The network for 'multicellular organismal water homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

multicellular organismal water homeostasis

Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.

NameDescriptionProbabilityFunc Analog Organism
Trp63transformation related protein 630.844
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.697
Psapl1prosaposin-like 10.629
Krt6akeratin 6A0.623
Irf6interferon regulatory factor 60.612
Krt19keratin 190.582
Crb3crumbs homolog 3 (Drosophila)0.523
Cela3bchymotrypsin-like elastase family, member 3B0.507
Cldn3claudin 30.425
Il1f5interleukin 1 family, member 5 (delta)0.416
Sprr1asmall proline-rich protein 1A0.407
Krt5keratin 50.406
Krt15keratin 150.392
Krt17keratin 170.380
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.351
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.334
Rab25RAB25, member RAS oncogene family0.296
Alox5aparachidonate 5-lipoxygenase activating protein0.284
Krt1keratin 10.240
Aqp2aquaporin 20.236
Tmprss2transmembrane protease, serine 20.224
Dsg2desmoglein 20.216
Tcfap2ctranscription factor AP-2, gamma0.213
Tgm3transglutaminase 3, E polypeptide0.203
Cldn4claudin 40.202
Foxn1forkhead box N10.201
Dsc3desmocollin 30.194
Elf3E74-like factor 30.176
Krt71keratin 710.172
Cdcp1CUB domain containing protein 10.169
Elf5E74-like factor 50.165
Krt8keratin 80.163
Prss8protease, serine, 8 (prostasin)0.155
Rdh8retinol dehydrogenase 80.155
Krtdapkeratinocyte differentiation associated protein0.151
Tjp1tight junction protein 10.148
Krt14keratin 140.138
Wnt10awingless related MMTV integration site 10a0.126
Pdzk1ip1PDZK1 interacting protein 10.125
Lrrk2leucine-rich repeat kinase 20.125
Cdx2caudal type homeobox 20.124
Dlx3distal-less homeobox 30.122
Trp73transformation related protein 730.120
Krt33bkeratin 33B0.116
Slc5a11solute carrier family 5 (sodium/glucose cotransporter), member 110.113
Trpv5transient receptor potential cation channel, subfamily V, member 50.110
Flgfilaggrin0.106
Sfnstratifin0.103
Pvalbparvalbumin0.103
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.096
Hrhairless0.095
1600029D21RikRIKEN cDNA 1600029D21 gene0.095
Fam83ffamily with sequence similarity 83, member F0.094
Gm13011predicted gene 130110.094
Cyp26c1cytochrome P450, family 26, subfamily c, polypeptide 10.091
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.087
Scnn1bsodium channel, nonvoltage-gated 1 beta0.087
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.085
Nkx6-1NK6 homeobox 10.082
Mogat2monoacylglycerol O-acyltransferase 20.080
Krt31keratin 310.080
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.077
Rpgrip1lRpgrip1-like0.077
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.076
Wnk4WNK lysine deficient protein kinase 40.074
Alox12earachidonate lipoxygenase, epidermal0.074
Adam28a disintegrin and metallopeptidase domain 280.073
Pplperiplakin0.072
Wfdc2WAP four-disulfide core domain 20.072
Krt4keratin 40.070
Dctdopachrome tautomerase0.069
Trim29tripartite motif-containing 290.068
Ctrb1chymotrypsinogen B10.068
BsndBartter syndrome, infantile, with sensorineural deafness (Barttin)0.067
Slc12a1solute carrier family 12, member 10.067
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.066
Krt13keratin 130.065
Tmem30btransmembrane protein 30B0.065
Slc46a2solute carrier family 46, member 20.064
Krt86keratin 860.064
Upk3auroplakin 3A0.064
Krtap8-1keratin associated protein 8-10.063
Calm4calmodulin 40.061
Ly6g6clymphocyte antigen 6 complex, locus G6C0.060
Klk7kallikrein related-peptidase 7 (chymotryptic, stratum corneum)0.060
Krt75keratin 750.059
Mpdzmultiple PDZ domain protein0.058
Pkp1plakophilin 10.058
Krt72-pskeratin 72, pseudogene0.058
Aqp3aquaporin 30.057
Evplenvoplakin0.057
Asprv1aspartic peptidase, retroviral-like 10.056
Ggt1gamma-glutamyltransferase 10.055
Cldn2claudin 20.055
Serpinb5serine (or cysteine) peptidase inhibitor, clade B, member 50.054
Tmem79transmembrane protein 790.053
Prss2protease, serine, 20.052
Spint1serine protease inhibitor, Kunitz type 10.052
Slc6a13solute carrier family 6 (neurotransmitter transporter, GABA), member 130.052
Trpv6transient receptor potential cation channel, subfamily V, member 60.052
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tp63tumor protein p630.579
cldniclaudin i0.575
krt5keratin 50.452
zgc:92533zgc:925330.431
cldn7bclaudin 7b0.385
avplarginine vasopressin-like0.359
krt4keratin 40.333
tp73tumor protein p730.321
tagln2transgelin 20.320
rab3cRAB3C, member RAS oncogene family0.308
oxtloxytocin-like0.293
krt18keratin 180.262
cldnbclaudin b0.234
uts1urotensin 10.208
gad2glutamate decarboxylase 20.204
cfl1cofilin 1 (non-muscle)0.200
anxa1aannexin A1a0.186
cx27.5connexin 27.50.156
aqp8a.1aquaporin 8a, tandem duplicate 10.146
mc4rmelanocortin 4 receptor0.141
cyp1acytochrome P450, family 1, subfamily A0.136
drd2bdopamine receptor D2b0.131
si:ch211-166a6.5si:ch211-166a6.50.128
gad1bglutamate decarboxylase 1b0.124
cldneclaudin e0.120
crabp1acellular retinoic acid binding protein 1a0.109
ntng1netrin G10.107
gnrh3gonadotropin-releasing hormone 30.102
nmnat2nicotinamide nucleotide adenylyltransferase 20.097
calb2bcalbindin 2b, (calretinin)0.097
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.096
sst3somatostatin 30.096
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.094
vgll4lvestigial like 4 like0.091
zgc:92061zgc:920610.089
otx2orthodenticle homolog 20.086
vdravitamin D receptor a0.084
capn9calpain 90.076
jupjunction plakoglobin0.073
npy8brneuropeptide Y receptor Y8b0.068
eomesaeomesodermin homolog a0.068
pbx1apre-B-cell leukemia transcription factor 1a0.068
kif5aakinesin family member 5A, a0.066
akap12bA kinase (PRKA) anchor protein (gravin) 12b0.062
nppclnatriuretic peptide precursor C-like protein0.059
chrm2acholinergic receptor, muscarinic 2a0.059
aqp3aaquaporin 3a0.058
slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.056
nlgn4aneuroligin 4a0.055
pcsk1nlproprotein convertase subtilisin/kexin type 1 inhibitor, like0.053
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.051
ascl1bachaete-scute complex-like 1b (Drosophila)0.051
pplperiplakin0.049
aqp1a.1aquaporin 1a, tandem duplicate 10.048
esr1estrogen receptor 10.048
nlgn1neuroligin 10.045
adra2dbadrenergic, alpha-2D-, receptor b0.045
nkx2.3NK2 transcription factor related 30.044
LOC100334363Sperm acrosome membrane-associated protein 4-like0.043
adra2badrenergic, alpha-2B-, receptor0.043
aqp7aquaporin 70.042
gnrh2gonadotropin-releasing hormone 20.042
grin1aglutamate receptor, ionotropic, N-methyl D-aspartate 1a0.042
nr2f1anuclear receptor subfamily 2, group F, member 1a0.040
epcamepithelial cell adhesion molecule0.040
col1a1bcollagen, type I, alpha 1b0.040
col1a1acollagen, type I, alpha 1a0.039
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.038
cacnb2acalcium channel, voltage-dependent, beta 2a0.038
aqp10baquaporin 10b0.038
LOC100332193growth hormone secretagogue receptor type 1-like0.037
si:ch211-209p5.2si:ch211-209p5.20.037
LOC100005283Gig2-like protein DreE0.037
bactin1bactin10.036
pyyapeptide YYa0.036
pcp4aPurkinje cell protein 4a0.036
fabp11afatty acid binding protein 11a0.036
ca2carbonic anhydrase II0.035
gfra1bgdnf family receptor alpha 1b0.035
kiss1rbKISS1 receptor b0.035
chrnb3acholinergic receptor, nicotinic, beta polypeptide 3a0.034
sox5SRY-box containing gene 50.034
sncgbsynuclein, gamma b (breast cancer-specific protein 1)0.033
ghrlghrelin/obestatin preprohormone0.033
sox8SRY-box containing gene 80.032
vipr2vasoactive intestinal peptide receptor 20.032
ucn3lurocortin 3, like0.031
adra2aadrenergic, alpha-2A-, receptor0.031
cyt1type I cytokeratin, enveloping layer0.030
npy4rneuropeptide Y receptor Y40.030
efna5bephrin A5b0.030
trpv1transient receptor potential cation channel subfamily V member 10.030
crhcorticotropin releasing hormone0.029
pth2parathyroid hormone 20.029
klf2bKruppel-like factor 2b0.028
tbr1bT-box, brain, 1b0.028
aqp8a.2aquaporin 8a, tandem duplicate 20.027
tfap2atranscription factor AP-2 alpha0.027
pycardPYD and CARD domain containing0.027
egr1early growth response 10.027
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TACSTD2tumor-associated calcium signal transducer 20.857
KRT5keratin 50.841
NEDD4neural precursor cell expressed, developmentally down-regulated 40.432
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.365
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.332
CTNND1catenin (cadherin-associated protein), delta 10.316
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.176
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.150
MYOCDmyocardin0.087
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.066
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.065
MKL1megakaryoblastic leukemia (translocation) 10.062
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.048
TJP3tight junction protein 3 (zona occludens 3)0.047
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.040
LAD1ladinin 10.038
ST14suppression of tumorigenicity 14 (colon carcinoma)0.032
CDH3cadherin 3, type 1, P-cadherin (placental)0.032
CABLES1Cdk5 and Abl enzyme substrate 10.029
MYOGmyogenin (myogenic factor 4)0.026
HOXA1homeobox A10.019
MDFIMyoD family inhibitor0.018
FAM107Afamily with sequence similarity 107, member A0.017
JUPjunction plakoglobin0.017
EPN1epsin 10.017
KCTD17potassium channel tetramerisation domain containing 170.017
PTPRJprotein tyrosine phosphatase, receptor type, J0.017
KRT6Ckeratin 6C0.017
TMEM40transmembrane protein 400.016
ADAMTSL4ADAMTS-like 40.016
PKP3plakophilin 30.016
CLDN16claudin 160.014
KRTAP4-12keratin associated protein 4-120.014
FGFR1fibroblast growth factor receptor 10.013
MKL2MKL/myocardin-like 20.013
SLC17A1solute carrier family 17 (sodium phosphate), member 10.013
AP1M2adaptor-related protein complex 1, mu 2 subunit0.013
GLTPD1glycolipid transfer protein domain containing 10.013
SCNN1Gsodium channel, nonvoltage-gated 1, gamma0.013
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.012
CATSPER1cation channel, sperm associated 10.012
SPDEFSAM pointed domain containing ets transcription factor0.012
MUC1mucin 1, cell surface associated0.012
WFDC2WAP four-disulfide core domain 20.011
HMOX2heme oxygenase (decycling) 20.011
SCGB1A1secretoglobin, family 1A, member 1 (uteroglobin)0.011
ALOX12Barachidonate 12-lipoxygenase, 12R type0.010
PSEN1presenilin 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Scnn1gsodium channel, nonvoltage-gated 1, gamma0.359
Tacstd2tumor-associated calcium signal transducer 20.177
Muc1mucin 1, cell surface associated0.132
Dync1h1dynein cytoplasmic 1 heavy chain 10.109
Gja5gap junction protein, alpha 50.107
Scnn1bsodium channel, nonvoltage-gated 1, beta0.101
Tcp11t-complex protein 110.065
Eporerythropoietin receptor0.057
Bmp7bone morphogenetic protein 70.047
RGD1310262hypothetical LOC3046500.042
Sostdc1sclerostin domain containing 10.041
Gp2glycoprotein 2 (zymogen granule membrane)0.041
Prss8protease, serine, 80.039
Lrch4leucine-rich repeats and calponin homology (CH) domain containing 40.037
Plinperilipin0.036
Myogmyogenin0.036
Olr1500olfactory receptor 15000.034
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.034
Stra6stimulated by retinoic acid gene 60.033
Dpep1dipeptidase 1 (renal)0.032
Hexahexosaminidase A0.030
Ptgesprostaglandin E synthase0.030
Adrb3adrenergic, beta-3-, receptor0.029
Desdesmin0.029
Gpx2glutathione peroxidase 20.027
Krt5keratin 50.027
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.027
Folh1folate hydrolase 10.026
Vtcn1V-set domain containing T cell activation inhibitor 10.026
Prkcshprotein kinase C substrate 80K-H0.025
Atp6v1g3ATPase, H+ transporting, lysosomal V1 subunit G30.024
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.023
Taf6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.023
Ctrb1chymotrypsinogen B10.022
Thtyrosine hydroxylase0.021
Olr1082olfactory receptor 10820.020
Tmem79transmembrane protein 790.020
Ageradvanced glycosylation end product-specific receptor0.019
Cdcp1CUB domain containing protein 10.019
Pdzk1ip1PDZK1 interacting protein 10.019
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.018
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.018
Samd4bsterile alpha motif domain containing 4B0.017
Galr2galanin receptor 20.017
Tinagl1tubulointerstitial nephritis antigen-like 10.017
S1pr2sphingosine-1-phosphate receptor 20.017
Scnn1asodium channel, nonvoltage-gated 1 alpha0.017
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.016
Kcnk3potassium channel, subfamily K, member 30.016
Tpsab1tryptase alpha/beta 10.016
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.016
LOC679475hypothetical protein LOC6794750.016
Foxq1forkhead box Q10.016
Cgaglycoprotein hormones, alpha polypeptide0.016
Hnf1bHNF1 homeobox B0.016
Cnga4cyclic nucleotide gated channel alpha 40.015
Lhcgrluteinizing hormone/choriogonadotropin receptor0.015
C1qtnf6C1q and tumor necrosis factor related protein 60.015
Clcnkachloride channel Ka0.015
Tmprss2transmembrane protease, serine 20.015
Mcpt4mast cell protease 40.015
Nraddneurotrophin receptor associated death domain0.015
Ddr1discoidin domain receptor tyrosine kinase 10.015
Tacr1tachykinin receptor 10.015
Slc13a2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 20.014
Ckmcreatine kinase, muscle0.014
Eci1enoyl-Coenzyme A delta isomerase 10.014
F2rl1coagulation factor II (thrombin) receptor-like 10.014
Irs3insulin receptor substrate 30.014
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.013
Mylk2myosin light chain kinase 20.013
Npffr2neuropeptide FF receptor 20.013
Ehfets homologous factor0.013
Slc44a4solute carrier family 44, member 40.013
Defb1defensin beta 10.013
Msx2msh homeobox 20.013
Prss1protease, serine, 1 (trypsin 1)0.012
Olr1496olfactory receptor 14960.012
Rsph1radial spoke head 1 homolog (Chlamydomonas)0.012
Ugt8UDP glycosyltransferase 80.012
Gabrr2gamma-aminobutyric acid (GABA) receptor, rho 20.012
Serpina4serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 40.012
Acaa1bacetyl-Coenzyme A acyltransferase 1B0.012
Ghrhrgrowth hormone releasing hormone receptor0.012
Celcarboxyl ester lipase0.012
RGD1305347similar to RIKEN cDNA 2610528J110.012
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.012
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.012
Cuzd1CUB and zona pellucida-like domains 10.012
Tgm1transglutaminase 1, K polypeptide0.012
LOC652956p55 protein0.011
Ctf1cardiotrophin 10.011
Pde1cphosphodiesterase 1C0.011
Cldn7claudin 70.011
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.011
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.011
Tmem171transmembrane protein 1710.011
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.011
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.011
Nkx3-1NK3 homeobox 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism