The network for 'positive regulation of inflammatory response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

NameDescriptionProbabilityFunc Analog Organism
Ptgs2prostaglandin-endoperoxide synthase 20.996
Ccl2chemokine (C-C motif) ligand 20.987
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.970
Ccr1chemokine (C-C motif) receptor 10.967
Stat3signal transducer and activator of transcription 30.957
Il1r1interleukin 1 receptor, type I0.955
Lyz2lysozyme 20.924
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.902
Cd40CD40 antigen0.897
Il1binterleukin 1 beta0.896
Tlr4toll-like receptor 40.893
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.888
Tnftumor necrosis factor0.887
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.853
Icosinducible T-cell co-stimulator0.839
Ccr2chemokine (C-C motif) receptor 20.838
Ccl12chemokine (C-C motif) ligand 120.800
Il1rl1interleukin 1 receptor-like 10.793
Il4rainterleukin 4 receptor, alpha0.787
Clec4dC-type lectin domain family 4, member d0.771
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.766
C3complement component 30.755
Il6interleukin 60.750
Cd7CD7 antigen0.744
Selpselectin, platelet0.733
S100a8S100 calcium binding protein A8 (calgranulin A)0.733
Pdcd1programmed cell death 10.729
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.725
FaslFas ligand (TNF superfamily, member 6)0.722
Il4interleukin 40.718
Apoeapolipoprotein E0.716
Il18rapinterleukin 18 receptor accessory protein0.690
Prdm1PR domain containing 1, with ZNF domain0.684
Ifnginterferon gamma0.672
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.669
Fcgr2bFc receptor, IgG, low affinity IIb0.654
Ccl3chemokine (C-C motif) ligand 30.646
Nos3nitric oxide synthase 3, endothelial cell0.642
S100a9S100 calcium binding protein A9 (calgranulin B)0.630
Cxcl13chemokine (C-X-C motif) ligand 130.628
FasFas (TNF receptor superfamily member 6)0.575
Ccl7chemokine (C-C motif) ligand 70.572
Il18r1interleukin 18 receptor 10.567
Ldb3LIM domain binding 30.560
Traf3ip2TRAF3 interacting protein 20.555
Cd14CD14 antigen0.552
C3ar1complement component 3a receptor 10.532
TyrobpTYRO protein tyrosine kinase binding protein0.520
Stat5bsignal transducer and activator of transcription 5B0.516
Osmroncostatin M receptor0.496
Myd88myeloid differentiation primary response gene 880.491
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.490
Klrk1killer cell lectin-like receptor subfamily K, member 10.472
Cd44CD44 antigen0.462
Cxcl2chemokine (C-X-C motif) ligand 20.459
C1qccomplement component 1, q subcomponent, C chain0.455
C1qacomplement component 1, q subcomponent, alpha polypeptide0.452
C1qbcomplement component 1, q subcomponent, beta polypeptide0.451
Ccl4chemokine (C-C motif) ligand 40.450
Tnfaip3tumor necrosis factor, alpha-induced protein 30.447
Mmp12matrix metallopeptidase 120.443
Csf1colony stimulating factor 1 (macrophage)0.434
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.413
Arntlaryl hydrocarbon receptor nuclear translocator-like0.403
Gzmkgranzyme K0.396
Ccl17chemokine (C-C motif) ligand 170.395
Folr2folate receptor 2 (fetal)0.383
Gpr132G protein-coupled receptor 1320.380
Plauplasminogen activator, urokinase0.375
Klrg1killer cell lectin-like receptor subfamily G, member 10.375
Ltalymphotoxin A0.370
Spp1secreted phosphoprotein 10.363
Socs1suppressor of cytokine signaling 10.357
Ccr6chemokine (C-C motif) receptor 60.357
Ch25hcholesterol 25-hydroxylase0.354
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.349
Ccl8chemokine (C-C motif) ligand 80.341
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.338
C5ar1complement component 5a receptor 10.337
Ccl22chemokine (C-C motif) ligand 220.334
Nos2nitric oxide synthase 2, inducible0.332
Casp4caspase 4, apoptosis-related cysteine peptidase0.330
Cd96CD96 antigen0.328
Mmp8matrix metallopeptidase 80.323
Map3k14mitogen-activated protein kinase kinase kinase 140.321
Batfbasic leucine zipper transcription factor, ATF-like0.314
Klra9killer cell lectin-like receptor subfamily A, member 90.300
Cd5CD5 antigen0.291
Ccr7chemokine (C-C motif) receptor 70.289
BlkB lymphoid kinase0.288
Il2rbinterleukin 2 receptor, beta chain0.280
Platplasminogen activator, tissue0.276
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.274
Clec4eC-type lectin domain family 4, member e0.271
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.266
Sh2d2aSH2 domain protein 2A0.260
Ccr3chemokine (C-C motif) receptor 30.259
Il10interleukin 100.255
Tnfsf8tumor necrosis factor (ligand) superfamily, member 80.255
Ccr5chemokine (C-C motif) receptor 50.251
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
il1binterleukin 1, beta and interleukin 1, beta0.645
tlr9toll-like receptor 90.372
stc1lstanniocalcin 1, like0.366
ptger2aprostaglandin E receptor 2a (subtype EP2)0.344
tnfatumor necrosis factor a (TNF superfamily, member 2)0.330
fasFas (TNF receptor superfamily, member 6)0.303
mmp13amatrix metalloproteinase 13a0.296
il8interleukin 80.279
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.257
irf8interferon regulatory factor 80.224
mpxmyeloid-specific peroxidase0.177
gcm2glial cells missing homolog 2 (Drosophila)0.175
cygb2cytoglobin 20.168
fabp11afatty acid binding protein 11a0.137
LOC557072caspase recruitment domain-containing protein 11-like0.133
crhcorticotropin releasing hormone0.114
hspb6heat shock protein, alpha-crystallin-related, b60.114
mstnamyostatin a0.110
ncf1neutrophil cytosolic factor 10.107
ctsl1acathepsin L, 1 a0.104
ccr6achemokine (C-C motif) receptor 6a0.100
hspb9heat shock protein, alpha-crystallin-related, 90.098
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.097
LOC553366hypothetical protein LOC5533660.092
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.084
egfraepidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)0.081
cry1acryptochrome 1a0.081
fabp7bfatty acid binding protein 7, brain, b0.079
ccrl1achemokine (C-C motif) receptor-like 1a0.079
ppargperoxisome proliferator activated receptor gamma0.079
pou1f1POU domain, class 1, transcription factor 10.076
grk7aG-protein-coupled receptor kinase 7a0.075
tectbtectorin beta0.072
hcrthypocretin (orexin) neuropeptide precursor0.072
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.070
itm2bbintegral membrane protein 2Bb0.069
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.067
s1pr3sphingosine-1-phosphate receptor 30.067
gpr182G protein-coupled receptor 1820.066
acp5bacid phosphatase 5b, tartrate resistant0.065
dab1adisabled homolog 1a (Drosophila)0.065
sla1Src-like-adaptor 10.064
vegfabvascular endothelial growth factor Ab0.059
plxnb2aplexin b2a0.058
ccr12.2chemokine (C-C motif) receptor 12.20.057
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.057
mmp9matrix metalloproteinase 90.056
dao.2D-amino-acid oxidase 20.055
apoebapolipoprotein Eb0.054
alpalkaline phosphatase0.052
tnfsf18tumor necrosis factor (ligand) superfamily, member 180.052
hspb11heat shock protein, alpha-crystallin-related, b110.050
cald1caldesmon 10.049
ripk2receptor-interacting serine-threonine kinase 20.049
atoh1catonal homolog 1c0.049
per2period homolog 2 (Drosophila)0.048
ptgesprostaglandin E synthase0.048
crfb17cytokine receptor family member B170.047
olig1oligodendrocyte lineage transcription factor 10.046
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.046
samsn1aSAM domain, SH3 domain and nuclear localisation signals, 1a0.045
retsatlretinol saturase (all-trans-retinol 13,14-reductase) like0.044
timp2btissue inhibitor of metalloproteinase 2b0.044
chst11carbohydrate (chondroitin 4) sulfotransferase 110.043
lta4hleukotriene A4 hydrolase0.043
mfap4microfibrillar-associated protein 40.043
rtn4rreticulon 4 receptor0.043
coro1acoronin, actin binding protein, 1A0.043
mep1a.2meprin A, alpha.20.042
rhagRhesus blood group-associated glycoprotein0.042
thtyrosine hydroxylase0.042
LOC100151215phosphodiesterase 7A-like0.040
mpp1membrane protein, palmitoylated 10.039
cdkn1acyclin-dependent kinase inhibitor 1A0.039
ifng1-2interferon, gamma 1-20.039
slc15a1bsolute carrier family 15 (oligopeptide transporter), member 1b0.038
igfbp1ainsulin-like growth factor binding protein 1a0.038
faslgFas ligand (TNF superfamily, member 6)0.038
slc9a3.2solute carrier family 9 (sodium/hydrogen exchanger), member 3.20.038
cybacytochrome b-245, alpha polypeptide0.038
polbpolymerase (DNA directed), beta0.038
cspg4chondroitin sulfate proteoglycan 40.037
zp3a.2zona pellucida glycoprotein 3a.20.037
spry2sprouty homolog 20.037
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.037
adora2aaadenosine A2a receptor a0.036
chrm5acholinergic receptor, muscarinic 5a0.036
grnagranulin a0.035
rtn4rl2areticulon 4 receptor-like 2 a0.035
tlr3toll-like receptor 30.034
runx2arunt-related transcription factor 2a0.033
c1qbcomplement component 1, q subcomponent, B chain0.033
pdgfbplatelet derived growth factor, B polypeptide0.032
ptrfbpolymerase I and transcript release factor b0.032
cecr1acat eye syndrome chromosome region, candidate 1a0.032
sat1aspermidine/spermine N1-acetyltransferase 1a0.032
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
S100BS100 calcium binding protein B0.935
S100A9S100 calcium binding protein A90.692
S100A8S100 calcium binding protein A80.493
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.482
S100A1S100 calcium binding protein A10.441
SYKspleen tyrosine kinase0.395
PLAURplasminogen activator, urokinase receptor0.360
PTPN1protein tyrosine phosphatase, non-receptor type 10.340
IL8interleukin 80.254
S100A6S100 calcium binding protein A60.250
CCR5chemokine (C-C motif) receptor 50.160
S100A4S100 calcium binding protein A40.128
CXCL2chemokine (C-X-C motif) ligand 20.125
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.088
PLAUplasminogen activator, urokinase0.086
IL1Binterleukin 1, beta0.074
CD163CD163 molecule0.068
ESR1estrogen receptor 10.060
ANXA2annexin A20.055
S100A14S100 calcium binding protein A140.054
INSRinsulin receptor0.049
CCL2chemokine (C-C motif) ligand 20.047
CXCL3chemokine (C-X-C motif) ligand 30.039
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.035
IDEinsulin-degrading enzyme0.034
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.033
NCF4neutrophil cytosolic factor 4, 40kDa0.032
CCL4chemokine (C-C motif) ligand 40.031
PLATplasminogen activator, tissue0.030
LY96lymphocyte antigen 960.029
TLR2toll-like receptor 20.028
CCR1chemokine (C-C motif) receptor 10.027
TNFtumor necrosis factor0.026
TRADDTNFRSF1A-associated via death domain0.025
RPS28ribosomal protein S280.024
C3complement component 30.023
TNFAIP3tumor necrosis factor, alpha-induced protein 30.022
MDM2Mdm2 p53 binding protein homolog (mouse)0.022
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.022
IL6interleukin 6 (interferon, beta 2)0.022
RPS12ribosomal protein S120.020
MYD88myeloid differentiation primary response gene (88)0.020
CFHcomplement factor H0.019
S100A11S100 calcium binding protein A110.018
IL6Rinterleukin 6 receptor0.018
IL1R1interleukin 1 receptor, type I0.017
GRAP2GRB2-related adaptor protein 20.017
S100PS100 calcium binding protein P0.017
METmet proto-oncogene (hepatocyte growth factor receptor)0.016
TNFAIP6tumor necrosis factor, alpha-induced protein 60.016
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.016
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.016
LGALS3lectin, galactoside-binding, soluble, 30.015
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.015
TLR1toll-like receptor 10.015
ICAM1intercellular adhesion molecule 10.014
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.013
TICAM2toll-like receptor adaptor molecule 20.013
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.013
CLEC7AC-type lectin domain family 7, member A0.013
CXCL10chemokine (C-X-C motif) ligand 100.013
CCL20chemokine (C-C motif) ligand 200.012
TRAF1TNF receptor-associated factor 10.012
RNASE6ribonuclease, RNase A family, k60.012
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.011
AGERadvanced glycosylation end product-specific receptor0.011
FN1fibronectin 10.011
MAGEB18melanoma antigen family B, 180.011
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.011
TIMP1TIMP metallopeptidase inhibitor 10.011
NCF2neutrophil cytosolic factor 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd14CD14 molecule0.481
Il1binterleukin 1 beta0.234
Ccl2chemokine (C-C motif) ligand 20.180
Gzmkgranzyme K0.085
Il6interleukin 60.083
Gzmbgranzyme B0.082
Ccl3chemokine (C-C motif) ligand 30.079
Cd86CD86 molecule0.078
Ccr1chemokine (C-C motif) receptor 10.071
Slco2b1solute carrier organic anion transporter family, member 2b10.068
Cd44Cd44 molecule0.065
Folr2folate receptor 2 (fetal)0.058
Ptafrplatelet-activating factor receptor0.054
Icam1intercellular adhesion molecule 10.050
Mmp10matrix metallopeptidase 100.049
Flt1FMS-related tyrosine kinase 10.044
Ccl5chemokine (C-C motif) ligand 50.043
S1pr2sphingosine-1-phosphate receptor 20.041
Il1r1interleukin 1 receptor, type I0.040
Ccl4chemokine (C-C motif) ligand 40.038
Calcrlcalcitonin receptor-like0.037
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.036
Socs5suppressor of cytokine signaling 50.035
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.035
C5ar1complement component 5a receptor 10.034
Igsf6immunoglobulin superfamily, member 60.034
Stfa2l3stefin A2-like 30.033
Cd4Cd4 molecule0.032
Il1ainterleukin 1 alpha0.032
Tmem163transmembrane protein 1630.032
Cxcl2chemokine (C-X-C motif) ligand 20.032
Socs3suppressor of cytokine signaling 30.031
Fosl1fos-like antigen 10.031
Ednraendothelin receptor type A0.031
Sellselectin L0.030
Il4interleukin 40.030
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.030
Pla1aphospholipase A1 member A0.030
Lst1leukocyte specific transcript 10.029
Calcrcalcitonin receptor0.028
Il1rl1interleukin 1 receptor-like 10.027
Tgm1transglutaminase 1, K polypeptide0.027
Klrd1killer cell lectin-like receptor, subfamily D, member 10.027
Cd38CD38 molecule0.026
Angpt4angiopoietin 40.026
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.023
P2rx5purinergic receptor P2X, ligand-gated ion channel, 50.023
F13a1coagulation factor XIII, A1 polypeptide0.023
Tlr7toll-like receptor 70.023
Cxcl10chemokine (C-X-C motif) ligand 100.023
Plaurplasminogen activator, urokinase receptor0.023
Loxlysyl oxidase0.022
Olfml2bolfactomedin-like 2B0.022
Prm2protamine 20.022
C1qtnf3C1q and tumor necrosis factor related protein 30.022
Prf1perforin 1 (pore forming protein)0.022
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.021
Cgm4carcinoembryonic antigen gene family 40.021
Inmtindolethylamine N-methyltransferase0.021
Hes2hairy and enhancer of split 2 (Drosophila)0.021
Ccl7chemokine (C-C motif) ligand 70.021
Pax6paired box 60.021
Ptger2prostaglandin E receptor 2 (subtype EP2)0.021
Pebp1phosphatidylethanolamine binding protein 10.021
Rab32RAB32, member RAS oncogene family0.020
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.020
Ccdc102acoiled-coil domain containing 102A0.020
Cxcl3chemokine (C-X-C motif) ligand 30.020
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.020
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.020
Prl7a3prolactin family 7, subfamily a, member 30.020
Cd80Cd80 molecule0.020
Egfl7EGF-like-domain, multiple 70.020
Myh9myosin, heavy chain 9, non-muscle0.020
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.020
Anpepalanyl (membrane) aminopeptidase0.020
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.020
Il2rbinterleukin 2 receptor, beta0.019
Hpgdshematopoietic prostaglandin D synthase0.019
Neurl3neuralized homolog 3 (Drosophila)0.019
Leprleptin receptor0.019
Plauplasminogen activator, urokinase0.019
Ciitaclass II, major histocompatibility complex, transactivator0.019
Metmet proto-oncogene0.018
Il8rbinterleukin 8 receptor, beta0.018
Timp1TIMP metallopeptidase inhibitor 10.018
Casp12caspase 120.018
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.018
Ccr5chemokine (C-C motif) receptor 50.018
Fgf7fibroblast growth factor 70.018
Adora2aadenosine A2a receptor0.018
Tfectranscription factor EC0.018
Mrc1mannose receptor, C type 10.018
Ier3immediate early response 30.018
Ednrbendothelin receptor type B0.017
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism