The network for 'camera type eye development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

camera type eye development

The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.

NameDescriptionProbabilityFunc Analog Organism
Pax6paired box gene 61.000
Fgfr2fibroblast growth factor receptor 21.000
Shhsonic hedgehog1.000
Pax3paired box gene 31.000
Sox2SRY-box containing gene 20.999
Tbx3T-box 30.999
Foxc1forkhead box C10.999
Ctnnb1catenin (cadherin associated protein), beta 10.999
Bmp4bone morphogenetic protein 40.998
Otx2orthodenticle homolog 2 (Drosophila)0.997
Gli3GLI-Kruppel family member GLI30.997
Isl1ISL1 transcription factor, LIM/homeodomain0.996
Pax2paired box gene 20.995
Pou4f2POU domain, class 4, transcription factor 20.995
Pitx2paired-like homeodomain transcription factor 20.995
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.993
Hand1heart and neural crest derivatives expressed transcript 10.992
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.992
Tcfap2atranscription factor AP-2, alpha0.992
Vegfavascular endothelial growth factor A0.991
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.987
Gata4GATA binding protein 40.986
Zic3zinc finger protein of the cerebellum 30.986
Trp63transformation related protein 630.985
Emx2empty spiracles homolog 2 (Drosophila)0.985
Ptenphosphatase and tensin homolog0.985
Pbx1pre B-cell leukemia transcription factor 10.984
Pou5f1POU domain, class 5, transcription factor 10.983
Msx2homeobox, msh-like 20.981
Smad6MAD homolog 6 (Drosophila)0.981
Pax8paired box gene 80.979
Fgfr1fibroblast growth factor receptor 10.975
Trp53transformation related protein 530.975
Tgfb2transforming growth factor, beta 20.975
Atoh7atonal homolog 7 (Drosophila)0.972
Foxc2forkhead box C20.971
Eya1eyes absent 1 homolog (Drosophila)0.970
Smad4MAD homolog 4 (Drosophila)0.970
Jag1jagged 10.969
Bmpr1abone morphogenetic protein receptor, type 1A0.969
Hoxd13homeobox D130.968
Alx4aristaless-like homeobox 40.968
Tcfcp2l1transcription factor CP2-like 10.966
Fgf8fibroblast growth factor 80.964
Apcadenomatosis polyposis coli0.962
Efnb2ephrin B20.961
Fgf10fibroblast growth factor 100.960
Gata6GATA binding protein 60.959
Nos3nitric oxide synthase 3, endothelial cell0.955
Pitx1paired-like homeodomain transcription factor 10.953
Ror2receptor tyrosine kinase-like orphan receptor 20.953
Arid1aAT rich interactive domain 1A (SWI-like)0.953
Hmx1H6 homeobox 10.952
Hand2heart and neural crest derivatives expressed transcript 20.951
Smad3MAD homolog 3 (Drosophila)0.944
Rargretinoic acid receptor, gamma0.931
Acvr1activin A receptor, type 10.931
Pitx3paired-like homeodomain transcription factor 30.931
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.928
Efna2ephrin A20.924
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.923
Ephb2Eph receptor B20.923
Hes1hairy and enhancer of split 1 (Drosophila)0.921
Smosmoothened homolog (Drosophila)0.921
Zeb1zinc finger E-box binding homeobox 10.921
Gli2GLI-Kruppel family member GLI20.910
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.909
Foxg1forkhead box G10.907
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.902
Fzd4frizzled homolog 4 (Drosophila)0.901
Tcfap2ctranscription factor AP-2, gamma0.901
Gscgoosecoid homeobox0.900
Zic1zinc finger protein of the cerebellum 10.895
Ptch1patched homolog 10.894
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.887
Ntf3neurotrophin 30.883
Nr5a1nuclear receptor subfamily 5, group A, member 10.881
Npr3natriuretic peptide receptor 30.880
Gpc3glypican 30.878
Ep400E1A binding protein p4000.873
Foxf1aforkhead box F1a0.870
Tbx5T-box 50.869
Runx2runt related transcription factor 20.866
Prph2peripherin 20.861
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.860
Tbx2T-box 20.859
Esrrbestrogen related receptor, beta0.853
Insm1insulinoma-associated 10.852
Hoxa13homeobox A130.852
Dlx5distal-less homeobox 50.847
Tbx15T-box 150.846
Hoxd11homeobox D110.844
Lamc1laminin, gamma 10.839
Hdac1histone deacetylase 10.837
Ptk7PTK7 protein tyrosine kinase 70.830
Emx1empty spiracles homolog 1 (Drosophila)0.825
Gucy2eguanylate cyclase 2e0.825
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal1.000
pax2apaired box gene 2a0.997
pax6apaired box gene 6a0.997
gdf6agrowth differentiation factor 6a0.992
crb2acrumbs homolog 2a0.991
lamc1laminin, gamma 10.987
atoh7atonal homolog 70.984
fgf8afibroblast growth factor 8 a0.981
pax6bpaired box gene 6b0.979
otx2orthodenticle homolog 20.972
six3bsine oculis homeobox homolog 3b0.970
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.969
rx1retinal homeobox gene 10.969
six3asine oculis homeobox homolog 3a0.962
guca1cguanylate cyclase activator 1C0.959
jag2jagged 20.941
fezf2FEZ family zinc finger 20.940
rx3retinal homeobox gene 30.939
tbx2bT-box 2b0.936
pitx3paired-like homeodomain transcription factor 30.932
rx2retinal homeobox gene 20.930
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.929
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.926
ahctf1AT hook containing transcription factor 10.922
dctn1adynactin 1a0.921
bmp2abone morphogenetic protein 2a0.921
flhfloating head0.920
lamb1alaminin, beta 1a0.919
bmp2bbone morphogenetic protein 2b0.917
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.916
hnf1baHNF1 homeobox Ba0.913
wnt11wingless-type MMTV integration site family, member 110.907
notch3notch homolog 30.905
cyfip2cytoplasmic FMR1 interacting protein 20.904
gbx2gastrulation brain homeo box 20.903
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.882
runx1runt-related transcription factor 10.879
ndr2nodal-related 20.875
etv2ets variant gene 20.860
sox1aSRY-box containing gene 1a0.859
raraaretinoic acid receptor, alpha a0.845
six4bsine oculis homeobox homolog 4b0.843
eya1eyes absent homolog 10.842
socs3asuppressor of cytokine signaling 3a0.831
sox3SRY-box containing gene 30.831
bmperBMP binding endothelial regulator0.825
gli1GLI-Kruppel family member 10.821
otpborthopedia homolog b0.821
tbx18T-box 180.820
mab21l2mab-21-like 20.818
wnt4awingless-type MMTV integration site family, member 4a0.814
slc45a2solute carrier family 45, member 20.812
crabp2acellular retinoic acid binding protein 2, a0.811
crygm4crystallin, gamma M40.809
cdh6cadherin 60.809
ephb3aeph receptor B3a0.804
esr2aestrogen receptor 2a0.804
shhasonic hedgehog a0.801
hdac1histone deacetylase 10.796
lhx2bLIM homeobox 2b0.790
dnmt7DNA (cytosine-5-)-methyltransferase 70.789
shhbsonic hedgehog b0.788
aldh1a2aldehyde dehydrogenase 1 family, member A20.783
tbx5aT-box 5a0.781
ptf1apancreas specific transcription factor, 1a0.781
pvrl1apoliovirus receptor-related 1a0.777
nr2e3nuclear receptor subfamily 2, group E, member 30.776
mibmind bomb0.774
epb41l5erythrocyte membrane protein band 4.1 like 50.771
tal1T-cell acute lymphocytic leukemia 10.771
dlx4bdistal-less homeobox gene 4b0.768
dmbx1adiencephalon/mesencephalon homeobox 1a0.764
ascl1aachaete-scute complex-like 1a (Drosophila)0.762
lmx1b.1LIM homeobox transcription factor 1, beta 10.759
dnmt1DNA (cytosine-5-)-methyltransferase 10.739
neurodneurogenic differentiation0.737
emx3empty spiracles homeobox 30.736
osr1odd-skipped related 1 (Drosophila)0.733
metmet proto-oncogene (hepatocyte growth factor receptor)0.726
irx1airoquois homeobox protein 1, a0.717
hey1hairy/enhancer-of-split related with YRPW motif 10.715
meis2.1myeloid ecotropic viral integration site 2.10.714
nrp2bneuropilin 2b0.705
ptch1patched 10.705
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.699
dag1dystroglycan 10.697
pmelapremelanosome protein a0.694
otx1aorthodenticle homolog 1a0.690
gbx1gastrulation brain homeobox 10.688
her1hairy-related 10.687
notch1anotch homolog 1a0.681
fn1fibronectin 10.679
vsx1visual system homeobox 1 homolog, chx10-like0.677
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.673
otx1borthodenticle homolog 1b0.671
zfyve26zinc finger, FYVE domain containing 260.661
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.956
E(spl)Enhancer of split0.915
HLHmdeltaE(spl) region transcript mdelta0.858
HLHm7E(spl) region transcript m70.837
wbwing blister0.733
stanstarry night0.722
G-oalpha47AG protein oalpha 47A0.667
mbcmyoblast city0.653
emsempty spiracles0.627
malphaE(spl) region transcript malpha0.615
slp1sloppy paired 10.564
nkdnaked cuticle0.541
svpseven up0.510
bratbrain tumor0.473
HLHmbetaE(spl) region transcript mbeta0.456
TomTwin of m40.448
snssticks and stones0.437
opaodd paired0.427
HLHm5E(spl) region transcript m50.425
CG8155CG8155 gene product from transcript CG8155-RA0.418
Sema-1aCG18405 gene product from transcript CG18405-RD0.392
Rya-r44FRyanodine receptor 44F0.381
toytwin of eyeless0.374
elavembryonic lethal abnormal vision0.374
amosabsent MD neurons and olfactory sensilla0.367
Cg25CCollagen type IV0.365
Hsp26Heat shock protein 260.338
HLHm3E(spl) region transcript m30.318
myoglianinCG1838 gene product from transcript CG1838-RD0.301
HLHmgammaE(spl) region transcript mgamma0.300
ash2absent, small, or homeotic discs 20.293
eyaeyes absent0.292
m4E(spl) region transcript m40.288
Fas2Fasciclin 20.280
MhcMyosin heavy chain0.276
ImpIGF-II mRNA-binding protein0.272
Ced-12CG5336 gene product from transcript CG5336-RA0.267
m2E(spl) region transcript m20.266
Vha68-2CG3762 gene product from transcript CG3762-RA0.266
Lim1CG11354 gene product from transcript CG11354-RA0.264
Caf1Chromatin assembly factor 1 subunit0.263
cutletCG33122 gene product from transcript CG33122-RA0.259
SmoxSmad on X0.256
MED19Mediator complex subunit 190.254
argosCG4531 gene product from transcript CG4531-RA0.252
vvlventral veins lacking0.246
sogshort gastrulation0.246
PoxnPox neuro0.245
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SIN3ASIN3 homolog A, transcription regulator (yeast)0.750
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.557
SMAD2SMAD family member 20.530
CTBP1C-terminal binding protein 10.427
NCOR2nuclear receptor corepressor 20.375
HDAC1histone deacetylase 10.374
HIPK2homeodomain interacting protein kinase 20.337
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.312
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.283
CTSAcathepsin A0.236
EGFRepidermal growth factor receptor0.222
SP1Sp1 transcription factor0.220
EP300E1A binding protein p3000.217
PBX1pre-B-cell leukemia homeobox 10.210
CAV1caveolin 1, caveolae protein, 22kDa0.192
TP53tumor protein p530.184
CRYBB2crystallin, beta B20.182
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.179
SMAD3SMAD family member 30.164
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.162
ZFYVE9zinc finger, FYVE domain containing 90.151
BBS10Bardet-Biedl syndrome 100.148
ESR1estrogen receptor 10.141
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.138
RUNX1runt-related transcription factor 10.138
SMAD4SMAD family member 40.132
PPARAperoxisome proliferator-activated receptor alpha0.124
NCOR1nuclear receptor corepressor 10.121
CREBBPCREB binding protein0.118
SOX2SRY (sex determining region Y)-box 20.117
CDK4cyclin-dependent kinase 40.114
CRYBA2crystallin, beta A20.113
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.112
MYOD1myogenic differentiation 10.111
COL4A1collagen, type IV, alpha 10.105
CRYAAcrystallin, alpha A0.102
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.101
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.100
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.099
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.097
RXRAretinoid X receptor, alpha0.092
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.090
RARAretinoic acid receptor, alpha0.087
TGFB1transforming growth factor, beta 10.083
INADLInaD-like (Drosophila)0.082
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.081
PTPN11protein tyrosine phosphatase, non-receptor type 110.079
CRYBB3crystallin, beta B30.077
NOSTRINnitric oxide synthase trafficker0.075
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.072
NKX2-1NK2 homeobox 10.071
ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d10.069
USP11ubiquitin specific peptidase 110.069
DCAF7DDB1 and CUL4 associated factor 70.069
PRMT1protein arginine methyltransferase 10.068
SKILSKI-like oncogene0.067
FYNFYN oncogene related to SRC, FGR, YES0.067
GATA4GATA binding protein 40.066
ATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit b0.065
MDM2Mdm2 p53 binding protein homolog (mouse)0.064
TJP1tight junction protein 1 (zona occludens 1)0.063
UHRF2ubiquitin-like with PHD and ring finger domains 20.062
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.061
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.060
FGF1fibroblast growth factor 1 (acidic)0.060
PAX7paired box 70.059
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.059
CHAF1Achromatin assembly factor 1, subunit A (p150)0.058
LBX1ladybird homeobox 10.057
WNT3Awingless-type MMTV integration site family, member 3A0.057
HNF4Ahepatocyte nuclear factor 4, alpha0.056
PTPN1protein tyrosine phosphatase, non-receptor type 10.056
BCL9B-cell CLL/lymphoma 90.054
ACVR1activin A receptor, type I0.054
ATP6AP1ATPase, H+ transporting, lysosomal accessory protein 10.054
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.053
SIX6SIX homeobox 60.052
NCOA1nuclear receptor coactivator 10.051
SOX1SRY (sex determining region Y)-box 10.049
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.049
TCF12transcription factor 120.049
POU5F1POU class 5 homeobox 10.048
CDK6cyclin-dependent kinase 60.048
PMLpromyelocytic leukemia0.048
CTGFconnective tissue growth factor0.047
MED25mediator complex subunit 250.046
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.045
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.044
BMPR1Abone morphogenetic protein receptor, type IA0.044
HIC1hypermethylated in cancer 10.044
CBX4chromobox homolog 40.043
DVL3dishevelled, dsh homolog 3 (Drosophila)0.042
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.042
COL4A2collagen, type IV, alpha 20.042
TAL1T-cell acute lymphocytic leukemia 10.040
CRYBB1crystallin, beta B10.040
CBX8chromobox homolog 80.039
NR4A1nuclear receptor subfamily 4, group A, member 10.039
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.038
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.668
Mipmajor intrinsic protein of lens fiber0.484
Chrnb4cholinergic receptor, nicotinic, beta 40.350
Crybb3crystallin, beta B30.288
Actbactin, beta0.257
Cryaacrystallin, alpha A0.193
Il1r1interleukin 1 receptor, type I0.184
Tgfbr2transforming growth factor, beta receptor II0.176
Pax4paired box 40.143
Vom1r97vomeronasal 1 receptor 970.125
Hist1h1dhistone cluster 1, H1d0.108
Grifingalectin-related inter-fiber protein0.097
Cryba1crystallin, beta A10.096
Drd1adopamine receptor D1A0.096
Prdx4peroxiredoxin 40.093
Dlg4discs, large homolog 4 (Drosophila)0.089
Crygscrystallin, gamma S0.088
Aebp1AE binding protein 10.087
Kcnb2potassium voltage gated channel, Shab-related subfamily, member 20.086
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.084
Adam17ADAM metallopeptidase domain 170.084
Cnn1calponin 1, basic, smooth muscle0.084
Raxretina and anterior neural fold homeobox0.083
Foxd3forkhead box D30.082
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.080
Rararetinoic acid receptor, alpha0.078
Tubb5tubulin, beta 50.078
Casp3caspase 30.076
Csf3colony stimulating factor 3 (granulocyte)0.075
Sdc3syndecan 30.071
Dusp6dual specificity phosphatase 60.070
Opn1swopsin 1 (cone pigments), short-wave-sensitive0.069
Olr1493olfactory receptor gene Olr14930.067
Qarsglutaminyl-tRNA synthetase0.067
C1rcomplement component 1, r subcomponent0.067
Prph2peripherin 20.066
Sf3b1splicing factor 3b, subunit 10.065
Nek9NIMA (never in mitosis gene a)- related kinase 90.063
Adam9ADAM metallopeptidase domain 9 (meltrin gamma)0.063
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.061
Mpeg1macrophage expressed 10.060
Fgfr2fibroblast growth factor receptor 20.059
C7complement component 70.059
Stat5bsignal transducer and activator of transcription 5B0.058
Tcfe2atranscription factor E2a0.057
Slc12a5solute carrier family 12 (potassium-chloride transporter), member 50.057
Ccnd2cyclin D20.056
Col8a1collagen, type VIII, alpha 10.056
Ciitaclass II, major histocompatibility complex, transactivator0.054
Fgf17fibroblast growth factor 170.054
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.054
Agtr1bangiotensin II receptor, type 1b0.054
Fgf11fibroblast growth factor 110.052
Crhr2corticotropin releasing hormone receptor 20.051
Folr1folate receptor 1 (adult)0.050
Galr3galanin receptor 30.049
Ncam1neural cell adhesion molecule 10.049
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.049
Rgs19regulator of G-protein signaling 190.047
Crygacrystallin, gamma A0.047
Mll5myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)0.047
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.047
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.047
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.046
Ghrhgrowth hormone releasing hormone0.045
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.045
St18suppression of tumorigenicity 180.045
Amnamnionless homolog (mouse)0.045
Unc5bunc-5 homolog B (C. elegans)0.045
Vkorc1vitamin K epoxide reductase complex, subunit 10.045
Sp1Sp1 transcription factor0.044
Acacbacetyl-Coenzyme A carboxylase beta0.044
Shox2short stature homeobox 20.044
Tubg1tubulin, gamma 10.044
Sox17SRY (sex determining region Y)-box 170.044
Atp7bATPase, Cu++ transporting, beta polypeptide0.044
Bmp3bone morphogenetic protein 30.044
Gjd2gap junction protein, delta 20.044
Asipagouti signaling protein0.043
Crhbpcorticotropin releasing hormone binding protein0.043
Arntaryl hydrocarbon receptor nuclear translocator0.042
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.042
Foxd1forkhead box D10.042
Prl8a9prolactin family 8, subfamily a, member 90.042
Aldh3a1aldehyde dehydrogenase 3 family, member A10.041
Gata6GATA binding protein 60.041
Lim2lens intrinsic membrane protein 20.041
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.041
Gja3gap junction protein, alpha 30.040
Ctsccathepsin C0.040
Krtap1-5keratin associated protein 1-50.040
Rbp3retinol binding protein 3, interstitial0.040
Lphn2latrophilin 20.040
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism