The network for 't cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t cell differentiation

The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

NameDescriptionProbabilityFunc Analog Organism
Ikzf1IKAROS family zinc finger 11.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
FynFyn proto-oncogene0.999
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.998
FasFas (TNF receptor superfamily member 6)0.998
Stat3signal transducer and activator of transcription 30.997
Map3k14mitogen-activated protein kinase kinase kinase 140.996
Socs1suppressor of cytokine signaling 10.996
Fgfr2fibroblast growth factor receptor 20.996
Foxp3forkhead box P30.995
Efnb2ephrin B20.993
Il2rginterleukin 2 receptor, gamma chain0.993
Tgfb1transforming growth factor, beta 10.993
Ptenphosphatase and tensin homolog0.993
Tnftumor necrosis factor0.992
Lcklymphocyte protein tyrosine kinase0.992
Cd28CD28 antigen0.992
Cd247CD247 antigen0.991
Cd19CD19 antigen0.981
Il2rbinterleukin 2 receptor, beta chain0.978
Cd40CD40 antigen0.976
Icosinducible T-cell co-stimulator0.976
Batfbasic leucine zipper transcription factor, ATF-like0.975
Shhsonic hedgehog0.970
Leprleptin receptor0.969
Apcadenomatosis polyposis coli0.969
Hoxa1homeobox A10.969
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.968
Latlinker for activation of T cells0.968
Rag1recombination activating gene 10.965
Bmp4bone morphogenetic protein 40.962
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.962
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.961
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.954
Socs3suppressor of cytokine signaling 30.954
Smad4MAD homolog 4 (Drosophila)0.949
Ctnnb1catenin (cadherin associated protein), beta 10.943
Runx1runt related transcription factor 10.942
Trp53transformation related protein 530.939
Pax2paired box gene 20.939
Vegfavascular endothelial growth factor A0.933
Ccr7chemokine (C-C motif) receptor 70.931
Wnt3awingless-related MMTV integration site 3A0.927
Ifnginterferon gamma0.922
Csf1colony stimulating factor 1 (macrophage)0.914
Lef1lymphoid enhancer binding factor 10.913
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.912
Gata3GATA binding protein 30.904
Jak2Janus kinase 20.901
Rargretinoic acid receptor, gamma0.898
Zeb1zinc finger E-box binding homeobox 10.892
Ptgs2prostaglandin-endoperoxide synthase 20.891
Tnfaip3tumor necrosis factor, alpha-induced protein 30.883
Ighimmunoglobulin heavy chain complex0.880
Rxraretinoid X receptor alpha0.878
Bcl3B-cell leukemia/lymphoma 30.874
Nckap1lNCK associated protein 1 like0.861
Rararetinoic acid receptor, alpha0.857
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.853
Ccr1chemokine (C-C motif) receptor 10.851
Cd4CD4 antigen0.847
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.847
Ctswcathepsin W0.841
Gata6GATA binding protein 60.839
Smad3MAD homolog 3 (Drosophila)0.832
Cdkn1bcyclin-dependent kinase inhibitor 1B0.832
Foxf1aforkhead box F1a0.831
H2-DMb2histocompatibility 2, class II, locus Mb20.829
Inpp5dinositol polyphosphate-5-phosphatase D0.826
Stat5bsignal transducer and activator of transcription 5B0.823
Pdcd1programmed cell death 10.820
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.807
RybpRING1 and YY1 binding protein0.804
Relreticuloendotheliosis oncogene0.802
Arandrogen receptor0.801
Tbx21T-box 210.795
Ptprcprotein tyrosine phosphatase, receptor type, C0.792
Itgaxintegrin alpha X0.792
CblCasitas B-lineage lymphoma0.792
Lyz2lysozyme 20.791
Pitx1paired-like homeodomain transcription factor 10.789
TcraT-cell receptor alpha chain0.787
Dlx5distal-less homeobox 50.787
Hic1hypermethylated in cancer 10.787
Pbx1pre B-cell leukemia transcription factor 10.785
Gli3GLI-Kruppel family member GLI30.784
Gata4GATA binding protein 40.780
Hoxa3homeobox A30.779
Sox2SRY-box containing gene 20.779
Rnf2ring finger protein 20.777
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.777
Cd44CD44 antigen0.770
Dll4delta-like 4 (Drosophila)0.769
Rag2recombination activating gene 20.769
Bcl6B-cell leukemia/lymphoma 60.764
Ccl3chemokine (C-C motif) ligand 30.760
Hoxd13homeobox D130.758
Bcl2B-cell leukemia/lymphoma 20.754
Ltblymphotoxin B0.750
Kitkit oncogene0.748
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cmybtranscription factor cmyb0.969
bmp2bbone morphogenetic protein 2b0.557
runx2arunt-related transcription factor 2a0.555
runx1runt-related transcription factor 10.340
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.336
lef1lymphocyte enhancer binding factor 10.285
cdh1cadherin 1, epithelial0.243
kitakit receptor a0.240
fgf3fibroblast growth factor 30.223
cd247lCD247 antigen like0.211
runx3runt-related transcription factor 30.198
il7rinterleukin 7 receptor0.186
fgf4fibroblast growth factor 40.182
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.180
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.173
foxi1forkhead box I10.170
notch3notch homolog 30.166
foxa1forkhead box A10.148
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.132
foxa2forkhead box A20.126
npm4nucleophosmin/nucleoplasmin, 40.122
gbx2gastrulation brain homeo box 20.110
mmp9matrix metalloproteinase 90.109
eomesbeomesodermin homolog b0.104
rpl7aribosomal protein L7a0.103
pax5paired box gene 50.102
lcklymphocyte-specific protein tyrosine kinase0.100
ccnd1cyclin D10.097
fzd8afrizzled homolog 8a0.092
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.091
ikzf1IKAROS family zinc finger 1 (Ikaros)0.082
anxa1bannexin A1b0.081
cd247CD247 antigen0.079
cd8aCD8 antigen, alpha polypeptide0.078
cdx4caudal type homeo box transcription factor 40.076
jak1Janus kinase 10.072
tal1T-cell acute lymphocytic leukemia 10.070
trim33tripartite motif-containing 330.067
krt4keratin 40.067
dlx6adistal-less homeobox gene 6a0.066
tbpTATA box binding protein0.064
mitfamicrophthalmia-associated transcription factor a0.064
wnt1wingless-type MMTV integration site family, member 10.061
gata1aGATA binding protein 1a0.060
zgc:64115zgc:641150.059
nitr9novel immune-type receptor 90.057
rag1recombination activating gene 10.056
crfa31.2IL-4RA-like protein 20.051
sox9bSRY-box containing gene 9b0.048
ihhaIndian hedgehog homolog a0.048
satb2SATB homeobox 20.047
tyrobpTYRO protein tyrosine kinase binding protein0.046
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.044
jag1bjagged 1b0.044
kitlgakit ligand a0.043
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.041
lft1lefty10.039
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.038
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.037
lmo4aLIM domain only 4a0.036
eya2eyes absent homolog 2 (Drosophila)0.035
ighzimmunoglobulin heavy constant zeta0.035
lmx1b.1LIM homeobox transcription factor 1, beta 10.035
jag2jagged 20.034
tp63tumor protein p630.034
egr2bearly growth response 2b0.033
ptpn6protein tyrosine phosphatase, non-receptor type 60.033
ifnphi1interferon phi 10.033
LOC100151531zinc finger protein Gfi-1b-like0.031
il4rinterleukin 4 receptor0.030
ncor1nuclear receptor co-repressor 10.029
ptgs2aprostaglandin-endoperoxide synthase 2a0.029
bcl2B-cell leukemia/lymphoma 20.029
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.028
irx7iroquois homeobox protein 70.028
dnmt4DNA (cytosine-5-)-methyltransferase 40.027
csf1racolony stimulating factor 1 receptor, a0.027
tshz1teashirt family zinc finger 10.026
sox2SRY-box containing gene 20.025
foxi2forkhead box I20.025
id1inhibitor of DNA binding 10.024
abcg2cATP-binding cassette, sub-family G (WHITE), member 2c0.024
hey1hairy/enhancer-of-split related with YRPW motif 10.023
sox19aSRY-box containing gene 19a0.023
hlxb9lahomeo box HB9 like a0.022
elk4ELK4, ETS-domain protein0.022
ihhbIndian hedgehog homolog b0.021
gata3GATA-binding protein 30.021
ptch1patched 10.021
rpl23aribosomal protein L23a0.021
cdkn1acyclin-dependent kinase inhibitor 1A0.020
dusp6dual specificity phosphatase 60.020
wu:fb18f06wu:fb18f060.020
dll4delta-like 4 (Drosophila)0.020
ccr9bchemokine (C-C motif) receptor 9b0.019
nrp2bneuropilin 2b0.019
LOC553366hypothetical protein LOC5533660.019
fgf20afibroblast growth factor 20a0.018
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.017
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.017
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.998
EGFRepidermal growth factor receptor0.941
TP53tumor protein p530.844
TRAF1TNF receptor-associated factor 10.748
PTPN6protein tyrosine phosphatase, non-receptor type 60.731
NCOR2nuclear receptor corepressor 20.693
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.619
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.575
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.566
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.508
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.479
HLA-Emajor histocompatibility complex, class I, E0.479
BIRC3baculoviral IAP repeat containing 30.472
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.458
IL4Rinterleukin 4 receptor0.452
EP300E1A binding protein p3000.419
PPARAperoxisome proliferator-activated receptor alpha0.407
LATlinker for activation of T cells0.396
CASP8caspase 8, apoptosis-related cysteine peptidase0.383
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.372
SIN3ASIN3 homolog A, transcription regulator (yeast)0.358
HLA-Bmajor histocompatibility complex, class I, B0.352
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.330
SYKspleen tyrosine kinase0.307
HLA-Gmajor histocompatibility complex, class I, G0.305
HLA-Fmajor histocompatibility complex, class I, F0.281
AKT1v-akt murine thymoma viral oncogene homolog 10.278
RB1retinoblastoma 10.276
PMLpromyelocytic leukemia0.261
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.252
NOTCH1notch 10.245
RUNX1runt-related transcription factor 10.243
HLA-Amajor histocompatibility complex, class I, A0.239
ZFYVE9zinc finger, FYVE domain containing 90.221
ICAM1intercellular adhesion molecule 10.219
CD2CD2 molecule0.211
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.201
LIN9lin-9 homolog (C. elegans)0.201
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.195
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.194
PLCG1phospholipase C, gamma 10.188
IL2RBinterleukin 2 receptor, beta0.182
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.180
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.177
CD247CD247 molecule0.175
CREBBPCREB binding protein0.173
B2Mbeta-2-microglobulin0.164
BCL3B-cell CLL/lymphoma 30.163
IL2RGinterleukin 2 receptor, gamma0.161
DLG1discs, large homolog 1 (Drosophila)0.156
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.153
CD3DCD3d molecule, delta (CD3-TCR complex)0.151
CD80CD80 molecule0.146
CTBP1C-terminal binding protein 10.145
HLA-Cmajor histocompatibility complex, class I, C0.135
FASFas (TNF receptor superfamily, member 6)0.135
CD86CD86 molecule0.127
BMPR1Abone morphogenetic protein receptor, type IA0.123
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.120
PTPN1protein tyrosine phosphatase, non-receptor type 10.117
APLFaprataxin and PNKP like factor0.114
RXRAretinoid X receptor, alpha0.109
CFLARCASP8 and FADD-like apoptosis regulator0.105
IL23Ainterleukin 23, alpha subunit p190.105
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.101
PRKCQprotein kinase C, theta0.097
NR0B1nuclear receptor subfamily 0, group B, member 10.095
NCOA1nuclear receptor coactivator 10.094
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.090
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.086
WIPF1WAS/WASL interacting protein family, member 10.082
FYNFYN oncogene related to SRC, FGR, YES0.081
GHRgrowth hormone receptor0.081
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.080
TGFB1transforming growth factor, beta 10.079
FSTL1follistatin-like 10.078
TGIF1TGFB-induced factor homeobox 10.077
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.072
TAL1T-cell acute lymphocytic leukemia 10.070
CD28CD28 molecule0.069
EGR2early growth response 20.068
CASP10caspase 10, apoptosis-related cysteine peptidase0.068
MPZL3myelin protein zero-like 30.067
SH2D1ASH2 domain containing 1A0.065
CXCR4chemokine (C-X-C motif) receptor 40.064
NCK1NCK adaptor protein 10.063
DAXXdeath-domain associated protein0.063
CD48CD48 molecule0.062
MAPK14mitogen-activated protein kinase 140.062
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.062
IL7Rinterleukin 7 receptor0.062
HCKhemopoietic cell kinase0.061
SMAD7SMAD family member 70.061
CHD7chromodomain helicase DNA binding protein 70.060
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.059
FASLGFas ligand (TNF superfamily, member 6)0.059
SPRR2Asmall proline-rich protein 2A0.059
NOTCH3notch 30.058
SIRT1sirtuin 10.057
IFNGinterferon, gamma0.055
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.817
RT1-Db1RT1 class II, locus Db10.774
Cd5Cd5 molecule0.495
RT1-BbRT1 class II, locus Bb0.448
Junbjun B proto-oncogene0.350
Cd37CD37 molecule0.332
Cd247Cd247 molecule0.166
Spnsialophorin0.157
Cd2Cd2 molecule0.143
Nr4a1nuclear receptor subfamily 4, group A, member 10.118
TcrbT-cell receptor beta chain0.110
Il2rbinterleukin 2 receptor, beta0.108
Ccl5chemokine (C-C motif) ligand 50.092
Vav1vav 1 guanine nucleotide exchange factor0.088
Igh-6immunoglobulin heavy chain 60.082
Laptm5lysosomal protein transmembrane 50.063
Cxcr4chemokine (C-X-C motif) receptor 40.061
Btg2BTG family, member 20.060
Il1r1interleukin 1 receptor, type I0.054
Anpepalanyl (membrane) aminopeptidase0.048
Gja4gap junction protein, alpha 40.047
LOC100361571keratin associated protein 1-3-like0.039
Il2rginterleukin 2 receptor, gamma0.039
Tgfbr2transforming growth factor, beta receptor II0.034
Ptger4prostaglandin E receptor 4 (subtype EP4)0.033
Slfn2schlafen 20.033
Sod3superoxide dismutase 3, extracellular0.032
Hdac7histone deacetylase 70.032
Pld1phospholipase D10.030
Rararetinoic acid receptor, alpha0.029
Gzmkgranzyme K0.028
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.027
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.026
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.025
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.025
Fth1ferritin, heavy polypeptide 10.025
Egr2early growth response 20.025
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.024
Mapk7mitogen-activated protein kinase 70.024
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.023
Gimap4GTPase, IMAP family member 40.023
Lilrb3lleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like0.022
Nek9NIMA (never in mitosis gene a)- related kinase 90.022
RT1-DMaRT1 class II, locus DMa0.022
Hckhemopoietic cell kinase0.022
Itgadintegrin, alpha D0.021
Podxlpodocalyxin-like0.021
RT1-DMbRT1 class II, locus DMb0.021
Bin2bridging integrator 20.020
Hyal2hyaluronoglucosaminidase 20.020
Prkchprotein kinase C, eta0.020
Foxs1forkhead box S10.020
Lrg1leucine-rich alpha-2-glycoprotein 10.020
Engendoglin0.019
Acp5acid phosphatase 5, tartrate resistant0.018
TekTEK tyrosine kinase, endothelial0.018
RT1-ClRT1 class Ib, locus Cl0.018
Cd3gCD3 molecule, gamma0.017
Notch4Notch homolog 4 (Drosophila)0.017
Il1binterleukin 1 beta0.017
Zap70zeta-chain (TCR) associated protein kinase0.017
Lyz2lysozyme 20.016
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.016
Tgfbr3transforming growth factor, beta receptor III0.016
Ehfets homologous factor0.015
Ddr1discoidin domain receptor tyrosine kinase 10.015
Napsanapsin A aspartic peptidase0.015
Cybbcytochrome b-245, beta polypeptide0.015
Itgb4integrin, beta 40.014
Itgb7integrin, beta 70.014
Crygecrystallin, gamma E0.014
Klf13Kruppel-like factor 130.014
Cd53Cd53 molecule0.014
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.013
Nos3nitric oxide synthase 3, endothelial cell0.013
Calcrlcalcitonin receptor-like0.013
Cd4Cd4 molecule0.013
Batf3basic leucine zipper transcription factor, ATF-like 30.013
Gata6GATA binding protein 60.013
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.012
Mylk2myosin light chain kinase 20.012
Cd3dCD3 molecule, delta0.012
Map3k3mitogen activated protein kinase kinase kinase 30.012
Prom2prominin 20.012
Cfpcomplement factor properdin0.011
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.011
Dusp6dual specificity phosphatase 60.011
Unc5bunc-5 homolog B (C. elegans)0.011
Angpt2angiopoietin 20.011
Mef2dmyocyte enhancer factor 2D0.011
Sftpdsurfactant protein D0.011
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.011
Stat4signal transducer and activator of transcription 40.011
Arhgap25Rho GTPase activating protein 250.011
ShprhSNF2 histone linker PHD RING helicase0.011
Prm1protamine 10.011
Srysex determining region Y0.011
Ciitaclass II, major histocompatibility complex, transactivator0.010
Hmha1histocompatibility (minor) HA-10.010
Efna5ephrin A50.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism