The network for 'myeloid cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

myeloid cell differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.

NameDescriptionProbabilityFunc Analog Organism
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Csf1colony stimulating factor 1 (macrophage)1.000
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.999
Notch1Notch gene homolog 1 (Drosophila)0.999
FosFBJ osteosarcoma oncogene0.999
Ctnnb1catenin (cadherin associated protein), beta 10.998
Eporerythropoietin receptor0.997
Ptenphosphatase and tensin homolog0.995
Slc4a1solute carrier family 4 (anion exchanger), member 10.994
JunJun oncogene0.993
Gata1GATA binding protein 10.990
Spna1spectrin alpha 10.990
Hoxa5homeobox A50.988
Notch2Notch gene homolog 2 (Drosophila)0.988
Stat3signal transducer and activator of transcription 30.987
Sfpi1SFFV proviral integration 10.986
Ikzf1IKAROS family zinc finger 10.986
Hbb-b1hemoglobin, beta adult major chain0.986
Ank1ankyrin 1, erythroid0.985
Cd40CD40 antigen0.984
Runx1runt related transcription factor 10.984
Tal1T-cell acute lymphocytic leukemia 10.983
Map3k14mitogen-activated protein kinase kinase kinase 140.982
Zfp36zinc finger protein 360.977
Pbx1pre B-cell leukemia transcription factor 10.976
Gata4GATA binding protein 40.976
Tnftumor necrosis factor0.975
Lyz2lysozyme 20.974
Ptpn11protein tyrosine phosphatase, non-receptor type 110.973
Smad3MAD homolog 3 (Drosophila)0.972
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.966
Runx2runt related transcription factor 20.962
Fgfr2fibroblast growth factor receptor 20.959
Robo1roundabout homolog 1 (Drosophila)0.959
Ascl1achaete-scute complex homolog 1 (Drosophila)0.958
Hes1hairy and enhancer of split 1 (Drosophila)0.954
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.952
Arandrogen receptor0.950
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.949
Smad1MAD homolog 1 (Drosophila)0.940
Nos3nitric oxide synthase 3, endothelial cell0.940
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.939
Ifnginterferon gamma0.938
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.938
Ccr5chemokine (C-C motif) receptor 50.936
Pax6paired box gene 60.927
JunbJun-B oncogene0.926
Klf1Kruppel-like factor 1 (erythroid)0.923
Klrk1killer cell lectin-like receptor subfamily K, member 10.913
Rb1retinoblastoma 10.912
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.908
Hoxa10homeobox A100.906
Rspo2R-spondin 2 homolog (Xenopus laevis)0.906
Smad4MAD homolog 4 (Drosophila)0.904
Hoxb5homeobox B50.904
Chukconserved helix-loop-helix ubiquitous kinase0.903
Shc1src homology 2 domain-containing transforming protein C10.901
Nr5a1nuclear receptor subfamily 5, group A, member 10.899
Prlrprolactin receptor0.890
Trp53transformation related protein 530.883
Flt4FMS-like tyrosine kinase 40.883
CblCasitas B-lineage lymphoma0.883
Acvrl1activin A receptor, type II-like 10.878
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.877
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.875
Il2rbinterleukin 2 receptor, beta chain0.875
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.873
Kiss1KiSS-1 metastasis-suppressor0.871
Creb1cAMP responsive element binding protein 10.867
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.865
Pax8paired box gene 80.865
Neurod1neurogenic differentiation 10.864
Ptf1apancreas specific transcription factor, 1a0.862
Kitkit oncogene0.859
Dll1delta-like 1 (Drosophila)0.857
Rxraretinoid X receptor alpha0.854
Prkceprotein kinase C, epsilon0.854
Acvr1activin A receptor, type 10.854
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.853
Il4interleukin 40.846
Ephb2Eph receptor B20.846
Egr1early growth response 10.842
Socs1suppressor of cytokine signaling 10.836
Tcf21transcription factor 210.833
Hoxc4homeobox C40.831
Ncoa3nuclear receptor coactivator 30.830
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.828
Spnb1spectrin beta 10.826
Snai1snail homolog 1 (Drosophila)0.822
CrebbpCREB binding protein0.821
Hbb-b2hemoglobin, beta adult minor chain0.820
Tgfb2transforming growth factor, beta 20.819
BtkBruton agammaglobulinemia tyrosine kinase0.818
Isl1ISL1 transcription factor, LIM/homeodomain0.818
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.817
Mapk14mitogen-activated protein kinase 140.817
Ccr7chemokine (C-C motif) receptor 70.813
Itgalintegrin alpha L0.813
Myod1myogenic differentiation 10.809
Prkcdprotein kinase C, delta0.806
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hbbe1.1hemoglobin beta embryonic-1.10.988
gata6GATA-binding protein 60.980
tfr1atransferrin receptor 1a0.934
LOC566708FL cytokine receptor-like0.924
alas2aminolevulinate, delta-, synthetase 20.909
pax2apaired box gene 2a0.854
hbae3hemoglobin alpha embryonic-30.835
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.821
cmybtranscription factor cmyb0.818
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.810
mycamyelocytomatosis oncogene a0.804
hbbe3hemoglobin beta embryonic-30.785
runx1runt-related transcription factor 10.764
slc4a1asolute carrier family 4, anion exchanger, member 1a0.741
hdrhematopoietic death receptor0.741
gata1aGATA binding protein 1a0.739
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.729
kitakit receptor a0.714
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.693
plcg1phospholipase C, gamma 10.685
wnt5bwingless-type MMTV integration site family, member 5b0.675
etv2ets variant gene 20.670
fn1fibronectin 10.639
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.633
hhexhematopoietically expressed homeobox0.623
eporerythropoietin receptor0.619
spns2spinster homolog 2 (Drosophila)0.602
notch3notch homolog 30.591
lmo2LIM domain only 2 (rhombotin-like 1)0.591
hand2heart and neural crest derivatives expressed transcript 20.579
cahzcarbonic anhydrase0.578
elk4ELK4, ETS-domain protein0.546
gata3GATA-binding protein 30.541
fli1afriend leukemia integration 1a0.535
fgf10afibroblast growth factor 10a0.533
klf4Kruppel-like factor 40.528
hoxc6ahomeo box C6a0.511
hoxd4ahomeo box D4a0.495
tbx5aT-box 5a0.493
f2rcoagulation factor II (thrombin) receptor0.489
pdcd2programmed cell death 20.486
hbae1hemoglobin alpha embryonic-10.476
gfi1.1growth factor independent 1.10.476
sox7SRY-box containing gene 70.455
gdf6agrowth differentiation factor 6a0.447
sulf1sulfatase 10.441
metap2methionyl aminopeptidase 20.441
rpl11ribosomal protein L110.434
tbx1T-box 10.428
hmbsbhydroxymethylbilane synthase, b0.416
wnt7bawingless-type MMTV integration site family, member 7Ba0.414
ntlano tail a0.404
gata5GATA-binding protein 50.401
cdx4caudal type homeo box transcription factor 40.400
tal1T-cell acute lymphocytic leukemia 10.389
klf2aKruppel-like factor 2a0.378
ikzf1IKAROS family zinc finger 1 (Ikaros)0.378
wnt2bbwingless-type MMTV integration site family, member 2Bb0.370
trpv6transient receptor potential cation channel, subfamily V, member 60.370
znfl2azinc finger-like gene 2a0.363
bmp4bone morphogenetic protein 40.358
cpoxcoproporphyrinogen oxidase0.354
tshz1teashirt family zinc finger 10.344
ppoxprotoporphyrinogen oxidase0.341
aldh1l1aldehyde dehydrogenase 1 family, member L10.336
hoxc8ahomeo box C8a0.332
mpxmyeloid-specific peroxidase0.331
hbaa1hemoglobin alpha adult-10.325
fzd5frizzled homolog 50.301
nod1nucleotide-binding oligomerization domain containing 10.299
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.297
igfbp3insulin-like growth factor binding protein 30.281
csf1racolony stimulating factor 1 receptor, a0.280
znf703zinc finger protein 7030.279
per3period homolog 3 (Drosophila)0.277
wnt8bwingless-type MMTV integration site family, member 8b0.267
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.266
nf1aneurofibromin 1a0.264
tlr3toll-like receptor 30.261
uroduroporphyrinogen decarboxylase0.261
dusp5dual specificity phosphatase 50.259
etfaelectron-transfer-flavoprotein, alpha polypeptide0.248
tmem14ctransmembrane protein 14C0.245
rhagRhesus blood group-associated glycoprotein0.245
socs3asuppressor of cytokine signaling 3a0.234
kdrlkinase insert domain receptor like0.232
foxp1bforkhead box P1b0.232
atoh1batonal homolog 1b0.230
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.225
eomesaeomesodermin homolog a0.223
acvr2bactivin receptor IIb0.222
hoxa13bhomeo box A13b0.216
hmgb2bhigh-mobility group box 2b0.215
alcamaactivated leukocyte cell adhesion molecule a0.214
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
NCOR2nuclear receptor corepressor 20.999
JUNjun proto-oncogene0.999
MDM2Mdm2 p53 binding protein homolog (mouse)0.999
ESR1estrogen receptor 10.998
SMAD2SMAD family member 20.996
ARandrogen receptor0.993
CREBBPCREB binding protein0.992
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.989
GRB2growth factor receptor-bound protein 20.988
TRAF1TNF receptor-associated factor 10.983
PTPN11protein tyrosine phosphatase, non-receptor type 110.980
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.978
SMAD3SMAD family member 30.977
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.972
ZNF43zinc finger protein 430.964
UBCubiquitin C0.957
PTPN1protein tyrosine phosphatase, non-receptor type 10.948
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.941
CCR5chemokine (C-C motif) receptor 50.940
RUNX1runt-related transcription factor 10.935
NOTCH1notch 10.934
ATF3activating transcription factor 30.933
C1QAcomplement component 1, q subcomponent, A chain0.930
IL8interleukin 80.923
EP300E1A binding protein p3000.920
CASP8caspase 8, apoptosis-related cysteine peptidase0.915
DDIT3DNA-damage-inducible transcript 30.906
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.902
PBX1pre-B-cell leukemia homeobox 10.902
FASFas (TNF receptor superfamily, member 6)0.900
TP53tumor protein p530.899
JUNBjun B proto-oncogene0.897
TRAF5TNF receptor-associated factor 50.896
HDAC3histone deacetylase 30.890
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.887
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.885
TAL1T-cell acute lymphocytic leukemia 10.885
TRAF2TNF receptor-associated factor 20.876
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.867
BCAR1breast cancer anti-estrogen resistance 10.867
RIPK2receptor-interacting serine-threonine kinase 20.858
HNF4Ahepatocyte nuclear factor 4, alpha0.858
CAV1caveolin 1, caveolae protein, 22kDa0.850
PTPN6protein tyrosine phosphatase, non-receptor type 60.848
SH2D4ASH2 domain containing 4A0.842
XIAPX-linked inhibitor of apoptosis0.839
KLF4Kruppel-like factor 4 (gut)0.838
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.836
JAG1jagged 10.835
SMAD1SMAD family member 10.830
BMP2bone morphogenetic protein 20.828
CXCL9chemokine (C-X-C motif) ligand 90.828
RARAretinoic acid receptor, alpha0.826
HIST1H2AJhistone cluster 1, H2aj0.816
HIST1H2BGhistone cluster 1, H2bg0.815
EGFRepidermal growth factor receptor0.812
NFE2L2nuclear factor (erythroid-derived 2)-like 20.810
CXCL2chemokine (C-X-C motif) ligand 20.798
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.793
SHC1SHC (Src homology 2 domain containing) transforming protein 10.792
CCL5chemokine (C-C motif) ligand 50.787
SP1Sp1 transcription factor0.778
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.758
NRP1neuropilin 10.748
REREarginine-glutamic acid dipeptide (RE) repeats0.743
RXRAretinoid X receptor, alpha0.740
ZNF253zinc finger protein 2530.736
CXCL3chemokine (C-X-C motif) ligand 30.725
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.723
CASP10caspase 10, apoptosis-related cysteine peptidase0.716
HIST1H2BFhistone cluster 1, H2bf0.713
ANXA1annexin A10.701
BIRC3baculoviral IAP repeat containing 30.690
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.686
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.685
WASLWiskott-Aldrich syndrome-like0.681
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.675
DAXXdeath-domain associated protein0.668
CXCL10chemokine (C-X-C motif) ligand 100.664
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.657
CCL4chemokine (C-C motif) ligand 40.655
CD40CD40 molecule, TNF receptor superfamily member 50.653
GATA1GATA binding protein 1 (globin transcription factor 1)0.650
CCR1chemokine (C-C motif) receptor 10.645
SOS1son of sevenless homolog 1 (Drosophila)0.640
BIRC2baculoviral IAP repeat containing 20.637
ZNF273zinc finger protein 2730.635
MEIS1Meis homeobox 10.631
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.630
IL6interleukin 6 (interferon, beta 2)0.601
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.600
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.598
FASLGFas ligand (TNF superfamily, member 6)0.596
NCOA2nuclear receptor coactivator 20.584
GRB10growth factor receptor-bound protein 100.576
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.574
SETD8SET domain containing (lysine methyltransferase) 80.573
HBBhemoglobin, beta0.571
DUSP1dual specificity phosphatase 10.571
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100134871beta globin minor gene0.444
Jak1Janus kinase 10.367
Alas2aminolevulinate, delta-, synthase 20.196
Tgfbr3transforming growth factor, beta receptor III0.091
Klf4Kruppel-like factor 4 (gut)0.083
Ptprcprotein tyrosine phosphatase, receptor type, C0.078
Errfi1ERBB receptor feedback inhibitor 10.075
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.075
Slco2b1solute carrier organic anion transporter family, member 2b10.072
Fgfr1Fibroblast growth factor receptor 10.069
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.064
Dusp1dual specificity phosphatase 10.057
Mylk2myosin light chain kinase 20.056
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.056
Stat4signal transducer and activator of transcription 40.052
Sirpasignal-regulatory protein alpha0.052
Il8rbinterleukin 8 receptor, beta0.051
Arrb1arrestin, beta 10.043
Lypd3Ly6/Plaur domain containing 30.043
Mycmyelocytomatosis oncogene0.043
Cd4Cd4 molecule0.043
Nfyanuclear transcription factor-Y alpha0.041
Nr5a2nuclear receptor subfamily 5, group A, member 20.040
Adora2aadenosine A2a receptor0.039
Smad7SMAD family member 70.038
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.038
Tnftumor necrosis factor (TNF superfamily, member 2)0.038
Bcl2B-cell CLL/lymphoma 20.038
Smad1SMAD family member 10.038
Cfpcomplement factor properdin0.038
Plxnd1plexin D10.033
Foxs1forkhead box S10.032
Gja3gap junction protein, alpha 30.032
Klf6Kruppel-like factor 60.032
Stk3serine/threonine kinase 3 (STE20 homolog, yeast)0.031
Hckhemopoietic cell kinase0.031
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.030
Gucy2dguanylate cyclase 2d0.030
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.030
Bmp6bone morphogenetic protein 60.029
Gpihbp1glycosylphosphatidylinositol anchored high density lipoprotein binding protein 10.029
Hoxc4homeo box C40.029
Ccl5chemokine (C-C motif) ligand 50.029
Casp3caspase 30.028
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.028
Il1r1interleukin 1 receptor, type I0.028
Adam17ADAM metallopeptidase domain 170.027
Flt4fms-related tyrosine kinase 40.027
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.026
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.026
Prrx1paired related homeobox 10.026
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.025
Prf1perforin 1 (pore forming protein)0.024
Prl8a7prolactin family 8, subfamily a, member 70.024
TcrbT-cell receptor beta chain0.024
Ccl4chemokine (C-C motif) ligand 40.024
Ppp1r9bprotein phosphatase 1, regulatory subunit 9B0.024
Il1rninterleukin 1 receptor antagonist0.023
Gdf10growth differentiation factor 100.023
Man2b1mannosidase, alpha, class 2B, member 10.023
Mrc1mannose receptor, C type 10.023
Ptger4prostaglandin E receptor 4 (subtype EP4)0.023
Map4k1mitogen activated protein kinase kinase kinase kinase 10.023
Cd3gCD3 molecule, gamma0.023
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.023
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.022
Il1binterleukin 1 beta0.022
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.022
Fosl2fos-like antigen 20.022
B3gnt7UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 70.022
Psgb1pregnancy-specific beta 1-glycoprotein0.022
Ccl3chemokine (C-C motif) ligand 30.021
Il7interleukin 70.021
LOC687711similar to small nuclear ribonucleoprotein D30.021
Rassf5Ras association (RalGDS/AF-6) domain family member 50.021
Jak2Janus kinase 20.021
Dnase1l3deoxyribonuclease 1-like 30.021
Arntaryl hydrocarbon receptor nuclear translocator0.020
Lrrc17leucine rich repeat containing 170.020
Polr2gpolymerase (RNA) II (DNA directed) polypeptide G0.020
Gzmkgranzyme K0.020
Dcaf17DDB1 and CUL4 associated factor 170.020
Apoa1apolipoprotein A-I0.020
Sp1Sp1 transcription factor0.020
Mark2MAP/microtubule affinity-regulating kinase 20.019
Grm5glutamate receptor, metabotropic 50.019
Fcn1ficolin (collagen/fibrinogen domain containing) 10.019
Ppyr1pancreatic polypeptide receptor 10.019
Nrg2neuregulin 20.019
Zfp36zinc finger protein 360.019
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.019
Hspa1aheat shock 70kD protein 1A0.019
Dckdeoxycytidine kinase0.019
Igfbp5insulin-like growth factor binding protein 50.019
Fgf18fibroblast growth factor 180.018
Cckarcholecystokinin A receptor0.018
Pde3aphosphodiesterase 3A, cGMP inhibited0.018
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.018
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism