The network for 'demethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


The process of removing one or more methyl groups from a molecule.

NameDescriptionProbabilityFunc Analog Organism
Rnf2ring finger protein 20.958
Idi1isopentenyl-diphosphate delta isomerase0.626
Zfp292zinc finger protein 2920.550
Kdm1alysine (K)-specific demethylase 1A0.507
Sin3atranscriptional regulator, SIN3A (yeast)0.433
Kdm2blysine (K)-specific demethylase 2B0.340
Csnk2a1casein kinase 2, alpha 1 polypeptide0.276
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.250
Ctbp1C-terminal binding protein 10.245
Sqlesqualene epoxidase0.200
Trim28tripartite motif-containing 280.196
Clk1CDC-like kinase 10.161
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.154
BcorBCL6 interacting corepressor0.144
Ddx3yDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.139
Gm5806predicted gene 58060.132
Men1multiple endocrine neoplasia 10.120
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.098
Sc4molsterol-C4-methyl oxidase-like0.096
Cbx5chromobox homolog 5 (Drosophila HP1a)0.091
Otcornithine transcarbamylase0.090
Cbx8chromobox homolog 8 (Drosophila Pc class)0.087
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.078
Nup62nucleoporin 620.069
Clk4CDC like kinase 40.065
Arid4bAT rich interactive domain 4B (RBP1-like)0.062
Rnps1ribonucleic acid binding protein S10.061
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.052
Eif2s3yeukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked0.049
Mbtd1mbt domain containing 10.048
Hsd17b7hydroxysteroid (17-beta) dehydrogenase 70.044
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.043
NanogNanog homeobox0.040
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.040
Zfp654zinc finger protein 6540.038
Cdk2ap1CDK2 (cyclin-dependent kinase 2)-associated protein 10.038
Trim24tripartite motif-containing 240.037
Hdac1histone deacetylase 10.034
A930001N09RikRIKEN cDNA A930001N09 gene0.031
Srmspermidine synthase0.029
Cyp3a16cytochrome P450, family 3, subfamily a, polypeptide 160.028
Lin28alin-28 homolog A (C. elegans)0.028
Ces2acarboxylesterase 2A0.027
Snrpasmall nuclear ribonucleoprotein polypeptide A0.026
Ints3integrator complex subunit 30.026
Nr1i2nuclear receptor subfamily 1, group I, member 20.026
Ints5integrator complex subunit 50.026
Utyubiquitously transcribed tetratricopeptide repeat gene, Y chromosome0.025
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.025
Jarid2jumonji, AT rich interactive domain 20.025
Morf4l1mortality factor 4 like 10.025
Zmym2zinc finger, MYM-type 20.025
Kdm4clysine (K)-specific demethylase 4C0.024
Sult1d1sulfotransferase family 1D, member 10.024
Impdh2inosine 5'-phosphate dehydrogenase 20.024
Pcgf2polycomb group ring finger 20.024
Sult1b1sulfotransferase family 1B, member 10.023
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.023
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.023
Tdgthymine DNA glycosylase0.023
Ubap2ubiquitin-associated protein 20.023
Klhl24kelch-like 24 (Drosophila)0.023
Xrn15'-3' exoribonuclease 10.022
F9coagulation factor IX0.022
Cyp3a41bcytochrome P450, family 3, subfamily a, polypeptide 41B0.022
Eif4a2eukaryotic translation initiation factor 4A20.022
Srsf4serine/arginine-rich splicing factor 40.021
Arid1aAT rich interactive domain 1A (SWI-like)0.021
March7membrane-associated ring finger (C3HC4) 70.021
Csnk2a2casein kinase 2, alpha prime polypeptide0.021
Sc5dsterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)0.021
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.020
Avl9AVL9 homolog (S. cerevisiase)0.019
Ino80eINO80 complex subunit E0.019
Lsslanosterol synthase0.019
MgaMAX gene associated0.019
Zfc3h1zinc finger, C3H1-type containing0.019
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.019
Phc1polyhomeotic-like 1 (Drosophila)0.019
Ccnt2cyclin T20.019
Cps1carbamoyl-phosphate synthetase 10.018
Tex10testis expressed gene 100.018
Ces1gcarboxylesterase 1G0.018
Pom121nuclear pore membrane protein 1210.018
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.018
Ldlrlow density lipoprotein receptor0.018
U2af2U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 20.018
Rlfrearranged L-myc fusion sequence0.018
Upf2UPF2 regulator of nonsense transcripts homolog (yeast)0.018
Prdm1PR domain containing 1, with ZNF domain0.018
Stard4StAR-related lipid transfer (START) domain containing 40.018
Kti12KTI12 homolog, chromatin associated (S. cerevisiae)0.018
Fiz1Flt3 interacting zinc finger protein 10.018
Slco1a1solute carrier organic anion transporter family, member 1a10.018
Rbm14RNA binding motif protein 140.017
Fbxo38F-box protein 380.017
Bap1Brca1 associated protein 10.017
Mogsmannosyl-oligosaccharide glucosidase0.017
Cul9cullin 90.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cyp1acytochrome P450, family 1, subfamily A0.037
tm4sf4transmembrane 4 L six family member 40.012
npeppsaminopeptidase puromycin sensitive0.012
dopey1dopey family member 10.012
dedd1death effector domain-containing 10.012
hnf4ghepatocyte nuclear factor 4, gamma0.011
myef2myelin expression factor 20.011
fabp10afatty acid binding protein 10a, liver basic0.010
abca3ATP-binding cassette, sub-family A (ABC1), member 30.010
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.010
ankrd12ankyrin repeat domain 120.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Aos1CG12276 gene product from transcript CG12276-RA0.027
CG11985CG11985 gene product from transcript CG11985-RA0.020
Ssb-c31aSingle stranded-binding protein c31A0.014
Rab11Rab-protein 110.014
gemininCG3183 gene product from transcript CG3183-RA0.011
Ras85DRas oncogene at 85D0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.925
BCORBCL6 corepressor0.865
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.616
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.485
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.324
DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.306
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.298
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.297
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.224
BRD4bromodomain containing 40.214
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.211
ZFXzinc finger protein, X-linked0.205
SSRP1structure specific recognition protein 10.199
USP9Yubiquitin specific peptidase 9, Y-linked0.195
HDAC3histone deacetylase 30.186
MAGEA2melanoma antigen family A, 20.180
CCNL1cyclin L10.174
NCOR1nuclear receptor corepressor 10.169
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.157
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.154
RPS4Y1ribosomal protein S4, Y-linked 10.151
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.148
HIST1H3Bhistone cluster 1, H3b0.140
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.139
CHD4chromodomain helicase DNA binding protein 40.138
RLFrearranged L-myc fusion0.135
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.134
ZNF217zinc finger protein 2170.132
UBXN7UBX domain protein 70.122
CYorf15Achromosome Y open reading frame 15A0.121
EIF1AYeukaryotic translation initiation factor 1A, Y-linked0.112
PRPF8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)0.111
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.103
IMPDH2IMP (inosine 5'-monophosphate) dehydrogenase 20.101
HDAC1histone deacetylase 10.098
PHB2prohibitin 20.093
C8Acomplement component 8, alpha polypeptide0.089
ZNF512Bzinc finger protein 512B0.087
ZCCHC17zinc finger, CCHC domain containing 170.087
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.087
YBX1Y box binding protein 10.085
ZNF292zinc finger protein 2920.083
PGRMC1progesterone receptor membrane component 10.074
F9coagulation factor IX0.073
MKRN1makorin ring finger protein 10.068
UBR1ubiquitin protein ligase E3 component n-recognin 10.066
PABPC4poly(A) binding protein, cytoplasmic 4 (inducible form)0.064
NONOnon-POU domain containing, octamer-binding0.063
A1CFAPOBEC1 complementation factor0.062
KDM5Dlysine (K)-specific demethylase 5D0.061
RIOK3RIO kinase 3 (yeast)0.059
NUDT3nudix (nucleoside diphosphate linked moiety X)-type motif 30.058
BCL6B-cell CLL/lymphoma 60.057
MASP2mannan-binding lectin serine peptidase 20.056
FBXO33F-box protein 330.051
MTA1metastasis associated 10.051
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.051
MED13Lmediator complex subunit 13-like0.051
SENP3SUMO1/sentrin/SMT3 specific peptidase 30.049
PRMT6protein arginine methyltransferase 60.049
HBP1HMG-box transcription factor 10.048
ADH6alcohol dehydrogenase 6 (class V)0.047
RXRAretinoid X receptor, alpha0.046
HIST1H4Fhistone cluster 1, H4f0.042
UTYubiquitously transcribed tetratricopeptide repeat gene, Y-linked0.042
ELLelongation factor RNA polymerase II0.041
CHD8chromodomain helicase DNA binding protein 80.041
HELZhelicase with zinc finger0.041
BRD2bromodomain containing 20.041
USP9Xubiquitin specific peptidase 9, X-linked0.040
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.040
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.040
NCOA3nuclear receptor coactivator 30.038
ZFYzinc finger protein, Y-linked0.037
KLHL24kelch-like 24 (Drosophila)0.036
NOB1NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)0.035
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.034
OXA1Loxidase (cytochrome c) assembly 1-like0.033
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.033
SNAI1snail homolog 1 (Drosophila)0.032
POLHpolymerase (DNA directed), eta0.032
CCNG2cyclin G20.031
PPP4Cprotein phosphatase 4, catalytic subunit0.030
WDR48WD repeat domain 480.030
MEPCEmethylphosphate capping enzyme0.029
RCOR3REST corepressor 30.029
EIF3Deukaryotic translation initiation factor 3, subunit D0.029
EIF3CLeukaryotic translation initiation factor 3, subunit C-like0.028
ALDOBaldolase B, fructose-bisphosphate0.028
TP53BP1tumor protein p53 binding protein 10.028
PELI1pellino homolog 1 (Drosophila)0.028
SKILSKI-like oncogene0.028
LAMC3laminin, gamma 30.027
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.027
SMAD7SMAD family member 70.027
C6complement component 60.027
JARID2jumonji, AT rich interactive domain 20.027
ZCCHC6zinc finger, CCHC domain containing 60.026
H3F3CH3 histone, family 3C0.026
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sc4molsterol-C4-methyl oxidase-like0.212
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.181
Sqlesqualene epoxidase0.152
Idi1isopentenyl-diphosphate delta isomerase 10.146
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.092
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.061
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.060
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.045
Acat3acetyl-Coenzyme A acetyltransferase 30.042
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.038
Insig1insulin induced gene 10.035
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.031
Dhcr77-dehydrocholesterol reductase0.030
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.022
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.017
A1i3alpha-1-inhibitor III0.017
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.016
Otcornithine carbamoyltransferase0.016
Sc5dlsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.016
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.015
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.014
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.013
LOC293989cytochrome P450-like0.013
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.013
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.012
Arid4aAT rich interactive domain 4A (Rbp1 like)0.012
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.011
Nr0b2nuclear receptor subfamily 0, group B, member 20.011
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.011
Olr1701olfactory receptor 17010.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism