The network for 'striated muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

striated muscle tissue development

The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.

NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Pitx2paired-like homeodomain transcription factor 21.000
Pax3paired box gene 31.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Foxc2forkhead box C21.000
Gli3GLI-Kruppel family member GLI30.999
Gata4GATA binding protein 40.999
Trp53transformation related protein 530.999
Fgfr1fibroblast growth factor receptor 10.998
Tgfb2transforming growth factor, beta 20.998
Ptenphosphatase and tensin homolog0.997
Fgfr2fibroblast growth factor receptor 20.997
Pax2paired box gene 20.996
Otx2orthodenticle homolog 2 (Drosophila)0.996
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.996
Tbx1T-box 10.995
Dmddystrophin, muscular dystrophy0.994
Eya1eyes absent 1 homolog (Drosophila)0.993
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.993
Rargretinoic acid receptor, gamma0.992
Bmp4bone morphogenetic protein 40.992
Isl1ISL1 transcription factor, LIM/homeodomain0.991
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.990
Pax8paired box gene 80.990
Itgb1integrin beta 1 (fibronectin receptor beta)0.987
Foxc1forkhead box C10.985
Ctnnb1catenin (cadherin associated protein), beta 10.985
Hand1heart and neural crest derivatives expressed transcript 10.984
Gata6GATA binding protein 60.984
Gscgoosecoid homeobox0.982
Ror2receptor tyrosine kinase-like orphan receptor 20.981
Fgf8fibroblast growth factor 80.979
Tbx3T-box 30.978
Sox9SRY-box containing gene 90.978
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.977
Vegfavascular endothelial growth factor A0.976
Pbx1pre B-cell leukemia transcription factor 10.976
Nos3nitric oxide synthase 3, endothelial cell0.976
Ptpn11protein tyrosine phosphatase, non-receptor type 110.975
Smad4MAD homolog 4 (Drosophila)0.971
Tbx5T-box 50.965
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.964
Notch1Notch gene homolog 1 (Drosophila)0.962
Tcf21transcription factor 210.961
Smad3MAD homolog 3 (Drosophila)0.960
Tcfap2atranscription factor AP-2, alpha0.960
Scn5asodium channel, voltage-gated, type V, alpha0.958
Col1a1collagen, type I, alpha 10.958
Hoxd11homeobox D110.958
Notch2Notch gene homolog 2 (Drosophila)0.957
Wt1Wilms tumor 1 homolog0.957
Trp63transformation related protein 630.956
Xirp1xin actin-binding repeat containing 10.954
Zeb1zinc finger E-box binding homeobox 10.949
Egfrepidermal growth factor receptor0.949
Wnt11wingless-related MMTV integration site 110.947
Smad6MAD homolog 6 (Drosophila)0.946
Bmpr1abone morphogenetic protein receptor, type 1A0.945
Emx2empty spiracles homolog 2 (Drosophila)0.944
Flt4FMS-like tyrosine kinase 40.941
Mesp1mesoderm posterior 10.941
Hes1hairy and enhancer of split 1 (Drosophila)0.940
Meox2mesenchyme homeobox 20.938
Mybphmyosin binding protein H0.937
Pax9paired box gene 90.932
Gli2GLI-Kruppel family member GLI20.931
Gdnfglial cell line derived neurotrophic factor0.929
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.924
Foxf1aforkhead box F1a0.923
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.919
Tcf15transcription factor 150.918
Gja1gap junction protein, alpha 10.917
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.916
JunJun oncogene0.912
Hoxd13homeobox D130.912
Ntf3neurotrophin 30.910
Foxg1forkhead box G10.910
Cd19CD19 antigen0.907
Tbx2T-box 20.906
Hoxa13homeobox A130.903
Ascl1achaete-scute complex homolog 1 (Drosophila)0.903
Rxraretinoid X receptor alpha0.902
Actc1actin, alpha, cardiac muscle 10.901
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.900
Pax6paired box gene 60.894
Ror1receptor tyrosine kinase-like orphan receptor 10.894
AxlAXL receptor tyrosine kinase0.891
En1engrailed 10.888
Nr3c1nuclear receptor subfamily 3, group C, member 10.884
Bcl2B-cell leukemia/lymphoma 20.883
Sox10SRY-box containing gene 100.883
Cdx1caudal type homeobox 10.881
Lmx1aLIM homeobox transcription factor 1 alpha0.881
Col11a1collagen, type XI, alpha 10.880
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myod1myogenic differentiation 10.994
tbx1T-box 10.987
bmp2bbone morphogenetic protein 2b0.965
ndr2nodal-related 20.957
tbx20T-box 200.951
smyd1bSET and MYND domain containing 1b0.933
wnt11rwingless-type MMTV integration site family, member 11, related0.921
foxd3forkhead box D30.896
hey2hairy/enhancer-of-split related with YRPW motif 20.872
osr1odd-skipped related 1 (Drosophila)0.870
rx3retinal homeobox gene 30.867
pcdh8protocadherin 80.865
tbx2bT-box 2b0.855
actn3aactinin alpha 3a0.833
tnni1altroponin I, skeletal, slow like0.816
stac3SH3 and cysteine rich domain 30.810
pax2apaired box gene 2a0.801
myf6myogenic factor 60.799
cdh2cadherin 2, neuronal0.790
lama4laminin, alpha 40.786
tnnc1btroponin C type 1b (slow)0.779
vmhcventricular myosin heavy chain0.774
bmp2abone morphogenetic protein 2a0.765
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.763
foxi1forkhead box I10.763
myhz2myosin, heavy polypeptide 2, fast muscle specific0.758
myf5myogenic factor 50.757
tnni2a.4troponin I, skeletal, fast 2a.40.747
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.743
lama2laminin, alpha 20.740
six3bsine oculis homeobox homolog 3b0.738
tbx2aT-box gene 2a0.717
mef2camyocyte enhancer factor 2ca0.693
tbx18T-box 180.688
aldh1a2aldehyde dehydrogenase 1 family, member A20.682
smyhc2slow myosin heavy chain 20.655
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.652
tbx16T-box gene 160.646
pdlim7PDZ and LIM domain 70.642
fstl1bfollistatin-like 1b0.642
gli1GLI-Kruppel family member 10.639
flhfloating head0.638
hsp90a.1heat shock protein 90-alpha 10.632
tnni1btroponin I, skeletal, slow b0.612
unc45bunc-45 homolog B (C. elegans)0.607
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.605
mef2cbmyocyte enhancer factor 2cb0.593
smyhc1slow myosin heavy chain 10.589
actn2actinin, alpha 20.588
synpo2lbsynaptopodin 2-like b0.583
wnt5bwingless-type MMTV integration site family, member 5b0.579
junjun proto-oncogene0.568
snai1bsnail homolog 1b (Drosophila)0.564
mbnl2muscleblind-like 2 (Drosophila)0.563
ryr3ryanodine receptor 30.536
cmlc1cardiac myosin light chain-10.531
sox8SRY-box containing gene 80.524
efnb2aephrin B2a0.518
tnnc1atroponin C type 1a (slow)0.504
satb2SATB homeobox 20.500
rxrgaretinoid x receptor, gamma a0.498
dmrt2adoublesex and mab-3 related transcription factor 2a0.489
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.485
muskmuscle, skeletal, receptor tyrosine kinase0.482
jag2jagged 20.479
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.477
vgll2bvestigial like 2b0.471
nppanatriuretic peptide precursor A0.462
ogg18-oxoguanine DNA glycosylase0.462
cav1caveolin 10.459
myl7myosin, light polypeptide 7, regulatory0.458
kdrlkinase insert domain receptor like0.453
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.447
pitx2paired-like homeodomain transcription factor 20.444
notch1bnotch homolog 1b0.439
tal1T-cell acute lymphocytic leukemia 10.437
rbm24aRNA binding motif protein 24a0.437
phox2apaired-like homeobox 2a0.434
nrxn1aneurexin 1a0.429
hoxa13bhomeo box A13b0.428
acvr1bactivin A receptor, type IB0.422
bmp4bone morphogenetic protein 40.419
hspg2heparan sulfate proteoglycan 20.411
tbx5bT-box 5b0.408
tnnt2atroponin T2a, cardiac0.404
fbn2bfibrillin 2b0.404
fabp11afatty acid binding protein 11a0.403
tbx5aT-box 5a0.396
ihhbIndian hedgehog homolog b0.395
bmp7bbone morphogenetic protein 7b0.394
notch3notch homolog 30.392
edn1endothelin 10.386
mitfamicrophthalmia-associated transcription factor a0.385
fgfr1afibroblast growth factor receptor 1a0.383
ttnatitin a0.382
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MhcMyosin heavy chain0.993
snssticks and stones0.983
S6kRPS6-p70-protein kinase0.961
EcREcdysone receptor0.959
cicubitus interruptus0.850
Mef2Myocyte enhancer factor 20.680
Actnalpha actinin0.675
nabCG33545 gene product from transcript CG33545-RC0.659
EgfrEpidermal growth factor receptor0.657
slmbsupernumerary limbs0.606
Tm2Tropomyosin 20.436
Zasp52Z band alternatively spliced PDZ-motif protein 520.402
LanB1CG7123 gene product from transcript CG7123-RA0.367
rolsrolling pebbles0.297
LanALaminin A0.284
Akt1CG4006 gene product from transcript CG4006-RA0.257
DadDaughters against dpp0.231
DatDopamine N acetyltransferase0.225
lbeladybird early0.219
Pp2B-14DProtein phosphatase 2B at 14D0.219
Rya-r44FRyanodine receptor 44F0.200
HLH54FCG5005 gene product from transcript CG5005-RA0.194
howheld out wings0.191
Act57BActin 57B0.152
KhcKinesin heavy chain0.148
emsempty spiracles0.147
LanB2Laminin B20.147
Tsc1CG6147 gene product from transcript CG6147-RA0.144
Act87EActin 87E0.131
norpAno receptor potential A0.131
abd-Aabdominal A0.131
wupAwings up A0.127
MadMothers against dpp0.125
AlkCG8250 gene product from transcript CG8250-RA0.123
mbcmyoblast city0.122
Rac1CG2248 gene product from transcript CG2248-RA0.117
laceCG4162 gene product from transcript CG4162-RA0.111
Fas2Fasciclin 20.110
gbbglass bottom boat0.107
PvrPDGF- and VEGF-receptor related0.105
aopanterior open0.101
lunaCG33473 gene product from transcript CG33473-RB0.095
RalaRas-related protein0.090
wbwing blister0.089
Zasp66Z band alternatively spliced PDZ-motif protein 660.082
emcextra macrochaetae0.080
Mi-2CG8103 gene product from transcript CG8103-RA0.079
CRMPCollapsin Response Mediator Protein0.075
sosine oculis0.074
Syx1ASyntaxin 1A0.072
GripGlutamate receptor binding protein0.071
Rac2CG8556 gene product from transcript CG8556-RA0.071
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TRIM63tripartite motif containing 630.999
SRFserum response factor (c-fos serum response element-binding transcription factor)0.972
ESR1estrogen receptor 10.966
FGFR2fibroblast growth factor receptor 20.958
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.942
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.942
FN1fibronectin 10.939
FLNAfilamin A, alpha0.937
MYH9myosin, heavy chain 9, non-muscle0.935
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.929
TNNI1troponin I type 1 (skeletal, slow)0.911
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.886
ATXN1ataxin 10.849
MAPK8mitogen-activated protein kinase 80.839
CAV1caveolin 1, caveolae protein, 22kDa0.814
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.795
JAG1jagged 10.786
EGFRepidermal growth factor receptor0.774
MYOD1myogenic differentiation 10.765
CREBBPCREB binding protein0.723
TNNC1troponin C type 1 (slow)0.696
RARAretinoic acid receptor, alpha0.661
FGF1fibroblast growth factor 1 (acidic)0.633
FLNCfilamin C, gamma0.613
ESR2estrogen receptor 2 (ER beta)0.612
APPamyloid beta (A4) precursor protein0.589
NRP1neuropilin 10.586
FYNFYN oncogene related to SRC, FGR, YES0.565
TPM1tropomyosin 1 (alpha)0.563
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.549
SMYD1SET and MYND domain containing 10.527
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.523
NCOR2nuclear receptor corepressor 20.504
MEF2Cmyocyte enhancer factor 2C0.497
IGF2insulin-like growth factor 2 (somatomedin A)0.496
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.494
JUNjun proto-oncogene0.486
ARandrogen receptor0.472
TBX5T-box 50.465
SMAD1SMAD family member 10.442
EPAS1endothelial PAS domain protein 10.437
TCAPtitin-cap (telethonin)0.424
BMP2bone morphogenetic protein 20.421
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.409
FHL2four and a half LIM domains 20.397
MYOZ1myozenin 10.395
FKBP1AFK506 binding protein 1A, 12kDa0.391
ATF3activating transcription factor 30.389
CKMcreatine kinase, muscle0.382
TNNI2troponin I type 2 (skeletal, fast)0.379
COL1A1collagen, type I, alpha 10.377
ACTA1actin, alpha 1, skeletal muscle0.376
TNNT3troponin T type 3 (skeletal, fast)0.373
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.372
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.345
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.344
GSK3Bglycogen synthase kinase 3 beta0.341
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.333
NCOA3nuclear receptor coactivator 30.333
HIC1hypermethylated in cancer 10.309
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.301
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.297
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.296
COL4A2collagen, type IV, alpha 20.295
BMPR1Abone morphogenetic protein receptor, type IA0.290
EP300E1A binding protein p3000.287
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.285
ACTN1actinin, alpha 10.279
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.277
JUNDjun D proto-oncogene0.272
NCOA1nuclear receptor coactivator 10.269
FGF8fibroblast growth factor 8 (androgen-induced)0.265
NCOR1nuclear receptor corepressor 10.262
TNNT2troponin T type 2 (cardiac)0.246
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.245
LRP6low density lipoprotein receptor-related protein 60.230
SHC1SHC (Src homology 2 domain containing) transforming protein 10.229
PDLIM7PDZ and LIM domain 7 (enigma)0.227
GATA4GATA binding protein 40.223
MYL2myosin, light chain 2, regulatory, cardiac, slow0.221
FBN1fibrillin 10.217
FGFR1fibroblast growth factor receptor 10.216
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.211
FGF3fibroblast growth factor 30.208
JUNBjun B proto-oncogene0.204
LDB3LIM domain binding 30.197
TGFBR1transforming growth factor, beta receptor 10.193
PDX1pancreatic and duodenal homeobox 10.193
NCK2NCK adaptor protein 20.192
TPM2tropomyosin 2 (beta)0.191
PSEN1presenilin 10.190
SMAD2SMAD family member 20.190
PTRFpolymerase I and transcript release factor0.189
FSTL1follistatin-like 10.189
MYL4myosin, light chain 4, alkali; atrial, embryonic0.186
CTGFconnective tissue growth factor0.186
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Egr1early growth response 10.517
Cav1caveolin 1, caveolae protein0.361
Actc1actin, alpha, cardiac muscle 10.283
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.246
Casq2calsequestrin 2 (cardiac muscle)0.230
MosMoloney sarcoma oncogene0.208
Dusp1dual specificity phosphatase 10.196
Tnni2troponin I type 2 (skeletal, fast)0.189
Fgf7fibroblast growth factor 70.184
Myh7myosin, heavy chain 7, cardiac muscle, beta0.164
Tnni1troponin I type 1 (skeletal, slow)0.163
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.159
Myf6myogenic factor 60.158
Egr2early growth response 20.154
Pgam2phosphoglycerate mutase 2 (muscle)0.145
Ckmcreatine kinase, muscle0.134
Anxa2annexin A20.130
Chrnb2cholinergic receptor, nicotinic, beta 2 (neuronal)0.129
Syt8synaptotagmin VIII0.126
Col15a1collagen, type XV, alpha 10.115
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.109
Rararetinoic acid receptor, alpha0.108
Klk1lkallikrein 1-like peptidase0.105
Jak1Janus kinase 10.104
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.104
Col10a1collagen, type X, alpha 10.102
Prrx1paired related homeobox 10.101
Fgfr2fibroblast growth factor receptor 20.101
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.100
Col1a1collagen, type I, alpha 10.099
Ncr1natural cytotoxicity triggering receptor 10.097
Sod3superoxide dismutase 3, extracellular0.094
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.094
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.091
Tgfbr2transforming growth factor, beta receptor II0.090
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.090
Mr1major histocompatibility complex, class I-related0.089
Myl3myosin, light chain 3, alkali; ventricular, skeletal, slow0.089
Apba1amyloid beta (A4) precursor protein-binding, family A, member 10.086
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.085
Ifnb1interferon beta 1, fibroblast0.085
Ednraendothelin receptor type A0.084
Mybphmyosin binding protein H0.082
Neurl2neuralized homolog 2 (Drosophila)0.081
FosFBJ osteosarcoma oncogene0.081
Pdia3protein disulfide isomerase family A, member 30.080
Grin2cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.079
Foxa3forkhead box A30.079
Myl7myosin, light chain 7, regulatory0.079
Foxd3forkhead box D30.079
LOC100362824caveolin 2-like0.078
Igfbp5insulin-like growth factor binding protein 50.077
Ptmaprothymosin alpha0.075
Muskmuscle, skeletal, receptor tyrosine kinase0.075
Tnni3troponin I type 3 (cardiac)0.073
Tnnc2troponin C type 2 (fast)0.073
Adra2cadrenergic, alpha-2C-, receptor0.073
Dchs1dachsous 1 (Drosophila)0.072
Lamc1laminin, gamma 10.072
Myl1myosin, light chain 10.072
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.071
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.071
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.070
Junbjun B proto-oncogene0.070
Mgpmatrix Gla protein0.070
Nr4a1nuclear receptor subfamily 4, group A, member 10.069
S100a10S100 calcium binding protein A100.069
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.067
Cav3caveolin 30.067
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.067
Gja5gap junction protein, alpha 50.066
S100a6S100 calcium binding protein A60.066
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.065
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.065
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.064
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.064
Smad3SMAD family member 30.064
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.064
Hspa5heat shock protein 50.063
Psgb1pregnancy-specific beta 1-glycoprotein0.063
Tcfe2atranscription factor E2a0.063
Lgals3lectin, galactoside-binding, soluble, 30.063
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.062
Top2atopoisomerase (DNA) II alpha0.062
LOC690358similar to PR domain containing 110.061
Cyp51cytochrome P450, family 510.061
Xirp1xin actin-binding repeat containing 10.061
Ube2d4ubiquitin-conjugating enzyme E2D 40.061
Col3a1collagen, type III, alpha 10.061
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism