The network for 'antigen processing and presentation of exogenous peptide antigen' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

antigen processing and presentation of exogenous peptide antigen

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.

NameDescriptionProbabilityFunc Analog Organism
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)1.000
H2-Aahistocompatibility 2, class II antigen A, alpha1.000
H2-Ab1histocompatibility 2, class II antigen A, beta 11.000
H2-Eb1histocompatibility 2, class II antigen E beta0.999
B2mbeta-2 microglobulin0.998
H2-K1histocompatibility 2, K1, K region0.998
H2-D1histocompatibility 2, D region locus 10.987
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.979
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.977
H2-DMahistocompatibility 2, class II, locus DMa0.911
TapbpTAP binding protein0.898
Lyz2lysozyme 20.847
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.826
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.740
Cd40CD40 antigen0.732
C1qacomplement component 1, q subcomponent, alpha polypeptide0.728
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.664
Ptprcprotein tyrosine phosphatase, receptor type, C0.588
H2-DMb2histocompatibility 2, class II, locus Mb20.582
C1qccomplement component 1, q subcomponent, C chain0.579
H2-Q7histocompatibility 2, Q region locus 70.575
TyrobpTYRO protein tyrosine kinase binding protein0.515
Mavsmitochondrial antiviral signaling protein0.442
Ciitaclass II transactivator0.402
Gm2aGM2 ganglioside activator protein0.342
H2-Q6histocompatibility 2, Q region locus 60.291
Ly86lymphocyte antigen 860.262
Lcklymphocyte protein tyrosine kinase0.243
TcraT-cell receptor alpha chain0.229
Latlinker for activation of T cells0.222
Psmb10proteasome (prosome, macropain) subunit, beta type 100.216
C1qbcomplement component 1, q subcomponent, beta polypeptide0.208
Il2rginterleukin 2 receptor, gamma chain0.197
Unc93b1unc-93 homolog B1 (C. elegans)0.180
Ctsbcathepsin B0.177
Irf8interferon regulatory factor 80.176
Ccl5chemokine (C-C motif) ligand 50.165
H2-Q8histocompatibility 2, Q region locus 80.159
Cd247CD247 antigen0.139
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.127
H2-Obhistocompatibility 2, O region beta locus0.119
Psapprosaposin0.118
Birc3baculoviral IAP repeat-containing 30.106
C920025E04RikRIKEN cDNA C920025E04 gene0.104
Aif1allograft inflammatory factor 10.103
Tgfb1transforming growth factor, beta 10.102
Plbd1phospholipase B domain containing 10.086
Cpceruloplasmin0.082
Cd3gCD3 antigen, gamma polypeptide0.080
AF251705cDNA sequence AF2517050.080
Gbp2guanylate binding protein 20.067
BlkB lymphoid kinase0.062
Gabarapgamma-aminobutyric acid receptor associated protein0.061
Cxcl9chemokine (C-X-C motif) ligand 90.060
Csf1rcolony stimulating factor 1 receptor0.055
Ptpn18protein tyrosine phosphatase, non-receptor type 180.051
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.046
Map3k7mitogen-activated protein kinase kinase kinase 70.044
Hexahexosaminidase A0.042
Tbxas1thromboxane A synthase 1, platelet0.041
Cd52CD52 antigen0.040
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.039
Klrk1killer cell lectin-like receptor subfamily K, member 10.039
Agtr1aangiotensin II receptor, type 1a0.038
Pld4phospholipase D family, member 40.038
Cd2CD2 antigen0.036
Klrd1killer cell lectin-like receptor, subfamily D, member 10.035
Lyz1lysozyme 10.034
AW112010expressed sequence AW1120100.033
Ptprcapprotein tyrosine phosphatase, receptor type, C polypeptide-associated protein0.032
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.031
Cybacytochrome b-245, alpha polypeptide0.031
Calcrlcalcitonin receptor-like0.030
Ctshcathepsin H0.027
S1pr4sphingosine-1-phosphate receptor 40.027
Fcnaficolin A0.026
Sh2d2aSH2 domain protein 2A0.026
Clec4nC-type lectin domain family 4, member n0.025
Shisa5shisa homolog 5 (Xenopus laevis)0.025
Ccl6chemokine (C-C motif) ligand 60.024
Ccr7chemokine (C-C motif) receptor 70.024
Ccr9chemokine (C-C motif) receptor 90.023
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.023
Ly6dlymphocyte antigen 6 complex, locus D0.022
H2-Oahistocompatibility 2, O region alpha locus0.021
Hcsthematopoietic cell signal transducer0.021
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.021
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.021
Irf5interferon regulatory factor 50.021
FaslFas ligand (TNF superfamily, member 6)0.021
Ifngr1interferon gamma receptor 10.021
Cd27CD27 antigen0.020
Napsanapsin A aspartic peptidase0.020
Cd6CD6 antigen0.020
Cxcr3chemokine (C-X-C motif) receptor 30.020
Rhohras homolog gene family, member H0.019
Glis2GLIS family zinc finger 20.019
Bst2bone marrow stromal cell antigen 20.019
Ctswcathepsin W0.019
Il2interleukin 20.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.993
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.956
HLA-DMBmajor histocompatibility complex, class II, DM beta0.896
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.861
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.646
SYKspleen tyrosine kinase0.594
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.201
HLA-DRB5major histocompatibility complex, class II, DR beta 50.140
HLA-DPB1major histocompatibility complex, class II, DP beta 10.094
TAPBPTAP binding protein (tapasin)0.086
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.081
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.068
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.040
CTSAcathepsin A0.040
AIF1allograft inflammatory factor 10.033
PSAPprosaposin0.028
HLA-DRB4major histocompatibility complex, class II, DR beta 40.025
PTPN6protein tyrosine phosphatase, non-receptor type 60.024
UBASH3Bubiquitin associated and SH3 domain containing B0.019
BLNKB-cell linker0.019
LAPTM5lysosomal protein transmembrane 50.019
TYROBPTYRO protein tyrosine kinase binding protein0.017
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.015
XIAPX-linked inhibitor of apoptosis0.015
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.013
HLA-DQA2major histocompatibility complex, class II, DQ alpha 20.013
FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)0.012
HLA-Amajor histocompatibility complex, class I, A0.012
CTSHcathepsin H0.012
HFEhemochromatosis0.012
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.686
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.556
RT1-EC2RT1 class Ib, locus EC20.125
Aif1allograft inflammatory factor 10.026
RT1-DMbRT1 class II, locus DMb0.023
RT1-DMaRT1 class II, locus DMa0.021
Psapprosaposin0.019
RT1-Db1RT1 class II, locus Db10.014
Ctsscathepsin S0.012
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.012
Lyz2lysozyme 20.011
C1qbcomplement component 1, q subcomponent, B chain0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism