The network for 'branching morphogenesis of an epithelial tube' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

branching morphogenesis of an epithelial tube

The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.

NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 21.000
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Bmp4bone morphogenetic protein 41.000
Pax2paired box gene 21.000
Foxc1forkhead box C11.000
Fgfr1fibroblast growth factor receptor 11.000
Meox2mesenchyme homeobox 21.000
Nos3nitric oxide synthase 3, endothelial cell1.000
Gli2GLI-Kruppel family member GLI21.000
Pbx1pre B-cell leukemia transcription factor 11.000
Pitx2paired-like homeodomain transcription factor 20.999
Prrx1paired related homeobox 10.998
Ctnnb1catenin (cadherin associated protein), beta 10.998
Pax3paired box gene 30.998
Foxc2forkhead box C20.997
Eya1eyes absent 1 homolog (Drosophila)0.997
Ptch1patched homolog 10.996
Hoxd11homeobox D110.996
Retret proto-oncogene0.995
Vangl2vang-like 2 (van gogh, Drosophila)0.995
Ptenphosphatase and tensin homolog0.994
Jag1jagged 10.994
Tbx3T-box 30.993
Hand2heart and neural crest derivatives expressed transcript 20.993
Ror2receptor tyrosine kinase-like orphan receptor 20.993
Tcf21transcription factor 210.992
Smad3MAD homolog 3 (Drosophila)0.991
Sox2SRY-box containing gene 20.990
Efnb2ephrin B20.990
Wt1Wilms tumor 1 homolog0.989
Pax8paired box gene 80.988
Wnt5awingless-related MMTV integration site 5A0.988
Bcl2B-cell leukemia/lymphoma 20.987
Fgfr3fibroblast growth factor receptor 30.986
Vdrvitamin D receptor0.985
Hand1heart and neural crest derivatives expressed transcript 10.985
Fgf10fibroblast growth factor 100.984
Pcsk5proprotein convertase subtilisin/kexin type 50.983
Vegfavascular endothelial growth factor A0.980
Gbx2gastrulation brain homeobox 20.980
Rargretinoic acid receptor, gamma0.979
Hoxa11homeobox A110.978
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.976
Zeb1zinc finger E-box binding homeobox 10.975
Tbx2T-box 20.975
Egfrepidermal growth factor receptor0.973
Arandrogen receptor0.968
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.966
Twist2twist homolog 2 (Drosophila)0.962
Apcadenomatosis polyposis coli0.959
Notch1Notch gene homolog 1 (Drosophila)0.955
Dkk1dickkopf homolog 1 (Xenopus laevis)0.954
Tgfb2transforming growth factor, beta 20.953
Sox7SRY-box containing gene 70.952
Msx1homeobox, msh-like 10.950
Fgf8fibroblast growth factor 80.944
Gdnfglial cell line derived neurotrophic factor0.942
Prrx2paired related homeobox 20.941
Tgfb1transforming growth factor, beta 10.940
Ednraendothelin receptor type A0.940
Hspg2perlecan (heparan sulfate proteoglycan 2)0.938
Hoxa1homeobox A10.937
Lhx1LIM homeobox protein 10.936
Ptpn11protein tyrosine phosphatase, non-receptor type 110.933
Dlx5distal-less homeobox 50.931
Bmp7bone morphogenetic protein 70.924
Acvr1activin A receptor, type 10.921
Nf1neurofibromatosis 10.919
Gata6GATA binding protein 60.905
Foxg1forkhead box G10.900
Rarbretinoic acid receptor, beta0.899
Emx2empty spiracles homolog 2 (Drosophila)0.897
Rspo2R-spondin 2 homolog (Xenopus laevis)0.897
Gata3GATA binding protein 30.897
Fgf3fibroblast growth factor 30.892
Pou3f3POU domain, class 3, transcription factor 30.889
Epha4Eph receptor A40.884
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.883
Ptk2PTK2 protein tyrosine kinase 20.883
Meox1mesenchyme homeobox 10.881
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.880
Hoxa13homeobox A130.879
Sox9SRY-box containing gene 90.878
Snai1snail homolog 1 (Drosophila)0.876
Nr5a1nuclear receptor subfamily 5, group A, member 10.875
Ren1renin 1 structural0.875
Hoxa5homeobox A50.859
Hoxd13homeobox D130.858
Itgb1integrin beta 1 (fibronectin receptor beta)0.852
Tbx1T-box 10.851
Sox11SRY-box containing gene 110.847
Rararetinoic acid receptor, alpha0.844
Nkx2-1NK2 homeobox 10.844
Gscgoosecoid homeobox0.843
Sfrp2secreted frizzled-related protein 20.840
Pax6paired box gene 60.839
Hes1hairy and enhancer of split 1 (Drosophila)0.839
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.989
notch3notch homolog 30.964
pax2apaired box gene 2a0.869
tbx1T-box 10.866
jag1bjagged 1b0.855
kdrlkinase insert domain receptor like0.812
fbn2bfibrillin 2b0.626
wnt4awingless-type MMTV integration site family, member 4a0.581
jag2jagged 20.567
mecomMDS1 and EVI1 complex locus0.550
eya1eyes absent homolog 10.534
osr2odd-skipped related 2 (Drosophila)0.512
notch1anotch homolog 1a0.509
ntn1anetrin 1a0.507
cdh2cadherin 2, neuronal0.503
bocbrother of CDO0.488
hey1hairy/enhancer-of-split related with YRPW motif 10.466
myod1myogenic differentiation 10.454
etv2ets variant gene 20.444
pitx3paired-like homeodomain transcription factor 30.439
bmp4bone morphogenetic protein 40.424
dll4delta-like 4 (Drosophila)0.395
foxd3forkhead box D30.395
hoxb8ahomeo box B8a0.383
wnt10awingless-type MMTV integration site family, member 10a0.381
bmp2abone morphogenetic protein 2a0.350
sox10SRY-box containing gene 100.345
lmx1b.1LIM homeobox transcription factor 1, beta 10.342
fgf10afibroblast growth factor 10a0.340
wnt11wingless-type MMTV integration site family, member 110.314
wnt2bbwingless-type MMTV integration site family, member 2Bb0.313
plcg1phospholipase C, gamma 10.292
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.291
nrp1aneuropilin 1a0.284
smosmoothened homolog (Drosophila)0.269
hey2hairy/enhancer-of-split related with YRPW motif 20.264
wnt3wingless-type MMTV integration site family, member 30.263
grem2gremlin 2, cysteine knot superfamily0.263
six4bsine oculis homeobox homolog 4b0.262
traf4atnf receptor-associated factor 4a0.232
ptgs1prostaglandin-endoperoxide synthase 10.219
cxcr4achemokine (C-X-C motif) receptor 4a0.218
hs6st2heparan sulfate 6-O-sulfotransferase 20.217
frem3Fras1 related extracellular matrix 30.212
wnt5bwingless-type MMTV integration site family, member 5b0.199
igfbp3insulin-like growth factor binding protein 30.199
rfx2regulatory factor X, 2 (influences HLA class II expression)0.198
nkx3.2NK3 homeobox 20.189
tll1tolloid-like 10.181
wt1bwilms tumor 1b0.181
foxa2forkhead box A20.173
foxi1forkhead box I10.169
hoxb2ahomeo box B2a0.162
fstafollistatin a0.160
wt1awilms tumor 1a0.159
msxbmuscle segment homeobox B0.156
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.155
hoxd4ahomeo box D4a0.154
slit3slit (Drosophila) homolog 30.152
lamb1alaminin, beta 1a0.138
gli1GLI-Kruppel family member 10.137
wnt3awingless-type MMTV integration site family, member 3A0.136
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.128
sema3absemaphorin 3ab0.122
hoxb5bhomeo box B5b0.121
eng1aengrailed 1a0.119
lamc1laminin, gamma 10.118
hoxc6ahomeo box C6a0.117
pou3f3aPOU class 3 homeobox 3a0.116
fgf3fibroblast growth factor 30.113
edn1endothelin 10.113
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.108
cxcr4bchemokine (C-X-C motif), receptor 4b0.108
tp53tumor protein p530.106
sulf1sulfatase 10.106
pea3ETS-domain transcription factor pea30.105
pax5paired box gene 50.103
hoxa2bhomeo box A2b0.101
brd2abromodomain-containing 2a0.098
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.097
hapln3hyaluronan and proteoglycan link protein 30.096
unc45aunc-45 homolog A (C. elegans)0.093
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.093
sema3aasemaphorin 3aa0.093
wnt9bwingless-type MMTV integration site family, member 9B0.091
disc1disrupted in schizophrenia 10.091
bmp2bbone morphogenetic protein 2b0.089
efnb2aephrin B2a0.087
mmp2matrix metalloproteinase 20.086
barx1BarH-like homeobox 10.086
sarsseryl-tRNA synthetase0.085
cnnm2acyclin M2a0.083
aldh1a2aldehyde dehydrogenase 1 family, member A20.081
nkx2.3NK2 transcription factor related 30.081
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.928
salmspalt major0.866
argosCG4531 gene product from transcript CG4531-RA0.860
lolalongitudinals lacking0.805
mewmultiple edematous wings0.799
vvlventral veins lacking0.782
Nsf2NEM-sensitive fusion protein 20.772
CctgammaCG8977 gene product from transcript CG8977-RC0.772
BicDBicaudal D0.723
GckIIIGerminal centre kinase III0.600
EgfrEpidermal growth factor receptor0.553
jingCG9397 gene product from transcript CG9397-RI0.461
Sra-1specifically Rac1-associated protein 10.434
fz2frizzled 20.428
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.419
ik2IkappaB kinase-like 20.406
stanstarry night0.395
JraJun-related antigen0.315
WASpCG1520 gene product from transcript CG1520-RA0.296
MrtfMyocardin-related transcription factor0.287
sosine oculis0.283
Src42ASrc oncogene at 42A0.281
HphHIF prolyl hydroxylase0.274
Ras85DRas oncogene at 85D0.247
stumpsCG31317 gene product from transcript CG31317-RC0.247
elBelbow B0.232
wbwing blister0.226
FhosCG42610 gene product from transcript CG42610-RC0.215
Fas2Fasciclin 20.206
PtenCG5671 gene product from transcript CG5671-RB0.200
beta-Specbeta Spectrin0.199
LanB2Laminin B20.195
MtpMicrosomal triacylglycerol transfer protein0.184
grhgrainy head0.184
lunaCG33473 gene product from transcript CG33473-RB0.172
Gyc76CGuanylyl cyclase at 76C0.171
DAAMDishevelled Associated Activator of Morphogenesis0.162
e(y)3enhancer of yellow 30.161
cicubitus interruptus0.161
pashapartner of drosha0.157
dallydivision abnormally delayed0.156
LamCLamin C0.153
Vhlvon Hippel-Lindau0.145
Ptp69DProtein tyrosine phosphatase 69D0.132
nkdnaked cuticle0.131
drkdownstream of receptor kinase0.130
membrinCG4780 gene product from transcript CG4780-RA0.129
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.992
VEGFAvascular endothelial growth factor A0.990
FGFR2fibroblast growth factor receptor 20.971
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.963
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.921
MDM2Mdm2 p53 binding protein homolog (mouse)0.877
NCOR2nuclear receptor corepressor 20.864
COL4A2collagen, type IV, alpha 20.859
RARAretinoic acid receptor, alpha0.839
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.823
NRP1neuropilin 10.807
GAS6growth arrest-specific 60.799
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.727
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.718
EGFRepidermal growth factor receptor0.665
PAX8paired box 80.664
FGFR1fibroblast growth factor receptor 10.636
TBX5T-box 50.616
EGR1early growth response 10.574
NCOA1nuclear receptor coactivator 10.538
SMN1survival of motor neuron 1, telomeric0.521
PTK2PTK2 protein tyrosine kinase 20.513
THBS1thrombospondin 10.498
CREBBPCREB binding protein0.487
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.471
PGFplacental growth factor0.462
FN1fibronectin 10.440
RUNX1runt-related transcription factor 10.426
BMPR1Abone morphogenetic protein receptor, type IA0.417
FGF10fibroblast growth factor 100.414
ADAM17ADAM metallopeptidase domain 170.372
JAG1jagged 10.372
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.368
NKX2-1NK2 homeobox 10.361
IQGAP1IQ motif containing GTPase activating protein 10.345
TIMP3TIMP metallopeptidase inhibitor 30.344
MEIS1Meis homeobox 10.333
EGR2early growth response 20.318
SHC1SHC (Src homology 2 domain containing) transforming protein 10.310
BCL2L1BCL2-like 10.297
FSTL1follistatin-like 10.281
COL4A4collagen, type IV, alpha 40.278
PKD2polycystic kidney disease 2 (autosomal dominant)0.278
HOXA10homeobox A100.265
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.258
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.254
MEIS2Meis homeobox 20.242
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.229
RB1retinoblastoma 10.227
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.227
SKIv-ski sarcoma viral oncogene homolog (avian)0.225
MYOD1myogenic differentiation 10.222
BMPR1Bbone morphogenetic protein receptor, type IB0.221
ESR1estrogen receptor 10.220
FGF8fibroblast growth factor 8 (androgen-induced)0.213
COL4A6collagen, type IV, alpha 60.213
TGFB1transforming growth factor, beta 10.206
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.203
FGF1fibroblast growth factor 1 (acidic)0.200
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.192
COL2A1collagen, type II, alpha 10.188
TM4SF1transmembrane 4 L six family member 10.174
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.164
BMP2bone morphogenetic protein 20.163
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.159
BMP7bone morphogenetic protein 70.156
CDH5cadherin 5, type 2 (vascular endothelium)0.154
CDK6cyclin-dependent kinase 60.152
CTGFconnective tissue growth factor0.148
NOTCH1notch 10.146
ARNTaryl hydrocarbon receptor nuclear translocator0.144
DVL3dishevelled, dsh homolog 3 (Drosophila)0.144
EGR3early growth response 30.142
GATA4GATA binding protein 40.142
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.139
HIPK2homeodomain interacting protein kinase 20.138
TP53tumor protein p530.133
COL6A1collagen, type VI, alpha 10.127
EP300E1A binding protein p3000.127
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.123
COL4A5collagen, type IV, alpha 50.119
COL4A1collagen, type IV, alpha 10.118
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.118
S100A4S100 calcium binding protein A40.118
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.112
TGFB3transforming growth factor, beta 30.111
ARandrogen receptor0.111
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.110
TGFBR1transforming growth factor, beta receptor 10.110
HOXB5homeobox B50.110
RASSF2Ras association (RalGDS/AF-6) domain family member 20.110
CTNND1catenin (cadherin-associated protein), delta 10.105
POU5F1POU class 5 homeobox 10.101
FOXD3forkhead box D30.100
MED25mediator complex subunit 250.092
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nek9NIMA (never in mitosis gene a)- related kinase 90.187
Fgfr2fibroblast growth factor receptor 20.180
RGD1564327similar to integrin alpha 80.086
Smad7SMAD family member 70.083
Flt1FMS-related tyrosine kinase 10.063
Gata6GATA binding protein 60.061
Lig3ligase III, DNA, ATP-dependent0.059
Unc5bunc-5 homolog B (C. elegans)0.054
Gja5gap junction protein, alpha 50.042
Arntaryl hydrocarbon receptor nuclear translocator0.040
Foxe3forkhead box E30.039
Sox17SRY (sex determining region Y)-box 170.037
Igfbp5insulin-like growth factor binding protein 50.034
Lims1LIM and senescent cell antigen-like domains 10.033
Tnctenascin C0.031
GperG protein-coupled estrogen receptor 10.027
Trhr2thyrotropin releasing hormone receptor 20.026
Prrx1paired related homeobox 10.025
Nos3nitric oxide synthase 3, endothelial cell0.025
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.025
Dcaf17DDB1 and CUL4 associated factor 170.022
Nkd1naked cuticle homolog 1 (Drosophila)0.022
Cgaglycoprotein hormones, alpha polypeptide0.022
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.022
Sirpasignal-regulatory protein alpha0.021
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.020
Stat5bsignal transducer and activator of transcription 5B0.020
Nfibnuclear factor I/B0.020
Esr1estrogen receptor 10.020
Grm7glutamate receptor, metabotropic 70.019
LOC286992peptide HP (rs14)0.019
Atp6v1g3ATPase, H+ transporting, lysosomal V1 subunit G30.019
Dchs1dachsous 1 (Drosophila)0.019
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.019
Rab3il1RAB3A interacting protein (rabin3)-like 10.018
Bmp6bone morphogenetic protein 60.017
MosMoloney sarcoma oncogene0.017
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.017
Piglphosphatidylinositol glycan anchor biosynthesis, class L0.017
RGD1564163similar to RIKEN cDNA 1700025K230.017
Il1r1interleukin 1 receptor, type I0.016
Nfianuclear factor I/A0.015
FcgrtFc fragment of IgG, receptor, transporter, alpha0.015
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.015
Syt9synaptotagmin IX0.015
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.015
Lhx5LIM homeobox 50.015
Twist2twist homolog 2 (Drosophila)0.014
Gna12guanine nucleotide binding protein (G protein) alpha 120.014
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.014
Cacna1gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.014
Cckarcholecystokinin A receptor0.014
Foxd3forkhead box D30.014
Ptgfrprostaglandin F receptor0.013
Srysex determining region Y0.013
Zfp382zinc finger protein 3820.013
Plauplasminogen activator, urokinase0.013
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.013
Ptger3prostaglandin E receptor 3 (subtype EP3)0.013
Notch2Notch homolog 2 (Drosophila)0.013
Creb1cAMP responsive element binding protein 10.013
Galr2galanin receptor 20.013
Mapk9mitogen-activated protein kinase 90.013
Metmet proto-oncogene0.013
Tcf4transcription factor 40.013
Grem1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)0.012
Insrrinsulin receptor-related receptor0.012
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.012
Adam5a disintegrin and metallopeptidase domain 50.012
Agtr1aangiotensin II receptor, type 1a0.012
Arnt2aryl hydrocarbon receptor nuclear translocator 20.012
Bcl2B-cell CLL/lymphoma 20.012
Ugt1a1UDP glucuronosyltransferase 1 family, polypeptide A10.012
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.012
Nop58nucleolar protein NOP580.012
Ednraendothelin receptor type A0.012
Hist1h2bahistone cluster 1, H2ba0.012
Pgcpplasma glutamate carboxypeptidase0.012
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.012
Cma1chymase 1, mast cell0.012
Akr1a1aldo-keto reductase family 1, member A1 (aldehyde reductase)0.012
Csn1s2acasein alpha s2-like A0.011
RT1-DOaRT1 class II, locus DOa0.011
Gjb3gap junction protein, beta 30.011
Actr2ARP2 actin-related protein 2 homolog (yeast)0.011
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.011
Baiap2BAI1-associated protein 20.011
Tff3trefoil factor 3, intestinal0.011
Avpr2arginine vasopressin receptor 20.011
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.011
Slco2a1solute carrier organic anion transporter family, member 2a10.011
Aif1lallograft inflammatory factor 1-like0.011
Akr1c18aldo-keto reductase family 1, member C180.011
Ptger4prostaglandin E receptor 4 (subtype EP4)0.010
Scarf2scavenger receptor class F, member 20.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism