The network for 'hepaticobiliary system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hepaticobiliary system development

The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.

NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.997
Ptenphosphatase and tensin homolog0.994
Gata4GATA binding protein 40.989
Bmp4bone morphogenetic protein 40.986
Stat3signal transducer and activator of transcription 30.946
Pitx2paired-like homeodomain transcription factor 20.941
Hes1hairy and enhancer of split 1 (Drosophila)0.934
Shhsonic hedgehog0.922
Fgf8fibroblast growth factor 80.901
Notch1Notch gene homolog 1 (Drosophila)0.870
Gli3GLI-Kruppel family member GLI30.867
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.861
Onecut1one cut domain, family member 10.839
Cdkn1bcyclin-dependent kinase inhibitor 1B0.824
Pkd1polycystic kidney disease 1 homolog0.813
Chd7chromodomain helicase DNA binding protein 70.809
Tgfbr2transforming growth factor, beta receptor II0.792
Meox2mesenchyme homeobox 20.780
Isl1ISL1 transcription factor, LIM/homeodomain0.760
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.742
Hand2heart and neural crest derivatives expressed transcript 20.742
Vegfavascular endothelial growth factor A0.740
Hhexhematopoietically expressed homeobox0.709
AxlAXL receptor tyrosine kinase0.654
Rxraretinoid X receptor alpha0.623
Acvr1activin A receptor, type 10.621
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.619
Ptpn11protein tyrosine phosphatase, non-receptor type 110.618
Pax3paired box gene 30.604
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.599
Smad4MAD homolog 4 (Drosophila)0.589
Trp53transformation related protein 530.580
Smad3MAD homolog 3 (Drosophila)0.549
Nos3nitric oxide synthase 3, endothelial cell0.535
Pbx1pre B-cell leukemia transcription factor 10.535
Ptgs2prostaglandin-endoperoxide synthase 20.526
Map3k14mitogen-activated protein kinase kinase kinase 140.513
Retret proto-oncogene0.511
Apoeapolipoprotein E0.499
Foxa2forkhead box A20.474
Gopcgolgi associated PDZ and coiled-coil motif containing0.468
Rb1retinoblastoma 10.465
Hnf4ahepatic nuclear factor 4, alpha0.459
Alx4aristaless-like homeobox 40.452
Tbx1T-box 10.449
Gata6GATA binding protein 60.436
Apcadenomatosis polyposis coli0.403
Nos1nitric oxide synthase 1, neuronal0.390
FosFBJ osteosarcoma oncogene0.389
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.388
Fgfr1fibroblast growth factor receptor 10.376
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.374
Cdk6cyclin-dependent kinase 60.373
Smad6MAD homolog 6 (Drosophila)0.367
Jag1jagged 10.366
Gdnfglial cell line derived neurotrophic factor0.355
Rargretinoic acid receptor, gamma0.346
Nf1neurofibromatosis 10.341
Sox17SRY-box containing gene 170.337
Map3k7mitogen-activated protein kinase kinase kinase 70.329
Pax2paired box gene 20.322
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.317
Notch2Notch gene homolog 2 (Drosophila)0.297
Ece1endothelin converting enzyme 10.296
Ascl1achaete-scute complex homolog 1 (Drosophila)0.292
Dll1delta-like 1 (Drosophila)0.289
Tcfap2atranscription factor AP-2, alpha0.273
Gli2GLI-Kruppel family member GLI20.271
Nr3c1nuclear receptor subfamily 3, group C, member 10.262
Ezh2enhancer of zeste homolog 2 (Drosophila)0.261
Erbb2ipErbb2 interacting protein0.259
Hand1heart and neural crest derivatives expressed transcript 10.251
Fzd1frizzled homolog 1 (Drosophila)0.250
Gli1GLI-Kruppel family member GLI10.250
Alx3aristaless-like homeobox 30.249
Tefthyrotroph embryonic factor0.248
Wnt6wingless-related MMTV integration site 60.244
Wnt5awingless-related MMTV integration site 5A0.243
Shesrc homology 2 domain-containing transforming protein E0.241
Mks1Meckel syndrome, type 10.240
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.236
Traf6TNF receptor-associated factor 60.234
Ror2receptor tyrosine kinase-like orphan receptor 20.233
Ighimmunoglobulin heavy chain complex0.232
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.232
CrebbpCREB binding protein0.229
Tgfb2transforming growth factor, beta 20.229
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.226
Tbx2T-box 20.220
Rarbretinoic acid receptor, beta0.218
Cdk4cyclin-dependent kinase 40.215
Tyro3TYRO3 protein tyrosine kinase 30.211
Foxc1forkhead box C10.210
Arid1aAT rich interactive domain 1A (SWI-like)0.210
Bcl2B-cell leukemia/lymphoma 20.208
Kif3akinesin family member 3A0.206
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.204
Foxp3forkhead box P30.201
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gata6GATA-binding protein 60.985
tbx1T-box 10.958
gata5GATA-binding protein 50.933
fgf3fibroblast growth factor 30.926
tp53tumor protein p530.907
rargaretinoic acid receptor gamma a0.882
notch3notch homolog 30.859
jag2jagged 20.853
hnf1baHNF1 homeobox Ba0.852
metmet proto-oncogene (hepatocyte growth factor receptor)0.845
ahr2aryl hydrocarbon receptor 20.803
bmp2abone morphogenetic protein 2a0.773
sec61al1Sec61 alpha like 10.765
wnt5bwingless-type MMTV integration site family, member 5b0.718
eya1eyes absent homolog 10.712
cdx4caudal type homeo box transcription factor 40.703
foxa3forkhead box A30.702
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.701
bhlhe40basic helix-loop-helix family, member e400.694
fzd8afrizzled homolog 8a0.666
gdf6agrowth differentiation factor 6a0.643
flhfloating head0.606
dkk1bdickkopf 1b0.590
bmp2bbone morphogenetic protein 2b0.589
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.586
bmpr1aabone morphogenetic protein receptor, type 1aa0.562
axin2axin 2 (conductin, axil)0.559
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.550
fzd7afrizzled homolog 7a0.542
osr1odd-skipped related 1 (Drosophila)0.532
tcf7transcription factor 7 (T-cell specific, HMG-box)0.530
id1inhibitor of DNA binding 10.529
notch2notch homolog 20.483
her6hairy-related 60.458
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.456
LOC564872monocarboxylate transporter 7-like0.456
ahctf1AT hook containing transcription factor 10.451
wnt3wingless-type MMTV integration site family, member 30.444
lef1lymphocyte enhancer binding factor 10.433
wif1wnt inhibitory factor 10.428
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.423
pea3ETS-domain transcription factor pea30.402
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.402
tal1T-cell acute lymphocytic leukemia 10.397
cxcr4achemokine (C-X-C motif) receptor 4a0.395
hhexhematopoietically expressed homeobox0.377
nf1aneurofibromin 1a0.373
gata2aGATA-binding protein 2a0.363
ndr2nodal-related 20.363
gata4GATA-binding protein 40.345
etv2ets variant gene 20.319
pitx3paired-like homeodomain transcription factor 30.318
krit1KRIT1, ankyrin repeat containing0.314
slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.311
nav3neuron navigator 30.310
nrp2bneuropilin 2b0.295
hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.293
lmo4aLIM domain only 4a0.291
egr2bearly growth response 2b0.289
cdh1cadherin 1, epithelial0.280
kdrlkinase insert domain receptor like0.279
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.277
vcanaversican a0.274
wnt2bbwingless-type MMTV integration site family, member 2Bb0.272
tagln2transgelin 20.269
jag1bjagged 1b0.265
fgfr1afibroblast growth factor receptor 1a0.263
pax6bpaired box gene 6b0.263
rfx2regulatory factor X, 2 (influences HLA class II expression)0.261
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.257
map2k4amitogen-activated protein kinase kinase 4a0.256
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.254
fn1fibronectin 10.254
spry4sprouty (Drosophila) homolog 40.253
ifnphi1interferon phi 10.252
pcdh18aprotocadherin 18a0.247
ftr82finTRIM family, member 820.247
wnt11wingless-type MMTV integration site family, member 110.245
slc2a11lsolute carrier family 2 (facilitated glucose transporter), member 11-like0.244
bmp4bone morphogenetic protein 40.243
prkciprotein kinase C, iota0.240
tgfbr2transforming growth factor, beta receptor II0.238
wnt2bawingless-type MMTV integration site family, member 2Ba0.236
tlr21toll-like receptor 210.232
myh11amyosin, heavy polypeptide 11, smooth muscle a0.230
sox9bSRY-box containing gene 9b0.227
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.226
snapc4small nuclear RNA activating complex, polypeptide 40.225
mycamyelocytomatosis oncogene a0.220
appbamyloid beta (A4) precursor protein b0.220
dnmt1DNA (cytosine-5-)-methyltransferase 10.218
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.215
flt4fms-related tyrosine kinase 40.209
ahcyS-adenosylhomocysteine hydrolase0.208
ventventral expressed homeobox0.206
sox17SRY-box containing gene 170.206
dhrs9dehydrogenase/reductase (SDR family) member 90.205
sec13SEC13 homolog (S. cerevisiae)0.205
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JAG1jagged 10.601
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.550
HNF4Ahepatocyte nuclear factor 4, alpha0.384
CCND1cyclin D10.381
NOTCH1notch 10.356
NCOA1nuclear receptor coactivator 10.350
E2F7E2F transcription factor 70.319
NOTCH3notch 30.261
DDIT3DNA-damage-inducible transcript 30.234
CCND3cyclin D30.232
E2F8E2F transcription factor 80.178
UHRF2ubiquitin-like with PHD and ring finger domains 20.164
EP300E1A binding protein p3000.162
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.157
HDAC2histone deacetylase 20.137
CDK6cyclin-dependent kinase 60.127
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.125
RUNX1runt-related transcription factor 10.105
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.101
CDK2cyclin-dependent kinase 20.089
BMPR1Abone morphogenetic protein receptor, type IA0.081
SIRT1sirtuin 10.078
CCNE1cyclin E10.069
MDM2Mdm2 p53 binding protein homolog (mouse)0.066
PKD2polycystic kidney disease 2 (autosomal dominant)0.065
IARSisoleucyl-tRNA synthetase0.064
FGF1fibroblast growth factor 1 (acidic)0.059
SETD7SET domain containing (lysine methyltransferase) 70.058
MED25mediator complex subunit 250.057
CDK19cyclin-dependent kinase 190.051
PTPN1protein tyrosine phosphatase, non-receptor type 10.045
ARNTaryl hydrocarbon receptor nuclear translocator0.041
BBS10Bardet-Biedl syndrome 100.039
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.039
BBS1Bardet-Biedl syndrome 10.038
ATF3activating transcription factor 30.036
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.035
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.034
NR0B2nuclear receptor subfamily 0, group B, member 20.033
KLF4Kruppel-like factor 4 (gut)0.031
NCK2NCK adaptor protein 20.029
GHRgrowth hormone receptor0.029
MED13Lmediator complex subunit 13-like0.027
TP53tumor protein p530.025
NOTCH2notch 20.025
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.025
TNIP2TNFAIP3 interacting protein 20.024
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.024
ACAA2acetyl-CoA acyltransferase 20.024
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.023
CSNK1Ecasein kinase 1, epsilon0.022
PKD1polycystic kidney disease 1 (autosomal dominant)0.022
RIPK2receptor-interacting serine-threonine kinase 20.022
NRIP1nuclear receptor interacting protein 10.021
RXRAretinoid X receptor, alpha0.021
MAP3K5mitogen-activated protein kinase kinase kinase 50.021
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.020
NCOA6nuclear receptor coactivator 60.020
NR4A1nuclear receptor subfamily 4, group A, member 10.019
ALDH1A1aldehyde dehydrogenase 1 family, member A10.019
NCOR2nuclear receptor corepressor 20.019
PMLpromyelocytic leukemia0.018
SP3Sp3 transcription factor0.017
ARRB1arrestin, beta 10.017
RARAretinoic acid receptor, alpha0.017
MED13mediator complex subunit 130.017
SUZ12suppressor of zeste 12 homolog (Drosophila)0.017
EZH2enhancer of zeste homolog 2 (Drosophila)0.017
HADHhydroxyacyl-CoA dehydrogenase0.016
TGIF1TGFB-induced factor homeobox 10.016
GARSglycyl-tRNA synthetase0.016
DUSP1dual specificity phosphatase 10.016
PCGF2polycomb group ring finger 20.016
SEC31ASEC31 homolog A (S. cerevisiae)0.016
STAG2stromal antigen 20.015
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.015
NCOA3nuclear receptor coactivator 30.015
VAC14Vac14 homolog (S. cerevisiae)0.015
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.014
AGXT2alanine--glyoxylate aminotransferase 20.014
VEZF1vascular endothelial zinc finger 10.014
ALDH2aldehyde dehydrogenase 2 family (mitochondrial)0.014
FSTL1follistatin-like 10.013
HNF1BHNF1 homeobox B0.013
DLL1delta-like 1 (Drosophila)0.013
CEBPACCAAT/enhancer binding protein (C/EBP), alpha0.013
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif, 100.013
EGFRepidermal growth factor receptor0.013
PDX1pancreatic and duodenal homeobox 10.012
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.012
JUNjun proto-oncogene0.012
FOXA2forkhead box A20.012
APOEapolipoprotein E0.012
RB1retinoblastoma 10.012
ERBB2IPerbb2 interacting protein0.011
SMAD1SMAD family member 10.011
HRhairless homolog (mouse)0.011
FGF2fibroblast growth factor 2 (basic)0.011
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.011
MAML1mastermind-like 1 (Drosophila)0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.712
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.605
Azgp1alpha-2-glycoprotein 1, zinc-binding0.587
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.560
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.554
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.457
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.450
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.412
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.409
Mug1murinoglobulin 10.385
Slco2a1solute carrier organic anion transporter family, member 2a10.381
Otcornithine carbamoyltransferase0.376
Fabp1fatty acid binding protein 1, liver0.365
Il13interleukin 130.346
Cps1carbamoyl-phosphate synthetase 10.344
Metmet proto-oncogene0.338
Pzppregnancy-zone protein0.327
Dhfrdihydrofolate reductase0.316
Gsta5glutathione S-transferase Yc2 subunit0.308
Cyp51cytochrome P450, family 510.305
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.303
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.299
Sardhsarcosine dehydrogenase0.298
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.297
Gstm2glutathione S-transferase mu 20.282
Nr1h4nuclear receptor subfamily 1, group H, member 40.277
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.269
Il1rapinterleukin 1 receptor accessory protein0.266
Atp7bATPase, Cu++ transporting, beta polypeptide0.253
LOC293989cytochrome P450-like0.247
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.239
Tgfbr2transforming growth factor, beta receptor II0.237
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.235
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.231
Ptprqprotein tyrosine phosphatase, receptor type, Q0.210
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.193
Ech1enoyl coenzyme A hydratase 1, peroxisomal0.190
Prlrprolactin receptor0.187
Bmp7bone morphogenetic protein 70.186
Hnf4ahepatocyte nuclear factor 4, alpha0.180
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.179
Lipclipase, hepatic0.177
Agxt2alanine-glyoxylate aminotransferase 20.176
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.174
Cdk2cyclin dependent kinase 20.172
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.170
Mbl2mannose-binding lectin (protein C) 20.168
Ctsbcathepsin B0.167
Dmgdhdimethylglycine dehydrogenase0.166
Top2atopoisomerase (DNA) II alpha0.165
Creb1cAMP responsive element binding protein 10.162
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.158
Aqp8aquaporin 80.154
Ifitm3interferon induced transmembrane protein 30.153
Ctsccathepsin C0.152
Myh9myosin, heavy chain 9, non-muscle0.151
LOC100361864UDP-glucuronosyltransferase 2B3-like0.151
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.150
Adam7ADAM metallopeptidase domain 70.149
Apobapolipoprotein B0.148
G6pcglucose-6-phosphatase, catalytic subunit0.145
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.144
Asgr1asialoglycoprotein receptor 10.144
Sult2al1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 10.141
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.140
Gsta2glutathione S-transferase A20.139
Serp1stress-associated endoplasmic reticulum protein 10.138
Ldhalactate dehydrogenase A0.137
LOC494499LOC494499 protein0.136
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.135
Sox17SRY (sex determining region Y)-box 170.133
Cyp2b15cytochrome P450, family 2, subfamily b, polypeptide 150.133
Mettl7bmethyltransferase like 7B0.132
Gjb1gap junction protein, beta 10.130
Dock8dedicator of cytokinesis 80.130
Mbl1mannose-binding lectin (protein A) 10.125
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.124
Gbp2guanylate binding protein 20.124
Eno1enolase 1, (alpha)0.122
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.122
Hnf1bHNF1 homeobox B0.122
PorP450 (cytochrome) oxidoreductase0.122
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.120
Ctf1cardiotrophin 10.119
RGD1305347similar to RIKEN cDNA 2610528J110.118
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.115
Mgst2microsomal glutathione S-transferase 20.115
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.115
Gcgroup specific component0.113
RT1-EC2RT1 class Ib, locus EC20.112
Fbp1fructose-1,6-bisphosphatase 10.112
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.111
Rararetinoic acid receptor, alpha0.111
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.109
Acaa2acetyl-Coenzyme A acyltransferase 20.108
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism