The network for 'neural tube development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neural tube development

The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.

NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Pitx2paired-like homeodomain transcription factor 21.000
Foxc1forkhead box C11.000
Fgfr2fibroblast growth factor receptor 21.000
Pax6paired box gene 61.000
Rnf2ring finger protein 21.000
Pax2paired box gene 21.000
Pax3paired box gene 31.000
Gli2GLI-Kruppel family member GLI20.999
Bmp4bone morphogenetic protein 40.999
Ctnnb1catenin (cadherin associated protein), beta 10.999
Tcfap2atranscription factor AP-2, alpha0.999
Msx2homeobox, msh-like 20.998
Zic3zinc finger protein of the cerebellum 30.998
Psen1presenilin 10.997
Ptenphosphatase and tensin homolog0.997
Fgf8fibroblast growth factor 80.997
Sox2SRY-box containing gene 20.997
Lhx1LIM homeobox protein 10.996
Foxg1forkhead box G10.994
Foxh1forkhead box H10.994
Pbx1pre B-cell leukemia transcription factor 10.994
Sall4sal-like 4 (Drosophila)0.994
Hand1heart and neural crest derivatives expressed transcript 10.993
Alx4aristaless-like homeobox 40.992
Fgfr1fibroblast growth factor receptor 10.992
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.990
Mks1Meckel syndrome, type 10.989
Pou5f1POU domain, class 5, transcription factor 10.988
Foxc2forkhead box C20.986
Otx1orthodenticle homolog 1 (Drosophila)0.985
Bmp7bone morphogenetic protein 70.984
Rargretinoic acid receptor, gamma0.983
Notch1Notch gene homolog 1 (Drosophila)0.980
Efnb2ephrin B20.980
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.980
Chd7chromodomain helicase DNA binding protein 70.978
RybpRING1 and YY1 binding protein0.977
Lrp6low density lipoprotein receptor-related protein 60.977
Dvl3dishevelled 3, dsh homolog (Drosophila)0.976
Fgf10fibroblast growth factor 100.974
Jag1jagged 10.974
Kif3akinesin family member 3A0.972
Smosmoothened homolog (Drosophila)0.969
Notch2Notch gene homolog 2 (Drosophila)0.967
Arid1aAT rich interactive domain 1A (SWI-like)0.966
Smad4MAD homolog 4 (Drosophila)0.965
Ascl1achaete-scute complex homolog 1 (Drosophila)0.964
Megf8multiple EGF-like-domains 80.960
Sox3SRY-box containing gene 30.960
Dll1delta-like 1 (Drosophila)0.959
Lmx1bLIM homeobox transcription factor 1 beta0.955
Lef1lymphoid enhancer binding factor 10.954
Sfrp2secreted frizzled-related protein 20.952
Gbx2gastrulation brain homeobox 20.951
Eya1eyes absent 1 homolog (Drosophila)0.949
Lmx1aLIM homeobox transcription factor 1 alpha0.948
Emx2empty spiracles homolog 2 (Drosophila)0.944
Ephb2Eph receptor B20.941
Sox11SRY-box containing gene 110.941
Apcadenomatosis polyposis coli0.939
Wt1Wilms tumor 1 homolog0.938
Hoxa11homeobox A110.937
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.934
Hoxa13homeobox A130.934
En1engrailed 10.932
Gdnfglial cell line derived neurotrophic factor0.929
Tbx1T-box 10.925
Pitx1paired-like homeodomain transcription factor 10.924
Gata4GATA binding protein 40.919
Lhx3LIM homeobox protein 30.917
Neurod1neurogenic differentiation 10.916
Wnt5awingless-related MMTV integration site 5A0.914
Wnt1wingless-related MMTV integration site 10.912
Hes1hairy and enhancer of split 1 (Drosophila)0.912
Ptch1patched homolog 10.907
Tbx15T-box 150.906
Smad3MAD homolog 3 (Drosophila)0.901
Dlx5distal-less homeobox 50.897
NanogNanog homeobox0.894
Prrx1paired related homeobox 10.892
Meox2mesenchyme homeobox 20.892
Msx1homeobox, msh-like 10.890
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.876
Insm1insulinoma-associated 10.870
Wnt3awingless-related MMTV integration site 3A0.868
Ptk7PTK7 protein tyrosine kinase 70.866
Hoxd11homeobox D110.861
Pax8paired box gene 80.860
Zeb1zinc finger E-box binding homeobox 10.858
Col2a1collagen, type II, alpha 10.857
Hoxa1homeobox A10.855
Apaf1apoptotic peptidase activating factor 10.850
Fzd8frizzled homolog 8 (Drosophila)0.848
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
foxi1forkhead box I10.999
shhasonic hedgehog a0.998
tbx1T-box 10.996
fgf3fibroblast growth factor 30.994
gli2aGLI-Kruppel family member GLI2a0.988
mibmind bomb0.987
wnt11wingless-type MMTV integration site family, member 110.984
flhfloating head0.978
cdh2cadherin 2, neuronal0.973
sox2SRY-box containing gene 20.963
notch3notch homolog 30.962
hoxb1bhomeo box B1b0.959
sox3SRY-box containing gene 30.958
foxj1aforkhead box J1a0.957
gli1GLI-Kruppel family member 10.956
foxd3forkhead box D30.945
ndr2nodal-related 20.943
foxa2forkhead box A20.937
bocbrother of CDO0.937
lhx5LIM homeobox 50.932
eng2aengrailed 2a0.926
tbx16T-box gene 160.916
pax2apaired box gene 2a0.913
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.912
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.910
pax8paired box gene 80.907
hnf1baHNF1 homeobox Ba0.901
wnt5bwingless-type MMTV integration site family, member 5b0.883
eya1eyes absent homolog 10.881
otx2orthodenticle homolog 20.870
zic4zic family member 40.864
foxg1aforkhead box G1a0.862
gata3GATA-binding protein 30.862
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.854
lrrc6leucine rich repeat containing 60.853
fgf8afibroblast growth factor 8 a0.839
grhl2bgrainyhead-like 2b (Drosophila)0.836
irx3airoquois homeobox protein 3a0.835
dzip1DAZ interacting protein 10.802
odz4odd Oz/ten-m homolog 40.798
tbx2bT-box 2b0.795
wnt8bwingless-type MMTV integration site family, member 8b0.789
sox10SRY-box containing gene 100.781
epb41l5erythrocyte membrane protein band 4.1 like 50.781
mab21l2mab-21-like 20.778
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.774
neurodneurogenic differentiation0.754
egr2bearly growth response 2b0.751
fgf4fibroblast growth factor 40.750
hoxb3ahomeo box B3a0.742
irx1airoquois homeobox protein 1, a0.724
foxa1forkhead box A10.709
notch1anotch homolog 1a0.707
cdx4caudal type homeo box transcription factor 40.703
fzd7afrizzled homolog 7a0.693
prdm1aPR domain containing 1a, with ZNF domain0.677
lef1lymphocyte enhancer binding factor 10.658
smosmoothened homolog (Drosophila)0.652
skianuclear oncoprotein skia0.650
bmp7abone morphogenetic protein 7a0.639
fgfr3fibroblast growth factor receptor 30.637
emx1empty spiracles homeobox 10.630
wnt4awingless-type MMTV integration site family, member 4a0.618
pou3f3bPOU class 3 homeobox 3b0.606
wnt1wingless-type MMTV integration site family, member 10.599
pcdh18bprotocadherin 18b0.591
alcambactivated leukocyte cell adhesion molecule b0.589
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.587
rx3retinal homeobox gene 30.587
spry4sprouty (Drosophila) homolog 40.582
hhiphedgehog interacting protein0.581
six3asine oculis homeobox homolog 3a0.580
dlx3bdistal-less homeobox gene 3b0.577
olig2oligodendrocyte lineage transcription factor 20.571
etv5bets variant 5b0.568
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.553
jag2jagged 20.543
her5hairy-related 50.532
zic5zic family member 5 (odd-paired homolog, Drosophila)0.532
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.527
fn1fibronectin 10.525
gbx2gastrulation brain homeo box 20.522
ift88intraflagellar transport 88 homolog0.522
hey1hairy/enhancer-of-split related with YRPW motif 10.515
emx3empty spiracles homeobox 30.512
lmx1b.1LIM homeobox transcription factor 1, beta 10.512
her4.2hairy-related 4.20.510
pkd2polycystic kidney disease 20.509
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.508
her3hairy-related 30.504
bhlhe22basic helix-loop-helix family, member e220.504
irx1biroquois homeobox protein 1, b0.500
gpc4glypican 40.499
hmx4H6 family homeobox 40.499
disp1dispatched homolog 1 (Drosophila)0.498
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.998
PSEN1presenilin 10.925
HDAC2histone deacetylase 20.860
APCadenomatous polyposis coli0.846
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.798
BCL2B-cell CLL/lymphoma 20.647
AXIN1axin 10.577
DVL3dishevelled, dsh homolog 3 (Drosophila)0.536
PRKCZprotein kinase C, zeta0.482
SMAD3SMAD family member 30.451
JAG1jagged 10.432
ESR1estrogen receptor 10.377
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.355
BECN1beclin 1, autophagy related0.318
INADLInaD-like (Drosophila)0.285
GSK3Bglycogen synthase kinase 3 beta0.277
NR4A1nuclear receptor subfamily 4, group A, member 10.248
NOTCH3notch 30.237
SQSTM1sequestosome 10.205
PKD2polycystic kidney disease 2 (autosomal dominant)0.192
BADBCL2-associated agonist of cell death0.176
TSC2tuberous sclerosis 20.175
STK4serine/threonine kinase 40.175
CASP3caspase 3, apoptosis-related cysteine peptidase0.159
SIN3ASIN3 homolog A, transcription regulator (yeast)0.150
SEC24DSEC24 family, member D (S. cerevisiae)0.140
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.132
LRRK2leucine-rich repeat kinase 20.132
XIAPX-linked inhibitor of apoptosis0.132
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.130
SMOsmoothened homolog (Drosophila)0.122
TRRAPtransformation/transcription domain-associated protein0.122
CTNND1catenin (cadherin-associated protein), delta 10.120
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.118
CENPJcentromere protein J0.114
PTCH1patched 10.103
STK3serine/threonine kinase 30.096
BCORBCL6 corepressor0.087
BCL2L1BCL2-like 10.086
YAP1Yes-associated protein 10.081
BMP7bone morphogenetic protein 70.079
PKD1polycystic kidney disease 1 (autosomal dominant)0.077
SMAD4SMAD family member 40.077
FZD1frizzled homolog 1 (Drosophila)0.074
FLNBfilamin B, beta0.069
TP53tumor protein p530.069
C9orf89chromosome 9 open reading frame 890.068
RASA1RAS p21 protein activator (GTPase activating protein) 10.067
MEOX2mesenchyme homeobox 20.064
USP9Xubiquitin specific peptidase 9, X-linked0.062
SEC23ASec23 homolog A (S. cerevisiae)0.059
CREBBPCREB binding protein0.057
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.055
CDC27cell division cycle 27 homolog (S. cerevisiae)0.054
PKP4plakophilin 40.052
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.051
FLNAfilamin A, alpha0.051
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.047
BCL2L11BCL2-like 11 (apoptosis facilitator)0.047
SETD8SET domain containing (lysine methyltransferase) 80.047
SKIv-ski sarcoma viral oncogene homolog (avian)0.046
JUPjunction plakoglobin0.046
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.046
MBD2methyl-CpG binding domain protein 20.046
BIDBH3 interacting domain death agonist0.045
IQGAP1IQ motif containing GTPase activating protein 10.045
ACTBactin, beta0.044
CTBP2C-terminal binding protein 20.042
EP300E1A binding protein p3000.042
FOXA2forkhead box A20.041
VHLvon Hippel-Lindau tumor suppressor0.040
AKAP11A kinase (PRKA) anchor protein 110.037
WNT3Awingless-type MMTV integration site family, member 3A0.037
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.037
DVL1dishevelled, dsh homolog 1 (Drosophila)0.036
ZFXzinc finger protein, X-linked0.036
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.035
SOX10SRY (sex determining region Y)-box 100.035
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.033
STK36serine/threonine kinase 360.033
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.031
FKBP8FK506 binding protein 8, 38kDa0.031
HIC1hypermethylated in cancer 10.030
SP1Sp1 transcription factor0.029
STRN3striatin, calmodulin binding protein 30.029
POU3F2POU class 3 homeobox 20.027
WASF2WAS protein family, member 20.027
HDAC1histone deacetylase 10.027
TCF4transcription factor 40.026
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.026
SLMAPsarcolemma associated protein0.025
RANBP2RAN binding protein 20.025
ACTG1actin, gamma 10.025
PCM1pericentriolar material 10.024
SGSM2small G protein signaling modulator 20.024
CSNK1Ecasein kinase 1, epsilon0.024
CASP9caspase 9, apoptosis-related cysteine peptidase0.023
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.023
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism