receptor for; alpha polypeptide0.015
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.015
Tlr4toll-like receptor 40.015
C5ar1complement component 5a receptor 10.015
Il1r2interleukin 1 receptor, type II0.015
Slasrc-like adaptor0.015
Map3k8mitogen-activated protein kinase kinase kinase 80.013
Prf1perforin 1 (pore forming protein)0.013
Arl11ADP-ribosylation factor-like 110.013
Il6interleukin 60.013
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.013
Gifgastric intrinsic factor0.013
Fcn1ficolin (collagen/fibrinogen domain containing) 10.013
Ccl4chemokine (C-C motif) ligand 40.013
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.012
Errfi1ERBB receptor feedback inhibitor 10.011
Ccr2chemokine (C-C motif) receptor 20.011
Nox4NADPH oxidase 40.011
Il8rbinterleukin 8 receptor, beta0.011
Xcl1chemokine (C motif) ligand 10.011
Slc9a2solute carrier family 9 (sodium/hydrogen exchanger), member 20.011
Dusp1dual specificity phosphatase 10.011
Cd86CD86 molecule0.010
Mmp3matrix metallopeptidase 30.010
Galr2galanin receptor 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism