The network for 'cytoplasmic translational initiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cytoplasmic translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.

Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Eif3geukaryotic translation initiation factor 3, subunit G0.995
Eif3beukaryotic translation initiation factor 3, subunit B0.980
Eif3ceukaryotic translation initiation factor 3, subunit C0.969
Eif4g1eukaryotic translation initiation factor 4, gamma 10.517
Larsleucyl-tRNA synthetase0.429
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.372
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.321
Eif3keukaryotic translation initiation factor 3, subunit K0.202
Eif3ieukaryotic translation initiation factor 3, subunit I0.177
Wdr74WD repeat domain 740.128
Eprsglutamyl-prolyl-tRNA synthetase0.104
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.102
Nclnucleolin0.092
Rpl8ribosomal protein L80.087
Aimp1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.083
Lrrc59leucine rich repeat containing 590.082
Polr1cpolymerase (RNA) I polypeptide C0.078
Aarsalanyl-tRNA synthetase0.074
Eif3eeukaryotic translation initiation factor 3, subunit E0.073
Tsta3tissue specific transplantation antigen P35B0.064
Ddx54DEAD (Asp-Glu-Ala-Asp) box polypeptide 540.063
Rarsarginyl-tRNA synthetase0.063
Tarsthreonyl-tRNA synthetase0.058
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.058
Nhp2NHP2 ribonucleoprotein homolog (yeast)0.049
Sarsseryl-aminoacyl-tRNA synthetase0.048
Eftud2elongation factor Tu GTP binding domain containing 20.040
Nsun2NOL1/NOP2/Sun domain family member 20.040
Tprtranslocated promoter region0.037
Phb2prohibitin 20.035
Bola2bolA-like 2 (E. coli)0.034
Mrps18bmitochondrial ribosomal protein S18B0.034
Varsvalyl-tRNA synthetase0.033
Tcp1t-complex protein 10.033
Rpl18ribosomal protein L180.033
Zc3h15zinc finger CCCH-type containing 150.029
Arl6ip4ADP-ribosylation factor-like 6 interacting protein 40.029
Impdh2inosine 5'-phosphate dehydrogenase 20.029
Eif2b4eukaryotic translation initiation factor 2B, subunit 4 delta0.028
Srp68signal recognition particle 680.028
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.027
Gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2 like 10.027
Narsasparaginyl-tRNA synthetase0.026
Esf1ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)0.026
Rpl14ribosomal protein L140.025
Eif3deukaryotic translation initiation factor 3, subunit D0.025
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.024
Srmspermidine synthase0.022
Dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.022
Rpl36ribosomal protein L360.022
Prpf8pre-mRNA processing factor 80.021
Eif4beukaryotic translation initiation factor 4B0.021
Rpl27ribosomal protein L270.020
SetSET nuclear oncogene0.020
Trim28tripartite motif-containing 280.020
Lsg1large subunit GTPase 1 homolog (S. cerevisiae)0.019
Eef1deukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)0.018
Gnl3guanine nucleotide binding protein-like 3 (nucleolar)0.017
Gps1G protein pathway suppressor 10.017
Mrpl52mitochondrial ribosomal protein L520.016
Imp3IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)0.016
Rps27lribosomal protein S27-like0.016
Garsglycyl-tRNA synthetase0.015
U2af1U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 10.015
D10Wsu52eDNA segment, Chr 10, Wayne State University 52, expressed0.015
Vcpvalosin containing protein0.015
Ubxn1UBX domain protein 10.014
Ddb1damage specific DNA binding protein 10.014
Fblfibrillarin0.014
Ddx3xDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked0.014
Supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.014
Tbrg1transforming growth factor beta regulated gene 10.013
Tcerg1transcription elongation regulator 1 (CA150)0.013
Rpl4ribosomal protein L40.013
Usp39ubiquitin specific peptidase 390.013
Ssrp1structure specific recognition protein 10.013
Naa15N(alpha)-acetyltransferase 15, NatA auxiliary subunit0.013
2700060E02RikRIKEN cDNA 2700060E02 gene0.012
Gnl2guanine nucleotide binding protein-like 2 (nucleolar)0.012
Arcn1archain 10.012
Gtf2f1general transcription factor IIF, polypeptide 10.011
Eif6eukaryotic translation initiation factor 60.011
Prmt1protein arginine N-methyltransferase 10.011
Dnttip2deoxynucleotidyltransferase, terminal, interacting protein 20.011
Tsr1TSR1, 20S rRNA accumulation, homolog (yeast)0.011
Kif5bkinesin family member 5B0.011
Ruvbl2RuvB-like protein 20.011
Ipo7importin 70.010
Eef1b2eukaryotic translation elongation factor 1 beta 20.010
Lsm4LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.010
Marsmethionine-tRNA synthetase0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Tango7Transport and Golgi organization 70.035
eIF3-S8CG4954 gene product from transcript CG4954-RA0.034
eIF3-S9CG4878 gene product from transcript CG4878-RA0.029
eIF-3p40Eukaryotic initiation factor 3 p40 subunit0.019
Ef1betaElongation factor 1 beta0.018
eIF-3p66Eukaryotic initiation factor 3 p66 subunit0.017
Int6Int6 homologue0.014
Ef1gammaCG11901 gene product from transcript CG11901-RC0.012
CG8636CG8636 gene product from transcript CG8636-RA0.011
CG8801CG8801 gene product from transcript CG8801-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EIF3Feukaryotic translation initiation factor 3, subunit F1.000
EIF3Deukaryotic translation initiation factor 3, subunit D1.000
EIF3Beukaryotic translation initiation factor 3, subunit B1.000
EIF3Heukaryotic translation initiation factor 3, subunit H1.000
EIF3Geukaryotic translation initiation factor 3, subunit G0.990
EIF3Meukaryotic translation initiation factor 3, subunit M0.958
EIF3Leukaryotic translation initiation factor 3, subunit L0.912
EIF3Aeukaryotic translation initiation factor 3, subunit A0.904
EIF4G1eukaryotic translation initiation factor 4 gamma, 10.752
MCTS1malignant T cell amplified sequence 10.748
EIF4Beukaryotic translation initiation factor 4B0.656
EIF3Keukaryotic translation initiation factor 3, subunit K0.482
EIF3Eeukaryotic translation initiation factor 3, subunit E0.447
ESF1ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)0.400
EIF3Ceukaryotic translation initiation factor 3, subunit C0.232
EIF3Jeukaryotic translation initiation factor 3, subunit J0.163
EIF4A1eukaryotic translation initiation factor 4A10.149
RPTORregulatory associated protein of MTOR, complex 10.138
HNRNPMheterogeneous nuclear ribonucleoprotein M0.076
DENRdensity-regulated protein0.069
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.066
EIF4Eeukaryotic translation initiation factor 4E0.063
RBM22RNA binding motif protein 220.046
GARSglycyl-tRNA synthetase0.044
USP3ubiquitin specific peptidase 30.037
EIF4A2eukaryotic translation initiation factor 4A20.036
SF1splicing factor 10.033
CEBPZCCAAT/enhancer binding protein (C/EBP), zeta0.029
RBM25RNA binding motif protein 250.029
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.023
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.019
EIF4G2eukaryotic translation initiation factor 4 gamma, 20.018
SHMT2serine hydroxymethyltransferase 2 (mitochondrial)0.018
MTORmechanistic target of rapamycin (serine/threonine kinase)0.018
EIF3Ieukaryotic translation initiation factor 3, subunit I0.015
WDR43WD repeat domain 430.015
EPRSglutamyl-prolyl-tRNA synthetase0.014
LARSleucyl-tRNA synthetase0.014
PPIGpeptidylprolyl isomerase G (cyclophilin G)0.014
UPF1UPF1 regulator of nonsense transcripts homolog (yeast)0.014
PTBP2polypyrimidine tract binding protein 20.014
CCAR1cell division cycle and apoptosis regulator 10.013
YARStyrosyl-tRNA synthetase0.012
THOC2THO complex 20.010
AQRaquarius homolog (mouse)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
TIF35Tif35p0.666
SUI1Sui1p0.508
PRT1Prt1p0.368
RPG1Rpg1p0.261
NIP1Nip1p0.253
TIF34Tif34p0.153
SUI2Sui2p0.126
SUI3Sui3p0.122
FUN12Fun12p0.056
GCD11Gcd11p0.049
TIF5Tif5p0.045
HCR1Hcr1p0.027
YLR264C-Ahypothetical protein0.025
SRD1Srd1p0.023
LEU2Leu2p0.020
YLR162Whypothetical protein0.018
MER1Mer1p0.017
TSR1Tsr1p0.017
YOL038C-Ahypothetical protein0.017
ARP10Arp10p0.016
ARG8Arg8p0.016
YAR068Whypothetical protein0.016
URA3Ura3p0.015
SPL2Spl2p0.015
YLR042Chypothetical protein0.014
YPR157Whypothetical protein0.014
ESF1Esf1p0.014
ATP6Atp6p0.014
URA6Ura6p0.013
CUP1-1Cup1-1p0.013
HXT3Hxt3p0.013
BSC1Bsc1p0.013
KTR5Ktr5p0.013
PRS2Prs2p0.013
YIR035Chypothetical protein0.013
YHB1Yhb1p0.012
CCT8Cct8p0.012
AUA1Aua1p0.012
ZPS1Zps1p0.012
DPS1Dps1p0.012
FMT1Fmt1p0.012
HPF1Hpf1p0.012
YOL013W-Ahypothetical protein0.012
RPL10Rpl10p0.012
TMA22Tma22p0.011
YAR066Whypothetical protein0.011
PTI1Pti1p0.011
MF(ALPHA)2Mf(alpha)2p0.011
YOR342Chypothetical protein0.011
HOHop0.011
SRP54Srp54p0.011
YBR013Chypothetical protein0.011
SWC7Swc7p0.011
IZH4Izh4p0.011
TIM50Tim50p0.011
DED1Ded1p0.010
SCM4Scm4p0.010