The network for 'positive regulation of sphingolipid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of sphingolipid biosynthetic process

Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

NameDescriptionProbabilityFunc Analog Organism
Cyr61cysteine rich protein 610.364
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.318
Dusp1dual specificity phosphatase 10.221
Thbs1thrombospondin 10.190
Ctgfconnective tissue growth factor0.130
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.104
Tnfrsf12atumor necrosis factor receptor superfamily, member 12a0.070
Tnctenascin C0.066
FosFBJ osteosarcoma oncogene0.062
Ighimmunoglobulin heavy chain complex0.054
Atf3activating transcription factor 30.045
F3coagulation factor III0.040
Amotl2angiomotin-like 20.038
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.037
JunJun oncogene0.036
Loxlysyl oxidase0.034
BlnkB-cell linker0.032
Thbs2thrombospondin 20.028
Gli2GLI-Kruppel family member GLI20.027
Zeb1zinc finger E-box binding homeobox 10.027
Platplasminogen activator, tissue0.026
Prss23protease, serine, 230.024
Fkbp10FK506 binding protein 100.024
Wwtr1WW domain containing transcription regulator 10.024
Nr4a1nuclear receptor subfamily 4, group A, member 10.024
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.023
Egr1early growth response 10.019
Ltbp2latent transforming growth factor beta binding protein 20.019
Col8a1collagen, type VIII, alpha 10.018
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.018
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.017
Col5a2collagen, type V, alpha 20.017
Tinagl1tubulointerstitial nephritis antigen-like 10.016
Ctskcathepsin K0.016
Taglntransgelin0.015
Zfp36zinc finger protein 360.015
Errfi1ERBB receptor feedback inhibitor 10.015
Tll1tolloid-like0.015
Ier3immediate early response 30.015
Klf6Kruppel-like factor 60.014
Klf4Kruppel-like factor 4 (gut)0.014
Fgfrl1fibroblast growth factor receptor-like 10.013
Timp1tissue inhibitor of metalloproteinase 10.013
Cd40CD40 antigen0.013
Osmroncostatin M receptor0.012
Figfc-fos induced growth factor0.012
Egr2early growth response 20.011
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.011
Fbln2fibulin 20.011
Ptgs2prostaglandin-endoperoxide synthase 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.927
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.674
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.635
ZNF71zinc finger protein 710.505
NUMBnumb homolog (Drosophila)0.446
PRKCZprotein kinase C, zeta0.298
CCDC115coiled-coil domain containing 1150.163
NCF1neutrophil cytosolic factor 10.124
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.091
NOXA1NADPH oxidase activator 10.086
CTGFconnective tissue growth factor0.083
F11RF11 receptor0.081
PPP2R4protein phosphatase 2A activator, regulatory subunit 40.077
DCTN1dynactin 10.074
VHLvon Hippel-Lindau tumor suppressor0.052
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.051
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.037
MAPTmicrotubule-associated protein tau0.033
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.031
SH3RF1SH3 domain containing ring finger 10.026
PICK1protein interacting with PRKCA 10.026
PDPK13-phosphoinositide dependent protein kinase-10.025
NMT2N-myristoyltransferase 20.025
BADBCL2-associated agonist of cell death0.023
LLGL1lethal giant larvae homolog 1 (Drosophila)0.022
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.022
SQSTM1sequestosome 10.020
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.020
AMOTL2angiomotin like 20.019
CDCP1CUB domain containing protein 10.017
CD2CD2 molecule0.016
PRKCBprotein kinase C, beta0.016
MAP3K5mitogen-activated protein kinase kinase kinase 50.015
TSC22D1TSC22 domain family, member 10.015
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.013
NCOA1nuclear receptor coactivator 10.012
CDC37cell division cycle 37 homolog (S. cerevisiae)0.012
MAPKAP1mitogen-activated protein kinase associated protein 10.011
TRIM9tripartite motif containing 90.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism