The network for 'acetyl coa biosynthetic process from pyruvate' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

acetyl coa biosynthetic process from pyruvate

The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.

NameDescriptionProbabilityFunc Analog Organism
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.963
Idh3aisocitrate dehydrogenase 3 (NAD+) alpha0.238
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.182
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.173
Uqcrc2ubiquinol cytochrome c reductase core protein 20.144
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.132
Tmem70transmembrane protein 700.126
Suclg1succinate-CoA ligase, GDP-forming, alpha subunit0.120
Etfaelectron transferring flavoprotein, alpha polypeptide0.100
Pmpcbpeptidase (mitochondrial processing) beta0.087
Vdac2voltage-dependent anion channel 20.084
Gfm1G elongation factor, mitochondrial 10.083
Fh1fumarate hydratase 10.081
Pdha1pyruvate dehydrogenase E1 alpha 10.080
Hibch3-hydroxyisobutyryl-Coenzyme A hydrolase0.080
Lrpprcleucine-rich PPR-motif containing0.066
Cycscytochrome c, somatic0.062
Afg3l2AFG3(ATPase family gene 3)-like 2 (yeast)0.060
Pex7peroxisomal biogenesis factor 70.060
Liaslipoic acid synthetase0.055
Iars2isoleucine-tRNA synthetase 2, mitochondrial0.055
Pdhxpyruvate dehydrogenase complex, component X0.044
Acadmacyl-Coenzyme A dehydrogenase, medium chain0.042
Hadhbhydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit0.039
Ndufaf1NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 10.038
Sod2superoxide dismutase 2, mitochondrial0.037
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.037
Cscitrate synthase0.037
Prdx3peroxiredoxin 30.035
Ghitmgrowth hormone inducible transmembrane protein0.034
Chpt1choline phosphotransferase 10.034
Dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.032
Dlddihydrolipoamide dehydrogenase0.031
Mtx2metaxin 20.030
Bnip3BCL2/adenovirus E1B interacting protein 30.030
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.027
Uqcrbubiquinol-cytochrome c reductase binding protein0.027
Mrpl39mitochondrial ribosomal protein L390.027
Wdtc1WD and tetratricopeptide repeats 10.026
Etfdhelectron transferring flavoprotein, dehydrogenase0.026
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.026
Chchd3coiled-coil-helix-coiled-coil-helix domain containing 30.024
Isca1iron-sulfur cluster assembly 1 homolog (S. cerevisiae)0.022
Mmachcmethylmalonic aciduria cblC type, with homocystinuria0.022
Ndrg2N-myc downstream regulated gene 20.021
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.020
Coq3coenzyme Q3 homolog, methyltransferase (yeast)0.018
Bckdhbbranched chain ketoacid dehydrogenase E1, beta polypeptide0.018
Opa1optic atrophy 1 homolog (human)0.017
Pink1PTEN induced putative kinase 10.017
Acsl1acyl-CoA synthetase long-chain family member 10.016
Ap4s1adaptor-related protein complex AP-4, sigma 10.016
Echdc1enoyl Coenzyme A hydratase domain containing 10.015
Mutmethylmalonyl-Coenzyme A mutase0.015
Hsdl2hydroxysteroid dehydrogenase like 20.015
Mtfp1mitochondrial fission process 10.015
Mfn1mitofusin 10.014
Apooapolipoprotein O0.014
Nudt19nudix (nucleoside diphosphate linked moiety X)-type motif 190.014
Atl2atlastin GTPase 20.014
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.014
Acad11acyl-Coenzyme A dehydrogenase family, member 110.014
Sucla2succinate-Coenzyme A ligase, ADP-forming, beta subunit0.014
Ndufs4NADH dehydrogenase (ubiquinone) Fe-S protein 40.013
Ppa2pyrophosphatase (inorganic) 20.013
Acat1acetyl-Coenzyme A acetyltransferase 10.013
Slc25a23solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 230.013
Mtch2mitochondrial carrier homolog 2 (C. elegans)0.012
Dnaja3DnaJ (Hsp40) homolog, subfamily A, member 30.012
Sar1bSAR1 gene homolog B (S. cerevisiae)0.012
Clyblcitrate lyase beta like0.012
Hspa9heat shock protein 90.012
Macrod1MACRO domain containing 10.012
Suclg2succinate-Coenzyme A ligase, GDP-forming, beta subunit0.011
Ptgr2prostaglandin reductase 20.011
Namptnicotinamide phosphoribosyltransferase0.011
Phyhphytanoyl-CoA hydroxylase0.011
Gbe1glucan (1,4-alpha-), branching enzyme 10.011
Immtinner membrane protein, mitochondrial0.011
Fahd1fumarylacetoacetate hydrolase domain containing 10.011
2310061I04RikRIKEN cDNA 2310061I04 gene0.010
Stard7START domain containing 70.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDHBpyruvate dehydrogenase (lipoamide) beta0.995
PDHXpyruvate dehydrogenase complex, component X0.989
DLATdihydrolipoamide S-acetyltransferase0.964
PDHA1pyruvate dehydrogenase (lipoamide) alpha 10.960
NDUFS1NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)0.269
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.143
CYCScytochrome c, somatic0.130
SUCLA2succinate-CoA ligase, ADP-forming, beta subunit0.086
UQCRC2ubiquinol-cytochrome c reductase core protein II0.041
PFDN1prefoldin subunit 10.035
DLDdihydrolipoamide dehydrogenase0.029
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha0.027
IARS2isoleucyl-tRNA synthetase 2, mitochondrial0.027
FHfumarate hydratase0.013
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.011
SDHAsuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.959
Uqcrc2ubiquinol cytochrome c reductase core protein 20.923
Sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.752
Pdhbpyruvate dehydrogenase (lipoamide) beta0.747
Dlatdihydrolipoamide S-acetyltransferase0.528
Cycscytochrome c, somatic0.444
Ube2bubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)0.269
Pdhxpyruvate dehydrogenase complex, component X0.223
Dnm1ldynamin 1-like0.190
RGD1565095similar to hypothetical protein MGC521100.179
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.157
Me1malic enzyme 1, NADP(+)-dependent, cytosolic0.149
Dlddihydrolipoamide dehydrogenase0.129
Pdha1pyruvate dehydrogenase (lipoamide) alpha 10.073
Idh3Bisocitrate dehydrogenase 3 (NAD+) beta0.065
Prdx3peroxiredoxin 30.058
Mrps14mitochondrial ribosomal protein S140.055
Vdac1voltage-dependent anion channel 10.045
Pink1PTEN induced putative kinase 10.034
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.031
Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)0.030
Pgk1phosphoglycerate kinase 10.030
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.029
Bpnt13'(2'), 5'-bisphosphate nucleotidase 10.027
Trappc6btrafficking protein particle complex 6B0.023
Tfrctransferrin receptor0.023
Dynlt3dynein light chain Tctex-type 30.020
Hadhbhydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit0.017
Capza2capping protein (actin filament) muscle Z-line, alpha 20.017
Gfm1G elongation factor, mitochondrial 10.016
Sod2superoxide dismutase 2, mitochondrial0.016
Got1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.016
Ccng1cyclin G10.015
RGD1310686similar to chromosome 16 open reading frame 50.015
Pfkmphosphofructokinase, muscle0.015
Slc16a1solute carrier family 16, member 1 (monocarboxylic acid transporter 1)0.014
Rab18RAB18, member RAS oncogene family0.014
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.013
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.013
Cdadc1cytidine and dCMP deaminase domain containing 10.012
Oxct13-oxoacid CoA transferase 10.012
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.011
Hibadh3-hydroxyisobutyrate dehydrogenase0.010
Etfaelectron-transfer-flavoprotein, alpha polypeptide0.010
Etfdhelectron-transferring-flavoprotein dehydrogenase0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
LAT1Lat1p0.535
PDB1Pdb1p0.297
CYM1Cym1p0.109
LPD1Lpd1p0.044
PDA1Pda1p0.043
DUG1Dug1p0.018
LEU2Leu2p0.015
SRD1Srd1p0.014
YLR162Whypothetical protein0.012
YOL038C-Ahypothetical protein0.012
SPL2Spl2p0.011
ARP10Arp10p0.011
MER1Mer1p0.011
YLR264C-Ahypothetical protein0.011