The network for 'negative regulation of myeloid cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of myeloid cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)0.998
Pbx1pre B-cell leukemia transcription factor 10.998
Hoxa10homeobox A100.998
Runx1runt related transcription factor 10.997
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.995
Hoxa9homeobox A90.995
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.983
Gata4GATA binding protein 40.982
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.972
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.968
Hoxa11homeobox A110.964
Hoxc4homeobox C40.956
Ikzf1IKAROS family zinc finger 10.952
Robo1roundabout homolog 1 (Drosophila)0.951
Foxp3forkhead box P30.947
Hoxb5homeobox B50.946
Hoxb6homeobox B60.939
Hoxa5homeobox A50.936
Tal1T-cell acute lymphocytic leukemia 10.933
Hoxc5homeobox C50.928
Stat5bsignal transducer and activator of transcription 5B0.914
Rxraretinoid X receptor alpha0.905
Sfrp2secreted frizzled-related protein 20.871
Gata1GATA binding protein 10.867
Lyz2lysozyme 20.830
Gli3GLI-Kruppel family member GLI30.797
Hes1hairy and enhancer of split 1 (Drosophila)0.786
Isl1ISL1 transcription factor, LIM/homeodomain0.774
Dll1delta-like 1 (Drosophila)0.768
Gata3GATA binding protein 30.733
Hoxd9homeobox D90.721
Shhsonic hedgehog0.721
Hoxc6homeobox C60.716
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.709
Hoxb4homeobox B40.683
Hoxc8homeobox C80.644
Wt1Wilms tumor 1 homolog0.630
Hoxd4homeobox D40.617
Ascl1achaete-scute complex homolog 1 (Drosophila)0.597
Trp53transformation related protein 530.595
Irf9interferon regulatory factor 90.560
Zfp36zinc finger protein 360.557
Nhlh1nescient helix loop helix 10.546
Slit2slit homolog 2 (Drosophila)0.544
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.533
Hoxa1homeobox A10.533
Meis1Meis homeobox 10.523
Hoxd10homeobox D100.518
Pitx1paired-like homeodomain transcription factor 10.511
JunbJun-B oncogene0.499
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.498
Pax2paired box gene 20.495
Socs1suppressor of cytokine signaling 10.490
Jak3Janus kinase 30.489
Pcsk5proprotein convertase subtilisin/kexin type 50.488
Tcf21transcription factor 210.475
Jag1jagged 10.470
Hand2heart and neural crest derivatives expressed transcript 20.468
Hoxb9homeobox B90.463
Tgfb1transforming growth factor, beta 10.454
Klf3Kruppel-like factor 3 (basic)0.451
JunJun oncogene0.448
Inpp5dinositol polyphosphate-5-phosphatase D0.446
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.429
Pbx3pre B-cell leukemia transcription factor 30.418
Neurod1neurogenic differentiation 10.414
Il4rainterleukin 4 receptor, alpha0.408
Dkk1dickkopf homolog 1 (Xenopus laevis)0.400
Slit1slit homolog 1 (Drosophila)0.397
Hoxd3homeobox D30.397
Sfpi1SFFV proviral integration 10.390
Efnb1ephrin B10.389
Ebf3early B-cell factor 30.381
Neurog2neurogenin 20.366
Lhx9LIM homeobox protein 90.358
Ptenphosphatase and tensin homolog0.354
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.348
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.347
Rararetinoic acid receptor, alpha0.341
Stat5asignal transducer and activator of transcription 5A0.331
Hoxb3homeobox B30.325
Fgfr2fibroblast growth factor receptor 20.325
C1qbcomplement component 1, q subcomponent, beta polypeptide0.321
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.320
Ptpn11protein tyrosine phosphatase, non-receptor type 110.316
Snai1snail homolog 1 (Drosophila)0.313
Sox2SRY-box containing gene 20.311
Foxg1forkhead box G10.298
TcraT-cell receptor alpha chain0.297
Bnc1basonuclin 10.297
Gmnngeminin0.291
Gabpb1GA repeat binding protein, beta 10.278
Socs3suppressor of cytokine signaling 30.276
FosFBJ osteosarcoma oncogene0.270
Gpr50G-protein-coupled receptor 500.264
Stat3signal transducer and activator of transcription 30.264
Stat6signal transducer and activator of transcription 60.261
Dok1docking protein 10.255
Il2interleukin 20.253
Chd7chromodomain helicase DNA binding protein 70.249
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cxcr4bchemokine (C-X-C motif), receptor 4b0.702
hoxd4ahomeo box D4a0.664
pax2apaired box gene 2a0.609
prrx1apaired related homeobox 1a0.568
hoxb1bhomeo box B1b0.516
hoxc6ahomeo box C6a0.452
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.450
hoxb5bhomeo box B5b0.341
dhrs3adehydrogenase/reductase (SDR family) member 3a0.334
dladeltaA0.316
hoxc8ahomeo box C8a0.315
hoxb3ahomeo box B3a0.315
spry4sprouty (Drosophila) homolog 40.289
hoxa4ahomeo box A4a0.251
hoxa3ahomeo box A3a0.237
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.216
hoxc4ahomeo box C4a0.199
lcp1lymphocyte cytosolic plastin 10.188
hhexhematopoietically expressed homeobox0.186
rargaretinoic acid receptor gamma a0.186
hoxb4ahomeo box B4a0.173
etv2ets variant gene 20.163
raraaretinoic acid receptor, alpha a0.155
lmo4aLIM domain only 4a0.154
rarabretinoic acid receptor, alpha b0.145
mpxmyeloid-specific peroxidase0.144
sox2SRY-box containing gene 20.140
hoxb5ahomeo box B5a0.131
tal1T-cell acute lymphocytic leukemia 10.125
hlxb9lbhomeo box HB9 like b0.121
fzd7bfrizzled homolog 7b0.120
dlbdeltaB0.118
notch3notch homolog 30.117
fn1fibronectin 10.111
wnt3awingless-type MMTV integration site family, member 3A0.109
hoxb8ahomeo box B8a0.103
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.099
wnt8awingless-type MMTV integration site family, member 8a0.094
dbx1adeveloping brain homeobox 1a0.093
nf1aneurofibromin 1a0.093
dlddeltaD0.092
lfnglunatic fringe homolog0.092
crip2cysteine-rich protein 20.090
gli2aGLI-Kruppel family member GLI2a0.089
jag2jagged 20.089
her6hairy-related 60.087
hoxa13bhomeo box A13b0.086
hand2heart and neural crest derivatives expressed transcript 20.085
hmgb1bhigh-mobility group box 1b0.085
hoxb6ahomeo box B6a0.083
nrarpanotch-regulated ankyrin repeat protein a0.083
hoxc5ahomeo box C5a0.082
hoxb6bhomeo box B6b0.081
aldh1a2aldehyde dehydrogenase 1 family, member A20.080
ets2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.073
cdx4caudal type homeo box transcription factor 40.072
mychmyelocytomatosis oncogene homolog0.071
hoxc9ahomeo box C9a0.070
lmo2LIM domain only 2 (rhombotin-like 1)0.069
neurog1neurogenin 10.068
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.067
gata1aGATA binding protein 1a0.066
drldraculin0.062
tagln2transgelin 20.061
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.060
pea3ETS-domain transcription factor pea30.060
gdf6agrowth differentiation factor 6a0.059
isl1islet10.058
hoxd10ahomeo box D10a0.058
axin2axin 2 (conductin, axil)0.056
osr1odd-skipped related 1 (Drosophila)0.055
nf1bneurofibromin 1b0.054
sox7SRY-box containing gene 70.054
hs6st2heparan sulfate 6-O-sulfotransferase 20.054
meis3myeloid ecotropic viral integration site 30.054
mycl1bv-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b0.054
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.053
metmet proto-oncogene (hepatocyte growth factor receptor)0.053
tgfbitransforming growth factor, beta-induced0.052
tbx16T-box gene 160.051
cpsf6cleavage and polyadenylation specific factor 60.051
si:ch211-235f6.2si:ch211-235f6.20.051
runx1runt-related transcription factor 10.048
cpoxcoproporphyrinogen oxidase0.047
fli1bfriend leukemia integration 1b0.047
tgfb2transforming growth factor, beta 20.046
fzd2frizzled homolog 20.046
znf711zinc finger protein 7110.046
cdh2cadherin 2, neuronal0.046
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.045
angptl2angiopoietin-like 20.045
myl7myosin, light polypeptide 7, regulatory0.045
irf8interferon regulatory factor 80.045
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.044
celf1cugbp, Elav-like family member 10.044
lef1lymphocyte enhancer binding factor 10.044
brd2abromodomain-containing 2a0.044
tmem88atransmembrane protein 88 a0.042
hoxc6bhomeo box C6b0.042
pitx2paired-like homeodomain transcription factor 20.042
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HIST1H3Dhistone cluster 1, H3d0.997
C1QAcomplement component 1, q subcomponent, A chain0.997
ZNF43zinc finger protein 430.995
HIST1H2BDhistone cluster 1, H2bd0.995
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.994
PTPN1protein tyrosine phosphatase, non-receptor type 10.994
BCAR1breast cancer anti-estrogen resistance 10.990
PBX1pre-B-cell leukemia homeobox 10.984
HIST1H2AEhistone cluster 1, H2ae0.982
HIST1H2BGhistone cluster 1, H2bg0.977
CTR9Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.963
ZNF273zinc finger protein 2730.960
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.955
ZNF253zinc finger protein 2530.934
PTPN6protein tyrosine phosphatase, non-receptor type 60.918
HIST1H2AJhistone cluster 1, H2aj0.907
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.896
PILRApaired immunoglobin-like type 2 receptor alpha0.886
CXCL3chemokine (C-X-C motif) ligand 30.878
CXCL2chemokine (C-X-C motif) ligand 20.874
CCR5chemokine (C-C motif) receptor 50.863
IL4Rinterleukin 4 receptor0.847
IL8interleukin 80.829
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.818
HIST1H1Chistone cluster 1, H1c0.813
HIST1H2BKhistone cluster 1, H2bk0.809
IL1Binterleukin 1, beta0.750
HOXB5homeobox B50.742
MDM2Mdm2 p53 binding protein homolog (mouse)0.729
ZNF675zinc finger protein 6750.726
CXCL10chemokine (C-X-C motif) ligand 100.710
CCL8chemokine (C-C motif) ligand 80.707
HIST1H2AMhistone cluster 1, H2am0.701
HIST1H4Dhistone cluster 1, H4d0.684
HIST1H2AIhistone cluster 1, H2ai0.665
TAL1T-cell acute lymphocytic leukemia 10.641
EPORerythropoietin receptor0.635
HIST1H4Bhistone cluster 1, H4b0.599
HIST1H4Hhistone cluster 1, H4h0.596
CCL4chemokine (C-C motif) ligand 40.591
CCND1cyclin D10.591
ESR1estrogen receptor 10.578
HIST2H2BEhistone cluster 2, H2be0.574
HIST1H2ABhistone cluster 1, H2ab0.563
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.560
HIST1H3Ahistone cluster 1, H3a0.531
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.495
HIST1H2ALhistone cluster 1, H2al0.495
C1QCcomplement component 1, q subcomponent, C chain0.494
ZNF117zinc finger protein 1170.490
NFE2L2nuclear factor (erythroid-derived 2)-like 20.482
TRIP6thyroid hormone receptor interactor 60.478
CREBBPCREB binding protein0.467
HIST1H4Ahistone cluster 1, H4a0.451
HOXA10homeobox A100.443
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.438
GHRgrowth hormone receptor0.437
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.408
ZNF430zinc finger protein 4300.386
ZNF254zinc finger protein 2540.383
CDK6cyclin-dependent kinase 60.381
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.375
CCL13chemokine (C-C motif) ligand 130.375
RBBP4retinoblastoma binding protein 40.365
HIST1H2BChistone cluster 1, H2bc0.364
TP53tumor protein p530.359
HIST1H2BJhistone cluster 1, H2bj0.346
TCEA1transcription elongation factor A (SII), 10.342
HIST1H4Jhistone cluster 1, H4j0.339
YY1YY1 transcription factor0.328
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.320
ZNF85zinc finger protein 850.320
ZNF708zinc finger protein 7080.318
HIST1H3Bhistone cluster 1, H3b0.310
ZNF91zinc finger protein 910.306
CXCL11chemokine (C-X-C motif) ligand 110.294
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.289
HIST1H4Ehistone cluster 1, H4e0.288
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.284
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.279
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.270
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.266
GATA2GATA binding protein 20.265
CDK4cyclin-dependent kinase 40.264
HOXA7homeobox A70.263
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.241
RXRAretinoid X receptor, alpha0.230
ZNF680zinc finger protein 6800.224
CXCL5chemokine (C-X-C motif) ligand 50.223
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.219
IL6interleukin 6 (interferon, beta 2)0.205
TGFB1transforming growth factor, beta 10.203
INCENPinner centromere protein antigens 135/155kDa0.202
HIST2H4Ahistone cluster 2, H4a0.199
CCR1chemokine (C-C motif) receptor 10.198
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.192
C1QBcomplement component 1, q subcomponent, B chain0.186
ZNF93zinc finger protein 930.182
HIST1H2AGhistone cluster 1, H2ag0.179
HOXB3homeobox B30.178
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
C1qbcomplement component 1, q subcomponent, B chain0.062
Nme1non-metastatic cells 1, protein (NM23A) expressed in0.037
Nedd8neural precursor cell expressed, developmentally down-regulated 80.035
Sec61bSec61 beta subunit0.033
Zfp36zinc finger protein 360.032
Psmb4proteasome (prosome, macropain) subunit, beta type 40.029
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.021
Polr2gpolymerase (RNA) II (DNA directed) polypeptide G0.021
Rassf5Ras association (RalGDS/AF-6) domain family member 50.021
Cfpcomplement factor properdin0.019
Folr2folate receptor 2 (fetal)0.019
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.019
Sgk1serum/glucocorticoid regulated kinase 10.018
Wisp1WNT1 inducible signaling pathway protein 10.017
Tgfbr3transforming growth factor, beta receptor III0.017
Elf1E74-like factor 10.017
Cfdcomplement factor D (adipsin)0.016
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.016
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.016
Mtx2metaxin 20.016
C1qacomplement component 1, q subcomponent, A chain0.016
LOC687711similar to small nuclear ribonucleoprotein D30.016
Rgs1regulator of G-protein signaling 10.015
Krtcap2keratinocyte associated protein 20.015
Apex1APEX nuclease (multifunctional DNA repair enzyme) 10.015
Errfi1ERBB receptor feedback inhibitor 10.015
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.015
Nhp2NHP2 ribonucleoprotein homolog (yeast)0.015
Arl11ADP-ribosylation factor-like 110.015
Ccdc102acoiled-coil domain containing 102A0.015
Tmem176atransmembrane protein 176A0.015
Eif5aeukaryotic translation initiation factor 5A0.014
Tmem208transmembrane protein 2080.014
Imp3IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)0.014
Tceb1transcription elongation factor B (SIII), polypeptide 10.014
Slit3slit homolog 3 (Drosophila)0.014
Psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.014
Snrpfsmall nuclear ribonucleoprotein polypeptide F0.014
Sirpasignal-regulatory protein alpha0.014
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.013
Smad3SMAD family member 30.013
Itpr2inositol 1,4,5-triphosphate receptor, type 20.013
Dhrs9dehydrogenase/reductase (SDR family) member 90.013
Rararetinoic acid receptor, alpha0.012
Upk3bluroplakin 3B-like0.012
Cxcl2chemokine (C-X-C motif) ligand 20.012
RGD1308165similar to hypothetical protein MGC173370.012
Eif3deukaryotic translation initiation factor 3, subunit D0.012
Hoxd9homeo box D90.012
Fam173afamily with sequence similarity 173, member A0.012
Pgfplacental growth factor0.012
Fcn1ficolin (collagen/fibrinogen domain containing) 10.012
Timm17atranslocase of inner mitochondrial membrane 17 homolog A (yeast)0.012
Dad1defender against cell death 10.012
Ddr1discoidin domain receptor tyrosine kinase 10.012
Cd4Cd4 molecule0.012
Ispdisoprenoid synthase domain containing0.012
Capn5calpain 50.012
Nrasneuroblastoma ras oncogene0.012
Fermt3fermitin family homolog 3 (Drosophila)0.012
Tgfbr2transforming growth factor, beta receptor II0.012
Irs1insulin receptor substrate 10.012
Prl6a1prolactin family 6, subfamily a, member 10.012
Git1G protein-coupled receptor kinase interacting ArfGAP 10.012
Cdk2cyclin dependent kinase 20.012
Cdc123cell division cycle 123 homolog (S. cerevisiae)0.012
Cd68Cd68 molecule0.011
Cox4nbCOX4 neighbor0.011
Kremen1kringle containing transmembrane protein 10.011
Podxlpodocalyxin-like0.011
Tmem37transmembrane protein 370.011
Psma7proteasome (prosome, macropain) subunit, alpha type 70.011
Prdm2PR domain containing 2, with ZNF domain0.011
Ccdc8coiled-coil domain containing 80.011
Jundjun D proto-oncogene0.011
Acbd5acyl-Coenzyme A binding domain containing 50.011
Laptm5lysosomal protein transmembrane 50.011
Apoeapolipoprotein E0.011
Fabp5fatty acid binding protein 5, epidermal0.011
Hist1h1dhistone cluster 1, H1d0.011
Ckap4cytoskeleton-associated protein 40.011
LOC100363783rCG53773-like0.011
Cybbcytochrome b-245, beta polypeptide0.011
C5ar1complement component 5a receptor 10.011
Psmb1proteasome (prosome, macropain) subunit, beta type 10.011
Ctsscathepsin S0.011
Pcmtd2protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 20.011
Capn1calpain 10.011
Gna15guanine nucleotide binding protein, alpha 150.011
LOC499779similar to RIKEN cDNA 2900010J230.011
Ifngr1interferon gamma receptor 10.010
Carhsp1calcium regulated heat stable protein 10.010
Tbcbtubulin folding cofactor B0.010
Il7interleukin 70.010
Igfbp5insulin-like growth factor binding protein 50.010
Aif1lallograft inflammatory factor 1-like0.010
Pim1pim-1 oncogene0.010
Prom2prominin 20.010
Igsf6immunoglobulin superfamily, member 60.010
Socs3suppressor of cytokine signaling 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism